Clinical trials: Vascular Disease Risk
Risk Drinking,Diabetes, Hypertension, Osteoporosis, Infertility
Women's Health Habits Study
The purpose of this randomized trial is to test the effectiveness of screening and brief intervention for risk drinking by nonpregnant women with specific medical problems exacerbated by excessive alcohol consumption.
- Trial name
- WHHS (NCT00846638)
- Testing
- Brief Intervention, Diagnostic assessment
- Where
- United States
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Intracranial Sacciform Aneurysm
Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm
The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation.
- Trial name
- AneBiote (NCT05914636)
- Testing
- analysis of foecal microbiota
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Decompensation
Evaluate Heart Failure Patients With Specially Designed Patient Adherence and Monitoring Software on Standard Mobile Devices
This is planned as a feasibility study. The objective is to evaluate a specially designed patient adherence and monitoring software on standard mobile devices in remote monitoring of heart failure patients.
- Trial name
- REMOTE-HF-1 (NCT01430936)
- Where
- 5 sites in United States, India and 1 more
- Volunteers
- 51 people
- Sponsor
- Aventyn, Inc.
Coronary Atherosclerosis
STRADIVARIUS (Strategy To Reduce Atherosclerosis Development InVolving Administration of Rimonabant - the Intravascular Ultrasound Study)
The purpose of this study is to determine if rimonabant 20 mg once daily (od) administered during 18-20 months will reduce progression of coronary atherosclerosis as assessed by intravascular ultrasound (IVUS) when administered…
- Trial name
- NCT00124332
- Testing
- Rimonabant (SR141716)
- Where
- 9 sites in United States, Australia and 7 more
- Volunteers
- 839 people
- Sponsor
- Sanofi
Venous Thromboembolism
Risk, Predictors, Impact and Outcome of Anticoagulation-associated Abnormal Menstrual Bleeding
This study is an international, multicenter, academically sponsored, observational study, that focusses on fertile female patients with proven symptomatic deep vein thrombosis of the legs (DVT) or acute pulmonary embolism (PE).
- Trial name
- TEAM-VTE (NCT04748393)
- Where
- 7 sites in Austria, France and 4 more
- Volunteers
- 90 people
- Sponsor
- Leiden University Medical Center
Cancer
Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer
RATIONALE: Learning about the amount of information on fertility and infertility by patients before they received treatment for cancer in a comprehensive cancer center may help doctors plan the best treatment.
- Trial name
- NCT01295463
- Testing
- questionnaire administration, study of socioeconomic and demographic variables, assessment of therapy complications
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Institut Català d'Oncologia
Preterm Labor, Preterm Birth
MIRACLE of LIFE Study
The goal of this observational study is to develop and validate cell-free RNA-based biomarkers for predicting a variety of adverse pregnancy outcomes in a pregnant person population. The main question it aims to answer are: 1.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Birth Complication, Preterm Premature Rupture of Membrane
- Trial name
- MoL (NCT06074601)
- Testing
- Mirvie Predictive Test for Adverse Pregnancy Outcomes
- Where
- 10 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Mirvie
Compartment Syndromes, Compartment Syndrome of Lower Leg
NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome
This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and…
- Conditions
- Compartment Syndromes, Compartment Syndrome of Lower Leg, Compartment Syndrome of Forearm
- Trial name
- NCT05672381
- Testing
- Lower extremity and/or upper extremity surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Acute Coronary Syndrome
A Study to Improve Cardiovascular Outcomes in High Risk PatieNts With Acute Coronary Syndrome
Coronary artery disease and heart attacks are the leading cause of death in the UK. Our population is ageing. The number of older patients suffering heart attacks and having angioplasty procedures to open up blocked heart…
- Trial name
- ICON1 (NCT01933581)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Venous Thromboembolism
Identification of New Genetic Markers of Risk of Venous Thromboembolism Recurrence by Analyzing Whole Genome
Venous thromboembolism (VTE) is a common and potentially fatal disease. It is considered a chronic disease with a recurrence rate of 30% at 10 years. Reduce the risk of recurrence is a serious public health issue.
- Trial name
- NCT02904967
- Testing
- Extra Blood Draw
- Where
- France
- Volunteers
- 221 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Coronary Heart Disease
A Programme Using a Mobile Application Versus Phone Advice on Patients at Risk of Coronary Heart Disease - A RCT
It aims to compare the effects of a professional -led support programme using a mobile application versus telephone advice on clients at risk of coronary heart disease.
- Trial name
- NCT04968067
- Testing
- App group, Nursing telephone advice (NTA) group
- Where
- Hong Kong
- Volunteers
- 168 people
- Sponsor
- The Hong Kong Polytechnic University
Multiple Myeloma
Etiology of Multiple Myeloma: A Case-Control Study
Objectives: The overall objective of this project is to identify risk factors associated with the development of multiple myeloma (MM) by integrating epidemiologic, clinical and molecular information.
- Trial name
- NCT00505999
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Blood Coagulation, Disorders, Surgical Procedures, Minimally Invasive
Is Plasma Transfusion Beneficial Prior to Low-Risk Procedures in Hospitalized Patients With Blood Clotting Abnormalities?
Blood clotting abnormalities or problems that happen during surgery ? even minor surgery ? are serious because of the possibility of serious bleeding that cannot be stopped.
- Trial name
- NCT00953901
- Testing
- Fresh Frozen Plasma Transfusion
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Coronary Heart Disease Risk
GENErating Behavior Change, An Integrative Health Coaching and Genetic Risk Testing Pilot
The purpose of this 4 group (2x2) pilot randomized controlled trial is to test the feasibility and logistics of incorporating genetic risk information (9p21)into standard Coronary Heart Disease (CHD) risk counseling or health…
- Trial name
- NCT01766271
- Testing
- Health Coaching, 9p21, Standard Risk Assessment
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Myocardial Infarction
Smart Device-based Cardiac Rehabilitation After Myocardial Intervention
The aim of this study is to evaluate the influence of cardiac rehabilitation based on smart band use and telemonitoring on functional capacity change and risk factors control among patients hospitalized for acute myocardial…
- Trial name
- SmartRehab (NCT03926312)
- Testing
- Smart device-based cardiac rehabilitation
- Where
- Czechia
- Volunteers
- 64 people
- Sponsor
- Charles University, Czech Republic
Coronary Artery Disease, Cerebral Stroke
Mechanistic Study of Bleeding Risk in Coronary Patients With Cerebrovascular Disease
Background: About 5% of patients with acute coronary syndrome (ACS) have had previously ischemic stroke (IS) or transitory ischemic attack (TIA).
- Conditions
- Coronary Artery Disease, Cerebral Stroke, TIA (Transient Ischemic Attack)
- Trial name
- NCT02316119
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Kidney Injury, Ischemia Reperfusion Injury
Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients
The purpose of this study is to find out if a drug called valproic acid (VPA) will protect organs (like the kidneys) from harmful effects caused by the temporary drop and then rise of blood flow and oxygen (called ischemia…
- Trial name
- NCT04531592
- Testing
- Valproic acid, Isotonic saline solution
- Where
- 4 sites in United States
- Sponsor
- Westat
Atrial Fibrillation, Stroke
AFLETES-MRI: A Cardiac and Cerebral Magnetic Resonance Imaging Study in Athletes With Atrial Fibrillation
Participation in exercise improves cardiovascular health. However, long-term endurance exercise may increase the risk of an irregular heart rhythm called atrial fibrillation (AF).
- Trial name
- AFLETES-MRI (NCT06424171)
- Testing
- Cardiac and brain magnetic resonance imaging.
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Cardiovascular Diseases, Metabolic Syndrome X
Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients at risk of a first heart attack.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome X, Atherosclerosis
- Trial name
- PAD (NCT00272311)
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Venous Thromboembolism
Individual Dose Adjustment of Low-molecular-weight-heparin by Thromodynamics Test.
The aim of this study is to evaluate the efficacy and safety of individual dose adjustment of low molecular weight heparin (LMWH) based on the results of the thrombodynamics test (TD) in patients at extremely high risk of…
- Trial name
- IDAHeT (NCT04710732)
- Testing
- Standard Enoxaparin 40 mg once-daily before randomization, Standard Enoxaparin 40 mg once-daily after randomization, Escalated Enoxaparin 30 mg twice-daily after randomization
- Where
- Russia
- Volunteers
- 9 people
- Sponsor
- Pirogov Russian National Research Medical University
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