Clinical trials: Vascular
Intra-dialytic Hypotension
Trial of Dialysate Sodium in Chronic Hospitalized Hemodialysis Patients
Intra-dialytic hypotensive (IDH) events can be defined as an abrupt decline in blood pressure that cause symptoms and/or require an intervention. They are common, affecting up to one third of maintenance HD sessions.
- Trial name
- NCT02145260
- Testing
- Lower dialysate sodium (138 mmol/L; using Renasol hemodialysis concentrate), Higher dialysate sodium (142 mmol/L; using Renasol hemodialysis concentrate)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Brigham and Women's Hospital
Peripheral Arterial Disease
Constrained Balloon Combined With Drug-coated Balloon Angioplasty for Femoropopliteal Lesion
This study will assess the safety and efficacy of Chocolate balloons as a combination with drug-coated balloons in the treatment of popliteal artery lesions in lower limb atherosclerotic occlusive disease and will compare them…
- Trial name
- NCT05894460
- Testing
- Chocolate balloon
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Xuanwu Hospital, Beijing
Ischemic Heart Disease
Ranolazine for Improving Symptoms of Palpitations
Patients with ischemic heart disease often report multiple symptoms, including angina and palpitations. Ranolazine has antiarrhythmic effects which are largely a result of the drug's effect on multiple ion channels.
- Trial name
- RYPPLE (NCT01495520)
- Testing
- Ranolazine
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Stroke
Efficacy and Safety of Early Supported Discharge for Post-Acute Stroke Patients in Korea
The study aims to examine the effect of early supported discharge (ESD) service on the functional outcomes and quality of life of acute stroke patients with mild to moderate disability in Korea.
- Trial name
- KOMPACT (NCT04720820)
- Testing
- Early Supported discharge with home based Rehabilitation, Conventional rehabilitation
- Where
- South Korea
- Volunteers
- 67 people
- Sponsor
- Seoul National University Bundang Hospital
Atherosclerosis, Metabolic Syndrome
Risk Factor Analysis for Coronary Atherosclerosis Measured by MDCT
Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as…
- Trial name
- NCT01589224
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Korea University
Multiple Myeloma
Bortezomib Consolidation Trial
The aim of this trial is to determine whether bortezomib improves response and delays progression for multiple myeloma patients after high dose therapy and autologous stem cell transplant.
- Trial name
- BCT (NCT01517724)
- Testing
- Bortezomib
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Carotid Stenosis
Study of Carotid Artery Stenosis Through the Integration of Multimodal Imaging and Computational Fluid Dynamics
Ischemic stroke affects 2.5 to 3 million people annually in China, ranking as the leading cause of death and disability. Cervical artery stenosis is a significant contributor to this problem, with about 50% of patients…
- Trial name
- NCT06294496
- Testing
- CEA/CAS
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sichuan Provincial People's Hospital
Retinopathy, Diabetic, Diastolic Dysfunction
REWARD: Using the REtina as a Window To Detect Cardiac microvasculAR Dysfunction In Diabetes Mellitus
Retinopathy may be associated with diastolic dysfunction and/or coronary flow reserve in the heart, and albuminuria in diabetic patients.
- Conditions
- Retinopathy, Diabetic, Diastolic Dysfunction, Microalbuminuria
- Trial name
- NCT04025996
- Testing
- Cardiac Assessments and Eye Assessments
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Vascular Cognitive Impairment no Dementia
Memory and Antioxidants in Vascular Impairment Trial
This is a 24-week randomized, double-blind, placebo-controlled parallel group design study involving Vascular cognitive impairment-no dementia (VCIND) patients to evaluate the efficacy and safety of oral NAC supplementation…
- Trial name
- NCT03306979
- Testing
- N Acetylcysteine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Urticaria Chronic
A Phase 2, Open-Label, Extension Study to Evaluate Long Term Safety and Clinical Activity of Briquilimab in Participants From Jasper-Sponsored Chronic Urticaria Trials
Phase 2, open-label, extension study to evaluate the long-term safety, clinical activity, and pharmacodynamics of briquilimab in participants previously enrolled in a Jasper sponsored CU clinical trial.
- Trial name
- NCT06736262
- Testing
- Briquilimab
- Where
- 19 sites in United States, Germany
- Volunteers
- 67 people
- Sponsor
- Jasper Therapeutics, Inc.
Leukemia, Lymphoma
Chemotherapy Plus Donor White Blood Cell Infusion in Treating Patients With Relapsed Hematologic Cancer Following Donor Peripheral Stem Cell Transplantation
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. White blood cells from donors may be able to prevent graft-versus-host disease in patients with hematologic…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00005946
- Testing
- filgrastim, therapeutic allogeneic lymphocytes, cyclophosphamide
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Pulmonary Embolism
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial
Phase II trial of TS23
- Trial name
- NAIL-IT (NCT05408546)
- Testing
- TS23
- Where
- 13 sites in United States
- Volunteers
- 64 people
- Sponsor
- Translational Sciences, Inc.
Chemotherapeutic Agent Toxicity, Pancreatic Cancer
Chemotherapy With or Without Dalteparin in Treating Patients With Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Chemotherapeutic Agent Toxicity, Pancreatic Cancer, Thromboembolism
- Trial name
- PAM07 (NCT00662688)
- Testing
- daltéparine, Chemotherapy at the investigator's discretion
- Where
- 6 sites in France
- Volunteers
- 42 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Coronary Artery Disease
Diagnostic Performance of On-site Automatic Coronary Computed Tomography Angiography-derived Fractional Flow Reserve
The current study evaluated the diagnostic performance for myocardial ischemia of on-site automatic CCTA-derived FFR (CT-FFR) using a commercially available workstation as compared with invasive FFR as a reference.
- Trial name
- NCT06153927
- Testing
- CT-FFR
- Where
- South Korea
- Volunteers
- 332 people
- Sponsor
- Seoul National University Hospital
Myocardial Ischaemia, Coronary Artery Disease
Evaluation of Effects of Rosuvastatin 40mg on Myocardial Ischemia in Subjects With Coronary Artery Disease
The purpose of this study is to determine whether treatment with 40mg of Rosuvastatin for 8 weeks will reduce the number of episodes of myocardial ischaemia suffered in subjects with coronary artery disease.
- Trial name
- NCT00657527
- Testing
- Rosuvastatin, Cholesterol lowering diet
- Volunteers
- 280 people
- Sponsor
- AstraZeneca
Hemianopia, Hemianopsia
Rehabilitating Visual Deficits Caused by Stroke
This research aims to understand the efficacy of a visual training task to improve visual loss after stroke, also known as hemianopia.
- Conditions
- Hemianopia, Hemianopsia, Quadrantanopia, Stroke Induced Vision Loss
- Trial name
- NCT04878861
- Testing
- Training in the blind field
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Stroke, Hemiparesis;Poststroke/CVA
Effectiveness of Paretic Lower Limb Loading During Over-ground Training Among Stroke Survivors
Post-stroke gait deviations contribute to significant functional disability, impaired walking ability and poor quality of life. Prior studies suggest that gait training with paretic lower limb loading may improve gait parameters…
- Trial name
- NCT05097391
- Testing
- Warm-up (5 minutes), Conventional physiotherapy exercise (15 minutes), Over-ground training with lower limb loading (15-25 minutes)
- Where
- Nigeria
- Volunteers
- 48 people
- Sponsor
- Bayero University Kano, Nigeria
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease
Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risk
The purpose of this study is to see if bemedoic acid (ETC-1002) is effective versus placebo in patients with high cardiovascular risk and elevated LDL cholesterol not adequately controlled by their current therapy.
- Trial name
- CLEAR Wisdom (NCT02991118)
- Testing
- bempedoic acid
- Where
- 2 sites in United States
- Volunteers
- 779 people
- Sponsor
- Esperion Therapeutics, Inc.
Coronary Artery Disease, Vascularization
Acceptance and Commitment Therapy for Patients Undergoing Coronary Artery Bypass Graft Surgery
Heart disease is the leading cause of death globally, accounting for 16% of the world's total deaths. The number of cases is expected to increase as our population ages. Heart disease also results in large economic burden.
- Trial name
- ACT for CABG (NCT06207318)
- Testing
- Acceptance and commitment therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Iowa
Telangiectasias
Treatment of Leg Telangiectasias With Nd:YAG 1064nm
Studying the results of treatment of dilated vessels of the lower limbs with laser, and compare them to those obtained with sclerotherapy.
- Trial name
- NCT01118390
- Testing
- Laser Nd:YAG 1064nm, Sclerotherapy
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Grupo de Cirurgia Vascular
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