Clinical trials: Variability
Fragility
Investigation of a Link Between Heart Rate Variability and Frailty in Geriatric Patients
The aim of this study is the evaluation of differences in heart rate variability (both time- and frequency-domain) [a]: between frail and non-frail patients and [b] at the beginning and end of a geriatric therapy which included…
- Trial name
- NCT03585985
- Testing
- Standard patient monitor, Photoplethysmographie-Imaging (PPGI) + Infrared thermography (IRT)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Cardiovascular Disease, Stress
Mindfulness, Yoga, and Cardiovascular Disease
In this study, we will conduct a preliminary, yet comprehensive evaluation of Mindfulness and Yoga, as compared to an exercise and education-based stress-reduction program.
- Conditions
- Cardiovascular Disease, Stress, Anxiety, Depression
- Trial name
- NCT00696852
- Testing
- Mindfulness Meditation, Yoga, Exercise, Relaxation, and Health Education
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Primary Prevention, Stress
Efficacy of Taiji Training as a Program for Stress Prevention
Background: Excessive exposure to psychosocial stress can be a potent trigger for somatic diseases and psychological disorders, a cause for missing work, and eventually lead to high economic loss.
- Conditions
- Primary Prevention, Stress, Tai ji, Adult
- Trial name
- NCT01122706
- Testing
- Taiji training
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Bern
Cardiovascular Disease Risk Reduction, Chronic Stress
Improving Minority Health Through Biofeedback and Stress Reduction
This study aims to evaluate the effectiveness of a four-week heart rate variability (HRV) biofeedback intervention to improve physiological stress response, emotion regulation, and anxiety-related symptoms in young ethnic…
- Conditions
- Cardiovascular Disease Risk Reduction, Chronic Stress, Anxiety, Emotional Regulation
- Trial name
- NCT07172152
- Testing
- HRV Biofeedback Training
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Amelia Saul, PhD, CTRS, BCB
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Menopause, Exercise
Ambulatory and Blood Pressure Variability Responses to Exercise in Normotensive and Hypertensive Women
This study evaluated the differences between normotensive and hypertensive menopausal women in ambulatory and blood pressure variability responses to combined aerobic and resistance exercise.
- Conditions
- Menopause, Exercise, Blood Pressure, High
- Trial name
- NCT03531034
- Testing
- Combined Exercise Training
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Obstructive Sleep Apnea
Abdominal Breathing for Depression, Anxiety, Heart Rate Variability in Obstructive Sleep Apnea Patients
The research topic is to explore the effectiveness of abdominal breathing on improving of depression, anxiety, and heart rate variability in obstructive sleep apnea patients with depressive symptoms.
- Trial name
- NCT05594212
- Testing
- Abdominal breathing training
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Healthy Participants, Tooth Extraction
Application Of Dentapen In Dental Local Infiltration Anesthesia
The goal of this clinical study is to compare patients' self-reported pain and mental stress during infiltration anesthesia between conventional syringe and Dentapen.
- Conditions
- Healthy Participants, Tooth Extraction, Orthodontic Patients
- Trial name
- NCT07431801
- Testing
- computer controlled local anesthesia delivery device (Dentapen), Control
- Where
- Vietnam
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Son Hoang Le
Closed Reduction Surgery for Nasal Bone Fracture
The Relationship Between the Surgery-related Anxiety and HRV: Prediction for Aggressive Emergence Behavior
Heart rate variability (HRV) is known to reflect the balance of autonomic nervous system. Anxiousness, which tend to result from the deficient action of parasympathetic nervous system, likely to show low HRV.
- Trial name
- NCT02282865
- Where
- South Korea
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Maraviroc Concentrations in Semen
Concentrations of Maraviroc in the Semen of HIV-Infected Men
The objective of this study is to determine if concentrations of maraviroc in semen exceed the 50% and 95% inhibitory concentrations of HIV during the dose interval.
- Trial name
- NCT01009034 (NCT01009034)
- Testing
- Measuring semen samples
- Where
- 2 sites in Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Canadian Immunodeficiency Research Collaborative
Older Adults (60 - 85 Years Old), Aging
Functional and Physiological Responses to Multicomponent Exercise in Older Adults
This study will examine functional and physiological responses to a 12-week multicomponent exercise program in community-dwelling older adults.
- Conditions
- Older Adults (60 - 85 Years Old), Aging, Functional Capacity, Heart Rate Variability (HRV)
- Trial name
- NCT07702227
- Testing
- Multicomponent Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Health Behavior, Quality of Life
Yoga Effects on Heart Rate Variability and Electroencephalography
Since yoga breathing exercises are traditionally used to tranquilize the mind, and have a well-known positive effect on the cardiovascular system, it is our hypothesis that a respiratory yoga exercise named bhastrika pranayama…
- Trial name
- NCT01866683
- Testing
- 1 month respiratory training, 1 month waiting period
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Opioid Induced Motor Disturbances
Opioid Induced Gait Variability
While the analgesic effects of opioids are well known, evidence suggest that there are differences in the adverse dizziness of the different opioid types, which may influence the gait function differently.
- Trial name
- NCT03121547
- Testing
- Tapentadol 50 mg Oral Tablet, Tramadol Hydrochloride 100 mg Extended Release Oral Tablet
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Cluster Headache, Sleep
Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients
Cluster headache is one of the most painful headaches, characterized by recurring episodes of unilateral, periorbital pain, which is accompanied by autonomic symptoms that seem to be of both sympathetic and parasympathetic…
- Trial name
- NCT03010189
- Testing
- Actigraphy, Heart-rate variability monitoring, Pupillometry
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Healthy
The Effects of Single-Pulse Transcranial Magnetic Stimulation on the Autonomic Nervous System in Healthy Adults
The purpose of this study is to determine the effects of TMS on the ANS. The investigator will determine whether single-pulse TMS of the primary motor cortex in the dominant hemisphere in healthy, young adults will affect 1)…
- Trial name
- NCT02833220
- Testing
- Single-Pulse Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obstructive Sleep Apnea
Effect of Longitudinal Sleep Monitoring on Diagnosis and Treatment Decision in Patients With Suspected Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a highly prevalent sleep-disordered breathing disease, caused by recurrent episodes of partial or complete collapse of the upper airway during sleep, resulting in intermittent hypoxia, fragmented…
- Trial name
- ELSA (NCT03819361)
- Testing
- pulse-oximetry
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Malcolm Kohler
Healthy
Exploring the Cortical Hemodynamic Variability of Prefrontal iTBS: a Concurrent TBS/fNIRS Study
An increasing number of studies have used the intermittent theta-burst stimulation (iTBS) protocol to investigate neural plasticity non-invasively in the prefontal cortex in healthy humans and in patients with psychiatric…
- Trial name
- NCT06104462
- Testing
- Intermittent theta burst stimulation (iTBS)
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Premature Birth, Newborn
Pain Management in Neonatal Intensive Care Units by Studying the Autonomic Balance
Fight against the pain caused by the disease or by the diagnostic and therapeutic procedures is a daily and essential concern for the caregiver neonatologist.
- Trial name
- NIPE-DOL (NCT02764424)
- Testing
- NIPE (MDoloris®)
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy
A Study Investigating Tablet Formulations of Lu AF11167 in Healthy Subjects
The purpose of this study is to investigate the extent to which Lu AF11167 enters the bloodstream following tablet intake and the influence of food on uptake in healthy men and women
- Trial name
- NCT04104503
- Testing
- Lu AF11167, [14C]-Lu AF11167, Lu AF11167 MR tablet prototype formulation selected from part A or 1 mg modified release tablet (reference formulation)
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Traumatic Lumbar Puncture
Variability of Infant LP Insertion Site Based On Procedural Experience
The reported rate of unsuccessful traditional LP in children (defined as the inability to obtain cerebrospinal fluid or obtaining a traumatic puncture) is as high as 50%.
- Trial name
- NCT02949869
- Testing
- Spinal Sonography
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital