Clinical trials: Variability
Health Behavior, Work Related Stress
HRV and Coaching Preparation Phase Study
This pilot study will evaluate possible intervention components to be included in a future stress management and health behaviour change trial and to pilot test their feasibility and acceptability in a small sample.
- Conditions
- Health Behavior, Work Related Stress, Job Stress, Anxiety Depression
- Trial name
- NCT05150574
- Testing
- Core Health Program, Daily resting HRV, Momentary HRV feedback
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Brock University
Glucose Tolerance, HRV
Effect of Hot Water Immersion on Heart Rate Variability and Glucose
Heat therapy has been shown to reduce risk of various diseases, including heart disease, alzheimers, and pneumonia, as well as all-cause mortality .
- Trial name
- HWI (NCT06193291)
- Testing
- Feet heating, Calf heating
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Accidental Falls
Trial to Reduce Falls Incidence Rate in Frail Elderly
Background: Approximately 750,000 elderly Dutch people fall at least once a year, which often results in physical injuries and a fear of falling, with high costs and far-reaching consequences on functionality, physical activity…
- Trial name
- CP (NCT00512655)
- Testing
- Fall prevention course
- Where
- 3 sites in Netherlands
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Stress, Psychological, Physiological
Effects of Yoga on Objective and Self-reported Health Indicators Among Female and Male Individuals
The purpose of this study is to determine whether inversions (specific yoga postures in which the heart is higher than the head) and other dynamic and static yoga postures affect heart rate variability, oxygen uptake, blood…
- Trial name
- NCT01305096
- Testing
- Yoga intervention
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Sleep Variability
The Effects of Sleep Variability in Youth
Daily sleep variability is prevalent in the young populations, yet its effects remain less clear. The experimental study aims to examine the impacts of intraindividual daily sleep variability on sleep characteristics…
- Trial name
- NCT04263428
- Testing
- Irregular sleep
- Where
- Hong Kong
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Vagus Nerve Stimulations
Acute Cardiovascular Effects of Transcutaneous Auricular Vagus Nerve Stimulation
Introduction Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with arterial hypertension representing the most significant modifiable risk factor (Lim et al., 2012; Mills et al., 2020).
- Trial name
- NCT07501611
- Testing
- Active taVNS condition
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Heart Rate Control, Recovery Following Exercise
Recovery of Heart Rate Variability in Handball Players
This study aimed to compare the acute effects of manual massage (MM) and foam rolling (FR) on heart rate variability (HRV) following a 20 m shuttle run test (20m-SRT) in elite male handball players.
- Trial name
- HRV-HANDBAll (NCT07648966)
- Testing
- Manul Massage (MM), Foam Rolling (FR)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uludag University
Postmenopausal Flushing, Cardiovascular Risk Factor
Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments
Hot flashes, vasomotor symptoms that affect many postmenopausal women, are associated with cardiovascular disease and endothelial dysfunction.
- Conditions
- Postmenopausal Flushing, Cardiovascular Risk Factor, Endothelial Dysfunction
- Trial name
- NCT03149419
- Testing
- Paroxetine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Inter-individual Variability
Using Electroencephalography (EEG) and Transcranial Current Stimulation (tCS) to Study and Modulate Cognition Study
Inter-individual variability in responsiveness to interventions poses great challenges for translational neuroscience, and health care in general.
- Trial name
- NCT03293316
- Testing
- Transcranial Random Noise Stimulation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Major Depressive Disorder
Heart Rate Variability in Depression
The purpose of this study is to understand if there is a relationship between the way that emotions are regulated by the brain and the way that heart rate is regulated by the brain.
- Trial name
- NCT02525978
- Testing
- Video Task, Imaginal Task
- Where
- 3 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emory University
Drug Metabolism Phenotype
Biomarkers of CYP2D6 and CYP3A4 Variability in Pediatrics
Cytochrome P450 2D6 (CYP2D6) is an important enzyme in the body for breaking down many medications that are commonly used in children of various ages.
- Trial name
- NCT01118858
- Where
- 2 sites in United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Rheumatoid Arthritis, Systemic Lupus Erythematosus
The Effect of Deep Breathing and Transcutaneus Electrical Nerve Stimulation on Heart Rate Variability
This interventional study aims to investigate the effect of deep breathing (DB) and transcutaneous electrical vagus nerve stimulation (tVNS) on heart rate variability (HRV) in healthy participants and patients with rheumatoid…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Healthy Participants
- Trial name
- NCT05157334
- Testing
- Non-invasive auricular electrical transcutaneous vagus nerve stimulation, Deep breathing
- Where
- Denmark
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Stress, Anxiety State
Effectiveness of Heart Rate Variability Biofeedback Training Versus a Meditation Program in Reducing Stress Levels in University Undergraduate Students
The objective of this trial is to evaluate the efficacy of a heart rate variability biofeedback training protocol, compared to a guided meditation program and a control group, in reducing stress and anxiety levels among…
- Trial name
- NCT06457932
- Testing
- Heart rate variability biofeedback training, Guided meditation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Seville
Influence of Espresso on Heart Rate Variability
Action of Caffeinated and Decaffeinated Espresso on Autonomic Function
More than 80% of the population in the USA consume coffee each day. However there not many studies on change of heart rate variability and placebo effects after consumption of coffee.
- Trial name
- NCT00576030
- Testing
- hab cof with water, hab cof with dec espresso, hab cof with caf espresso
- Where
- Germany
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Ventricular Septal Defect, Closure; Interventricular Septum
The Effect of Transcatheter Ventricular Septal Defect Closure on Heart Rate Variability Parameters
In this study; we evaluated the heart rate variability parameters of pediatric patients whose VSDs were closed with the transcatheter method before and after, and compared with the control group.
- Conditions
- Ventricular Septal Defect, Closure; Interventricular Septum, Autonomic Nervous System Imbalance
- Trial name
- NCT04859036
- Testing
- 24 hours ambulatory Holter monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Postmenopause
Effects of Breathing Training on Psychosocial Functioning and Heart Rate Variability in Postmenopausal Women With Depressive Symptoms
The specific aims of this study are: 1. To develop a breathing training protocol specifically designed to improve HRV and psychosocial functioning for postmenopausal women with depressive symptoms, 2.
- Trial name
- NCT01044563
- Testing
- Breathing training, Stress management
- Where
- Taiwan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- National Science and Technology Council, Taiwan
Autonomic Function
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- Trial name
- CPB_Atropine (NCT06912048)
- Testing
- Oral glucose tolerance test with double-tracer dilution and atropine infusion
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Asthma, Obesity
Study of the Physiology of the Asthma of the Obese Subjects. Breathing Obesity Asthma Study (BOA)
Asthma is more frequent in obese women, but the mechanisms underlying the causes of this increased frequency are unknown and are different from usual asthma pathophysiology (associated with allergy).
- Trial name
- BOA (NCT00577733)
- Where
- France
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Menopause, Irritable Mood
Estrogen Variability and Irritability During the Menopause Transition
Women in the menopause transition (perimenopause) experience substantial day-to-day variability in estradiol and have a 2-4-fold increase in major depression risk.
- Trial name
- NCT05388656
- Testing
- Estradiol Patch, 0.1 mg/24 Hours Weekly Transdermal Film, Extended Release, Progesterone 200 mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Aging, Mobility Disability
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults
To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.
- Trial name
- BRIO (NCT06940037)
- Testing
- Progressive Resistance Training, Health Education
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic