Clinical trials: Varix, Esophageal
Variceal Bleeding, Cirrhosis
Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding
This study is performed to compare the efficacy and safety of EBL, propranolol, and EBL combined with propranolol in patients with medium or large varices.
- Trial name
- NCT00965900
- Testing
- Endoscopic band ligation, Propranolol, EBL+Propranolol
- Where
- South Korea
- Volunteers
- 288 people
- Sponsor
- Korea University
Gastric Varices
Primary Prophylaxis of Gastric Variceal Bleed
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the prevention of gastric variceal bleeding.
- Trial name
- NCT02468180
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Gastric Variceal Hemorrhage
N-Butyl-2-Cyanoacrylate Injection Versus Band Ligation for Gastric Variceal Hemorrhage
The purpose of this study was to test the hypothesis by comparing the efficacy of cyanoacrylate injection (GVO) and band ligation (GVL) in the treatment of acute GVH in liver cirrhotic patients with or without concomitant…
- Trial name
- NCT00292331
- Testing
- cyanoacrylate injection to treat gastric variceal hemorrhage
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Esophageal and Gastric Varices
Evaluation of Endoscopic Treatment Effect Based on HVPG
This study aims to evaluate the endoscopic treatment effect and related influencing factors of patients with esophageal and gastric varices based on HVPG.
- Trial name
- NCT06863519
- Testing
- Endoscopic treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Venous Reflux, Venous Insufficiency
Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections
Randomized Controlled Trial to determine if the outcomes of sclerotherapy of the ulcer bed alone differ from a combination of ablation and sclerotherapy injections.
- Conditions
- Venous Reflux, Venous Insufficiency, Venous Ulcer, Venous Disease
- Trial name
- NCT05633277
- Testing
- Polidocanol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- ProMedica Health System
Gastric Varices
Pre-emptive RTO for An Early Detected Gastric Varices in CT/MR Angiogram Trial
A number of treatment modalities are currently in use for gastric variceal bleeding (GVB). Balloon-occluded, plug-assisted, and coil-assisted retrograde transvenous obliteration (RTO) procedures are described in the literature as…
- Trial name
- PRADA (NCT07168395)
- Testing
- Non-selective beta blockers, Retrograde transvenous obliteration
- Volunteers
- 68 people
- Sponsor
- University of California, Los Angeles
Esophageal and Gastric Varices
Trial of Monthly Versus Bi-weekly Endoscopic Variceal Ligation for the Prevention of Esophageal Variceal Rebleeding
Many physicians suggest repeating EVL every 1-2 weeks until esophageal varices are obliterated to prevent variceal rebleeding， however, the evidences supporting the efficacy of EVL intervals of 1-2 weeks are insufficient.This…
- Trial name
- NCT02719119
- Testing
- monthly Endoscopic Variceal Ligation (EVL), bi-weekly Endoscopic Variceal Ligation (EVL)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Cirrhosis, Portal Hypertension
Efficacy of Long-acting Octreotide (Sandostatin LAR) in Reducing Portal Pressure in Patients With Cirrhosis
Octreotide is used to control variceal bleeding. However, octreotide has to be given through the vein and is effective for less than two hours.
- Conditions
- Cirrhosis, Portal Hypertension, Esophageal Varices
- Trial name
- NCT01188733
- Testing
- Long acting octreotide 10mg, Long acting Octreotide 30mg, Saline
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Esophagogastric Varices, Portal Hypertension
Treatment Outcomes for Portal Hypertension Esophageal and Gastric Varices
This study is a single-center, prospective cohort study based on real-world data. Patients with portal hypertension and esophagogastric varices were enrolled and divided into an endoscopic treatment group and a non-endoscopic…
- Trial name
- NCT07358663
- Where
- China
- Volunteers
- 1,384 people
- Sponsor
- Shanghai Zhongshan Hospital
Liver Cirrhosis, Esophageal and Gastric Varices
Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of…
- Trial name
- NCT02593799
- Testing
- Endoscopy
- Where
- 17 sites in China
- Volunteers
- 363 people
- Sponsor
- General Hospital of Shenyang Military Region
Liver Cirrhosis, Gastroesophageal Varices Bleeding
Comparison of Underdilated Versus Standard TIPS in Preventing Variceal Rebleeding in Patients With Cirrhosis
Transjugular intrahepatic portosystemic shunt (TIPS) is a key therapeutic intervention for complications of portal hypertension.
- Trial name
- UVR-TIPS (NCT07253389)
- Testing
- Underdilated TIPS, Standard TIPS
- Where
- China
- Volunteers
- 648 people
- Sponsor
- Air Force Military Medical University, China
Acute Bleeding Esophageal Varices, Liver Cirrhosis
Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding
Study hypothesis: Hepatic venous pressure gradient (HVPG)-directed primary prophylaxis with nonselective beta-blocker therapy (NSBB) leads to a reduction in first variceal bleeding episodes and is cost-effective in the long term.
- Trial name
- Porthos (NCT01618890)
- Testing
- Hepatic venous pressure gradient measurement
- Where
- 6 sites in Belgium, Netherlands
- Volunteers
- 78 people
- Sponsor
- Leiden University Medical Center
Acute Bleeding Esophageal Varices, Portal Hypertension
A Trial of Somatostatin With Endoscopic Variceal Ligation (EVL) in Control of Acute Variceal Bleeding
Background: Efficacy of endoscopic variceal sclerotherapy in achieving initial control of acute variceal bleeding and five-day haemostasis has been shown to significantly improve when vasoactive drug is added.
- Conditions
- Acute Bleeding Esophageal Varices, Portal Hypertension, Cirrhosis
- Trial name
- AVB-EVL+S (NCT01267669)
- Testing
- Somatostatin
- Where
- India
- Volunteers
- 61 people
- Sponsor
- Govind Ballabh Pant Hospital
Hepatocellular Carcinoma, Liver Cirrhosis
Liver and Spleen Stiffness to Predict the Presence of Esaphageal Varices in Cirrhotic With Advanced HCC
Elasto-HCC is a prospective, uncontrolled, multicenter observational study involving several hepatology centers in Italy. Patients with liver cirrhosis and advanced hepatocellular carcinoma (HCC) who will need to undergo systemic…
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Portal Hypertension
- Trial name
- ELASTO-HCC (NCT06773260)
- Testing
- Liver and Spleen stiffness measurement.
- Where
- 12 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliero Universitaria Policlinico Modena
Gastric Varices
Dermabond Treatment for Gastric Variceal Bleeding
The purpose of having a database is to collect data related to endoscopic ultrasound procedures performed by Indiana University EUS physicians; specifically, for the treatment of gastric variceal bleeding This data will be used…
- Trial name
- NCT02037659
- Testing
- DermaBond treatment of Gastric Varices
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Indiana University
Esophageal Varices, Portal Hypertension
Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding
The main objective of this study is to determine the efficacy of early administration of Sanvar® in combination with endoscopic treatment for the control of acute variceal bleeding.
- Conditions
- Esophageal Varices, Portal Hypertension, Gastric Varices, Esophageal Bleeding
- Trial name
- NCT00331188
- Testing
- Sanvar® (vapreotide)
- Where
- 19 sites in United States
- Volunteers
- 70 people
- Sponsor
- Debiovision
Esophageal and Gastric Varices
Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding
Gastric variceal obturation is the current endoscopic therapy of choice for gastric variceal bleeding but is associated with a high rebleeding rate. Carvedilol is a potent non-selective β-blocker.
- Trial name
- NCT02504723
- Testing
- carvedilol, cyanoacrylate
- Where
- Taiwan
- Volunteers
- 121 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein
Mesenteric Vein Access for OPVT-Related Recurrent Variceal Bleeding: An Ambispective Cohort
Occlusive portal vein thrombosis (OPVT) is defined as complete thrombosis of the main portal vein trunk, resulting in total interruption of portal venous inflow and representing the most severe form of portal vein thrombosis.
- Conditions
- Occlusive Portal Vein Thrombosis (OPVT), Cavernous Transformation of Portal Vein, Gastroesophageal Varices Bleeding
- Trial name
- NCT07666256
- Testing
- Percutaneous mesenteric vein-assisted interventional treatment
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Air Force Military Medical University, China
Cirrhosis, Esophageal and Gastric Varices
Rifaximin in Patients With Gastroesophageal Variceal Bleeding
The purpose of the study is to evaluate the safety and efficacy of Rifaximin in the treatment of cirrhotic gastroesophageal variceal bleeding.
- Conditions
- Cirrhosis, Esophageal and Gastric Varices, Gastrointestinal Hemorrhage
- Trial name
- RFXM (NCT02991612)
- Testing
- Rifaximin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Zhongshan Hospital
Cirrhosis
Noninvasive Tests to Predict the Presence of Esophageal Varices in Patients With Liver Cirrhosis
Liver cirrhosis is caused by chronic liver diseases, varices exist in 30 - 60% of patients with liver cirrhosis. Variceal bleeding is one of the most important complications of cirrhosis, accelerating the progression of…
- Trial name
- NCT03513887
- Where
- China
- Volunteers
- 111 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University