Clinical trials: Vascular Disease Risk
Ischemic Stroke
Study of Tiprogrel in the Treatment of High-risk Patients with Acute Ischemic Cerebrovascular Events (THRIVE).
This study is designed to evaluate efficacy and safety of tiprogrel in the treatment of patients with acute ischemic cerebrovascular events.
- Trial name
- NCT06601127
- Testing
- Tiprogrel, Clopidogrel
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Tianjin Institute of Pharmaceutical Research Co., Ltd
Coronary Artery Disease
Study Of Costs Realized After Percutaneous Coronary intervenTion Employing Same Day Discharge
The purpose of this study is to determine whether the total costs of care associated with uncomplicated elective or low-risk urgent percutaneous coronary intervention (PCI) through 30-day follow up are lower among patients who…
- Trial name
- SOCRATES (NCT02207270)
- Testing
- Same day discharge, Overnight Stay
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Trinity Health Michigan
Silent Stroke, Silent Cerebral Infarct
Prevalence of Attributable Etiology and Modifiable Stroke Risk Factors in Patients With Covert Brain Infarctions
The CBI registry is a prospective, interdisciplinary, multimodal observational registry of patients with covert brain infarction.
- Conditions
- Silent Stroke, Silent Cerebral Infarct, Covert Brain Infarct, Covert Brain Infarction
- Trial name
- CBI-Registry (NCT05685069)
- Where
- 2 sites in France, Switzerland
- Volunteers
- 230 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hyperglycemia, Pregnancy
The Extension of HAPO Follow-up Study
The prevalence of diabetes mellitus (DM) and cardiovascular disease (CVD) escalate remarkably worldwide and obesity becomes an epidemic disease.
- Conditions
- Hyperglycemia, Pregnancy, Overnutrition, Maternal Obesity During Childbirth
- Trial name
- NCT05477511
- Where
- Hong Kong
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Obstructive Pulmonary Disease, Asthma
Evaluation of ST2 and IL-33 in Patients Presenting to the Emergency Department With Trouble Breathing
Trouble breathing (dyspnea) is a nonspecific symptom associated with many diseases such as chronic obstructive pulmonary disease (lung disorder in which the flow of air to the lungs is blocked), asthma, pneumonia, pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Pulmonary Embolism, Pneumonia
- Trial name
- NCT00707811
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- The Cleveland Clinic
Chronic Myeloproliferative Disorders, Fever, Sweats, and Hot Flashes
Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in Patients With Cancer
RATIONALE: Antibiotics such as amoxicillin, ciprofloxacin, and moxifloxacin may be effective in preventing or controlling fever and neutropenia in patients with cancer.
- Conditions
- Chronic Myeloproliferative Disorders, Fever, Sweats, and Hot Flashes, Infection, Leukemia
- Trial name
- NCT00062231
- Testing
- amoxicillin-clavulanate potassium, ciprofloxacin, moxifloxacin hydrochloride
- Where
- 23 sites in Belgium, France and 6 more
- Volunteers
- 351 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Soluble TREM-1 in Diabetes-Associated Cardiovascular Complications
Cardiovascular disease is the leading cause of illness and death among individuals with type 2 diabetes mellitus (T2DM). Chronic low-grade inflammation contributes significantly to blood vessel damage, atherosclerosis, and…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Diseases, Coronary Artery Disease, Heart Failure
- Trial name
- NCT07847112
- Volunteers
- 85 people
- Sponsor
- Assiut University
Hypertension, Dyslipidemia
Polypills Approach for Multiple Cardiovascular Risk Factors
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated…
- Conditions
- Hypertension, Dyslipidemia, Diabetes
- Trial name
- PACIF (NCT07679828)
- Testing
- Fixed-Dose Combination Strategy
- Where
- 15 sites in China
- Volunteers
- 8,252 people
- Sponsor
- China Medical University, China
Multiple Myeloma, Primary Plasma Cell Leukemia
Study to Evaluate the Safety and Efficacy of Daratumumab and Carfilzomib-based Induction/Consolidation/Maintenance Therapy in Transplant-eligible, Ultra High-risk, Newly Diagnosed Multiple Myeloma
This study will assess whether the combination of daratumumab and carfilzomib-based Induction/Consolidation/Maintenance Therapy with ASCT improves the outcome of patients with ultra high-risk, newly diagnosed multiple myeloma
- Conditions
- Multiple Myeloma, Primary Plasma Cell Leukemia, Extramedullary Multiple Myeloma
- Trial name
- NCT06140966
- Testing
- Daratumumab, Carfilzomib, Lenalidomide
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Dementia, Mild Cognitive Impairment
Norwegian COgnitive Impairment After STroke (NorCOAST) Study
A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke
- Conditions
- Dementia, Mild Cognitive Impairment, Stroke
- Trial name
- Nor-Coast (NCT02650531)
- Where
- Norway
- Volunteers
- 816 people
- Sponsor
- Norwegian University of Science and Technology
Pulmonary Embolism
Deferment of Imaging for Pulmonary Embolism
Background. Management of patients with suspected Pulmonary Embolism (PE) is problematic if diagnostic imaging is not available.
- Trial name
- NCT00381511
- Testing
- low molecular weight heparin
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico
Atrial Fibrillation, Thrombotic Risk
Regulation of Platelet Function in Older Patients With Atrial Fibrillation
The goal of this observational study is to learn about the effects of antiplatelet drugs on patients over the age of 80 with atrial fibrillation.
- Trial name
- NCT07724301
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Atherosclerotic Cardiovascular Diseases (ASCVD)
Prospective Assessment of Atherosclerotic Cardiovascular Disease (ASCVD) Risk
This study aims to conduct a 10-year follow-up to assess ASCVD risk in Pakistan among individuals aged 30 years and above without a known history of ASCVD.
- Trial name
- NCT06316453
- Testing
- Evaluating ASCVD risk over 10 and 30 year and lifetime
- Where
- Pakistan
- Volunteers
- 3,513 people, healthy volunteers welcome
- Sponsor
- Advanced Education & Research Center
Coronary Artery Disease, Coronary Angioplasty
Atorvastatin Pre-Treatment Influences the Risk of Percutaneous Coronary Intervention (PCI) Study 2
This study investigates potential protective effect of atorvastatin pre-treatment in patient with stable coronary artery disease undergoing percutaneous coronary intervention (PCI) on chronic statin therapy.
- Trial name
- TIPS-2 (NCT01058057)
- Testing
- atorvastatin
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital, Motol
Stroke
Vitamin D and Stroke
Stroke remains one of the most devastating neurological diseases, often causing death, or gross physical impairment. It is the second most common cause of death worldwide and a major cause of acquired disability in adults.Vitamin…
- Trial name
- NCT02916030
- Testing
- Vit D
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cardiovascular Disease
The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
Our main hypothesis is that EPC function is impaired in some populations with high cardiovascular risk as a result of reduced eNOS-dependent NO production.
- Trial name
- NCT00627068
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Peripheral Artery Disease, Critical Limb Ischemia
Comparison of Prevena Negative Pressure Incision Management System vs. Standard Dressing After Vascular Surgery
The purpose of this study is to evaluate the effectiveness of negative pressure incision management system (Prevena™ Incision Management System (PIMS) or ActiVAC® with the Prevena™ Dressings (Peel and Place™ or Customizable™)…
- Conditions
- Peripheral Artery Disease, Critical Limb Ischemia, Claudication
- Trial name
- NCT02389023
- Testing
- standard gauze dressing, Prevena Incision Management system
- Where
- 5 sites in United States
- Volunteers
- 242 people
- Sponsor
- University of Vermont Medical Center
Peripheral Vascular Disease
Systematic Assessment of Vascular Risk
It is hypothesized that patients with vascular disease are undertreated for modifiable risk factors, leading to increased morbidity and mortality in this population.
- Trial name
- NCT00378040
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Pulmonary Embolism, Pulmonary Thromboembolisms
Catheter-Directed Thrombolysis Versus Anticoagulation Monotherapy in Intermediate-High Risk PE
In an open-label parallel groups blinded-endpoint randomized clinical trial, the investigators aim to assess the safety and efficacy of conventional catheter-directed thrombolysis (CDT) vs anticoagulation monotherapy on outcomes…
- Conditions
- Pulmonary Embolism, Pulmonary Thromboembolisms, Embolism, Pulmonary, Right Ventricular Dysfunction
- Trial name
- CANARY (NCT05172115)
- Testing
- Conventional catheter-directed thrombolysis (CDT) with recombinant tissue plasminogen activator (rtPA), Enoxaparin
- Where
- Iran
- Volunteers
- 94 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Stroke, Cognitive Impairment
Cognitive and Emotional Impairment After Stroke
Cognitive and emotional symptoms are often seen in the acute phase of a stroke. The prevalence of such symptoms later and the mechanisms explaining the symptoms are not fully known.
- Conditions
- Stroke, Cognitive Impairment, Vascular Dementia
- Trial name
- NCT00506818
- Testing
- Multifactorial vascular-risk-factor-intervention
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Sykehuset Asker og Baerum
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