Clinical trials: Vascular
Stroke, Ischemic
Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK)
The best reperfusion strategy for medium-sized vessel occlusion (MeVO) is not well established. Given the proven treatment effect of intra-arterial thrombolysis in patients with large vessel occlusion (LVO), the investigators…
- Trial name
- NCT05657470
- Testing
- Tenecteplase
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Shenyang Military Region
Coronary Artery Disease
Safety and Efficacy Study of PB127 Ultrasound Contrast Agent in Patients With Suspected Coronary Artery Disease 007
This trial is to compare PB127 echocardiography to other heart imaging studies.
- Trial name
- NCT00595673
- Testing
- PB127 for injectable suspension
- Where
- 19 sites in United States
- Volunteers
- 428 people
- Sponsor
- Point Biomedical
Blood Clots, Vascular Disease
Single Center Post-Market Study of Thrombolytic Therapy Using the Versus™ Catheter
Assess the functionality of the Versus Catheter for catheter-directed thrombolysis of pulmonary blood clots, including advanced imaging assessment.
- Conditions
- Blood Clots, Vascular Disease, Embolism Thrombosis, Cardiovascular Diseases
- Trial name
- NCT06975969
- Testing
- Versus™ Endovascular Pulmonary Artery Drug Delivery Catheter
- Where
- United States
- Sponsor
- Liquet Medical Inc.
Stroke, Wearable Device
'Smart Reminder': a Randomized Controlled Trial on the Effect of a Wearable Device
Using wearable devices in the home setting allows continuous remote monitoring and feedback for intense self-directed training, an effective alternative to in-person rehabilitation.
- Trial name
- NCT05877183
- Testing
- Wearable device -'Smart Reminder'
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Urticaria, Angioedema
Vitamin D Levels in Subjects With Chronic Urticaria and Angioedema
The objective of this study is to perform an exploratory analysis to determine if a possible relationship between vitamin D and chronic urticaria and/or angioedema exists.
- Trial name
- NCT00876369
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Nebraska
Atherosclerosis
The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation
Ticagrelor and clopidogrel are FDA-approved drugs for inhibition of platelet hyper-reactivity in certain clinical situations. The platelet inhibition and patient outcomes (PLATO) trial showed that in patients with acute coronary…
- Trial name
- NCT02626169
- Testing
- Clopidogrel, Ticagrelor
- Where
- 2 sites in United States
- Sponsor
- Baylor College of Medicine
Peripheral Artery Disease, Diabetes Mellitus
Cocoa Flavanols and Painfree Walking Distance
To characterize potential vascular long-term effects of flavanols in patients with peripheral artery occlusive disease (PAOD), a placebo-controlled double-blinded randomized control study will be performed in 62 patients…
- Trial name
- NCT01064583
- Testing
- cocoa
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cancer
Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
RATIONALE: Giving itraconazole or fluconazole may be effective in preventing infections in patients undergoing peripheral stem cell or bone marrow transplantation.
- Trial name
- NCT00003883
- Testing
- fluconazole, itraconazole
- Where
- 2 sites in United States
- Volunteers
- 578 people
- Sponsor
- Fred Hutchinson Cancer Center
Hypertension
Treatment of Supine Hypertension in Autonomic Failure
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT00223717
- Testing
- Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University
Hypertension, Fracture
Immediate Fracture Risk After Antihypertensive Drug Initiation
This retrospective observational study aims to evaluate the short-term fracture risk associated with anti-hypertensive medication initiation using a self-controlled case series (SCCS) design and investigate temporal trends of…
- Trial name
- FADI (NCT06964217)
- Testing
- Monotherapy, Combination therapy
- Volunteers
- 10,000,000 people
- Sponsor
- Ajou University School of Medicine
Psoriasis Vulgaris
Low-Salt Diet Effect on Th17-Mediated Inflammation and Vascular Reactivity in Psoriasis
Psoriasis presents an independent cardiovascular risk factor characterized by chronic low-grade systemic inflammation and oxidative stress which altogether might lead to endothelial dysfunction.
- Trial name
- NCT05892640
- Testing
- Low-Salt Diet
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Liver Cirrhosis, Portal Hypertension
Anticoagulation Therapy After Splenectomy in Cirrhosis Patient
1. Inclusion and Exclusion Criteria Inclusion criteria: Inpatients who received laparotomy or laparoscopic splenectomy according to clinical, B-ultrasound scan, CT or MRI diagnosis of cirrhosis and portal hypertension.
- Conditions
- Liver Cirrhosis, Portal Hypertension, Anticoagulant-induced Bleeding, Thrombosis
- Trial name
- ATASICP (NCT04397289)
- Testing
- Heparin and Rivaroxaban
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cardiovascular Diseases, Heart Diseases
ACE Inhibition and Novel Cardiovascular Risk Factors
To determine the effects of an angiotensin converting enzyme inhibitor (ACE inhibitor), fosinopril, on multiple blood markers in 286 adults at high risk for cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00051389
- Testing
- Fosinopril
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Ischemic Stroke, rhTNK-tPA
Observational Study to Assess the Safety of rhTNK-tPA (Mingfule®) vs. Rt-PA (Actilyse®) in Treating Acute Ischemic Stroke
This is a multicenter, prospective, non-randomized, post-marketing safety surveillance cohort study with rt-PA (Actilyse®) as the control.
- Trial name
- NCT07519889
- Testing
- rhTNK-tPA, rt-PA
- Volunteers
- 4,500 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Hypertension
Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension
This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm.
- Trial name
- NCT05378750
- Testing
- Diuretic algorithm
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Cerebral Ischemia, Cardiac Arrest
Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients
The primary objective of the Neuroprotect trial is to assess whether or not a new goal directed hemodynamic optimization strategy can reduce cerebral ischemia in post-cardiac arrest (CA) patients.
- Trial name
- NEUROPROTECT (NCT02541591)
- Testing
- Neuroprotective goal directed hemodynamic optimization, MAP > 65mmHg
- Where
- 2 sites in Belgium
- Volunteers
- 112 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Retinal Nerve Fiber Layer Thickness, Chronic Kidney Disease
Retinal Protective Effects of Novel Finerenone in Patients With Chronic Kidney Disease
Interestingly, A hypothesis-generating analysis was conducted from two studies using routine ophthalmological examinations from clinical trial participants (ReFineDR/DeFineDR), suggesting a potential benefit of finerenone in the…
- Trial name
- NCT07235891
- Testing
- Finerenone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Aneurysm Aortic Root, Aortic Valve, Bicuspid
Aortic Valve Dynamics During Exercise After Valve Sparing Root Replacement Surgery
Aortic valve sparing operations are applied in patients with a non-calcified tricuspid or bicuspid aortic valve associated with a root aneurysm, in order to preserve the valve, and avoid new aortic dilatation by stabilizing the…
- Trial name
- NCT04205474
- Testing
- graded bicycle test
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Multiple Myeloma, Immune System Diseases
Study of ATLCAR.CD138 Cells for Relapsed/Refractory Multiple Myeloma
The body has different ways of fighting infection and disease. No single way seems perfect for fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells.
- Trial name
- NCT03672318
- Testing
- CAR138 T Cells
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Aortic Dissection
GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections
To assess the safety and effectiveness of the ASG device in the treatment of de novo Type A aortic dissections.
- Trial name
- ARISE III (NCT06827990)
- Testing
- GORE® Ascending Stent Graft (ASG device)
- Where
- 22 sites in United States
- Volunteers
- 112 people
- Sponsor
- W.L.Gore & Associates
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