Clinical trials: Variability
Type1 Diabetes Mellitus
Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes
The goal of this longitudinal clinical trial is to measure variability of interstitial glucose levels with a user-friendly real-time continuous glucose monitoring (CGM) technology at regular intervals in normo- and dysglycemic…
- Trial name
- NCT05777330
- Testing
- Oral glucose tolerance test (OGTT), Hyperglycemic clamp test, Continuous glucose monitoring
- Where
- 6 sites in Belgium
- Volunteers
- 75 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cancer
Temperature, Heart and Respiratory Rate Investigation Along With Variability Evaluation and Serum Biomarkers (THRRIVES)
The purpose of this study is to find a way of detecting infection earlier in patients receiving bone marrow transplant. This is accomplished by continuous individualized monitoring of heart rate, respiratory rate and temperature…
- Trial name
- THRRIVES (NCT01848912)
- Testing
- Zephyr Biopatch Device
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- Ottawa Hospital Research Institute
Sleep Apnea, Obstructive
Relationship Between Vascular Endothelial Dysfunction and Beat-to-beat Blood Pressure Variability in Patients With OSAS
It is thought that intermittent hypoxia, poor tissue oxygenation, and perfusion in OSA can lead to eNOS uncoupling. Uncoupled eNOS can reduce nitric oxide (NO), which will result in an imbalance of contraction and diastole.
- Trial name
- NCT05548569
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huai'an No.1 People's Hospital
Cancer Surgery
Prehabilitation to Improve Heart Rate Variability (PRIME)
Cancer patients require chronic management and care. For those individuals living with cancer, a comprehensive approach that acknowledges the interdisciplinary nature of their condition can help guide appropriate care strategies…
- Trial name
- PRIME (NCT06744413)
- Testing
- Multimodal prehabilitation program
- Where
- 4 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Università Vita-Salute San Raffaele
Type 1 Diabetes, Pregnancy
Pilot Study of Between Visit Interaction to Improve Glycemic Control in Pregnancy With Pre-existing Diabetes
Hypothesis: Increased contact with the diabetes care team throughout pregnancy will lead to improved glucose control during pregnancy.
- Trial name
- NCT02315274
- Testing
- Frequent remote contact between clinic visits.
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Hyperlipidemia
Standard Process 21 Day Purification Program Project
To determine the effects of a commercially available dietary modification plus nutritional supplement regimen, the Standard Process 21 day Purification Program (SPPP), on serum lipids, C-reactive protein (CRP), homocysteine, body…
- Trial name
- SPPP (NCT00724217)
- Testing
- Standard Process 21 Day Purification Program (SPPP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Logan College of Chiropractic
Pulse Pressure Variation, Stroke Volume Variation
Peripheral Venous Pressure Variation, Pulse Pressure Variation and Pleth Variability Index for Fluid Responsiveness
Pulse pressure variation (PPV) and pleth variability index (PVI) are widely used in clinical practice as indicators of the responsiveness to fluid therapy in patients receiving mechanical ventilation.
- Conditions
- Pulse Pressure Variation, Stroke Volume Variation, Pleth Variability Index
- Trial name
- NCT06733389
- Testing
- peripheral waveform collection
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Bundang Hospital
Acute Bronchiolitis, Viral Bronchiolitis
Internal Jugular Vein Respiratory Variability as a Marker of Disease Severity in Infant Bronchiolitis
This prospective observational cohort study evaluates whether respiratory-cycle variation in internal jugular vein (IJV) diameter, measured by point-of-care ultrasound, correlates with clinical disease severity in infants 1-23…
- Conditions
- Acute Bronchiolitis, Viral Bronchiolitis, Respiratory Syncytial Virus Infections
- Trial name
- IJV-BRONCH (NCT07778225)
- Testing
- Point-of-Care Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Eskisehir Osmangazi University
Gait, Spastic, Reliability
Reliability of Newly-acquired Gait in Toddlers With a Typical Development and a Unilateral Cerebral Palsy
gait reliability study of toddlers with typically developing and with unilateral cerebral palsy during the first 6 months of independent walking
- Trial name
- ReliabBB-AQM (NCT04559776)
- Testing
- gait analysis
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Clinical Center for Neuropsychomotor Recovery for Children Dr. Nicolae Robanescu
Peripheral Arterial Disease
Exoskeleton Variability Optimization
Exoskeletons, wearable devices that assist with walking, can improve mobility in clinical populations. With exoskeletons, it is crucial to optimize the assistance profile.
- Trial name
- NCT04338815
- Testing
- Exoskeleton Optimization, Endurance Evaluation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Stress, Pituitary-Adrenal System
Modulating Stress-Reactivity by Real-Time Multimodal Functional Neuroimaging Based Neurofeedback
The overall goal of the outlined study is to establish a Real-Time (RT) functional Magnetic Resonance Imaging (fMRI) Neurofeedback (NF) (RT-fMRI-NF) protocol aiming at modulating neural, endocrine, and subjective reactivity to…
- Trial name
- NCT02560233
- Testing
- Contingent RT-fMRI-NF
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
SARS-CoV2 Infection, COVID-19 Acute Respiratory Distress Syndrome
Impact of COVID-19 SARS-CoV-2 Variability in ICU Hospitalized Patients With Severe Disease
Background:The impact of the emergence of SARS-CoV-2 variants on the severity and clinical outcomes of COVID-19 is controversial.
- Conditions
- SARS-CoV2 Infection, COVID-19 Acute Respiratory Distress Syndrome, Mutation
- Trial name
- SEVARVIR (NCT05162508)
- Testing
- Nasopharyngeal swab
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Physiological Stress
Trial to Evaluate the Effects of Sound Modulation on Critically Ill Patients
The goal of the project is to determine the effects of noise masking and noise reduction on stress related physiological parameters in critically ill patients admitted to the intensive care unit.
- Conditions
- Critical Illness, Physiological Stress, Delirium, Sleep Deprivation
- Trial name
- SMART (NCT03019133)
- Testing
- Sound reduction, Sound masking
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brian Gehlbach
Decrease in Heart Rate Below Baseline Value
Genetic Determinants of Hemodynamic Response to Esmolol
Beta 1 Adrenergic antagonists (beta blockers) have major role in the treatment of CHF, IHD and hypertension. However, there is large interindividual variability in the response to beta blockers.
- Trial name
- NCT01388036
- Testing
- esmolol
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Waist Circumference Measurements, Schizophrenia
Waist Circumference Measurements in Schizophrenic Patients
The prevalence of metabolic syndrome(MS) among pt's with schizophrenia has been reported to be high, ranging from 24 to 43% in males and 27 to 52% in females.
- Conditions
- Waist Circumference Measurements, Schizophrenia, Cardiovascular Risk Factor
- Trial name
- NCT01243034
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Changhua Christian Hospital
Alcohol Dependence
Effectiveness of Naltrexone Versus Placebo to Reduce Craving for Alcohol With Evaluation of Genetic Variability.
The purpose of this study is to determine whether naltrexone (an opiate blocking agent approved for the treatment of alcohol dependence) is more effective in the reduction of alcohol craving and drinking compared to placebo in…
- Trial name
- NCT00366626
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Medical University of South Carolina
Abdomino-pelvic Surgery
Comparison of Intraoperative Volume Replacement Determined by the Plethysmograph Variability Index (PVI) With That Determined by the Delta PP in the Digestive, Gynecological, Urological, and Abdominal Surgery and Their Impact on the Length of Stay
An optimal intraoperative fluid replacement reduces the hospital stay, the admissions in the intensive care unit and the mortality rate after a major surgery.
- Trial name
- NCT02908256
- Testing
- Geloplasma (PVI), Geloplasma (delta PP)
- Volunteers
- 80 people
- Sponsor
- Brugmann University Hospital
PONV, Blood Pressure
Minimisation of Blood Pressure Variability and Postoperative Nausea and Vomiting
Intraoperative hypotension is associated with postoperative nausea and vomiting (PONV). Even though the exact mechanism linking PONV and hypotension is still unclear, a reduced intestinal tissue perfusion might trigger nausea and…
- Conditions
- PONV, Blood Pressure, Postoperative Recovery
- Trial name
- SICK (NCT05596695)
- Testing
- Minimizing blood pressure variability
- Where
- Austria
- Volunteers
- 272 people
- Sponsor
- Medical University of Vienna
Holistic Care, Mental Health
Using Integrated Care and Wearable Technology to Evaluate Outcomes of the Shields & Stripes Program for Veterans and First Responders
This study aims to evaluate outcomes from the Shields \& Stripes (S\&S) program - a 12-week, multidisciplinary wellness intervention designed for veterans and first responders.
- Conditions
- Holistic Care, Mental Health, Sleep, PTSD
- Trial name
- S&S Wellness (NCT07452900)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Baylor University
HIV Associated Polyneuropathy
Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy
This study looks at a non-invasive ear stimulation treatment to better understand nerve pain in people living with HIV. The study aims to assess how the body and nervous system respond to this treatment, including changes in…
- Trial name
- NCT07822932
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (AVNS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
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