Clinical trials: Vascular Conditions
Cerebral Hemorrhage, Acute Lobar Haematoma
Descriptive Study on MRI Contrast of Acute Cerebral Hemorrhage in Different Microangiopathies
Cerebral haemorrhage represents a minority of acute vascular syndromes (less frequent than ischemic stroke, at around 20%), but with a therapeutic impasse, having no specific treatment.
- Trial name
- GADO-ICH (NCT06781034)
- Testing
- None, pure observational study
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ascending Aorta Aneurism
Hypothermia and Circulatory Arrest During Surgery on the Ascending Aorta: A Comparison Between Two Cooling Methods
PURPOSE: To compare crash cooling versus gradient cooling methods for patients undergoing planned surgery on the ascending aorta in deep hypothermic circulatory arrest.
- Trial name
- NCT01306734
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Hemodialysis
HeRO Vascular Access Device Bacteremia Study
The purpose of this study is to compare the safety and effectiveness of the HeRO Vascular Access Device in access challenged (e.g., catheter-dependent) hemodialysis patients.
- Trial name
- NCT00889564
- Testing
- HeRO Vascular Access Device
- Where
- 7 sites in United States
- Volunteers
- 38 people
- Sponsor
- Merit Medical Systems, Inc.
Atrial Fibrillation
Left Atrial Appendage Closure Registry of Henri Mondor Hospital
Intro: Patients with atrial fibrillation are at significant risk of thrombus formation in the left atrial appendage, which can lead to strokes or systemic embolisms.
- Trial name
- FLAAC3 (NCT05565209)
- Testing
- SA brief descriptive name used to refer to the intervention(s) studied
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autonomic Nervous System Diseases, Orthostatic Hypotension
Treatment of Orthostatic Hypotension
The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system.
- Conditions
- Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance
- Trial name
- NCT00581477
- Testing
- Droxidopa Oral Product
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt University
Refractory Angina Pectoris, Spinal Cord Stimulation
Efficacy of Spinal Cord Stimulation in Patients With Refractory Angina Pectoris
There are a growing number of patients with refractory angina pectoris (RAP). RAP is defined as a 'chronic condition (> three months) characterized by diffuse coronary artery disease in the presence of proven ischemia, which is…
- Trial name
- SCRAP (NCT04915157)
- Testing
- Spinal Cord Stimulator
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Sudden Cardiac Death
Prospective Study to Identify Patients at Risk of Dangerous Ventricular Arrhythmias
The purpose of this study is to determine how well the device predicts susceptability to potentially lethal ventricular arrhythmias.
- Trial name
- HIP (NCT00562757)
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 320 people
- Sponsor
- Harbinger Medical, Inc.
Myocardial Infarction
Heart Attack Research Program- Imaging Study
The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each…
- Trial name
- HARP (NCT02905357)
- Testing
- OCT, CMR
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Low Cardiac Output Syndrome, Cardiogenic Shock
Milrinone Versus Dobutamine in Critically Ill Patients
The investigators are interested in determining if there is a meaningful difference between two of the most commonly used medications used to improve the pumping function of the heart among critically ill patients admitted to the…
- Conditions
- Low Cardiac Output Syndrome, Cardiogenic Shock, Acute Coronary Syndrome, Pulmonary Edema
- Trial name
- NCT03207165
- Testing
- Milrinone, Dobutamine
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ischemic Stroke, Anesthesia
The Effect of Sedoanalgesia and General Anaesthesia on Early Neurological Recovery in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy
The hypothesis of this study is that sedoanalgesia will provide better early neurological recovery than general anaesthesia in acute ischaemic stroke patients undergoing endovascular thrombectomy and to investigate the…
- Conditions
- Ischemic Stroke, Anesthesia, Neurologic Symptoms
- Trial name
- NCT06183567
- Testing
- Sedoanalgesia, general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Umraniye Education and Research Hospital
Atrial Fibrillation, Transient Ischemic Attack
Optimal Detection of Atrial Fibrillation in TIA
Transient ischemic attack (TIA) is a common neurologic emergency. Although the detection of atrial fibrillation (AF) has identical consequences for preventive therapy in patients with ischemic stroke and TIA, the management…
- Trial name
- ODEA-TIA (NCT04075500)
- Testing
- Subcutaneously implanted event recorder (REVEAL LINQ), 28-day non-invasive continuous ECG monitoring (patch)
- Where
- 27 sites in Germany, Spain
- Volunteers
- 516 people
- Sponsor
- Alfried Krupp Krankenhaus
Myocardial Infarction
Myocardial Ischemia and Transfusion
MINT: A pilot, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in patients with myocardial infarction.
- Trial name
- MINT (NCT02619136)
- Testing
- Transfusion
- Where
- 4 sites in Canada
- Volunteers
- 3,501 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Intra-Abdominal Hypertension, Inguinal Hernia
Measuring Intraabdominal Pressure, Lactic Acid, and Urine Output
This study serves as a pilot study with the intention to to measure intraabdominal pressure, lactic acid, and urine output in obese individuals undergoing laparoscopic inguinal hernia repair.
- Trial name
- NCT05070572
- Testing
- Accuryn Monitoring System
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Antonios Likourezos
Cancer, Neoplasms
A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK2816126 in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma, Transformed Follicular Lymphoma, Other Non-Hodgkin's Lymphomas, Solid Tumors and Multiple Myeloma
This is an open-label, multicenter, 2-part study to determine the recommended Phase 2 dose (RP2D) for GSK2816126 given twice weekly by intravenous (IV) infusion.
- Trial name
- NCT02082977
- Testing
- GSK2816126
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 41 people
- Sponsor
- GlaxoSmithKline
Arteriovenous Fistula
The Effectiveness of FRAME FR for AVF Repair in High-Flow Reduction & Stabilization, A Prospective Trial
Patients with end-stage renal disease require permanent vascular access to enable safe and effective hemodialysis. An arteriovenous fistula (AVF), where a vein is mobilized and connected to an artery in the arm, is considered the…
- Trial name
- FRAME (NCT04795401)
- Testing
- FRAME FR IFU
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Metabolic Syndrome
Canola Oil Multicentre Intervention Trial
The purpose of the study is to examine how the consumption of different dietary oil varieties affects a broad range of metabolic responses that are important in the development of cardiovascular diseases.
- Trial name
- COMIT (NCT01351012)
- Testing
- Corn and safflower oil, Canola oil, High oleic acid canola oil
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of Manitoba
Intraventricular Hemorrhage, Subarachnoid Hemorrhage
The Purpose of This Study is to Determine Whether CerebroFlo™ EVD Catheter is Effective During the Treatment of Intraventricular Hemorrhage (IVH)
The primary goal of this study is to assess the occurrence of flushing interventions to address occlusions during the treatment of interventricular hemorrhage (spontaneous primary IVH or secondary IVH due to ruptured aneurysm).
- Trial name
- NCT05113381
- Testing
- CerebroFlo™ EVD Catheter
- Where
- 10 sites in United States
- Volunteers
- 105 people
- Sponsor
- Integra LifeSciences Corporation
Stroke
Multifunctional Nutrition Tube on Social Condition and Experience in Cerebralvascular Accident
The aim of this clinical trial is to compare the psychological condition and experience of ischemic stroke patients who receive enteral nutrition support through either Intermittent Oro-esophageal Tube or Nasogastric Tube.
- Trial name
- NCT06328907
- Testing
- comprehensive rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric Tube Feeding
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Coronary Artery Disease, Plaque
PCCT-Defined High-Risk Plaque and Future Coronary Events: The PREDICT Study
This prospective cohort study aims to determine whether high-risk coronary plaques identified by novel Photon-Counting Detector CT (PCCT) independently predict future major adverse cardiovascular events (MACE).
- Conditions
- Coronary Artery Disease, Plaque, Photon-Counting Computed Tomography
- Trial name
- PREDICT (NCT07822737)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Kidney Disease, Acute Bleeding
The Strategy to Prevent Hemorrhage Associated With Anticoagulation in Renal Disease Management (STOP HARM) Trial
Patients with severe chronic kidney disease (CKD) who develop atrial fibrillation are at high risk for stroke. The use of blood thinking medication in dialysis patients is controversial and warfarin carries a serious risk for…
- Conditions
- Chronic Kidney Disease, Acute Bleeding, Cerebrovascular Stroke
- Trial name
- STOP-HARM (NCT02885545)
- Testing
- Watchman, Continued therapy with the prescribed oral anticoagulant
- Where
- Canada
- Sponsor
- Population Health Research Institute
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