Clinical trials: Variability
Diabetes Mellitus
Assessment of HGI (Hemoglobin Glycation Index) Variability Over Time in Patients Living With Diabetes Using Continuous Glucose Monitoring ( GAP OUEST )
The goal of this clinical trial is to learn about the variability of HGI (Hemoglobin Glycation Index) over time in patients living with diabetes using a continuous glucose monitoring.
- Trial name
- GAP OUEST (NCT06185491)
- Testing
- HGI
- Where
- 9 sites in France
- Volunteers
- 750 people
- Sponsor
- Nantes University Hospital
Hypertension, FXTAS
Diaphragmatic Breathing and Heart Rate Variability Training for Improving Hypertension in Fragile X Associated Tremor/Ataxia
To study whether heart rate variability training and respiratory coherence can improve hypertension in individuals with FXTAS. All patients will receive HRV biofeedback training for 20 sessions.
- Trial name
- NCT03816540
- Testing
- HRV and respiratory coherence biofeedback
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Multiple Myeloma (MM), Breathing Techniques
Effects of Controlled Breathing on Cardiorespiratory Variables in Multiple Myeloma
A randomized, parallel, double-blind, controlled, clinical trial. Two groups of participants will be included, both receiving a therapeutic exercise intervention and an educational session on the importance of proper breathing…
- Conditions
- Multiple Myeloma (MM), Breathing Techniques, Breathing Exercises, Exercise Activity
- Trial name
- NCT07376733
- Testing
- Controlled breathing exercise protocol + therapeutic exercise + initial education session, Therapeutic exercise + initial education session
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad Complutense de Madrid
Autonomic Function
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- Trial name
- CPB_Atropine (NCT06912048)
- Testing
- Oral glucose tolerance test with double-tracer dilution and atropine infusion
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Critical Illness, Hyperglycemia
Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients
Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood.
- Trial name
- GLUPTEN (NCT01796847)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Burnout, Sleep Disturbance
Non-Invasive Sleep Monitoring for Burnout and Retention Risk in Postgraduate Nurses
Newly graduated nurses often experience high levels of psychological stress, sleep disturbance, fatigue, and burnout during the early transition into clinical practice.
- Conditions
- Burnout, Sleep Disturbance, Occupational Stress, Mental Health
- Trial name
- NCT07666633
- Testing
- Non-Invasive Sleep Monitoring
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Armed Forces General Hospital
Motor Activity
The Reliability of the Box and Block Test in People After Stroke
The main aim of the pilot project is to establish inter-rater reliability, internal variability and variability of results got in Box and Block Test administered according to the new Czech extended version of its manual.
- Trial name
- NCT05009121
- Testing
- Box and Block Test
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Charles University, Czech Republic
COVID-19, Inpatient
Virtual Reality Therapy Influence on Heart Rate Variability of Inpatients With COVID-19
The end of 2019 saw the emergence of a new human coronavirus (COVID-19) spread rapidly around the world and has a high degree of lethality.
- Trial name
- NCT04537858
- Testing
- Virtual reality therapy first, Conventional therapy first
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Eye Movement Desensitization and Reprocessing, Cognitive Behavioral Therapy
RCT Comparing EMDR and CBT for Treatment of Resistant Depression
Depression is one of the most common invalidating mental disorders, ranked by World Health Organization as the single largest contributor to global disability.
- Conditions
- Eye Movement Desensitization and Reprocessing, Cognitive Behavioral Therapy, Neurobiological Processing, Depression
- Trial name
- NCT03972033
- Testing
- EMDR, CBT
- Where
- Italy
- Volunteers
- 128 people
- Sponsor
- University of Turin, Italy
Bipolar Disorders
Omega-3 Fatty Acids in Bipolar Patients With a Low Omega-3 Index and Reduced Heart Rate Variability
This study sets out to test the hypothesis that parameters of heart rate variability, as a non-invasive measure of cardiovascular risk, can be improved by the addition of omega-3 fatty acids in euthymic bipolar patients with a…
- Trial name
- NCT00891826
- Testing
- Omega-3 fatty acids (EPAX 6015 TG), Corn oil
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cystic Fibrosis
A Study to Determine the Variability of a 6-Minute Walk Test in Cystic Fibrosis Subjects With Advanced Lung Disease
This is an observational study to be conducted at approximately 25 sites in the United States. Approximately 25 subjects with severe obstructive CF lung disease (FVC <40% predicted) will be enrolled.
- Trial name
- NCT00311506
- Volunteers
- 25 people
- Sponsor
- Genentech, Inc.
Stress
Photobiomodulation, Heart Rate Variability, and Acute Stress
Photobiomodulation (PBM) is a form of light therapy that uses red or near-infrared light to influence biological processes. In prior studies, PBM has been shown to improve various physiological functions, including tissue repair…
- Trial name
- NCT07475858
- Testing
- Vielight Vagus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hypertension
The Effect of Acupuncture on Blood Pressure and Heart Rate Variability (HRV)
This research is designed to study the effects of needle acupuncture on blood pressure and HRV by stimulating certain acupuncture points and meridians.
- Trial name
- Acupuncture (NCT00724763)
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Type 2 Diabetes Mellitus
Efficacy of Sitagliptin and Glibenclamide on the Glucose Variability in Japanese Participants With Type 2 Diabetes Mellitus (MK-0431-355)
This is a study of the efficacy of sitagliptin and glibenclamide in a short-term treatment on the glucose variability using continuous glucose monitoring (CGM) in Japanese participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT02318693
- Testing
- Sitagliptin, Glibenclamide
- Volunteers
- 53 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Obstructive Pulmonary Disease (COPD)
Physical Training and Heart Rate Variability in COPD
To contrast the potential effects of physical exercise training program (PTP) of a 6 versus 12 weeks on cardiac autonomic modulation by linear and non-linear heart rate variability (HRV) indices and functional capacity in…
- Trial name
- NCT01889563
- Testing
- Physical Exercise Training Program Exercise
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Federal de Sao Carlos
Stress, Stress, Psychological
The Effect of SKY Breath Meditation on Health and Well-being
The goal of this pilot SKY (Sudarshan Kriya Yoga) Breath Meditation study is to establish feasibility and acceptability of the intervention; and investigate preliminary effectiveness of the intervention at the DNA methylation…
- Conditions
- Stress, Stress, Psychological, Stress, Physiological, Anxiety
- Trial name
- NCT05523414
- Testing
- SKY
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Stress
Psychophysiological Stress Response in Medical Students During Simulation-Based Communication Training -Study Protocol
In this study, researchers will examine key predictors of stress reactions in medical students participating in simulation-based communication training.
- Trial name
- SIMU2025 (NCT06906614)
- Testing
- Simulation-Based Communication Training
- Where
- Czechia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Depression
Effects of Tuijing Therapy on Heart Rate Variability and Psychological Symptoms
Background Mental disorders are recognized as a major cause of disability and disease burden across the lifespan. Gua Sha is believed to improve mental health and sleep quality significantly.
- Trial name
- TJ (NCT06888284)
- Testing
- Tui Jing therapy
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Type 2 Diabetes, Obesity
GENETIC VARIABILITY TO GLP1 TREATMENT
The goal of this retrospective study is to assess whether a selection of genetic variants may allow us to identify individuals who will have a satisfactory response after GLP-1 treatment in terms of weight loss, sugar level…
- Trial name
- GLP1 treatment (NCT06298799)
- Testing
- DNA Sequencing and Analysis, differential expression analysis with RNA-sequencing (RNA seq) experiments
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- GENGE
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