Clinical trials: Vascular
Hypertension
Using Lay Health Advisors to Improve Hypertension Management
Hypertension disproportionately affects and is inadequately controlled among African American and poor populations. The investigators propose to determine the impact of using trained lay health advisors to help patients address…
- Trial name
- NCT03515005
- Testing
- Lay Health Advisor
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- MetroHealth Medical Center
Unstable Blood Pressure, Hypotension
Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS
The goal of this study is to evaluate if a novel near-infrared spectroscopy (NIRS) device can accurately estimate blood pressure in newborns at risk for unstable blood pressure.
- Trial name
- NCT06994494
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Diabetic Retinopathy, Vitreous Hemorrhage Due to Diabetes Mellitus
Pre-operative Vabysmo in Patients With Non-clearing Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy
In this phase IV, randomized, double-masked, sham-controlled study the investigators hope to determine the efficacy in peri-operative faricimab (Vabysmo) compared to sham in limiting complications from pars plana vitrectomy for…
- Trial name
- NCT06191094
- Testing
- Faricimab Injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Hypertension
Chronobiology of Meal Timing: Effects on Vascular and Renal Function
The purpose of this study us to investigate the effects of mistimed eating on blood pressure, kidney function and vascular function.
- Trial name
- NCT05987566
- Testing
- Morning meal challenge, Evening meal challenge
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Virginia Commonwealth University
Myeloma
A Trial of TBL12 Sea Cucumber Extract in Patients With Untreated Asymptomatic Myeloma
This study proposes to determine the clinical activity of this agent in patients with asymptomatic multiple myeloma. It is believed that TBL12 will help delay the onset of active multiple myeloma, with very few-if any- side…
- Trial name
- NCT01302366
- Testing
- TBL12
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Heart Failure, Myocardial Infarct
Observational Study of the Remodelling Process Following Myocardial Infarct
This study will assess the relationship between collagen turnover, neurohormonal activation, scarring and left ventricle remodelling in patients 3 years following a myocardial infarction.
- Trial name
- NCT00338156
- Where
- Norway
- Volunteers
- 119 people
- Sponsor
- Helse Stavanger HF
Coronary Artery Disease, Non-Obstructive Coronary Atherosclerosis
WARRIOR Ancillary Study for CCTA Analysis
In this study, quantitative characterization of plaque using coronary computed tomographic angiography (CTA) will be used to determine if women who were treated with intensive medical therapy have a greater reduction in the…
- Conditions
- Coronary Artery Disease, Non-Obstructive Coronary Atherosclerosis, Ischemia
- Trial name
- NCT05035056
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Cedars-Sinai Medical Center
Hypertension, Pulmonary, Ventricular Dysfunction, Left
Hemodynamic and Echocardiographic Assessment of Riociguat Effects on Myocardial Wall Contractility and Relaxation Kinetics
The aim of this study is to assess whether oral Riociguat affects the left ventricular contractility and relaxation in patients with pulmonary hypertension associated with left ventricular systolic dysfunction
- Trial name
- HEARTWORK (NCT01065051)
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Bayer
Acute Ischemic Stroke
The Improve Acute Reperfusion Treatment Quality for Ischemic Stroke Through Spatiotemporal Computing Thecnology in China
This study intends to construct the goal-oriented integrated intervention model through the intelligent bracelet automatic positioning and feedback system based spatiotemporal computing technology (FAST model) to promote the…
- Trial name
- IMPROVE-II (NCT06330051)
- Testing
- The goal-oriented integrated intervention model through the intelligent bracelet automatic positioning and feedback system based spatiotemporal computing technology (FAST model)
- Where
- China
- Volunteers
- 2,219 people
- Sponsor
- Beijing Tiantan Hospital
Coronary Artery Disease, In-stent Restenosis
CT-FFR-guided Strategy for In-stent Restenosis
This study will be a prospective, randomized clinical trial to compare standard practice guided by usual care testing to CT-FFR-guided management in patients with in-stent restenosis.
- Trial name
- NCT05611190
- Testing
- CT-FFR, Usual Care
- Volunteers
- 294 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Coronary Arteriosclerosis, Myocardial Infarction
Impact of Daylight on Patients With Acute Myocardial Infarction
The study tests if intense light could be a potential therapy in humans after myocardial infarction by inducing Per2.
- Trial name
- NCT02490397
- Testing
- Day Light, Room Light
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aortic Dissection
Zenith® Dissection Clinical Trial
The Zenith® Dissection Clinical Trial is a clinical trial approved by US FDA to study the safety and effectiveness of the Zenith® Dissection Endovascular System in the treatment of acute, complicate Type B aortic dissection.
- Trial name
- NCT01568320
- Testing
- Endovascular Treatment (Zenith)
- Where
- 24 sites in United States, Japan
- Volunteers
- 73 people
- Sponsor
- Cook Research Incorporated
Hypertension
Randomized, Open Labeled Clinical Trial to Compare the Effectiveness of Amlodipine/Valsartan vs Hydrochlorothiazide/Telmisartan on Glucose Tolerance in Patients With Hypertension With Metabolic Syndrome
Recent studies have demonstrated that RAS inhibitors/calcium channel blockers are superior to RAS inhibitors/diuretics for reducing cardiovascular outcomes in hypertension.
- Trial name
- NCT01819220
- Testing
- amlodipine/valsartan, hydrochlorothiazide/telmisartan
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Kidney, Polycystic
HALT Progression of Polycystic Kidney Disease Study B
The efficacy of interruption of the renin-angiotensin-aldosterone system (RAAS) on the progression of cystic disease and on the decline in renal function in autosomal dominant kidney disease (ADPKD) will be assessed in two…
- Trial name
- HALT PKD B (NCT01885559)
- Testing
- Lisinopril, Telmisartan
- Where
- 7 sites in United States
- Volunteers
- 486 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetic Foot, Diabetes Type 2 With Diabetic Ulcer of Toe, Skin Breakdown
CGM and DFU Healing Post-discharge
The purpose of this study is to look at the benefits of using a Continuous Glucose Monitoring (CGM) system compared with standard-of-care testing for patients with type 2 diabetes and diabetic foot ulcers (DFU) and how this will…
- Trial name
- NCT06054659
- Testing
- Real Time Continuous Glucose Monitoring (rt-CGM), Fingerstick blood glucose (FBG) monitoring, Diabetes Education
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- Emory University
Acute Coronary Syndrome (ACS)
Improving Medication Adherence Through Graphically Enhanced Interventions in Acute Coronary Syndromes
Coronary heart disease (CHD) is the leading cause of death in the United States. Most people who die from CHD die of a heart attack.
- Trial name
- IMAGE-ACS (NCT00399880)
- Testing
- Health literacy intervention
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Vanderbilt University Medical Center
Diabetic Foot Ulcers
A Study to Investigate the Safety and Clinical Effect of Nexagon® as a Topical Treatment for Subjects With a Diabetic Foot Ulcer (DUNE)
This study is for Type I or Type II diabetic subjects with with a diabetic foot ulcer. The study is being done to determine if Nexagon® plus standard of care is more effective than placebo plus standard of care.
- Trial name
- DUNE (NCT01490879)
- Testing
- Nexagon® Low Dose, Nexagon® Medium Dose, Nexagon® High Dose
- Where
- 25 sites in United States, Russia and 1 more
- Volunteers
- 168 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Acute Ischemic Stroke
Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral Anticoagulant
The study will randomize patients with acute ischemic stroke and Direct Oral AntiCoagulants (DOAC) ingestion within 48 hours from enrollment (but otherwise eligible for thrombolysis) to administration of intravenous tenecteplase…
- Trial name
- ESTER-DOAC (NCT07621796)
- Testing
- Intravenous tenecteplase (TNK)
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- Hackensack Meridian Health
Morbid Obesity, Perioperative Hemorrhage
Effect of Tranexamic Acid on Bleeding After Bariatric Surgery
Postoperative bleeding is an important complication of bariatric surgery and may lead to increased morbidity, prolonged hospitalization, and higher healthcare costs.
- Conditions
- Morbid Obesity, Perioperative Hemorrhage, Obesity, Tranexamic Acid
- Trial name
- TXA-BARI (NCT07754396)
- Where
- Greece
- Volunteers
- 140 people
- Sponsor
- G.Gennimatas General Hospital
Carotid Atherosclerosis, Coronary Atheroscleroses
Carotid Atherosclerosis in Predicting Coronary Artery Disease
Carotid plaque burden and composition features, particularly lipid necrotic core, are significantly associated with severity of CAD stenosis.
- Trial name
- CACA (NCT06253962)
- Testing
- coronary agiongraphy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
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