Clinical trials: Vascular Disease Risk
Parkinson Disease, Orthostatic Hypotension
Cardiovascular Effects of Exercise in Patients With Parkinson's Disease
Abnormalities in the regulation of cardiovascular system due to autonomic nervous system (ANS) dysfunction may lead to a sudden decline in blood pressure (BP) upon standing, sitting or performing activities/exercises in patients…
- Trial name
- NCT03343574
- Testing
- Abdominal Strengthening Exercise
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Faizan Ahmed
Haematological Malignancy, Acute Myeloid Leukemia
Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies
A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 (inobrodib) in patients with Non-Hodgkin Lymphoma, Multiple Myeloma, Acute Myeloid Leukaemia or High Risk Myelodysplastic syndrome.
- Conditions
- Haematological Malignancy, Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Multiple Myeloma
- Trial name
- NCT04068597
- Testing
- CCS1477, Pomalidomide, Dexamethasone
- Where
- 39 sites in United States, France and 3 more
- Volunteers
- 250 people
- Sponsor
- CellCentric Ltd.
Acute Myeloid Leukemia/Transient Myeloproliferative Disorder, Acute Undifferentiated Leukemia
Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies
This clinical trial studies fludarabine phosphate and total-body radiation followed by donor peripheral blood stem cell transplant and immunosuppression in treating patients with hematologic malignancies.
- Conditions
- Acute Myeloid Leukemia/Transient Myeloproliferative Disorder, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT00014235
- Testing
- fludarabine phosphate, total-body irradiation, peripheral blood stem cell transplantation
- Where
- 11 sites in United States, Germany and 1 more
- Volunteers
- 160 people
- Sponsor
- Fred Hutchinson Cancer Center
Acute Stroke
A Study on the Status of Nutritional Risk Screening and Nutritional Therapy in Neurology Hospitalized Stroke Patients
Stroke is the leading cause of premature death and disability, and early recognition and treatment of dysphagia is fundamental to stroke management.
- Trial name
- NCT05454397
- Testing
- Observational study, no intervention
- Where
- 34 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Venous Thromboembolism, Postpartum Period
Pilot PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The pilot PARTUM trial is a randomized, multicenter, placebo-controlled trial. Women who are at modest risk of VTE (as defined by the inclusion criteria) will be identified during pregnancy, labor and delivery and up to 48 hours…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin
- Trial name
- PARTUM (NCT04153760)
- Testing
- Aspirin 81 mg
- Where
- 7 sites in Canada, France and 2 more
- Volunteers
- 257 people
- Sponsor
- University of Calgary
Postpartum Preeclampsia
Postpartum Preeclampsia Early Detection and Treatment: Nepal Pilot Study
The goal of this study is to address the significant morbidity associated with preeclampsia diagnosed after delivery. All participants will undergo biomarker evaluation with soluble fms-like tyrosine kinase-1 and placental growth…
- Trial name
- PREDiCT-NPL (NCT07185204)
- Testing
- Early detection and management of postpartum preeclampsia bundle
- Where
- 2 sites in United States, Nepal
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin
Coronary Artery Disease, Coronary Disease
Clinical Cohort Study - INTERCATH
Within a CAD patient cohort there is a wide variability of clinical manifestation and severity of coronary disease. Distinct determinants that would explain the variety of CAD phenotypes with differing prognosis are yet…
- Conditions
- Coronary Artery Disease, Coronary Disease, Coronary Syndrome, SCAD
- Trial name
- NCT04936438
- Where
- Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Hamburg-Eppendorf
Diabetic Retinopathy
Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)
Diabetic retinopathy (DR) is an eye disease that can occur in people with diabetes and can cause poor vision or blindness. The Action to Control Cardiovascular Risk in Diabetes (ACCORD) study is examining the effect of various…
- Trial name
- NCT00542178
- Testing
- Hypoglycemic Agents, Standard glycemia control, Intensive BP treatment
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,472 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Colchicine Use for Primary Prevention of Coronary Artery Disease
Colchicine has been widely used as an anti-gout medicine in the past decades. Some recent clinical trials have proved that low-dose colchicine can be used as a secondary prevention drug for coronary artery disease because of its…
- Trial name
- NCT05175274
- Testing
- Colchicine
- Where
- China
- Volunteers
- 6,792 people
- Sponsor
- Qingdao Central Hospital
Acute Coronary Syndrome, High Bleeding Risk
LEADERS FREE II: BioFreedom™ Pivotal Study
This study aims to confirm non-inferiority of the BioFreedom™ Drug Coated Stent to the Gazelle™ Bare Metal Stent arm of the Leaders Free study (NCT01623180) in high bleeding risk patients.
- Trial name
- NCT02843633
- Testing
- BioFreedom™ Drug Coated Coronary Stent System, Antiplatelet Drug
- Where
- 66 sites in United States, Canada and 5 more
- Volunteers
- 1,203 people
- Sponsor
- Biosensors Europe SA
Pulmonary Embolism
Reduced-Dose Thrombolysis in Intermediate-Risk Pulmonary Embolism With High-Risk Features
Alteplase, a recombinant tissue plasminogen activator (rt-PA), is commonly used for thrombolytic treatment in patients with high-risk acute pulmonary thromboembolism (PTE), whereas the role of thrombolysis in intermediate-risk…
- Trial name
- REDUCTION (NCT07917078)
- Testing
- Alteplase, Standard Anticoagulation
- Where
- 26 sites in China
- Volunteers
- 270 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension
Chinese PE Multimodality Imaging Artificial Intelligence Study
The CHinese pulmOnary Embolism Multimodality Imaging-artifiCial intelligencE Study (CHOICE) is a prospective observational multi-center study that will collect imaging text data and raw data of patients with pulmonary embolism…
- Conditions
- Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Disease
- Trial name
- NCT06526468
- Testing
- Artificial Intelligence
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- China-Japan Friendship Hospital
Myocardial Infarction
RElevance of Biomarkers for Future Risk of Thromboembolic Events in UnSelected Post-myocardial Infarction Patients
The study is an open, single center, observational study at the Cardiology Dept at Uppsala University Hospital. The number of patients included will be 410.
- Trial name
- REBUS (NCT01102933)
- Where
- Sweden
- Volunteers
- 425 people
- Sponsor
- Uppsala University
Cardiovascular Diseases, Coronary Arteriosclerosis
Stanford Coronary Risk Intervention Project (SCRIP)
To determine whether modification of risk factors altered the rate of progression of coronary artery disease in arteries with mild atherosclerosis and no mechanical intervention in patients who had coronary bypass surgery or…
- Conditions
- Cardiovascular Diseases, Coronary Arteriosclerosis, Coronary Disease, Heart Diseases
- Trial name
- NCT00000508
- Testing
- smoking cessation, diet, reducing, exercise
- Sponsor
- Stanford University
Cerebrovascular Stroke
Carotid Doppler Findings of High Risk Group of Stroke
To evaluate the effect of different risk factors on carotid arteries via ultrasonography parameters.
- Trial name
- NCT05920291
- Volunteers
- 85 people
- Sponsor
- Assiut University
Coronary Artery Disease, Coronary Atheroscleroses
Risk Evaluation by COronary Imaging and Artificial intelliGence Based fuNctIonal analyZing tEchniques - III
This is a single-center, prospective cohort study. This study is designed to accurately analyze coronary artery plaque characteristics and local hemodynamic parameters in patients diagnosed with chronic coronary syndrome (CCS) or…
- Conditions
- Coronary Artery Disease, Coronary Atheroscleroses, Acute Coronary Syndromes (ACS)
- Trial name
- RECOGNIZE-III (NCT06793774)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijin Hospital
Hypertension, Blood Pressure
HIRREM for Stage 1 Primary Hypertension
The purpose of this study is to determine that effects of an intervention called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), on Stage 1 Primary Hypertension (systolic BP 130-139, and/or…
- Conditions
- Hypertension, Blood Pressure, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- HIRREM (NCT03479697)
- Testing
- HIRREM, Continued Current Care
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University Health Sciences
Atherosclerosis
Trial of Ateronon in Patients With Coronary Disease to Evaluate Its Effectiveness in Assessing the Risk Factors of Atherosclerosis
This is a trial of Ateronon in Patients with Coronary Disease to Evaluate its Effectiveness in Assessing the Risk Factors of Atherosclerosis.
- Trial name
- NCT01287182
- Testing
- Ateronon
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Omicron Pharmaceuticals
Diabete Mellitus, Retina Vein Occlusion
Serum Cholinesterases, Paraoxonase, and Cardiovascular Risk After Intravitreal Bevacizumab
Bevacizumab, an anti-VEGF (vascular endothelial growth factor) agent used in the treatment of diabetic retinopathy and macular edema associated with retinal vein occlusion, is commonly administered in ophthalmology clinics…
- Conditions
- Diabete Mellitus, Retina Vein Occlusion, Age Macular Degeneration
- Trial name
- NCT07550777
- Testing
- blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Hypertension
Cornell Translational Behavioral Science Research Consortium: Hypertension Qualitative Study
To explore the meaning, causes and treatment of hypertension in eligible patients. In addition the cultural, social, and psychological factors that either facilitate or serve, as barriers to behavioral change will be illuminated…
- Trial name
- NCT00227175
- Testing
- Semi-structured, open ended interview
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Weill Medical College of Cornell University
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