Clinical trials: Variability
Parkinson Disease, Healthy Aging
Longitudinal Analysis of Gait Variability to Predict Falls in Parkinson's Disease
The broad goal of this research project is to improve the prediction of falls in patients with Parkinson's disease (PD) through a comprehensive multidisciplinary approach that includes longitudinal measurements of walking…
- Trial name
- NCT04339543
- Testing
- Cognitive dual-task walking
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cervix; Pregnancy, Cervical Stiffness
Pregnolia System Intra-observer Variability
The Pregnolia System is a CE-marked medical device assessing the mechanical stiffness of cervical tissue in women. The Pregnolia Probe has been engineered to minimize the influence of differences in handling and technique by the…
- Trial name
- NCT05200117
- Testing
- Pregnolia System
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pregnolia AG
Microbial Colonization
Variability in Microbial Response to Dietary Fiber
The goal of this clinical trial is to understand varying in responses to different dietary patterns in healthy people who are getting a health screening colonoscopy.
- Trial name
- TRIUMPH (NCT06023940)
- Testing
- High fiber
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Exercise, Overreaching
Impact of Training Load on the Gut miCrobiome And Its Relation to exeRcise Performance, mUscle Phenotype, and markerS of Overreaching in Healthy Men
The goal of this study is to learn how different amounts of supervised indoor cycling training change gut health (gut bacteria, the substances gut bacteria make, and the gut barrier integrity), and how these changes relate to…
- Conditions
- Exercise, Overreaching, Butyrate, Gut Microbiome
- Trial name
- ICARUS (NCT07481578)
- Testing
- Supplement, Moderate load exercise training, High load exercise training
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stefan De Smet
Autonomic Nervous System Modulation
Estimation of Autonomic Nervous System Modulation by Pulse Plethysmographic Analysis
Novel pulse plethysmography-derived indexes has been proposed as a tool to measure autonomic nervous system modulation in anaesthetized and awake patients, but nowadays a physiologic validation is lacking.
- Trial name
- NCT01966198
- Testing
- Tilt test
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy
Variability in Response to Non-steroidal Anti-inflammatory Drugs
This research study will evaluate inter-individual variability in the response to the non-steroidal anti-inflammatory drugs (NSAIDs), celecoxib and naproxen, among healthy adults.
- Trial name
- NCT02502006
- Testing
- Celecoxib, Naproxen
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cerebrovascular Accident
Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis
The results of this study will provide sound, scientific evidence of physiologic mechanisms responsible for upper-extremity weakness; evidence of the processes involved in neuromuscular adaptation; and will elucidate the…
- Trial name
- NCT00125658
- Testing
- Control, Experimental
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Endothelial Function
Physiological Assessment of the Endothelium - Circadian Rhythm and Role of the Sympathetic Nervous System
The purpose of this study is to determine whether interventions aimed at increasing sympathetic tone modify endothelial function measures as assessed by the measurement of flow-mediated dilation (FMD) and constriction (FMC).
- Trial name
- PAN (NCT01713374)
- Testing
- Mental stress, no intervention, Myogenic activation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
High Intensity Interval Training (Cycling), High Intensity Interval Training (Running)
Acute Effects of High-intensity Interval Aerobic and Functional Training at Different Intensities
Moderate-intensity physical exercise is widely recognized for its health benefits, yet time constraints limit adherence. High-intensity interval training (HIIT) has gained popularity as a more time-efficient alternative…
- Conditions
- High Intensity Interval Training (Cycling), High Intensity Interval Training (Running), High Intensity Functional Training, Moderate Intensity Functional Training
- Trial name
- HIIT-HIFT-FT (NCT07180550)
- Testing
- High-intensity interval training, running, High-intensity interval training, cycling, High-intensity functional training
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- European University Miguel de Cervantes
Stroke, Healthy Adults
Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function in Patients With Stroke
This study aims to compare the effects of mirror therapy combined with either neuromuscular electrical stimulation or binaural beat stimulation on post-stroke lower limb motor function recovery.
- Trial name
- NCT06011018
- Testing
- Mirror Therapy, Mirror Therapy + Electrical Stimulation, Mirror Therapy + Binaural Beat
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Healthy
A Replicate Crossover Trial on Nutritional Supplementation in Association Football (Soccer)
Problems of sleep disorders and disruption are common particularly in Arab populations, and sleep insufficiency hinders the pursuit of high performance and optimal recovery following training and competition.
- Trial name
- AANOF1 (NCT07190989)
- Testing
- Nutritional Supplement
- Where
- Qatar
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aspire Academy
Appetitive Behavior, Obesity
Individual Variability of Appetite Responses to a Standardised Meal
The aim of this study is to examine the interindividual variability of subjective and hormonal appetite responses to a standardised meal in healthy men and explore any moderating influence of the fat mass and obesity associated…
- Conditions
- Appetitive Behavior, Obesity, Genetic Predisposition to Disease
- Trial name
- NCT03771690
- Testing
- Standardised meal
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Hypercholesterolemia, Osteoporosis
Food Matrix and Genetic Variability as Determinants of Bioavailability and Biological Effects of Beta-cryptoxanthin and Phytosterols
Regular consumption of a beverage containing β-cryptoxanthin (b-Cx) and plant sterols (Ps) has been shown to exert a synergic effect in reducing cardiovascular risk and bone remodeling markers (formation and resorption).
- Trial name
- foodmagenpol (NCT02065024)
- Testing
- b-cryptoxanthin plus phytosterols
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Puerta de Hierro University Hospital
Insulin Resistance
Impact of Starch Digestibility on Glycemic Variability and Control, Cardiometabolic and Inflammatory Profiles, Microbiota and Intestinal Health in Subjects With Insulin Resistance
To study the potential impact of a diet rich in both Slowly Digestible Starch (SDS) and Resistant Starch (RS), we propose a 2-month nutritional intervention study in which we will study the evolution of carbohydrate variability…
- Trial name
- GLYMICARE (NCT07408479)
- Testing
- Balanced diet high in Slowly Digestible Starch and Resistant Starch, Balanced diet low in Slowly Digestible Starch and Resistant Starch
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Fetal Growth Retardation
Fetal Heart Rate Variability
Need statement a new way to distinguish between a healthy small fetus and a small fetus suffering from deprivation of nutrition and oxygen to prevent unnecessary induction of preterm birth and improve neonatal outcome.
- Trial name
- NCT04323865
- Testing
- fetal heart rate variability
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Effects of Alpha tACS
**Follow-up Control Study for Creativity Study Purpose: To investigate the effect of transcranial alternating current stimulation (tACS), a form of noninvasive brain stimulation, in healthy subjects.
- Trial name
- PACS (NCT03135639)
- Testing
- NeuroConn Plus Stimulator tACS
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Mitochondrial Oxygenation Measurement, Measurement Error
Mitochondrial Oxygen Measurement Variability in Critically Ill Patients (INOX Variability Study)
To determine the between- and within-subject variability of the mitochondrial oxygenation measurement with the COMET device over time in healthy subjects and in hemodynamically stable subjects admitted to the intensive care unit.
- Conditions
- Mitochondrial Oxygenation Measurement, Measurement Error, Healthy
- Trial name
- NCT04626661
- Testing
- COMET measurement system
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sanquin-LUMC J.J van Rood Center for Clinical Transfusion Research
Type 2 Diabetes
Evaluation of CYP450 Activities in Diabetic Patients vs. Non-diabetic Subjects
Type 2 diabetes (T2D) could modulate CYP450 activities involved in drug-metabolism and cardiovascular homeostasis. We propose to carry out, for the first time, a comprehensive characterization of the effects of T2D on the…
- Trial name
- NCT02291666
- Testing
- CRCHUM-MT cocktail
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Mindfulness
Effect of Mindfulness Induction on Taekwondo-Specific Performance and Autonomic Recovery
This randomized, counterbalanced crossover study investigated whether a mindfulness induction could improve kicking performance and facilitate psychophysiological recovery following fatigue manipulation in taekwondo athletes.
- Trial name
- NCT07775651
- Testing
- Mindfulness induction
- Where
- Taiwan
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University