Clinical trials: Variability
Critically Ill Mechanically Ventilated Subjects
The DIVINE Study: DIetary Management of Glucose VarIability iN thE ICU
To compare the nutritional effect on blood glucose of two commercially available enteral diets in overweight or obese patients in the Intensive Care Unit.
- Trial name
- NCT02337556
- Testing
- Peptamen Bariatric, Replete
- Where
- 7 sites in United States, Canada
- Volunteers
- 106 people
- Sponsor
- Société des Produits Nestlé (SPN)
Surgery
Validation of Noninvasive Hemoglobin, Comparison of PVI to Standard Methods, and Validation of Clinical Efficacy of ORI
The study goal is to establish the correlation of hemoglobin values determined by the noninvasive pulse oximetry-determined hemoglobin (SpHb) system with hemoglobin as measured by other validated devices.
- Trial name
- NCT02841397
- Testing
- Masimo Pulse CO-Oximeter
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Masimo Corporation
Healthy
Variability of Whole Blood Clotting Time Measurements in Ex Vivo Human Blood Samples Spiked With Anticoagulants
The study will assess the distribution and variability of whole blood clotting time (WBCT) measurement in human blood collected from healthy volunteers that is untreated and spiked with predetermined concentrations of edoxaban or…
- Trial name
- NCT03296982
- Testing
- Blood drawn by direct venipuncture, edoxaban, Enoxaparin
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
Heart Rate, Heart Rate Variability
Contactless Measurement of Heart Rate, Heart Rate Variability, Breathing Rate and Blood Pressure Using Remote Photoplethysmography
The purpose of this study it to evaluate the accuracy of heart rate, heart rate variability, breathing rate and blood pressure measurement with the use of Shen.AI software.
- Conditions
- Heart Rate, Heart Rate Variability, Breathing Rate, Blood Pressure
- Trial name
- NCT06829615
- Testing
- Shen.AI
- Where
- 2 sites in Poland
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- SHEN.AI spółka z ograniczoną odpowiedzialnością oddział w Polsce
Healthy
Variability in the Measurement of WBCT Between Blood Drawn From Indwelling Catheters and Direct Venipuncture
1. Determine if there is any difference between the whole blood clotting time results obtained from blood drawn from indwelling catheters and direct venipuncture 2. Determine the intra-subject variability in both procedures
- Trial name
- NCT02207205
- Testing
- Blood drawn from indwelling catheters versus direct venipuncture
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc.
Diabetes Mellitus, Type 2
Diabetes-Specific Formula on Long Term Glycemic Control
The study aims to investigate the effect of a diabetes-specific formula (DSF) used as a (partial) meal replacement on long-term glycemic control and short-term glycemic variability in individuals with type 2 diabetes.
- Trial name
- NCT04345497
- Testing
- Diabetes-Specific Formula, Standard Of Care
- Where
- 5 sites in Malaysia, Thailand
- Volunteers
- 251 people
- Sponsor
- Abbott Nutrition
Healthy
A Clinical Trial Investigating the Intra-subject Variability of Pharmacokinetics and Glucodynamics of BioChaperone Insulin Lispro U-100 Product and U-200 Product in Healthy Volunteers
This is a double-blinded, randomised, single-centre phase I pilot trial for exploring the feasibility of a pivotal clinical trial establishing bioequivalence between BioChaperone insulin lispro U-200 and BioChaperone insulin…
- Trial name
- NCT02529293
- Testing
- BioChaperone Lispro U-100, BioChaperone Lispro U-200
- Where
- Germany
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Adocia
Type 2 Diabetes Mellitus
Bioavailability of Technosphere® Insulin Versus Subcutaneous Regular Human Insulin in Type 2 Diabetes
The purpose of this study is to compare the kinetics and biodynamics of inhaled Technosphere Insulin with those of subcutaneous (SC) regular human insulin.
- Trial name
- NCT00511719
- Testing
- Technosphere Insulin, Actrapid
- Volunteers
- 13 people
- Sponsor
- Mannkind Corporation
Parkinson's Disease
Noninterventional Study Evaluating Parkinson's Disease Diary Use
This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide…
- Trial name
- NCT05363046
- Where
- 34 sites in United States, Canada and 3 more
- Volunteers
- 194 people
- Sponsor
- BlueRock Therapeutics
Heart Rate Variability, Exercise
Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Exercise Performance
Heart rate variability (HRV) is a measure of the variation in time between each heartbeat. It is an indirect and ubiquitous biomarker of performance readiness and recovery measured by most consumer-grade wearable fitness…
- Trial name
- NCT06425939
- Testing
- Force plate assessment, Whoop wrist band
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Heart Failure
Necklace-Shaped Sensor for Non-Invasive Monitoring of Stroke Volume and Cardiac Output
Study will compare measurements made with Necklace device for stroke volume/cardiac output with values from a FDA-approved reference device. The gold standard that will be used is Cardiac MRI.
- Trial name
- NCT02719301
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Healthy
Safety and Tolerability of Lu AG06479 in Healthy Young Men
The purpose of this study is to investigate the safety and tolerability of Lu AG06479 and what the body does to Lu AG06479 after swallowing single doses of the drug.
- Trial name
- NCT04473651
- Testing
- Lu AG06479
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Type 2 Diabetes Mellitus
Effect of 13-Week Treatment With Vildagliptin as Add-On Therapy to Improve Glucose Variability in Type II Diabetes
The purpose of the study is to assess if the addition of vildagliptin as add-on therapy improves glucose variability in type 2 diabetes mellitus (T2DM) patients inadequately controlled with insulin, with special emphasis in…
- Trial name
- VIDA (NCT01862263)
- Testing
- Vildagliptin, Insulin
- Where
- 13 sites in Mexico
- Volunteers
- 191 people
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteers
The Effects of Sex, Body Mass Index, Day-to-Day Subject Variability for the ProLung Test and Variability of a Single Device When Volume-Averaged Thoracic Bioconductance is Measured With the ProLung Test
Assess the repeatability of the ProLung Test
- Trial name
- NCT03993028
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fresh Medical Laboratories
Idiopathic Thrombocytopenia Purpura
A Study to Evaluate the Relative Bioavailability and Intra-Subject Variability of Two Lots of E5501 40 mg Tablets Administered Twice as Single Oral Doses to Healthy Subjects
The purpose of this study is to evaluate the relative bioavailability (BA) of two lots of E5501 40 mg tablets administered twice as single oral doses to healthy subjects.
- Trial name
- NCT01289509
- Testing
- E5501, Drug: E5501
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Hepatocellular Carcinoma
Characterization of Baseline Biomarker Variability in Participants With Hepatocellular Carcinoma (MK-0000-215)
The purpose of this study is to characterize the baseline variability of a panel of tissue (tumor and adjacent) and blood-based biomarkers obtained from participants with hepatocellular carcinoma (HCC).
- Trial name
- NCT01521780
- Testing
- MRI, Pathology, Blood Samples
- Volunteers
- 12 people
- Sponsor
- Merck Sharp & Dohme LLC
Healthy, Impaired Glucose Tolerance
Effects of an Intermittent Fasting and Dietary Supplement Regimen on Glycemic Variability
The purpose of this study is to determine the short-term effect of a nutritional program consisting of a yerba mate supplement, fiber supplement, and intermittent fasting on glycemic variability in men and women with risk factors…
- Trial name
- NCT05493553
- Testing
- Dietary supplement regimen, Dietary supplement and intermittent fasting regimen
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Unicity International, Inc.
Diabetes, Healthy
Within-subject Variability of Insulin Detemir in Healthy Volunteers
This trial is conducted in Europe. The aim of this trial is to compare the within-subject variability of insulin detemir to that of another basal insulin analogue, insulin glargine in healthy volunteers.
- Trial name
- NCT01497535
- Testing
- insulin detemir, insulin glargine
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Novo Nordisk A/S
Healthy
Study Investigating the Safety and Tolerability of Lu AF88434 in Healthy Young Men
This study evaluates the effect of Lu AF88434 on the body and what the body does to Lu AF88434 and the effect of food after swallowing single oral doses
- Trial name
- NCT04082325
- Testing
- Lu AF88434, Lu AF99722 14C spiked dosage ([14C]-radiolabelled Lu AF88434), Lu AF99723 14C spiked dosage ([14C]-radiolabelled Lu AF88434)
- Where
- Netherlands
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Gastroparesis
GEBT Lot-to-Lot and Biological Variability
The purpose of this study is to collect information regarding lot-to-lot variability in 13C-Spirulina test meal lets and within-subject biological variability.
- Trial name
- NCT04772261
- Testing
- 13C-Spirulina GEBT
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cairn Diagnostics