Clinical trials: Vascular Conditions
Intraventricular Hemorrhage, Subarachnoid Hemorrhage
Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System
The purpose of this non-significant risk study is to establish initial baseline infection rates for the Codman BACTISEAL External Ventricular Drainage (B-EVD) System (Antibiotic impregnated catheter) and to compare relative rates…
- Trial name
- NCT00197392
- Testing
- Bactiseal TM EVD, Standard EVD Catheter
- Where
- 20 sites in United States, Canada and 6 more
- Volunteers
- 434 people
- Sponsor
- Codman & Shurtleff
Diabetes, Chronic Kidney Disease
The Alberta Vascular Risk Reduction Community Pharmacy Project: RxEACH
Cardiovascular disease (disease of the heart and blood vessels) is one of the leading causes of death in Canada. It also carries a financial burden on the Canadian economy with a yearly cost close to $21 billion divided between…
- Conditions
- Diabetes, Chronic Kidney Disease, Established Atherosclerotic Vascular Disease, Framingham Risk Score More Than 20 Percent
- Trial name
- RxEACH (NCT01979471)
- Testing
- Advanced Care
- Where
- Canada
- Volunteers
- 723 people
- Sponsor
- University of Alberta
Congenital Diaphragmatic Hernia
Machine and Deep Learning for Congenital Diaphragmatic Hernia (CLANNISH)
Congenital Diaphragmatic Hernia (CDH) is characterized by an incomplete diaphragm formation, resulting in poor lung development (pulmonary hypoplasia), associated with altered vascularization of the lung (pulmonary hypertension)…
- Trial name
- CLANNISH (NCT04609163)
- Testing
- data collection
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypomagnesemia, Coagulopathy
Association Between Hypomagnesemia and Coagulopathy in Sepsis
This study aimed to investigate the association between hypomagnesemia and coagulopathy in patients with sepsis, with a focus on evaluating whether low serum magnesium levels are independently linked to the development of…
- Conditions
- Hypomagnesemia, Coagulopathy, Sepsis
- Trial name
- NCT07576621
- Testing
- Serum magnesium concentration
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Myocardial Infarction
Search for Methods to Predict the Development of Heart Failure After Myocardial Infarction
Introduction Despite significant progresses in the diagnosis of myocardial infarction and the development of reperfusion treatment methods, heart failure still often complicates its course.
- Trial name
- PHFMI (NCT05495516)
- Testing
- without Intervention
- Where
- Russia
- Volunteers
- 186 people
- Sponsor
- Novosibirsk State Medical University
Critically Ill, Central Venous Catheter Thrombosis
Incidence of Deep Vein Thrombosis on Central Venous Catheters in the Post Operative Period of Carcinologic Surgery
The objective is to determine the incidence of thrombosis on central venous catheters in patients hospitalized in a surgical critical care unit, in the immediate postoperative period of urological or digestive carcinological…
- Conditions
- Critically Ill, Central Venous Catheter Thrombosis, PARENTERAL NUTRITION, POST OPERATIVE
- Trial name
- THROMBOCAT (NCT03157245)
- Testing
- DOPPLER ULTRASOUND
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Myocardial Infarction (MI), Cardiogenic Shock
Optimal Timing of Microaxial Flow Pump(Impella CP) in AMI-related Cardiogenic Shock
PRIME-SHOCK is a prospective, single-center, open-label, randomized, superiority trial. Eligible participants with AMICS and a clinical decision to use Impella CP will be randomized in a 1:1 ratio before culprit-lesion PCI.
- Conditions
- Myocardial Infarction (MI), Cardiogenic Shock, ST-Segment Elevation Myocardial Infarction(STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- PRIME-SHOCK (NCT07817472)
- Testing
- Routine pre-PCI Impella CP, Selective post-PCI Impella CP
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Chonnam National University Hospital
Atrial Fibrillation, Acute Coronary Syndromes
DUAL Antithrombotic Therapy in Patients With AF and ACS
The study aims to show inferiority of rivaroxaban plus ticagrelor when compared to rivaroxaban plus clopidogrel in terms of safety.
- Trial name
- NCT04023630
- Testing
- Rivaroxaban 15 MG Oral Tablet, Clopidogrel 75 Mg Oral Tablet, Ticagrelor 90 MG Oral Tablet
- Volunteers
- 4,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Chronic Subdural Hematoma
Middle Meningeal Artery (MMA) Embolization Compared to Traditional Surgical Strategies to Treat Chronic Subdural Hematomas (cSDH)
Chronic Subdural Hematoma (cSDH) is a common hematologic problem particularly in older patients. The purpose of this study is to evaluate the safety and efficacy of middle meningeal artery (MMA) embolization compared to…
- Trial name
- NCT04095819
- Testing
- Middle Meningeal Artery procedure, Traditional Surgery
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Atlantic Health System
Myocardial Infarction, Ventricular Tachycardia
MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators
Implantable cardioverter-defibrillators (ICD) are currently recommended for the primary prevention of sudden cardiac death (SCD) in patients with a remote (>6 weeks) myocardial infarction (MI) and a low (≤35%) left ventricular…
- Conditions
- Myocardial Infarction, Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death
- Trial name
- SMART-DEF (NCT06269692)
- Testing
- MRI screening, Implantable Loop Recorder, Implantable Cardioverter Defibrillator
- Where
- France
- Volunteers
- 1,812 people
- Sponsor
- Central Hospital, Nancy, France
Hypoxic Ischemic Encephalopathy, Perinatal Asphyxia
Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy
Oxygen radicals and inflammation are important causes for brain injury in neonates following perinatal asphyxia. Animal studies demonstrated potential benefits to the brain when using both of vitamin C and ibuprofen.
- Trial name
- NCT00624871
- Testing
- Ascorbic acid (vitamin C), Ibuprofen
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
Vascular Calcification, Atherosclerosis
Atorvastatin Treatment to Attenuate the Progression of Cardiovascular Disease in Hemodialysis Patients
This prospective, randomized, controlled study aims to investigate the effects of atorvastatin treatment in hemodialysis patients concerning progression of coronary artery calcification, progression of carotid artery intima-media…
- Conditions
- Vascular Calcification, Atherosclerosis, Dyslipidemia, Inflammation
- Trial name
- NCT00481364
- Testing
- atorvastatin
- Where
- Turkey (Türkiye)
- Volunteers
- 446 people
- Sponsor
- Ercan OK
Critical Limb Ischemia
Evaluation of Safety and Tolerability of Libella Gene Therapy for Critical Limb Ischemia: AAV- hTERT
Using gene therapy to express active telomerase (hTERT) in human cells has the potential to treat many diseases related to aging, including critical limb ischemia (CLI).
- Trial name
- NCT04110964
- Testing
- AAV-hTERT
- Where
- Colombia
- Volunteers
- 5 people
- Sponsor
- Libella Gene Therapeutics
Chronic Lymphocytic Leukemia, Lymphoma
Pilot Study of Lymphoid Tumor Microenvironmental Dysruption Prior to Autologous Stem Cell Transplantation
In order to keep our immune systems healthy over our lifetime, certain cells in the bone marrow and lymph nodes called stromal cells nurture the immune cells and protect them from damage.
- Conditions
- Chronic Lymphocytic Leukemia, Lymphoma, Multiple Myeloma
- Trial name
- NCT01610999
- Testing
- Plerixafor
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Tufts Medical Center
Intracerebral Hemorrhage
Observational Study of Safety and Outcomes After Minimally Invasive Surgery for Intracerebral Hemorrhage
This pilot study will examine the safety and the clinical outcomes after minimally invasive surgery (using a parafascicular technique guided by diffusion-tensor imaging) for intracerebral hemorrhage in patients selected according…
- Trial name
- MiSPACE (NCT01920763)
- Testing
- Clinical Measurement
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Ischemic Stroke
Inflammatory faCtors AfteR acUte Ischemic Stroke
ICARUS is an interventional single-centre hospital-based cohort study in patients admitted to the stroke unit with an acute ischemic stroke.
- Trial name
- ICARUS (NCT04412187)
- Testing
- [18F]-GE-180 PET, 3T MRI, immune cell profiling in blood
- Where
- 2 sites in Germany
- Volunteers
- 36 people
- Sponsor
- Martin Dichgans
Aquired Brain Injury, Stroke
Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study
Difficulties in understanding and managing emotions may hinder recovery, rehabilitation, and participation in everyday life after acquired brain injury (ABI).
- Conditions
- Aquired Brain Injury, Stroke, MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- NCT07852936
- Testing
- TAU + Group Therapy (EAET), Treatment as Usual (TAU)
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Diagnostic Imaging, Peripheral Arterial Disease
Calf Muscle Perfusion in Patients With Intermittent Claudication by 3D-reconstruction of MSOT (MSOT_IC_3D)
The aim of the proposed study is to define independent parameters for the diagnostic assessment of the perfusion situation of the calf muscle based on 3D-reconstruction of multispectral optoacoustic tomography (MSOT) in a…
- Conditions
- Diagnostic Imaging, Peripheral Arterial Disease, Intermittent Claudication
- Trial name
- NCT05773534
- Testing
- MSOT
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ulrich Rother
Multiple Myeloma
QUIREDEX: Revlimid (Lenalidomide) and Dexamethasone (ReDex) Treatment Versus Observation in Patients With Smoldering Multiple Myeloma With High Risk of Progression
The primary objective is to evaluate when Revlimid and Dexamethasone treatment extend the time to progression to symptomatic MM in patients with smoldering MM.
- Trial name
- QUIREDEX (NCT00480363)
- Testing
- Maintenance with lower doses of lenalidomide and dexamethasone
- Where
- 13 sites in Spain
- Volunteers
- 120 people
- Sponsor
- PETHEMA Foundation
ST Elevation (STEMI) Myocardial Infarction
High-Dose Rosuvastatin Preloading for Enhanced Outcomes in STEMI Patients Undergoing Primary PCI
To compare the efficacy of high dose rosuvastatin preloading vs placebo before primary PCI in terms of MACE at 30 days
- Trial name
- HEROS-PCI (NCT06924684)
- Testing
- Statin monotherapy (rosuvastatin or atorvastatin)
- Where
- 2 sites in Pakistan
- Volunteers
- 66 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
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