Clinical trials: Varicose Veins Leg
Venous Leg Ulcer
Cyanoacrylate Closure for Treatment of Venous Leg Ulcers
Venous leg ulcers (VLUs) are a common wound with significant morbidity and cost, and suboptimal therapeutic options. VLUs result from chronic venous insufficiency, including venous reflux and post-thrombotic syndrome.
- Trial name
- NCT04011371
- Testing
- Cyanoacrylate closure
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Sunnybrook Health Sciences Centre
Varicose Veins of Lower Limb
Comparison of Radiofrequency Ablation With Concomitant or Staged Treatment for Tributary Varicose Veins
The purpose of this clinical trial is to know which is better to treat the branch vein at the same time or in stages during radiofrequency ablation.
- Trial name
- NCT07445425
- Testing
- Staged surgery group, Concomitant surgery group
- Where
- 21 sites in China
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Venous Leg Ulcer (VLU), Compression Bandages
A Randomized Non-Inferiority Study of Mepi™ Press 2 vs UrgoK2® for Compression Therapy in Venous Leg Ulcers
Venous leg ulcers (VLUs) account for approximately 70% of all lower limb ulcers and affect an estimated 0.032% to 1% of the population in Western countries, corresponding to approximately 265,000 to 650,000 individuals in France.
- Trial name
- NCT07600489
- Testing
- Compression bandage system (Mepi™ Press 2), Compression bandage system (UrgoK2®), Wound Dressing Material
- Where
- 8 sites in France
- Volunteers
- 386 people
- Sponsor
- Molnlycke Health Care AB
Venous Leg Ulcer
Combined Electromagnetic Field and a Plantar Resistance Exercise With Venous Leg Ulcer
The purpose of this study will investigate the effects of combined electromagnetic field and a plantar resistance exercise therapy versus electromagnetic field on healing of venous leg ulcer .
- Trial name
- NCT05410613
- Testing
- electromagnetic field and a plantar resistance exercise, Pulsed electromagnetic field, usual care
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mona Mohamed Taha
Diabetic Foot, Leg Ulcer
Obtaining and Storing Standard of Care Wound Biopsies for Immediate or Future Wound-Related Scientific Study
The objective of this study protocol is to use wound biopsies that have been obtained during standard of care management for further scientific evaluation after standard evaluation by a pathologist.
- Conditions
- Diabetic Foot, Leg Ulcer, Decubitus Ulcer
- Trial name
- NCT00759889
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Southwest Regional Wound Care Center
Varicose Veins
Study on Treatment of Varicose Veins by Endovenous Laser (1940 nm vs 1470 nm)
The goal of this clinical trial is to compare efficacy of two wavelength for EndoVenous Laser Ablation (EVLA) in treatment of varicose veins of the lower limbs. The main questions it aims to answers are : 1.
- Trial name
- NEWWAVE (NCT05663359)
- Testing
- EVLA 1940 nm, EVLA 1470 nm
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Clinique Pasteur
Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral)
Apixaban vs Rivaroxaban vs No Anticoagulant to Prevent EHIT After Great Saphenous Vein Laser Ablation
Endothermal heat-induced thrombosis (EHIT) is a thrombotic complication specific to endovenous thermal ablation of the great saphenous vein (GSV), for which no prophylactic regimen is standardized.
- Conditions
- Venous Thrombosis Deep (Limbs), Venous Insufficiency (Chronic)(Peripheral), Varicose Veins Leg, Venous Thrombosis
- Trial name
- NCT07699796
- Testing
- Apixaban, Rivaroxaban
- Where
- United States
- Volunteers
- 564 people
- Sponsor
- Heart, Artery, and Vein Center of Fresno
Varicose Veins of Lower Limb, Telangiectasia
Efficiency of Determining the Clinical Class of Chronic Venous Disorders by Artificial Intelligence
Purpose: To evaluate the sensitivity and specificity of the method for determining the clinical class of chronic venous diseases using the Ivenus application (within C0-C2 according to CEAP).
- Trial name
- IVENUS (NCT05978986)
- Testing
- Determining of the clinical class of chronic venous disorders by artificial intelligence
- Where
- 3 sites in Russia
- Volunteers
- 1,622 people
- Sponsor
- Clinic of Phlebology and Laser Surgery, Chelyabinsk, Russia
Varicose Veins of Lower Limb, Venous Insufficiency of Leg
Comparative Analysis of Radiofrequency Ablation and Microwave Ablation Procedures for the Treatment of Small Saphenous Varicose Veins
Objective: To investigate the clinical efficacy of ultrasound-guided radiofrequency ablation and microwave ablation in the treatment of primary saphenous varicose veins.
- Conditions
- Varicose Veins of Lower Limb, Venous Insufficiency of Leg, Vascular Disease，Peripheral
- Trial name
- NCT06711120
- Testing
- Radiofrequency ablation and microwave ablation are used to treat small saphenous varicose veins, respectively
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Venous Leg Ulcer
RCT Exudate Management Cutimed Sorbion Product Range
The fluid handling capacity of superabsorbent dressings varies depending on the design and construction. The use of effective advanced wound dressings is a promising strategy to achieve adequate absorption of wound exudate and…
- Trial name
- NCT06300762
- Testing
- Superabsorbent dressing application
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 152 people
- Sponsor
- BSN Medical GmbH
Venous Stasis Ulcers
Feasibility Study to Evaluate the Safety of Topically Applied Revera in Subjects With Venous Leg Ulcers
The purpose of this study is to perform a preliminary evaluation of the safety of Revera Wound Care when topically applied to venous leg ulcers for 8 weeks of treatment.
- Trial name
- NCT00823446
- Testing
- Revera Wound Care, Normal Saline
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Revalesio Corporation
Diabetic Foot, Venous Ulcer
Adipose Derived Regenerative Cellular Therapy of Chronic Wounds
Our study aims to explore the effects of Adipose Derived Stem Cells (ASCs) on chronic wounds.
- Conditions
- Diabetic Foot, Venous Ulcer, Pressure Ulcer
- Trial name
- NCT02092870
- Testing
- Adipose derived stem cells
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Tower Outpatient Surgical Center
Venous Ulcer
Shock Wave Versus Low Level Laser on Chronic Venous Ulcer
To find out the difference in the effect of shock wave therapy and low level laser therapy on venous ulcer patient As regards the following outcomes; 1.
- Trial name
- NCT06756386
- Testing
- extra corporeal shock wave therapy (ESWT ), Low Level Laser Therapy, conservative treatments
- Volunteers
- 45 people
- Sponsor
- Beni-Suef University
Venous Leg Ulcer
HM242-Gel vs Comparator
The primary objective of the study is to demonstrate that the HM242-Gel performs at least comparably to INTRASITE Gel with regard to wound healing.
- Trial name
- NCT04902651
- Testing
- HM242-Gel, Intrasite Gel
- Where
- 3 sites in Czechia, Slovakia
- Volunteers
- 73 people
- Sponsor
- B. Braun Ltd. Centre of Excellence Infection Control
Venous Leg Ulcers, Venous Leg Ulcers (VLUs)
Modified Platform Trial Assessing Multiple Umbilical Cord-based CAMPs and SOC v SOC Alone in the Treatment of Hard-to-Heal VLUs
The purpose of this study is to evaluate the efficacy of two dehydrated human umbilical cord-based medical devices, also defined as Cellular, Acellular, Matrix-like Products/skin substitutes, plus SOC versus SOC alone in…
- Conditions
- Venous Leg Ulcers, Venous Leg Ulcers (VLUs), Venous Leg, Leg Ulcers
- Trial name
- CORDSTIM-VLU (NCT07449988)
- Testing
- Standard of Care (SOC), Corplex P, Theracor
- Volunteers
- 272 people
- Sponsor
- StimLabs
Diabetic Foot Ulcers, Venous Ulcers
Registry Trial of the Effectiveness of Platelet Rich Plasma for Chronic Non-Healing Wounds
This study will examine differences in the process of wound-healing in patients treated with platelet rich plasma (a concentration of proteins derived from a patients own blood) applied to the wound as a gel; injected into the…
- Conditions
- Diabetic Foot Ulcers, Venous Ulcers, Pressure Ulcers
- Trial name
- CMS (NCT02071979)
- Testing
- Autologous PRP Gel, Autologous PRP Injections, Autologous PRP Gel plus PRP Injections
- Where
- 6 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Arteriocyte, Inc.
Venous Ulcer, Arterial Ulcer
PluroGel on Wounds of Mixed Etiology
A randomized controlled study (RCT) to investigate the topical effectiveness of PluroGel in healing venous and mixed aetiology leg ulcers.
- Trial name
- NCT03275831
- Testing
- PluroGel, Intrasite gel
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Medline Industries
Skin Ulcer Venous Stasis Chronic, Mixed Arteriovenous Leg Ulcer
Pilot Study Comparing NatroxTM Topical Oxygen Therapy to A Placebo in the Management of Non-Healing Leg Ulcers
The purpose of this study is to determine the effectiveness of the NatroxTM Topical Oxygen device versus a placebo in patients with non-healing leg ulceration in conjunction with standard best practice.
- Trial name
- NCT01913704
- Testing
- NatroxTM Device
- Where
- 2 sites in Czechia
- Sponsor
- Inotec AMD Limited
Varicose Veins
Ambulatory Surgery of Lower Extremity Varicose Vein
OBJECTIVE: To retrospectively analyze the results of ambulatory treatment on Taiwanese patients with primary varicosities of the lower extremities including the use of endovenous laser, phlebectomy, and sclerotherapy.
- Trial name
- NCT00702897
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Far Eastern Memorial Hospital
Varicose Ulcer
A Clinical Study to Assess a Compression Device in Patients With Venous Leg Ulcers
The purpose of this study is to evaluate the product performance of a new adjustable compression system for the treatment of venous leg ulcers.
- Trial name
- NCT02561013
- Testing
- 3M™ Coban™ Custom Fit Compression System, Profore
- Where
- 5 sites in United States, Canada
- Sponsor
- 3M