Clinical trials: Vaping
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Prevalence of smoking among individuals with opioid use disorder (OUD) is six-fold that of the general US adult population. The mortality rate of opioid-dependent smokers is four times that of opioid-dependent nonsmokers, and…
- Trial name
- NCT04092101
- Testing
- Cigarettes with varying nicotine content, E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Vaping, Electronic Cigarette Use
Vaping Adverse Lung and Heart Events Cohort
This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up.
- Trial name
- VapALERT (NCT06291597)
- Testing
- Vaping
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Laval University
Endothelial Dysfunction, Inflammation
The Cardiovascular Effects of Electronic Hookah Vaping
Hookah (water-pipe) tobacco smoking has quickly grown to become a major global tobacco epidemic among youth; with electronic (e-) hookahs more recently increasing in popularity especially among young female adults, who endorse…
- Conditions
- Endothelial Dysfunction, Inflammation, Oxidative Stress
- Trial name
- NCT03690427
- Testing
- Traditional hookah smoking, Electronic hookah vaping
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Electronic Nicotine Delivery System Flavors
Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers
This study aims to better understand how the availability of electronic nicotine delivery system (aka electronic cigarettes) flavors (e.g., menthol, tobacco) impacts tobacco use behaviors, toxicant exposure, and abuse liability…
- Trial name
- RVA Flavors (NCT05023096)
- Testing
- Tobacco product administration and assessment
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Nicotine, Nicotine Vaping
Developing E-liquid Product Standards (Sweet Spot Study)
The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of…
- Conditions
- Nicotine, Nicotine Vaping, E-cigarette Use
- Trial name
- NCT05864586
- Testing
- Vaping study EC A, Vaping study EC B, Vaping study EC C
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking
Effect of Electronic Cigarettes on Platelets, Endothelium and Inflammation
The primary purpose of this study is to evaluate the acute effects of electronic cigarette (e-cigarette) smoking on measurable biomarkers of platelet function, vascular endothelial function and inflammation in healthy active…
- Trial name
- NCT02662075
- Testing
- E-cigarette/tobacco Smoking Exposure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NYU Langone Health
Nicotine Vaping, Nicotine Dependence
Assess the Influence of Nicotine Flux and Nicotine Form on Subjective Effects Related to Dependency
Electronic nicotine delivery systems (ENDS) heat and vaporize a nicotine-containing liquid to produce an aerosol that can deliver nicotine to the blood and the brain.
- Conditions
- Nicotine Vaping, Nicotine Dependence, Nicotine Addiction
- Trial name
- NCT05430334
- Testing
- e-liquid 1, e-liquid 2, e-liquid 3
- Where
- Lebanon
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention
A Virtual Reality E-cigarette Prevention and Emotion Regulation Intervention for Adolescents
This study will examine E-Invite Only VR, a novel school-based universal e-cigarette prevention intervention that uses virtual reality (VR) to deliver prevention and emotion regulation skills-building content to middle school…
- Conditions
- E-cigarette Use/Vaping Prevention, Nicotine Dependence Prevention, Adolescent Mental Health
- Trial name
- NCT07460622
- Testing
- Virtual Reality E-Cigarette Prevention Program
- Where
- United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- Yale University
E-cigarette, Vaping
Understanding Vape Marketing Study
The purpose of this study is to develop an electronic cigarette (e-cigarette) counter-marketing lesson for adolescents. The lesson will involve short videos designed to improve adolescents' cognition of e-cigarette marketing in…
- Conditions
- E-cigarette, Vaping, Tobacco, Nicotine
- Trial name
- NCT07129265
- Testing
- Working group, Focus group
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Nicotine Dependence, Cigarettes
Epidemiology and Acute Oral Effects Electronic Cigarette
Electronic cigarettes are battery-powered vaporizers which have a similar feel to tobacco smoking. They do not produce cigarette smoke but rather an aerosol, which is frequently referred to as vapor.
- Trial name
- NCT03011710
- Testing
- ProVari v2.5 (E-cigarette), Marlboro Gold (Conventional cigarette), Cigarette tip
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Electronic Cigarette Related Lung Damage
Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology
A two-center, longitudinal assessment of 40 electronic cigarette users and 40 healthy controls at the initial visit and a follow-up visit 12 months later.
- Trial name
- ECig (NCT06856525)
- Testing
- Hyperpolarized xenon 129, Cardiopulmonary Stress Test, Pulmonary Function Test
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Y. Michael Shim, MD
Cigarette Smoking
E-Cigarettes and Financial Incentives to Promote Tobacco Harm Reduction Among Adults Accessing Shelter Services
This randomized controlled trial evaluated the feasibility and potential efficacy of 1) e-cigarette switching (EC) or 2) e-cigarette switching + financial incentives for combustible cigarette cessation (EC+FI)
- Trial name
- EXCHANGE (NCT03743532)
- Testing
- E-cigarette Switching, Financial Incentives
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Vaping, Pregnancy Related
The Impact of E-cigarettes During Pregnancy on Childhood Health Outcomes Study
Tobacco smoking in pregnancy is now widely accepted as having adverse health outcomes for both the mother and fetus. Tobacco smoking in pregnancy is associated with increased incidence of miscarriage, stillbirth and preterm birth…
- Conditions
- Vaping, Pregnancy Related, Pediatric Respiratory Diseases
- Trial name
- ECHO (NCT06297005)
- Where
- 3 sites in Ireland
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Smoking, Cigarette
Switching to a Vaping Device: Evaluating Risk Reduction Among Quitline Treatment Failures
The overall aim of the study is to evaluate the provision of e-cigarette (EC) versus NRT on smoking behavior, product use patterns and continued use, and iCO, a biomarker of toxicant exposure, among a sample of recent QL…
- Trial name
- NCT03502200
- Testing
- JUUL, Treatment As Usual
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Electronic Cigarettes
Determination of Liquid Flavor and Nicotine Form Outcomes
The purpose of this research study is to find out how different types of electronic cigarette/vape e-liquids with differing sweetness and forms of nicotine affect blood nicotine levels, use behavior (how people puff), and how…
- Trial name
- NCT05587504
- Testing
- E-cigarette with sweetness type 1 and pronation level 1, E-cigarette with sweetness type 1 and pronation level 2, E-cigarette with sweetness type 2 and pronation level 1
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Smoking, E-Cig Use
Clinical Alternatives for Reducing Harm Using E-cigarettes
For patients in cancer care, quitting smoking is critical, but a significant portion of patients in cancer care refuse all components of tobacco treatment, even when offered free of charge.
- Conditions
- Smoking, E-Cig Use, Oncology
- Trial name
- CARE (NCT07039292)
- Testing
- Harm Reduction (E-cigarette switching), Standard of Care
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cardiovascular Risk Factor
Comparison of Electronic Cigarettes and Tobacco Cigarettes on Cardiovascular Function and Oxidative Stress
Background: Electronic cigarettes (e-cigarettes) are battery-powered devices heating a liquid (e-liquid) composed of propylene glycol and/or vegetable glycerin, and most commonly, nicotine to form an aerosol (vapor) that is…
- Trial name
- NCT03036644
- Testing
- e-cigarette (PG+VG without nicotine; low temperature), e-cigarette (PG+VG with nicotine; low temperature), e-cigarette (PG+VG without nicotine; high temperature)
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Nicotine Dependence
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity
Background: Smoking is a difficult habit to quit, and some people find it more difficult to quit than others do. Nicotine is the substance in cigarettes that makes smoking so addictive.
- Trial name
- NCT01867411
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Smokers, Smoking Cessation
A Structured Protocol to Evaluate Efficacy and Safety of a Popular Electronic Nicotine Delivery Device (E-Cigarette) Efficacy and Safety of a Popular Electronic Nicotine Delivery Device (E-Cigarette)
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (E-Cigarette) loaded with low dose nicotine to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01188239
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Catania
Tobacco Smoking, Electronic Cigarette Use
Dual Use Approach Bias Training for Nicotine Addiction
The present project will evaluate the initial efficacy of approach bias retraining among dual combustible cigarette (CC) and electronic cigarette (ECIG) users.
- Conditions
- Tobacco Smoking, Electronic Cigarette Use, Substance Use
- Trial name
- NCT05306158
- Testing
- CC+ECIG Condition, CC Condition
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Houston