Clinical trials: Vascular Disease Risk
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
CEST-PROTECT: Proximal Flow Control With a Balloon Guide Catheter Plus Distal Embolic Protection: a Randomised, Open-label Trial Evaluating Cerebral Protection Techniques
This randomized controlled trial aims to evaluate whether a proximal-distal dual cerebral protection strategy can reduce the occurrence of new cerebral ischemic lesions compared with a single cerebral protection strategy in…
- Trial name
- CEST-PROTECT (NCT07841132)
- Testing
- BGC proximal flow control plus distal filter embolic protection device during carotid artery stenting, Single distal filter embolic protection device during carotid artery stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Coronary Syndrome
A Comparison of the TIMI, GRACE and HEART Scores
Various elements of patient history are checked and entered in the admission Case Recor Form (CRF). Three risk scores are calculated out of these elements, combined with physical examination, laboratory values and ECG-findings.
- Trial name
- HEART (NCT01398631)
- Where
- 10 sites in Netherlands
- Volunteers
- 2,440 people
- Sponsor
- R&D Cardiologie
Refractory Plasma Cell Myeloma
Autologous or Syngeneic Stem Cell Transplant Followed by Donor Stem Cell Transplant and Bortezomib in Treating Patients With Newly Diagnosed High-Risk, Relapsed, or Refractory Multiple Myeloma
This phase II trial studies the side-effects and anti-cancer effects of giving an autologous or syngeneic stem cell transplant followed by an allogeneic donor stem cell transplant and bortezomib.
- Trial name
- NCT00793572
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Bortezomib, Cyclosporine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Fred Hutchinson Cancer Center
Cardiovascular Disease, Diabetes
Meta-Analyses of Low-risk Lifestyle Behaviours and Patient Important Outcomes
Public health policy is universal in recommending the adoption of low risk low-risk lifestyle behaviors for health promotion and prevention of chronic or non-communicable diseases (NCDs).These behaviors generally include…
- Conditions
- Cardiovascular Disease, Diabetes, Cancer, Mortality
- Trial name
- NCT03234101
- Testing
- Low-risk lifestyle behaviours
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Dementia, Mild Cognitive Impairment
HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population
This study will investigate the validity of the HOGAR EEG/PSG monitoring kit designed by Bitbrain as a tool for characterizing and assessing cognitive function in older adults, as well as for detecting and predicting cognitive…
- Conditions
- Dementia, Mild Cognitive Impairment, Dementia Alzheimers, Dementia, Mixed
- Trial name
- Hogar (NCT06993207)
- Testing
- Home Lab
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Bitbrain
Cardiac Arrest
Cardiac Arrest and Intra Osseous Infusion
the international recommendations don't explain the place of the intraosseous infusion in the reanimation of adult cardiac arrest; the goal of this preliminary study is to inform the delay for obtaining a vascular access by…
- Trial name
- ACCIO (NCT01803971)
- Testing
- Obtention of vascular access in out-of-hospital cardiac arrest patients according to the current strategy
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
Coronary Artery Disease
A Coronary Computed Tomography Angiography-guided Intervention for High Risk Cardiovascular Disease Population in Rural China
The CARDIAC trial is a prospective, parallel, open-label cluster randomized trial that aims to determine the effectiveness of a coronary computed tomography angiography (CTA)-guided intensive intervention strategy, as compared…
- Trial name
- CARDIAC (NCT07416344)
- Testing
- CTA-guided Intensive Intervention Strategy, Comprehensive Intervention Strategy
- Where
- 16 sites in China
- Volunteers
- 14,980 people
- Sponsor
- Harbin Medical University
Diabetic Retinopathy, Diabetic Retinopathy Associated with Type 2 Diabetes Mellitus
Early Retinal Neurodegeneration As Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy
Despite the evidence that diabetic retinopathy (DR) remains the first cause of blindness among the working-age population, it lacks a specific preventive treatment.
- Trial name
- 2022-12376008 (NCT06582472)
- Testing
- Ophthalmological examination including imaging assessments, confocal analysis of cornea, Dynamic Vessel Analyzer (DVA)
- Where
- 2 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Hypertension, Vitamin D Deficiency
DAYLIGHT: Vitamin D Therapy in Individuals at High Risk of Hypertension
This is a randomized, double-blind, multicenter, 6-month follow-up trial of low (400 IU/day) versus high (4000 IU/day) dose vitamin D supplementation in individuals with pre- and early stage 1 hypertension and vitamin D…
- Conditions
- Hypertension, Vitamin D Deficiency, Pre-Hypertension
- Trial name
- DAYLIGHT (NCT01240512)
- Testing
- Cholecalciferol
- Where
- 3 sites in United States
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cardiovascular Disease
Effects of a Beverage Rich in Fruit Extracts on Risk Factors Associated With Cardiovascular Disease
The purpose of this study is to assess the effects of a novel beverage rich in polyphenols (compounds present in fruit extracts) on risk factors associated with cardiovascular disease.
- Trial name
- NCT00795834
- Testing
- High polyphenol beverage
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Cardiogenic Shock, Acute Coronary Syndrome
Score TO Predict SHOCK - STOP SHOCK
The goal of this international multicenter study is to develop a scoring system to identify the risk of developing cardiogenic shock (CS) in patients suffering from acute coronary syndrome (ACS) utilising artificial intelligence.
- Conditions
- Cardiogenic Shock, Acute Coronary Syndrome, Acute Myocardial Infarction
- Trial name
- NCT05570864
- Where
- Slovakia
- Volunteers
- 50,000 people
- Sponsor
- Premedix Academy
Atrial Fibrillation
Pleotropic Effect of New Oral Anticoagulants
Atrial fibrillation (AF) has been known to have several pathophysiologic mechanisms including endothelial dysfunction of heart and vessel.
- Trial name
- NCT02544932
- Testing
- dabigatran, ribaroxaban, Warfarin
- Where
- South Korea
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Chronic Renal Insufficiency, Disorder Related to Renal Transplantation
Bone and Cardiovascular Disease After Kidney Transplant
Bone disorder is a significant problem in chronic kidney disease (CKD), becoming almost universal in stage 5 CKD patients. Besides the healthcare costs, bone disorder is associated with life-threatening complications, including…
- Conditions
- Chronic Renal Insufficiency, Disorder Related to Renal Transplantation, Metabolic Bone Diseases, Vascular Disease
- Trial name
- NCT02751099
- Testing
- transplanted patients
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Multiple Myeloma
Allogeneic Hematopoietic Stem Cell Transplantation With Ixazomib for High Risk Multiple Myeloma (BMT CTN 1302)
This study is designed to compare progression-free survival (PFS) from randomization among patients randomized on the BMT CTN 1302 protocol, "Multicenter Phase II, Double-blind Placebo Controlled Trial of Maintenance Ixazomib…
- Trial name
- NCT02440464
- Testing
- Allogeneic HSCT, Fludarabine, Melphalan
- Where
- 15 sites in United States
- Volunteers
- 57 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Gestational Diabetes, Pregnancy Complications
Gestational Diabetes Monitoring and Management
The primary goal is to predict the clinical outcomes of mother and baby using blood glucose and other routinely collected clinical data in pregnancy to predict adverse outcomes at birth in women with GDM.
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT06963528
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- University of Oxford
Bronchopulmonary Dysplasia (BPD), Hypertension, Pulmonary
Predictors of Pulmonary Hypertension Risk in Premature Infants With Bronchopulmonary Dysplasia
A lung condition called bronchopulmonary dysplasia (BPD) is a major cause of poor outcomes and death for premature infants. Infants with BPD are also at high risk for pulmonary hypertension (PH)-an important contributor to their…
- Trial name
- NCT01516398
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obstructive Sleep Apnea/Hypopnea Syndrome
Comparison of Vascular Risk in Patients Treated for Obstructive Sleep Apnea/Hypopnea Syndrome
a monocentric,non interventional, prospective study to compare cardiovascular risk in patients with Obstructive Sleep Apnea/Hypopnea Syndrome treated with Continuous Positive Airway Pressure (CPAP) and Mandibular Advancement…
- Trial name
- SAHOSVAS (NCT05491967)
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier de Valence
Chronic Coronary Syndrome, Acute Coronary Syndromes
Optimal LDL-C Target in High-risk Patients After PCI
Extensive evidence from epidemiological, genetic, and randomized controlled trials (RCTs) of lipid-lowering therapies has firmly established a causal relationship between low-density lipoprotein cholesterol (LDL-C) and…
- Conditions
- Chronic Coronary Syndrome, Acute Coronary Syndromes, Percutaneous Coronary Intervention, High Risk Patient
- Trial name
- REC-SAFETARGET (NCT06821711)
- Testing
- Intensive LDL-C control, Conventional LDL-C control
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Xijing Hospital
Multiple Myeloma, Post-transplant MRD-guided Maintenance Therapy
Pre-transplant Purging and Post-transplant MRD-guided Maintenance Therapy With Elranatamab in Patients With High-risk Multiple Myeloma
To learn if giving elranatamab before and after an autologous stem cell transplant (ASTC) can help to control newly diagnosed, high-risk MM.
- Conditions
- Multiple Myeloma, Post-transplant MRD-guided Maintenance Therapy, Pre-transplant Purging
- Trial name
- NCT06207799
- Testing
- Elranatamab, Lenalidomide, Plerixafor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Coronary Artery Disease
Risk Evaluation by COronary CTA and Artificial IntelliGence Based fuNctIonal analyZing tEchniques - II
This study is a multicenter, prospective clinical cohort study. The study intends to continuously enroll patients with coronary heart disease.
- Trial name
- RECOGNIZE-II (NCT05856110)
- Where
- 9 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Ruijin Hospital
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