Clinical trials: Variability
Congestive Heart Failure, Chronic Kidney Diseases
Within Subject Variability Study of ER Torsemide 20 mg Tablet in Healthy Subjects
The study will evaluate the within-subject variability of 20mg ER torsemide as compared to 20mg IR torsemide (Demadex) in fully replicate double-crossover trial in healthy volunteers, who are consuming a high-salt diet (300…
- Trial name
- NCT03214874
- Testing
- Demadex 20mg Tablet, ER Torsemide 20mg Tablet
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Subjective Discomfort, General Mucosal Irritation
Controlled Human Exposure to Indoor Air, Dust and Ozone
The aim of the study is to provide information which may help to improve the quality of the life of persons exposed to indoor environments in Danish dwellings.
- Conditions
- Subjective Discomfort, General Mucosal Irritation, Acute Changes in Respiratory Outcomes, Acute Changes in Cardiovascular Outcomes
- Trial name
- XDOZ (NCT02017782)
- Testing
- Dust, Ozone, Dust and Ozone
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Individual Variability in (Poly)Phenol Metabolism, Cardiometabolic Health
Aggregate Metabolic Phenotypes for (Poly)Phenols: Development of an Oral (Poly)Phenol Challenge Test (OPCT)
The study is a single-dose acute clinical trial aiming at identifying aggregate metabolic phenotypes for the main dietary (poly)phenols and assessing the factors associated with their formation.
- Trial name
- OPCT (NCT05414084)
- Testing
- Oral (poly)phenol challenge test (OPCT)
- Where
- 2 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Parma
Heart Rate Control, Athlete
HRV-based Training Effects in Athletes
Monitoring individual responses to training is an important key factor to prescribe to most effective training programs. Heart-rate variability (HRV) could be used for monitoring the training status of endurance athletes in order…
- Conditions
- Heart Rate Control, Athlete, Emotions
- Trial name
- HRV-btA (NCT04150952)
- Testing
- HRV-based training, TRAD training
- Where
- Spain
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Menopause, Exercise
Ambulatory and Blood Pressure Variability Responses to Exercise in Normotensive and Hypertensive Women
This study evaluated the differences between normotensive and hypertensive menopausal women in ambulatory and blood pressure variability responses to combined aerobic and resistance exercise.
- Conditions
- Menopause, Exercise, Blood Pressure, High
- Trial name
- NCT03531034
- Testing
- Combined Exercise Training
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Healthy Adults
Effects of High-intensity Interval Training and Moderate-intensity Continuous Training on Functioning of Attentional Networks and Heart Rate Variability in Healthy Adults
This study investigated the effects of HIIT and MICT on functioning of attentional networks and explored the relationship between heart rate variability (HRV) and these networks in healthy adults.
- Trial name
- NCT06602700
- Testing
- HIIT, MICT
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Healthy
Effects of Race Pace Based Approach in Recreational Runners
The aim of the study was to compare the performance effects of the intensity demarcation model based on the race pace based approach with the triphasic physiological model and heart rate variability guidelines (HR+HRV)
- Trial name
- 22HUM23661 (NCT06216314)
- Testing
- Heart rate (HR), Race pace based approach (RP), Heart rate + heart rate variability (HRV)
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Elderly Subjects, Respiration Exercises
Effects of Respiratory Yoga Training on Heart Rate Variability and Baroreflex of Healthy Elderly Subjects
The decreases of physiological capacities which take place with senescence include diminishing respiratory capacity as well as a reduction of heart rate variability and baroreflex sensibility.
- Trial name
- NCT00969345
- Testing
- Stretching Exercises, Respiratory Exercises conducted twice a day for 10 minutes
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Weight Loss, Hormone Disturbance
Effects of Weight Loss on Nutritional Mediated Hormone Secretion
Investigative trial with aim of 1. the description of the hormonal and metabolic response to meals containing different compositions of macronutrients 2.
- Conditions
- Weight Loss, Hormone Disturbance, Weight Gain
- Trial name
- RepDiet (NCT02649907)
- Testing
- nutritional stimulation via different testmeals, Nutritional counseling, formula diet
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Healthy Volunteers
Genetic Sources of Variability of the Adaptation of the Ventricular Repolarisation
The main objective is to research for genetic factors involved in the extreme modifications of the QT interval of the electrocardiogram in answer to a pharmacological stimulation (sotalol) and physiological stimulation in the…
- Trial name
- Generepol (NCT00773201)
- Testing
- Sotalol 80 mg
- Where
- France
- Volunteers
- 997 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Rate Variability, Exercise
Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Exercise Performance
Heart rate variability (HRV) is a measure of the variation in time between each heartbeat. It is an indirect and ubiquitous biomarker of performance readiness and recovery measured by most consumer-grade wearable fitness…
- Trial name
- NCT06425939
- Testing
- Force plate assessment, Whoop wrist band
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy, Healthy Participants
Neck Static Stretching Acutely Reduces Blood Pressure Through Reduction of Tissue Stiffness
Stretching is usually done to improve flexibility and joint movement. Recent research suggests that stretching may also affect the body's heart and blood vessels.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects, Healthy Volunteers
- Trial name
- NCT07197047
- Testing
- Neck static stretching
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Doppler Measurement of Uterine Artery
Inter- and Intra-observer Variability in First-trimester Uterine Artery Doppler Measurements.
The aim of this study is to investigate the inter- and intra-observer variability of first-trimester Uterine Artery Doppler ultrasound measurements in pregnancies between 11+0 and 13+0 weeks of gestation.
- Trial name
- NCT06036550
- Testing
- Doppler ultrasound measurement
- Where
- Netherlands
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pain
Changes in Heart Rate in Response to Cold Pressor Test
Abstract: Pain, a subjective sensation, has been increasingly studied, as it has been recognized as an important factor in patients' recovery and quality of life. Pain is charted today as one of the vital signs.
- Trial name
- HRVW1 (NCT00678262)
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Pregnancy Related
Effectiveness of a 12-week Movement Intervention on Heart Rate Variability and Self-compassion Among New Mothers
This is a mixed-methods randomized controlled trial assessing the effects of an online and in person 12-week movement intervention compared to an education only control group on heart rate variability, self-compassion…
- Trial name
- MOM-mi (NCT05403983)
- Testing
- Yoga movement intervention, Education booklet
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of the Fraser Valley
Sedentary Behavior
Virtual Reality Training for Heart Rate Variability and Recovery Heart Rate
To determine effects of VR training on Heart Rate Variability (HRV), Recovery Heart rate (RHR), Rate Pressure Product (RPP) and Rate of Perceived Exertion (RPE) in sedentary Individuals.
- Trial name
- NCT06708364
- Testing
- Virtual Reality Training, Cycle Ergometer
- Where
- Pakistan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Cardiovascular Diseases in Old Age, Aging
Ketone Ester Supplementation and Nocturnal Blood Pressure
Cardiovascular disease (CVD) is the number one cause of death globally and high blood pressure (i.e., hypertension) is the leading modifiable risk factor for CVD and all-cause mortality.
- Conditions
- Cardiovascular Diseases in Old Age, Aging, Cardiovascular Diseases, Sleep
- Trial name
- NCT05888506
- Testing
- Ketone Ester
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Georgia Southern University
Peanut Consumption, High Intensity Aerobic Exercise
The Anti-Inflammatory Effects of Exercise and Peanut Consumption
This study will enroll and randomly assign 30 sedentary, healthy overweight men and women to two groups. Participants will either start by consuming peanuts for 4 weeks, and then go on to exercise at high intensity intervals…
- Trial name
- NCT03212144
- Testing
- High Intensity Interval Training, Peanut Consumption
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Healthy Subjects
Genetic Variability in the Response to Warfarin at Baseline and During Induction of CYP2C9
The genetic factors associated with variability in CYP2C9 induction have not been elucidated. The hypothesis underlying this study is that following 7 days treatment with rifampicin, a known CYP450 inducer, the genetic…
- Trial name
- NCT01388075
- Testing
- Rifampicin
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Caregivers
Cereset Research for Caregivers
Caregivers experience high levels of prolonged stress that can lead to chronic problems with health, including increased risk of cardiovascular disease that is linked to autonomic dysregulation.
- Trial name
- NCT05209438
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences