Clinical trials: Vascular Disease Risk
Hypertension
Interventions to Improve Hypertension Control and Reduce Cardiovascular Disease Risk
This study will test the separate and combined effects of a continuous quality improvement (CQI) intervention for physicians (MDs) and a behavioral intervention for patients on blood pressure control.
- Trial name
- HIP (NCT00201136)
- Testing
- Lifestyle interventions to lower blood pressure for patients, MD CQI-type intervention
- Where
- United States
- Volunteers
- 574 people
- Sponsor
- Duke University
Type 2 Diabetes, Hypertension
Step Monitoring to Improve ARTERial Health
Many people with diabetes and/or high blood pressure (hypertension) are not very active. When people are more active, they can reduce the chances of having a heart attack or stroke.
- Trial name
- SMARTER (NCT01475201)
- Testing
- Step count prescription, Usual care
- Where
- 6 sites in Canada
- Volunteers
- 347 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hypertension, Ischemic Heart Disease
Vibrometer Based Pulse Wave Analysis for Arterial Stiffness and Ischemic Heart Disease Risk Assessment
This clinical investigation will evaluate a novel contactless technology for assessing arterial stiffness and explore its potential in assessment of risk for and development of cardiovascular disease.
- Conditions
- Hypertension, Ischemic Heart Disease, Valvular Heart Disease, Heart Failure
- Trial name
- NCT06984211
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Intracranial Hemorrhages, Stroke
Risk of Intracranial Hemorrhage in Users of Oral Antithrombotic Drugs
The true incidence and risks of intracranial hemorrhage (ICH) in patients on various antithrombotic treatments remain unknown. Here a nationwide study is conducted to investigate the risk for and incidence rates of ICH in users…
- Trial name
- RICH (NCT02481011)
- Testing
- antithrombotic drugs
- Where
- Norway
- Volunteers
- 22,111 people
- Sponsor
- St. Olavs Hospital
Atherosclerosis, Cardiovascular Diseases
Non-Traditional Cardiovascular Risk Factors in Type 2 Diabetes Mellitus - Ancillary to VA Study of Glycemic Control
To test whether novel cardiovascular risk factors are related to the presence and development of atherosclerosis and macrovascular events in Type 2 diabetes mellitus and to determine whether intensive glucose lowering therapy…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- NCT00021944
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pulmonary Embolism
Crux Biomedical Vena Cava Filter Study - United States
The purpose of this study is to determine if the Crux Vena Cava Filter System is safe and effective in preventing pulmonary embolism.
- Trial name
- RETRIEVE 2 (NCT01120509)
- Testing
- Inferior Vena Cava Filter
- Where
- 17 sites in United States
- Volunteers
- 88 people
- Sponsor
- Crux Biomedical
Diabetes Mellitus, Type 2, Hypertension
The Effect of Progressive Resistance Exercise Training (PRET) on CVRF in Adults With ID.
Thanks to improved healthcare, the life expectancy of people with ID is increasing and is approaching that of the general population.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Hypercholesterolemia, Obesity
- Trial name
- PRET (NCT06579898)
- Testing
- Progressive resistance exercise training
- Where
- 3 sites in Netherlands
- Volunteers
- 36 people
- Sponsor
- Erasmus Medical Center
Coronary Disease
Bile Acids and Gut Microbiota as Potent Coronary Atheroma Risk Factors: a Prospective Study in Human
The purpose of this study is to describe the composition of bile acids and the gut microbiota comparing two populations: patients with coronary atheroma and the healthy subjects.
- Trial name
- MABAC (NCT02375893)
- Testing
- No intervention, Healthy subject
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Diabetes Mellitus
Effects of RF on Clopidogrel Resistance in Patients at High Cardiovascular Risk
Ramadan fasting (RF) has been shown to be associated with vascular and metabolic disorders including glycemic control and lipid profile. It may also alter pharmacologic properties of some medications.
- Trial name
- RFeCloR (NCT02624583)
- Where
- 2 sites in Tunisia
- Volunteers
- 98 people
- Sponsor
- University of Monastir
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypertriglyceridemia, Atherosclerotic Cardiovascular Disease
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia
The purpose of the study was to evaluate the effect of olezarsen on percent change in fasting triglyceride (TG) levels compared to placebo at Months 6 and 12 and the proportion of participants who achieve different thresholds in…
- Conditions
- Hypertriglyceridemia, Atherosclerotic Cardiovascular Disease, Severe Hypertriglyceridemia
- Trial name
- NCT05355402
- Testing
- Olezarsen
- Where
- 24 sites in United States, Canada
- Volunteers
- 154 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Diabetes Mellitus, Type 2, Liver Fibrosis
Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study)
In the Netherlands, there are many people with cardiometabolic diseases. More than half of these people also have fatty liver. This is a build-up of fat in the liver (steatosis) and can lead to long-term scarring (fibrosis) and…
- Conditions
- Diabetes Mellitus, Type 2, Liver Fibrosis, Liver Steatoses, Hepatic Steatosis
- Trial name
- MEDFAST (NCT06845345)
- Testing
- early time restricted Mediterranean diet, Mysimba
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Carmen Dietvorst
Solid Tumor Cancer, Medulloblastoma
Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).
Study in children and adolescents of 177Lu DOTATATE (Lutathera®) combined with the PARP inhibitor olaparib for treatment of recurrent or relapsed solid tumours expressing somatostatin receptors (SSTR) (LuPARPed)
- Conditions
- Solid Tumor Cancer, Medulloblastoma, High Risk Neuroblastoma, High Grade Gliomas
- Trial name
- LUPARPED (NCT06607692)
- Testing
- Olaparib; 177Lu-DOTATATE
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Fundación de investigación HM
Acute Ischemic Stroke Related to Tandem Occlusion, Acute Ischemic Stroke Due to Isolated Cervical Artery Occlusion
Risk Factors and Outcomes of Ischemic Stroke Associated With Tandem or Isolated Cervical Artery Occlusion in Anterior and Posterior Circulation
CERES-TANDEM is a multicenter study designed to improve the understanding of "tandem" ischemic stroke -those caused by two blockages in series, one in a neck artery and one in a brain artery-.
- Trial name
- CERES-TANDEM (NCT06965036)
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 2,880 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Coronary Heart Disease, Cardiovascular Risk Factor
Individual Variability of Coronary Heart Disease Risk Markers and Sleep Responses to Exercise
The aim of this study is to examine the reproducibility of postprandial coronary heart disease (CHD) risk marker and sleep responses to acute exercise bouts and to quantify the magnitude of individual variability in responses…
- Conditions
- Coronary Heart Disease, Cardiovascular Risk Factor, Arterial Stiffness, Blood Pressure
- Trial name
- NCT05022498
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Socioeconomic Status, Secondary Prevention
Socioeconomic Status, Secondary Prevention Activities and Recurrence After a Myocardial Infarction
This is a nationwide cohort study on real-world patients (n≈30,000) surviving a first myocardial infarction (MI) 2006-2013 and alive to attend a routine 1-year follow-up.
- Conditions
- Socioeconomic Status, Secondary Prevention, Myocardial Infarction, Cardiovascular Disease
- Trial name
- NCT04199663
- Volunteers
- 30,191 people
- Sponsor
- Karolinska Institutet
Autonomic Dysreflexia, Spinal Cord Injuries
Prevention of Complications Due to Autonomic Dysreflexia in SCI Individuals
Autonomic dysreflexia (AD) is a syndrome of unbalanced response of the sympathetic system to noxious stimuli below the level of spinal cord injury (SCI), characterized by paroxysmal hypertension.
- Trial name
- NCT05024487
- Testing
- Clinical Examination
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Assoc. Prof. Jiri Kriz, MD, PhD
Hypertension, Cardiovascular Risk Factor
Sleep and Circadian Mechanisms of Non-dipping Blood Pressure
This study will be the first to distinguish the relative contributions of sleep, circadian and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the groundwork for optimizing therapies dependent on…
- Trial name
- NCT03558893
- Testing
- Forced Desynchrony
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Intracerebral Hemorrhage, Sepsis
Machine Learning Predictive Models for Sepsis Risk in ICU Patients With Intracerebral Hemorrhage
Patients with intracerebral hemorrhage (ICH) in the intensive care unit (ICU) are at heightened risk of developing sepsis, significantly increasing mortality and healthcare burden.
- Trial name
- NCT06326385
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Xiangya Hospital of Central South University
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer
RATIONALE: Growth factors, such as palifermin, may prevent chronic graft-versus-host disease caused by donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01233921
- Testing
- palifermin, flow cytometry, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Martin, Paul