Clinical trials: Varix, Esophageal
Gastric Varices, Cirrhosis
Prophylactic Use of Antibiotics in Endoscopic Injection of Tissue Adhesive in Gastric Varices
The purpose of the study is to evaluate the efficacy and safety of prophylactic use of antibiotics in endoscopic injection of tissue adhesive in gastric varices.
- Trial name
- PUoA-EIoTA (NCT03045783)
- Testing
- Cefotiam
- Where
- China
- Volunteers
- 912 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal and Gastric Varices, Liver Cirrhosis
Pantoprazole After Prophylactic Endoscopic Variceal Treatment
Traditionally, it is considered that gastric acid delays ulcer healing, and acid suppression can reduce the risk of post-banding ulcer bleeding and promote mucosal healing at the ulcer site.
- Trial name
- NCT07248722
- Testing
- Pantoprazole
- Where
- China
- Volunteers
- 208 people
- Sponsor
- General Hospital of Shenyang Military Region
Cirrhosis, Portal Hypertension
Danish Carvedilol Study in Portal Hypertension
Patients with large esophageal varices who have not yet experienced bleeding, are normally treated with propranolol, a beta blocking agent that reduces the portal pressure and thereby diminish the risk of bleeding.
- Trial name
- DACAPO (NCT00493480)
- Testing
- carvedilol, propranolol
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Hvidovre University Hospital
Esophageal and Gastric Varices, Ulcer
Predictive Factors and Outcome of Esophageal Ulcers After Endoscopic Treatment of Esophageal Varices
Aim of this thesis is to predict the incidence of esophageal ulcer bleeding after endoscopic management of esophageal varices. This study will be in the department of Tropical Medicine and Infectious Diseases, Tanta University…
- Conditions
- Esophageal and Gastric Varices, Ulcer, Cirrhosis, Hypertension, Portal
- Trial name
- NCT02256046
- Testing
- Esophagogastroduodenoscope
- Where
- Egypt
- Volunteers
- 224 people
- Sponsor
- Tanta University
Cavernous Transformation of Portal Vein, Gastroesophageal Varices Bleeding
Efficacy and Safety of Variceal Embolization Combined With Partial Splenic Artery Embolization for Variceal Bleeding in Cavernous Transformation of Portal Vein.
The management of variceal bleeding in patients with cavernous transformation of portal vein (CTPV) generally adheres to the principles applied to cirrhotic portal hypertension, including pharmacological therapy, endoscopic…
- Trial name
- NCT07310316
- Testing
- Variceal Embolization Combined With Partial Splenic Artery Embolization
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Air Force Military Medical University, China
Cirrhosis, Portal Hypertension
A Study Evaluating the Utility of Ambrisentan in Lowering Portal Pressure in Patients With Liver Cirrhosis
Endothelin is a human hormone which has been associated with increased portal pressure in patients with liver cirrhosis (also called portal hypertension). Ambrisentan blocks the effects of endothelin.
- Conditions
- Cirrhosis, Portal Hypertension, Ascites
- Trial name
- NCT03827200
- Testing
- Ambrisentan
- Where
- 6 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Noorik Biopharmaceuticals AG
Esophageal Varices Bleeding, Portal Hypertension
Effectiveness of Treatments for Cirrhosis With Varicose Veins
Liver cirrhosis is the fifth leading cause of death among adults, characterized by diffuse fibrous tissue proliferation and the formation of regenerative nodules and false lobules on the basis of widespread hepatocyte necrosis…
- Trial name
- NCT06961474
- Testing
- Endoscopic treatment
- Where
- China
- Volunteers
- 1,900 people
- Sponsor
- Shanghai Zhongshan Hospital
Portal Hypertension Gastropathy, Esophageal Varices
Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal
This is a multicenter, randomized, double-blind, placebo-controlled study on the effectiveness of treatment with beta-blockers to prevent decompensation of cirrhosis with portal hypertension.
- Conditions
- Portal Hypertension Gastropathy, Esophageal Varices, Spontaneous Bacterial Peritonitis, Hepatic Encephalopathy
- Trial name
- PREDESCI (NCT01059396)
- Testing
- propranolol, carvedilol
- Where
- 8 sites in Spain
- Volunteers
- 201 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Esophageal Varices
Preventing Recurrent Bleeding After Eradication of Esophageal Varices
Esophageal variceal bleeding is a severe complication of portal hypertension. Banding ligation plus non-selective beta-blockers is the current recommendation for prevention of recurrent bleeding.
- Trial name
- NCT02740166
- Testing
- propranolol
- Where
- Taiwan
- Volunteers
- 212 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Esophageal Varices
Comparison of 2 Days Versus 5 Days of Octreotide After Endoscopic Therapy in Preventing Early Esophageal Varices Rebleed : A Randomized Controlled Study
The aim of this study is to compare the efficacy of 2-days versus 5-days octreotide infusion after endoscopic therapy in preventing early esophageal varices rebleed in patients with cirrhosis.
- Trial name
- NCT05199038
- Testing
- Octreotide
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Tanta University
Portal Hypertension, Cirrhosis
MRI to Assess the Effect of Non-selective Beta-blocker in Patients With Cirrhosis
Background: Standardization and new therapeutic treatments of variceal bleeding has significantly reduced the mortality the last 25 years, but there is still a high 6-week mortality around 15-20% and 1-year mortality of about…
- Conditions
- Portal Hypertension, Cirrhosis, Esophageal Varices, Gastric Varices Bleeding
- Trial name
- NCT03438916
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Hvidovre University Hospital
Esophageal Varices
Study of Capsule Endoscopy to Determine the Accuracy for Detection of Esophageal Varices
Esophageal capsule endoscopy is sedation-less alternative to upper endoscopy for evaluating esophageal lesions and potentially other upper gastrointestinal lesions.
- Trial name
- NCT01079416
- Testing
- Capsule endoscopy, Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Venous Insufficiency of Leg, Venous Leg Ulcer
Non Contrast MRI in Lower Extremity
We collected retrospectively the non contrast MRI in chia yi memorial hospital for different venous disease of lower extremity morphology and flow ananlysis were done.
- Conditions
- Venous Insufficiency of Leg, Venous Leg Ulcer, Venous Occlusion, Contrast Media Reaction
- Trial name
- NCT04995432
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Esophageal Varices in Cirrhosis of the Liver, Upper Gastrointestinal Bleeding
Endoscopic Variceal Ligation in Children
This is an ambispective single-center cohort study of pediatric patients with portal hypertension and esophageal varices. The study was designed to evaluate the efficacy and safety of primary prophylaxis with endoscopic variceal…
- Conditions
- Esophageal Varices in Cirrhosis of the Liver, Upper Gastrointestinal Bleeding, Endoscopy, Child
- Trial name
- NCT03943784
- Testing
- Endoscopic Variceal Ligation, Non-Selective Beta-Blocking Agent
- Volunteers
- 60 people
- Sponsor
- Hospital Vall d'Hebron
Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis
Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis
This seamless, adaptive, two-stage, Phase 2b/3, randomized, double-blind, multicenter, parallel-groups, placebo-controlled study will assess the efficacy, safety, and tolerability of belapectin compared with placebo in patients…
- Conditions
- Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
- Trial name
- NAVIGATE (NCT04365868)
- Testing
- belapectin
- Where
- 156 sites in United States, Argentina and 13 more
- Volunteers
- 357 people
- Sponsor
- Galectin Therapeutics Inc.
Esophageal Varices, Portal Hypertension
A Prospective Evaluation of Computerized Tomographic(CT) Scanning as a Screening Modality for Esophageal Varices
Patients with cirrhosis require endoscopic screening for large esophageal varices. The aims of this study were to determine the cost -effectiveness and patient preferences of a strategy employing abdominal computerized tomography…
- Conditions
- Esophageal Varices, Portal Hypertension, Gastric Varices
- Trial name
- NCT00587197
- Volunteers
- 134 people
- Sponsor
- Mayo Clinic
Cirrhosis, Liver, Portal Hypertension
Carvedilol for Prevention of Esophageal Varices Progression
Carvedilol has been shown to be more potent in decreasing portal hypertension to propranolol. But the efficacy of carvedilol to delay the growth of esophageal varices in chronic hepatitis B patients was unclear.
- Trial name
- Carvedilol (NCT03736265)
- Testing
- Carvedilol
- Where
- 6 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Friendship Hospital
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Variceal Bleeding
Efficacy and Safety of Intravenous Vitamin K1 in Management of Acute Variceal Bleeding
The administration of Vitamin K1 (Vit-K1) injection is frequently utilized in clinical practice for managing upper gastrointestinal bleeding (UGIB) associated with liver cirrhosis, despite insufficient evidence supporting its…
- Trial name
- NCT06839352
- Testing
- Vitamin K1
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Gastroesophageal Varices
MCCE in Assessing Efficacy of Gastro-oesophageal Varices
This study proposed for the first time the use of MCE to evaluate the efficacy of the treatment of gastroesophageal varices, and compared the examination results with the gold standard to explore whether MCE could replace the…
- Trial name
- NCT04984863
- Testing
- Magnetically controlled capsule endoscopy
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Ruijin Hospital