Clinical trials: Vancomycin Resistance
Coronary Artery Disease
Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft
Sternal or mediastinal infections after heart operation occurs infrequently but carries a high cost in money, morbidity, and mortality.
- Trial name
- NCT00711685
- Testing
- coronary artery bypass grafting via midline sternotomy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Far Eastern Memorial Hospital
Staphylococcal Infections, Meningitis
Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections
Methicillin-resistant Staphylococcus aureus (SA) is a major pathogen causing mainly health-care associated infections and, lately, also community acquired infections. Few treatment choices exist to treat these infections.
- Conditions
- Staphylococcal Infections, Meningitis, Sepsis, Pneumonia
- Trial name
- NCT00427076
- Testing
- Cotrimoxazole, Vancomycin
- Where
- 2 sites in Israel
- Volunteers
- 252 people
- Sponsor
- Rabin Medical Center
Staphylococcal Skin Infection
Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus
Study 0017 compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections.
- Trial name
- ATLAS1 (NCT00091819)
- Testing
- Telavancin, Vancomycin
- Where
- United States
- Volunteers
- 862 people
- Sponsor
- Cumberland Pharmaceuticals
MRSA - Methicillin Resistant Staphylococcus Aureus Infection
Prospective Evaluation of a Vancomycin Nomogram With a Continuous Infusion of Vancomycin for Surgical ICU Patients
Vancomycin is an essential antimicrobial which is frequently used in the ICU for suspected methicillin-resistant Staphylococcus aureus (MRSA) infection.
- Trial name
- CIV (NCT01786161)
- Testing
- Vancomycin continuous infusion, Vancomycin intermittent dosing interval
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Methicillin-resistant Staphylococcal Infections
Comparison of Two Dosage Adjustment Strategies of Vancomycin in Children
Vancomycin is the standard first-line treatment for MRSA infections and a first-line empiric therapy. The relationship between exposure to vancomycin and efficacy is admitted but because of an important intersubject variability…
- Trial name
- OPTIBAYE (NCT02694458)
- Testing
- Early vancomycin monitoring and bayesian dosage adjustment, usual vancomycin dose and monitoring strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multidrug-resistant Bacteria Screening
Carbapenemase-Producing Organism and Vancomycin-Resistant Enterococcus Management
Emergence of vancomycin-resistant enterococci (VRE) and carbapenemase-producing enterobacteria (CPE) is nowadays a major public health concern worldwide.
- Trial name
- CPO-VRE (NCT05200546)
- Testing
- molecular assays to screen for eXDR
- Where
- France
- Volunteers
- 3,921 people
- Sponsor
- University Hospital, Grenoble
Methicillin-resistant Staphylococcus Aureus Septicemia
The Most Appropriate Parameter Correlates With Clinical Effectiveness of Vancomycin: Trough Drug Concentration or Area Under Curve (AUC)/Minimum Inhibitory Concentration (MIC)?
The purpose of this study is to evaluate which is the most appropriate parameter correlates with clinical effectiveness of vancomycin: trough drug level or AUC/MIC.
- Trial name
- NCT01995760
- Where
- Taiwan
- Volunteers
- 123 people
- Sponsor
- National Taiwan University Hospital
Crohn Disease, Ulcerative Colitis
Safety and Efficacy of Fecal Microbiota Transplantation
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated in a number of disease…
- Conditions
- Crohn Disease, Ulcerative Colitis, Celiac Disease, Irritable Bowel Syndrome
- Trial name
- NCT04014413
- Testing
- Fecal Microbiota Transplantation
- Where
- Hong Kong
- Volunteers
- 450 people
- Sponsor
- Chinese University of Hong Kong
GI Colonization of Vancomycin-resistant Enterococcus
The Influence of Probiotics on Vancomycin-Resistant Enterococcus
Drinking probiotics in a the form of a yogurt drink will restore normal gastrointestinal (GI) bacteria in patients whose colon are colonized with vancomycin-resistant enterococcus (VRE).
- Trial name
- NCT00591474
- Testing
- probiotics, yogurt
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Multidrug Resistent Bacteria
Silver Nanoparticles in Multidrug Resistant Bacteria
Recently, silver nanoparticles (AgNPs) have been widely used in various applications as antimicrobial agents, anticancer, diagnostics, biomarkers, cell labels, and drug delivery systems for the treatment of various diseases.
- Trial name
- NCT04431440
- Testing
- silver nanoparticles
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Staphylococcal Skin Infections
Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSA
This was a real-world, prospective, open-label, multicenter study in which participants were randomized (1:1) to receive intravenous (IV) vancomycin or IV daptomycin.
- Trial name
- DAPHEOR1006 (NCT01419184)
- Testing
- Daptomycin, Vancomycin
- Where
- 26 sites in United States, Puerto Rico
- Volunteers
- 250 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Vancomycin (Glycopeptide) Resistant Enterococcus (VRE), Cancer
Cohort Study of German Hematological / Oncological Wards to Assess the Effect of Contact Precautions on Nosocomial Colonization With Vancomycin Resistant Enterococci
The study aims to evaluate the impact of contact precautions on the rate of VRE- the rate of colonization and infection aand hospital-acquired VRE transmissions.
- Trial name
- CONTROL (NCT02623413)
- Volunteers
- 950 people
- Sponsor
- University of Cologne
Nosocomial Infection, Healthcare-associated Infection
Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia
Hypothesis: The use of daptomycin to treat nosocomial or healthcare-associated bacteremia due to methicillin-resistant S. aureus (MRSA) would increase the proportion of patients whose blood cultures are sterilized after 72 hours…
- Trial name
- DAVASAB (NCT01515020)
- Testing
- vancomycin monotherapy, daptomycin monotherapy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infection Due to Resistant Organism
FMT for MDRO Colonization After Infection in Renal Transplant Recipients
Transplant patients are at increased risk of colonization and infection with Multidrug Resistant Organisms (MDROs) due to medications that modify their immune systems, increased healthcare and antibiotic exposure, and surgical…
- Trial name
- PREMIX (NCT02922816)
- Testing
- Fecal Microbiota Transplant (FMT), Bowel preparation, Stool or perirectal swab sampling
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Emory University
Staphylococcal Skin Infection
Comparison of Telavancin and Vancomycin for Complicated Skin and Skin Structure Infections With a Focus on Methicillin-resistant Staphylococcus Aureus
Study 0018 (NCT00107978) compares the safety and effectiveness of an investigational drug, telavancin, and an approved drug, vancomycin, for the treatment of complicated skin and skin structure infections.
- Trial name
- ATLAS2 (NCT00107978)
- Testing
- Telavancin, Vancomycin
- Where
- United States
- Volunteers
- 1,035 people
- Sponsor
- Cumberland Pharmaceuticals
Antibiotic Resistant Strain
A Trial of Encapsulated Fecal Microbiota for Vancomycin Resistant Enterococcus Decolonization
The objective of this study is to provide preliminary insight into the safety and efficacy of fecal microbiota transplantation (FMT) for the eradication of gastrointestinal carriage of vancomycin-resistant Enterococcus.
- Trial name
- NCT03063437
- Testing
- Encapsulated fecal microbiota preparation
- Where
- 2 sites in United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Research Institute
Liver Diseases
Vancomycin Resistant Enterococci in Patients Awaiting Liver Transplantation at the University of Michigan: Prevalence, Risk Factors, Natural History and Outcome of Colonization
Enterococci, especially vancomycin resistant enterococci (VRE), are increasing in prevalence in many hospitals in the United States.
- Trial name
- NCT00005667
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Patients at High Risk of Antibacterial Treatment Upon Admission
Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens
Extended-spectrum beta-lactamase producing Enterobacteriaceae (EPE), vancomycin-resistant enterococci (VRE) and Clostridium difficile have become a major threat to hospitalised patients worldwide.
- Trial name
- PILGRIM (NCT03765528)
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital of Cologne
Antimicrobial Drug Resistance, Antibiotic Resistant Infection
Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients
The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or…
- Conditions
- Antimicrobial Drug Resistance, Antibiotic Resistant Infection, Clostridium Difficile, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- DYNAMITE (NCT06258551)
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute