Clinical trials: Vascular; Damage
Stroke, Chronic Brain Injury
Automated Stereognosis to Treat Loss of Tactile Function After Brain Injury
Researchers aim to determine whether the ReTrieve system for tactile training can improve tactile function (sense of touch) in the hand after brain injury when used at home for 6 weeks.
- Conditions
- Stroke, Chronic Brain Injury, Peripheral Neuropathy
- Trial name
- ReTrieve (NCT05740553)
- Testing
- ReTrieve Automated Stereognosis System
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas at Dallas
Macular Polypoidal Choroidal Vasculopathy (PCV)
Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy
This study is a 60-week, two-arm, randomized, open-label, active-controlled, multi-center study in patients with Polypoidal choroidal vasculopathy (PCV) who have not previously received anti-Vascular endothelial growth factor…
- Trial name
- PROUD (NCT05666804)
- Testing
- Brolucizumab 6mg
- Where
- 15 sites in South Korea
- Volunteers
- 148 people
- Sponsor
- Novartis Pharmaceuticals
Left Ventricular Diastolic Dysfunction
Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage
Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures.
- Trial name
- NCT04549298
- Testing
- No interventions
- Volunteers
- 88 people
- Sponsor
- Neuromed IRCCS
Pediatrics, Muscle Spasticity
BOTOX® Treatment in Pediatric Upper Limb Spasticity
This study will evaluate the safety and efficacy of BOTOX® (botulinum toxin Type A) in pediatric patients with upper limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
- Trial name
- NCT01603602
- Testing
- botulinum toxin Type A
- Where
- 45 sites in United States, Canada and 7 more
- Volunteers
- 235 people
- Sponsor
- Allergan
Pediatric Hemiparesis
Brain Stimulation and Hand Training in Children With Hemiparesis
Hemiparetic cerebral palsy influences motor function in children during development and throughout their lifetime. The deficits one sees are the result both of the congenitally induced brain lesion and the subsequent plasticity…
- Trial name
- NCT02250092
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Ischaemic Heart Diseases
Loop Isolation-based Uploading Pre-conditioning
Myocardial protection is of crucial importance for surgical coronary revascularization in patients with ischaemic heart diseases.
- Trial name
- NCT03766529
- Testing
- loop isolation-based uploading preconditioning (LiuPhD)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing Medical University
Pressure Ulcer
Tissue Vascular Optics and Impedance Measurements for the Detection of Early Tissue Damage and Pressure Ulceration
Pressure ulcers are common, distressing and expensive. Currently scoring systems and checks by nursing staff are carried out to assess a patient's risk of developing a pressure ulcer.
- Trial name
- OPUS (NCT04113148)
- Testing
- Physiological measurements from heel
- Where
- United Kingdom
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Arterial Ischemic Stroke (AIS) in Children
Umbilical Cord Blood in the Treatment of Stroke in Children.
The specific aims of this study are: 1. To determine if Human Umbilical Cord Blood (hUCB) infusion is safe in children with perinatal arterial ischemic stroke (AIS). 2.
- Trial name
- Pedi Stroke (NCT01700166)
- Testing
- Autologous Human Cord Blood derived Stem Cell injection
- Where
- United States
- Sponsor
- Aryn Knight
Hypertension, Left Ventricular Hypertrophy
Vitamin D Therapy to Reduce Cardiac Damage Among Vulnerable Hypertensive Patients
This project seeks to reduce the disparity in hypertensive heart disease which exists for African-Americans who have poorly controlled hypertension (HTN), also known as blood pressure (BP).
- Trial name
- AdDReaCH (NCT01360476)
- Testing
- cholecalciferol (Vitamin D)
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- Wayne State University
Asperger's Syndrome, Dyslexia
My Scrivener® - Measuring Effectiveness and Dose Response in Children
This study will assess whether a computer haptic peripheral device programmed to provide repetitive motion training is as effective as the same repetitive motion training provided by a human being.
- Conditions
- Asperger's Syndrome, Dyslexia, Cerebral Palsy, Attention Deficit Disorder
- Trial name
- NCT00919906
- Testing
- My Scrivener(R)
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Obslap Research LLC
Amyotrophic Lateral Sclerosis, Brain Stem Stroke
Real World Testing of a Brain-Computer Interface
The goal of this project is to test a new AAC-BCI device comparing gel and dry electrode headgear used for communication while providing clinical care.
- Conditions
- Amyotrophic Lateral Sclerosis, Brain Stem Stroke, Cerebral Palsy, Traumatic Brain Injury
- Trial name
- NCT04026581
- Testing
- Speech generating device (SGD) evaluation including BCI access, Training and treatment
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
CABG, Coronary Artery Disease
Study of the Use of a Single Dose of Erythropoietin to Treat Acute Myocardial Ischemia
This is a phase 2 study that evaluates the effect of intravenous administration of a bolus EPO on the activation of EPOR-signal transduction cascades and myocardial apoptosis during cardiopulmonary bypass surgery.
- Trial name
- DREAM (NCT00524901)
- Testing
- Epoetin alpha, NaCl 0.9%
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Early Ambulation, Standard of Care
The Investigation of the Impact of Early Mobilization on the Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage.
The goal of the randomized clinical trial is to examine the effect of early mobilization on primary and secondary outcomes in patients with subarachnoid hemorrhage caused by aneurysm rupture.
- Conditions
- Early Ambulation, Standard of Care, Subarachnoid Hemorrhage, Aneurysmal
- Trial name
- NCT06436508
- Testing
- Early mobilization protocol, Standard care
- Where
- 3 sites in Hungary
- Volunteers
- 50 people
- Sponsor
- University of Pecs
Muscle Spasticity
Peripheral Modulation of Muscle Stiffness and Spasticity
This is a single-center, double-blind, randomized, placebo-controlled, sequential Phase II trial of human recombinant hyaluronidase injections in individuals with post-stroke upper limb muscle stiffness.
- Trial name
- NCT03306615
- Testing
- Hyaluronidase
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Johns Hopkins University
Ischemic Stroke
Modulation of Cerebral Ischemia by Albumin
A single-center, open-label, randomized, placebo-controlled, prospective phase II clinical trial to investigate the efficacy of low-dose albumin in patients with ischemic stroke with an indication for vasographic intervention.
- Trial name
- MOZEG (NCT07415655)
- Testing
- Albumin infusion
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Hypertension, Ischemic Heart Disease
A Morbidity-Mortality and Remodeling Study With Valsartan
The JIKEI HEART Study has been designed to investigate whether concomitant treatment with valsartan, an angiotensin II receptor blocker (ARB), in addition to conventional treatment, will improve the prognosis of 3000 Japanese…
- Conditions
- Hypertension, Ischemic Heart Disease, Congestive Heart Failure
- Trial name
- NCT00133328
- Testing
- valsartan
- Where
- Japan
- Volunteers
- 3,000 people
- Sponsor
- Jikei University School of Medicine
Myeloma
Prevention of Treatment Induced Neuropathy in Multiple Myeloma
The goal of this clinical research study is to see if Minocin® (minocycline) can help to control nerve damage that causes numbness and tingling in the hands and feet (neuropathy) in patients receiving thalidomide and/or…
- Trial name
- NCT01283997
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- M.D. Anderson Cancer Center
Neurologic Disorder, Stroke
Home Based Tele-exercise for People With Chronic Neurological Impairments
To assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI).
- Conditions
- Neurologic Disorder, Stroke, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- Telex (NCT04564495)
- Testing
- Seated exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Burke Medical Research Institute
Severe Mental Disorder, Obesity
Health Education Programme Through Physical Exercise for People With Severe Mental Disorders
The goal of this clinical trial is to [learn about, test, compare etc.] in individuals with severe mental disorders and obesity comorbid.
- Trial name
- HEPPE-PSMI (NCT06069739)
- Testing
- Guided physical activity, Standard physical activity
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Diabetes Mellitus
Blood Pressure and Subclinical Organ Damage
Background: The purpose of this study is to analyze the relationship between central and peripheral blood pressure (clinic and ambulatory) with vascular structure and function, assessed by carotid intima-media thickness (IMT)…
- Trial name
- Vasorisk (NCT01325064)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud