Clinical trials: Vascular Disease Risk
Myeloproliferative Neoplasm, Right Ventricular Dysfunction
Pulmonary Hypertension and RV Dysfunction in Myeloproliferative Neoplasms
This cross-sectional study aims to determine the prevalence of pulmonary hypertension and right ventricular dysfunction in patients with myeloproliferative neoplasms and to identify associated clinical and hematologic factors.
- Conditions
- Myeloproliferative Neoplasm, Right Ventricular Dysfunction, Pulmonary Hypertension
- Trial name
- NCT07834918
- Volunteers
- 145 people
- Sponsor
- Assiut University
Coronary Artery Disease
Active Detection of the Extension of Atherothrombosis in High Risk Coronary Patients
Coronary artery disease is the first cause of death related to atherothrombosis.
- Trial name
- AMERICA (NCT00445835)
- Testing
- Arterial doppler for screening asymptomatic and significant extracoronary arterial stenoses in all arterial beds, Conservative arm
- Where
- France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
PRO-POWER: Hypertension With Risk Factors for a Duration of 24 Weeks With Micardis 80mg/Micardis Plus 80mg/12.5mg
PRO-POWER is an observational cohort study for a period of 24 weeks. All recruited patients will have essential hypertension. In addition, the patients will have at least one other contributing risk factor for cardiovascular…
- Trial name
- NCT00936208
- Where
- 120 sites in Egypt, Saudi Arabia and 1 more
- Volunteers
- 3,184 people
- Sponsor
- Boehringer Ingelheim
Hypertension, Health Behavior
Nourish: A Digital Health Program to Promote the DASH Eating Plan Among Adults With High Blood Pressure
The goal of Nourish is to help adults with high blood pressure enjoy an eating pattern called DASH (Dietary Approaches to Stop Hypertension) to lower blood pressure and improve health.
- Trial name
- NCT03875768
- Testing
- Tracking plus coaching
- Where
- United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity, Sedentary Lifestyle
The Healthy Options Feasibility Study
The investigators hypothesize that having health care providers other than physicians within a "Groupe de Médecine de Famille" conduct cardiovascular risk assessments and teach lifestyle interventions to primary prevention…
- Conditions
- Obesity, Sedentary Lifestyle, Dyslipidemia, Hypertension
- Trial name
- NCT00746460
- Testing
- CVD risk profile
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University
Asymptomatic Hypertension
Innovative Approaches to Hypertension Management in High-Risk Emergency Department Populations
This single-center, single-arm quasi-experimental study will assess the feasibility and acceptability of a community health worker (CHW)-led intervention to address social determinants of health (SDOH) among emergency department…
- Trial name
- aHTN-Manage (NCT07539597)
- Testing
- Community Health Worker engagement
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Aortic Aneurysm
Evaluation of Aortic Aneurysms With Focus on Wall Stress and Wall Rupture Risk
Retrospective study to evaluate the impact of computational wall stress analysis based on computed tomography (CT) of ruptured and not-ruptured aortic aneurysms as an additional predictor for rupture with dedicated software.
- Trial name
- NCT02800876
- Testing
- CT-acquisition
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- University of Zurich
Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral
Spleen Volume Change Predicts 45-Day Mortality in Neurocritical Care: A Prospective Cohort Study
This study investigates whether changes in spleen size over 72 hours can help predict the risk of death within 45 days in patients who were admitted to the emergency department with a type of bleeding in the brain called…
- Conditions
- Intracerebral Hemorrhage (ICH), Hemorrhagic Stroke, Intracerebral, Neurocritical Care, Acute Brain Injury
- Trial name
- SCOPE (NCT07132996)
- Testing
- POCUS-based Splenic Volume Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara City Hospital Bilkent
Aortic Aneurysm, Abdominal, Popliteal Artery Aneurysm
Screening for Abdominal Aortic Aneurysm and Popliteal Artery Aneurysm
Observational, prospective, cohort study to evaluate, by an opportunistic screening program based on vascular ultrasound, the prevalence and characteristics of Abdominal Aortic Aneurysm (AAA) and Popliteal Artery Aneurysm (PAA)…
- Trial name
- DAAP-PR (NCT05360108)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 507 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
PreDiabetes, Abdominal Obesity
Effects of Berberine on Preventing Cardiovascular Disease and Diabetes Mellitus
This multicenter, double-blinded, randomized controlled trial aims to evaluate the effect of berberine on preventing cardiovascular disease and diabetes mellitus among individuals with high cardiometabolic risk in China.
- Conditions
- PreDiabetes, Abdominal Obesity, Hypertension, Dyslipidemias
- Trial name
- ABCD (NCT05749874)
- Testing
- Berberine plus lifestyle intervention
- Where
- China
- Volunteers
- 2,024 people
- Sponsor
- China National Center for Cardiovascular Diseases
ANCA Associated Vasculitis (AAV)
PET Assessment of Disease Activity and Cardiovascular Disease Risk in ANCA-associated Vasculitis
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a severe autoimmune condition characterised by inflammation of small blood vessels.
- Trial name
- PANDA-VASC (NCT07258524)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Hypertension
Renal Denervation for Uncontrolled Hypertension
This is a study investigating the safety and usefulness of the Renal Denervation Procedure in reducing high blood pressure in people whose blood pressure is not adequately controlled despite already being treated with 2 blood…
- Trial name
- RDNP-2012-02 (NCT02016573)
- Testing
- Renal Denervation
- Sponsor
- Baker Heart and Diabetes Institute
Cardiovascular Disease
Length of Effect of Extended Release Aspirin on Platelets in Patients With Diabetes and Heart Disease
This study is being conducted to evaluate the safety and the length of effect on platelet build-up in the arteries of Durlaza™ as compared to immediate-release Bayer® aspirin 81 mg or subject's current aspirin 81 mg of choice in…
- Trial name
- DURATION (NCT02370680)
- Testing
- Aspirin, Durlaza™
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- New Haven Pharmaceuticals, Inc.
Moderate Risk of CVD
A Study to Assess the Efficacy and Safety of Enteric-Coated Acetylsalicylic Acid in Patients at Moderate Risk of Cardiovascular Disease
The use of acetylsalicylic acid in the primary prevention of cardiovascular events has been extensively studied but to a lesser extent in patients with moderate levels of cardiovascular risk.
- Trial name
- ARRIVE (NCT00501059)
- Testing
- Aspirin (Acetylsalicylic acid, BAYE4465)
- Where
- 466 sites in United States, Germany and 6 more
- Volunteers
- 12,546 people
- Sponsor
- Bayer
Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2
The SWITCH (Substitution of High With Low Ultra-processed Soy Protein Foods In a Guideline-based Diet inTervention for Cardiometabolic Health) Trial
This is a randomized, controlled, parallel study with 3 experimental arms aimed to assess the effect of a digital dietary intervention (web-based app, online behavior change curriculum) enhanced with 10 servings of vegetables and…
- Conditions
- Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2, Dyslipidemia, Hypertension
- Trial name
- SWITCH (NCT06907862)
- Testing
- Reference Treatment, Control, Active Treatment
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of Toronto
Cardiovascular Diseases (CVD), Coronary Artery Disease
wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65
The wCAR-Austria Study is a multicentre, prospective, interventional study evaluating a novel women-specific cardiovascular risk score (wCAR) in 800 women aged 40-65 years across Austria.
- Conditions
- Cardiovascular Diseases (CVD), Coronary Artery Disease, Atheroscleroses
- Trial name
- wCAR-Austria (NCT07849127)
- Testing
- Arm 1: wCAR-CARE - Precision Prevention (Arm A), Guideline-directed standard of care
- Where
- Austria
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Women's Heart Austria
Infective Endocarditis, Infection Related to Ventricular Assist Device
Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk Patients
Acute kidney injury (AKI) is a frequent complication that occurs in 15 to 25% of patients after vascular surgery, and up to 40% of patients after cardiac surgery.
- Conditions
- Infective Endocarditis, Infection Related to Ventricular Assist Device, Infection Related to Vascular Prothesis, Surgical Site Infection
- Trial name
- DVN (NCT03961503)
- Testing
- Daptomycin (DAP) treatment, Vancomycin (VAN) treatment
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Depression
Omega-3 for Depression and Other Cardiac Risk Factors - 2
The purpose of this 10 week randomized, placebo-controlled, double-blind clinical trial is to determine whether antidepressant augmentation with two grams of EPA omega-3 per day is superior to antidepressant therapy alone for…
- Trial name
- Omega-3(2) (NCT02021669)
- Testing
- Omega-3 supplement
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Washington University School of Medicine
Depressive Symptoms, Inflammation
Reducing CVD Risk in Caregivers: A Brief Behavioral Activation Intervention
Cardiovascular disease and depression are some of the most costly illnesses to society, and caring for a loved-one with Alzheimer's disease has been associated with increased risk for both depression and cardiovascular disease.
- Trial name
- NCT01802554
- Testing
- Pleasant Events Program (PEP), Information Support (IS)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Cardiac Surgery
Perioperative Cerebral Function Assessment for Cardiac Surgery
Perioperative neurological complications in cardiovascular surgical procedures are associated with a significant risk of mortality and disability.
- Trial name
- PEACE (NCT06660602)
- Testing
- cardiac surgery
- Where
- China
- Volunteers
- 1,845 people
- Sponsor
- China National Center for Cardiovascular Diseases
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