Clinical trials: Vascular; Damage
Cardiovascular Risk Factor
Automatic Image Analyzer to Assess Retinal Vessel Caliber
The objective of this work is the development and validation (reliability and validity) of the Automatic image analyzer to assess it retinal vessel caliber (ALTAIR) platform to analyze and validate its utility in different…
- Trial name
- ALTAIR (NCT02087605)
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Knee Osteoarthritis
Autologous Stromal Vascular Fraction of Cells for Treatment of Knee Articular Cartilage Dystrophy
Stromal vascular fraction of cells (SVF) will be extracted from lipoaspirate by enzymatic digestion. SVF will be administered in a single dose intraarticularly 4 weeks after arthroscopic debridement.
- Trial name
- NCT02827851
- Testing
- Liposuction, SVF isolation, Intraarticular administration of autologous SVF
- Where
- 4 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
COVID, Vascular; Damage
Influence of COVID-19 on Vascular Endothelial Function
Rationale: Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) 2 could result in endothelial dysfunction with increased risk of arterial thrombotic events by downregulating the expression of angiotensin…
- Trial name
- COVAS (NCT04468412)
- Testing
- Carotid Artery Reactivity Testing
- Where
- Netherlands
- Volunteers
- 203 people
- Sponsor
- Radboud University Medical Center
Amyotrophic Lateral Sclerosis, Brain Stem Stroke
Real World Testing of a Brain-Computer Interface
The goal of this project is to test a new AAC-BCI device comparing gel and dry electrode headgear used for communication while providing clinical care.
- Conditions
- Amyotrophic Lateral Sclerosis, Brain Stem Stroke, Cerebral Palsy, Traumatic Brain Injury
- Trial name
- NCT04026581
- Testing
- Speech generating device (SGD) evaluation including BCI access, Training and treatment
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Intraabdominal Hypertension, Prone Postion
Changes of Intra Abdominal Pressure During Surgeries in Prone Position as a Marker of Renal Damage
Background: Patients undergoing surgical operations in prone position do not have a measure of intra abdominal pressure as a standard procedure.
- Conditions
- Intraabdominal Hypertension, Prone Postion, Spine Surgery
- Trial name
- NCT05626868
- Testing
- Intra abdominal pressure measurement
- Where
- Poland
- Volunteers
- 24 people
- Sponsor
- Medical University of Warsaw
Cardiac Surgery
Risk of Oxygen During Cardiac Surgery Trial
The investigators will recruit and randomize 200 elective cardiac surgery patients to receive physiologic oxygenation (normoxia) or hyper-oxygenation (hyperoxia) during surgery to test the hypothesis that intraoperative…
- Trial name
- ROCS (NCT02361944)
- Testing
- Oxygen - normoxia, Oxygen - hyperoxia
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Vanderbilt University
Essential Hypertension
Effectiveness of Eplerenone to Improve Target Organ Damage in Patients With Resistant Arterial Hypertension
Resistant hypertension is defined as hypertension not controlled (i.e. blood pressure not below 140/90 mmHg) with the use of adequate doses of at least three different anti-hypertensives including a diuretic.
- Trial name
- NCT00138944
- Testing
- eplerenone
- Where
- Germany
- Volunteers
- 85 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
Early Virtual Intervention for Infants With CP Following HIE Diagnosis
This will be a five year study that will be a prospective, randomized, controlled trial (RCT) to assess the effect of a virtual early intervention care delivery model in the provision of therapy to enhance the neurodevelopmental…
- Conditions
- Cerebral Palsy, Hypoxic-Ischemic Encephalopathy, Brain Injuries, Perinatal Hypoxia
- Trial name
- RECOVER (NCT04913324)
- Testing
- Virtual Care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- The Hospital for Sick Children
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypertension
Spironolactone Versus Indapamide in Obese and Hypertensive Patients
Most recent guidelines continue to recommend thiazide diuretics as first-line agents for patients with hypertension in spite of the potential metabolic side effects, while mineralocorticoid receptor antagonists (MRAs), such as…
- Trial name
- NCT03626506
- Testing
- Spironolactone, Indapamide, Amlodipine
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Hypertension, Menopause
The Impact of Menopause on the Development of Heart Failure and Organ Damage of Hypertension
Introduction: The average age of menopause in the Polish population is around 50 years. After the occurrence of the last menstruation in the woman's body there are series of hormonal changes that may result in the emergence of…
- Trial name
- NCT04822857
- Testing
- AMH
- Where
- Poland
- Volunteers
- 86 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Surgery
Mesenteric Vessel Sealing by Three Instruments
Ultrasonic cutting-coagulation devices (UCCD) are surgical instruments which use ultrasonic energy to cut through and coagulate tissue.
- Trial name
- NCT01121614
- Testing
- LOTUS, Ethicon Harmonic Scalpel, LigaSure bipolar vessel sealing device
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital Plymouth NHS Trust
Cerebral Palsy, Developmental Delay
SmarToyGym: Smart Detection of Atypical Toy-oriented Actions in At-risk Infants
The study aims to develop a SmarToyGym where sensitized, wireless toys are strategically hung and placed within reach of infants to elicit toy-oriented body and arm/hand movements.
- Conditions
- Cerebral Palsy, Developmental Delay, Stroke, Fine Motor Delay
- Trial name
- NCT02813889
- Testing
- SmarToyGym
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Hypertension
Renal Denervation for Resistant Hypertension
This is a study investigating the effectiveness of renal denervation in lowering blood pressure in people whose blood pressure is not adequately controlled despite treatment with 3 or more blood pressure lowering drugs.
- Trial name
- RDNP-2012-01 (NCT01865240)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Baker Heart and Diabetes Institute
Neurologic Disorders
Monitoring Everyday Life Motor Activity in Children
The overall aim of this project is to monitor everyday life activity of children with neurological disorders undergoing rehabilitation using wearable sensors capable of accurate and unobtrusive long-term measurement.
- Trial name
- MELMAC (NCT02236091)
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Rob Labruyere
Chronic Kidney Disease, Hypertension
Assessment of Blood Pressure Control and Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension -II
The purpose of this study is to find the change of blood pressure (BP) control pattern (true controlled, white-coat, masked, and sustained uncontrolled/ dipper, non-dipper, reverse-dipper, and extreme-dipper) in patients with…
- Trial name
- NCT02078115
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul National University Hospital
Hemiplegic Stroke, Hemiplegic Cerebral Palsy
Evaluating Human-Machine Interfaces in a Robotic Thumb Orthosis
We plan to investigate whether the Isolated Orthosis for Thumb Actuation (IOTA) can effectively facilitate the ability of participants to perform a specific set of clinically relevant tasks conducted in a clinic setting.
- Trial name
- IOTA (NCT01973426)
- Testing
- Isolated Orthosis for Thumb Actuation (IOTA)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wyss Institute at Harvard University
Heart Disease, Ischemic Heart Disease
Stem Cell Injection to Treat Heart Damage During Open Heart Surgery
Background: Bone marrow stromal stem cells (also known as mesenchymal stem cells) have been isolated and are found to make large amounts of growth factors.
- Conditions
- Heart Disease, Ischemic Heart Disease, Coronary Artery Disease, Coronary Artery Disease (CAD)
- Trial name
- NCT01557543
- Testing
- Cell Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cyanotic Congenital Heart Disease
Preventing Brain Injury in Infants With Congenital Heart Disease
Newborn babies with congenital heart disease often require surgery in the first month of life. The risks of brain damage from congenital heart disease and from the various corrective surgeries are high because of poor levels of…
- Trial name
- NCT01426542
- Testing
- Topiramate, No medication, but routine heart surgery
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Davis