Clinical trials: Varicose Vein Disease
Hemorrhoid, Hemorrhoidal Disease
Nimsai Herbal for Grade 2-3 Hemorrhoids: A Quadruple-Blind Placebo-Controlled Mechanistic Trial
This randomized, quadruple-blind, placebo-controlled clinical trial evaluates the efficacy and safety of Nimsai Herbal, a proprietary oral phytotherapeutic formulation, in 50 participants aged 18-70 years with endoscopically…
- Trial name
- NAJ2 (NCT07669662)
- Testing
- Nimsai Herbal
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Nimsai Academia
Venous Leg Ulcer
RCT Exudate Management Cutimed Sorbion Product Range
The fluid handling capacity of superabsorbent dressings varies depending on the design and construction. The use of effective advanced wound dressings is a promising strategy to achieve adequate absorption of wound exudate and…
- Trial name
- NCT06300762
- Testing
- Superabsorbent dressing application
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 152 people
- Sponsor
- BSN Medical GmbH
Venous Hypertension Ulcers, Venous Stasis Ulcer
Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence
The goal of this study is to test MUSTCOOL, a home-based self-monitoring and self-management ulcer prevention intervention for patients with newly healed chronic venous leg and diabetic foot ulcers.
- Conditions
- Venous Hypertension Ulcers, Venous Stasis Ulcer, Venous Ulcer, Venous Insufficiency
- Trial name
- MUSTCOOL (NCT02626156)
- Testing
- Cooling gel pack, Cooling cotton pack
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina
Compensated Advanced Chronic Liver Disease, Variceal Hemorrhage
Spleen Stiffness Combined With Liver Stiffness Measured by 2D-SWE for the Screening of High-risk Varices in Compensated Advanced Chronic Liver Disease (CHESS2004)
Variceal hemorrhage is the serious complication in patients with compensated advanced chronic liver disease (cACLD). To evaluate the bleeding risk of varices, esophagogastroduodenoscopy (EGD) should be performed.
- Trial name
- NCT04546360
- Testing
- Esophagogasrtoduodendoscopy, spleen stiffness measurement and liver stiffness measurement.
- Where
- 6 sites in China
- Volunteers
- 381 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Venous Leg Ulcer
Clinical Study Of Affinity Versus SOC In The Management Of VLUs
This prospective, multi-center, randomized, controlled clinical study compares Affinity® plus SOC to SOC alone in subjects with VLUs.
- Trial name
- NCT04901013
- Testing
- Affinity
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Organogenesis
Venous Leg Ulcer, Wound Heal
COMS for Chronic Ulcers Treatment
Chronic leg and foot ulcers are defined as wounds that fail to heal in a timely manner, typically persisting for over 4 to 8 weeks without substantial healing despite standard care.
- Conditions
- Venous Leg Ulcer, Wound Heal, Magnetic Field Exposure
- Trial name
- NAZARÉ (NCT06528873)
- Testing
- Concurrent optical and magnetic stimulation (COMS) treatment
- Where
- 10 sites in Austria, France and 2 more
- Volunteers
- 122 people
- Sponsor
- Sebastian Probst
Varicose Veins
COMFORT: A Multicenter, Open-label, Randomized, Crossover Study
The purpose of this study is to evaluate pain the patient experienced following treatment of varicose veins with Varithena® compared to radiofrequency ablation.
- Trial name
- COMFORT (NCT02462720)
- Testing
- Varithena®, Radiofrequency ablation
- Where
- 4 sites in United States
- Volunteers
- 35 people
- Sponsor
- Boston Scientific Corporation
Chronic Venous Leg Ulcer, Venous Ulcer
Effect of Ozonated Gel Phonophoresis on Chronic Venous Ulcer Healing
This study looks at whether adding ozone gel to ultrasound treatment (a method called phonophoresis) helps chronic leg wounds caused by poor vein function heal better than ultrasound or ozone gel used alone.
- Trial name
- NCT07803445
- Testing
- Ozonated Gel Phonophoresis, Ultrasound Therapy, Ozonated Gel
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Chronic Venous Insufficiency
Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins
Part I: Proof of concept trial to achieve normal venous pressure values under different provocation maneuvers in healthy persons Part II: Non invasive measurement of venous pressure under different provocation maneuvers in…
- Trial name
- NCT01000909
- Testing
- Ultrasound (venous pressure measurement)
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Varicose Veins
Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt
The purpose of this study is to determine the safety of the Varisolve® procedure in patients with right-to-left cardiac shunt (a defect in the heart).
- Trial name
- MRI (NCT00442364)
- Testing
- Polidocanol (1%) Microfoam (Varisolve), Endovenous Microfoam Occlusion
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Boston Scientific Corporation
Venous Ulcers
Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers
This study will test the safety and efficacy of nitric oxide gas in the treatment of venous leg ulcers
- Trial name
- NCT00545298
- Testing
- Nitric Oxide - same dose 6 wks, Nitric Oxide modified treatment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Nitric BioTherapeutics, Inc
Venous Ulcer
Preliminary Testing of New Treatment for Chronic Leg Wounds
The primary objectives of this study are to evaluate the efficacy, dosing, and safety of an intra-ulcer injection H5.020CMV.PDGF-b in adults who have a venous leg ulcer.
- Trial name
- NCT01858272
- Testing
- H5.020CMV.PDGF-b and limb compression bandage
- Volunteers
- 15 people
- Sponsor
- University of Pennsylvania
Leg Ulcer
Evaluation of a Ionic Silver and Honey Preparation to Treat Chronic Wounds of the Lower Legs
In this open study, the primary objective is to study the efficacy and clinical outcome of the chronic wounds treated with this preparation for 8 weeks on 30 adults.
- Trial name
- NCT01111695
- Testing
- ApisSept
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Venous Thrombosis
The GORE Viabahn Endoprosthesis for the Treatment of Venous Occlusions and Stenoses
To study the safety and efficacy of drug coated stents for the treatment of venous occlusions and stenoses in the lower extremity.
- Trial name
- NCT01406795
- Testing
- Gore Viabahn Heparin Coated Stent
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Venous Leg Ulcer
Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers
A Multicenter, Prospective, Randomized, Open-Label Study with a Crossover Extension Option to Evaluate the Safety and Efficacy of GrafixPL for the Treatment of Chronic VLUs
- Trial name
- NCT03629236
- Testing
- GrafixPL, Control
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Osiris Therapeutics
Chronic Venous Insufficiency
EU Post Market Clinical Follow-Up Study of the Venclose System for Saphenous Vein Incompetence
This is a prospective, non-randomized study in which patients who meet eligibility criteria and consent to participate will undergo a minimally invasive procedure using radiofrequency (RF) energy for ablation of the great…
- Trial name
- NCT04236245
- Testing
- Venclose RF System
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Venclose, Inc.
Chronic Ulcer, Venous Ulcer
Efficacy of PICO Single-use System in Chronic Ulcers
A clinical trial will be carried out comparing the efficacy of PICO system based on negative pressure therapy (NPT) in adults with chronic ulcers compared to conventional treatments.
- Conditions
- Chronic Ulcer, Venous Ulcer, Diabetic Foot Ulcer, Pressure Injury
- Trial name
- NCT05877378
- Testing
- Single-use negative pressure therapy (PICO)
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Varicose Veins, Dilated Veins
Primary Insufficiency of the GSV With a Diameter >/= 12 mm, Antero-lateral Branches, or Below the Knee
The goal of this registry study is to provide insight in the safety and efficacy of treatment with MOCA for primary insufficiency of the GSV with a diameter >/=12mm, insufficient antero-lateral branches and insufficiency of the…
- Trial name
- MOCA-XL (NCT02345018)
- Testing
- Mechano-chemical ablation
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Rijnstate Hospital
Venous Leg Ulcer
HM242-Gel vs Comparator
The primary objective of the study is to demonstrate that the HM242-Gel performs at least comparably to INTRASITE Gel with regard to wound healing.
- Trial name
- NCT04902651
- Testing
- HM242-Gel, Intrasite Gel
- Where
- 3 sites in Czechia, Slovakia
- Volunteers
- 73 people
- Sponsor
- B. Braun Ltd. Centre of Excellence Infection Control
Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers
Use of Hydroprep Wound Therapy With Motion Negative Pressure Therapy for Treatment of Chronic Lower Extremity Wounds
Use of a motorized waterjet to debride wounds to improve healing outcomes.
- Conditions
- Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers, Pressure Injuries, Traumatic Wounds and Injuries
- Trial name
- NCT07653165
- Testing
- Motion NPWT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- West Boca Center for Wound Healing