Clinical trials: Vascular Disease Risk
Biomarkers, ST Segment Elevation Myocardial Infarction
Biomarkers for Risk Stratification After STEMI
Despite modern reperfusion strategies, myocardial infarction leads to deleterious processes resulting in left ventricular remodelling (LVR) and heart failure (HF). Several biomarkers i.e.
- Conditions
- Biomarkers, ST Segment Elevation Myocardial Infarction, Primary Percutaneous Coronary Intervention, Heart Diseases
- Trial name
- NCT03735719
- Where
- Poland
- Volunteers
- 136 people
- Sponsor
- Medical University of Warsaw
Multiple Myeloma
Study Association of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab in Newly Diagnosed Standard Risk Multiple Myeloma
The main objective of this study is to evaluate the minimal residual disease-negativity rate after administration of the combination of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab as induction and consolidation therapy…
- Trial name
- IFM2018-01 (NCT03669445)
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 12 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Toulouse
Diabetes Mellitus, Foot Ulcer, Diabetic
Prevention of Primary Foot Ulcers in High-risk Diabetes Patients
This is a primary prevention study which aims to assess reduction in the rate of diabetic foot ulcers in patients with high-risk diabetic feet using 3D printed insoles compared to standard care
- Conditions
- Diabetes Mellitus, Foot Ulcer, Diabetic, Primary Prevention
- Trial name
- PROFOUND (NCT03958539)
- Testing
- 3D printed insoles for normal footware
- Where
- United Kingdom
- Volunteers
- 900 people
- Sponsor
- Countess of Chester NHS Foundation Trust
Atrial Fibrillation
Artificial Intelligence Models to Predict Clinically Relevant Cardiovascular Outcomes
Atrial fibrillation (AF) is a frequent and clinically relevant problem among the events that may occur during the hospitalization period in patients with cardiovascular disease.
- Trial name
- PERCARD (NCT06847100)
- Testing
- Blood withdrawal
- Where
- 4 sites in Finland, Germany and 1 more
- Volunteers
- 273 people
- Sponsor
- Centro Cardiologico Monzino
Fabry Disease
Fabry Aim Children Early (ACE) Project
The purpose of this study is to assess the frequency of Fabry disease in children with early symptoms.
- Trial name
- NCT04965467
- Testing
- Screening for Fabry disease
- Where
- 21 sites in China
- Sponsor
- Children's Hospital of Fudan University
Coronary Arterial Disease (CAD), Sudden Cardiac Arrest
Validation of Sudden Cardiac Arrest Risk Factors in Patients With CAD
Long-term sudden cardiac death (abbreviation: SCAR) focuses on improving the predictability of sudden cardiac death (SCD) in patients diagnosed with coronary artery disease.
- Conditions
- Coronary Arterial Disease (CAD), Sudden Cardiac Arrest, Sudden Cardiac Death
- Trial name
- SCAR (NCT07444931)
- Where
- 3 sites in Israel, Moldova and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Tampere Heart Hospital
Stroke
Visual Feedback Balance Training System Combined with RFE in Stroke
The goal of this clinical trial is to learn if visual feedback balance training system combined with repetitive facilitative exercise (RFE) work to treat stroke in adults.
- Trial name
- NCT06477445
- Testing
- Visual feedback balance training system, repetitive facilitative exercise, conventional therapy
- Volunteers
- 60 people
- Sponsor
- Nanjing Mingzhou Rehabilitation Hospital
Venous Thromboembolism (VTE), Cancer
Vortosiran for VTE Prevention
Blood clots remain a serious cause of illness and death. Long-term treatment and prevention of these clots with blood thinners is often limited by bleeding risk, drug interactions, and daily dosing, leading many patients to stop…
- Conditions
- Venous Thromboembolism (VTE), Cancer, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07850453
- Testing
- Vortosiran
- Where
- 30 sites in Bulgaria, France and 2 more
- Volunteers
- 150 people
- Sponsor
- Ribocure Pharmaceuticals AB
Stroke
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
The purpose of this study is to find risk factors for hemorrhagic stroke.
- Trial name
- GERFHS (NCT00682695)
- Where
- 7 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Ischemic Stroke, TIA
Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute…
- Trial name
- NCT05439356
- Testing
- Colchicine
- Where
- 244 sites in China
- Volunteers
- 8,343 people
- Sponsor
- Beijing Tiantan Hospital
Glial Tumors, Thrombosis
Usefulness of Thromboelastography as a Predictor of Prognosis in Patients Undergoing Surgery for Glial Tumors and of the Risk of Postoperative Thromboembolic Disease (GliTEM)
The objective of our study is to investigate the clinical significance of thromboelastometric values in the development of thrombotic events and survival in patients with glial tumors, to reduce thromboembolic complications and…
- Conditions
- Glial Tumors, Thrombosis, Pulmonary Embolism (Diagnosis)
- Trial name
- GliTEM (NCT07813377)
- Testing
- Thromboelastometry values: EXTEM CT, MCF, α-angle below the lower limit of normal. Measurement obtained after anesthetic induction. - PT, aPTT, fibrinogen, platelet count. - Thrombin generation. -
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Diabetic Foot Ulcer
Custom Insole With Transcutaneous Electrical Nerve Stimulation on Clinical Outcomes of Diabetic Foot Ulcers
Diabetic foot ulcers (DFUs) are one of the serious complications of diabetes, typically resulting from neuropathy or peripheral arterial disease, and can often lead to amputation.
- Trial name
- NCT07109895
- Testing
- Standard Care Only, Custom Insole + Standard Care, TENS + Custom Insole + Standard Care
- Where
- Pakistan
- Volunteers
- 159 people
- Sponsor
- University of Lahore
Hypertension, Cardiovascular Risk Factor
HIGH Altitude CArdiovascular REsearch Latin America Population Study
High blood pressure (BP) is one of the principal cardiovascular risk factors. While BP levels and hypertension prevalence are well characterized in many populations, information on BP and on cardiovascular risk profile in high…
- Conditions
- Hypertension, Cardiovascular Risk Factor, Altitude Hypoxia, Altitude Sickness
- Trial name
- HIGHCARE-LAPS (NCT04751292)
- Testing
- Exposure to high altitude
- Where
- Peru
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Breast Feeding, Cardiovascular Diseases
Effect of Breastfeeding Optimization on Early Vascular Development
This study aims to find out whether breast feeding optimization will increase breast feeding rates and to evaluate its effect on cardiovascular risk and general health of children.
- Trial name
- BRAVO (NCT01566812)
- Testing
- Breast feeding optimization, Usual care
- Where
- Indonesia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Stroke
Perturbation Training for Fall-risk Reduction Among Stroke Survivors
The long-term objective of this research is to develop an efficacious training paradigm to enhance stroke survivors' defense mechanisms against falls and possibly reduce healthcare cost.
- Trial name
- NCT03205527
- Testing
- Overground slip perturbation training
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Illinois Chicago
Hypertension, Cardiovascular Diseases
China Salt Substitute Study
Cardiovascular disease is a leading cause of death and disability worldwide, and blood pressure is a leading determinant of this risk.
- Trial name
- NCT00145756
- Testing
- low sodium high potassium salt substitute
- Where
- 6 sites in China
- Volunteers
- 600 people
- Sponsor
- The George Institute
Coronary Artery Disease
Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients
The primary objective of this study is to compare the efficacy and tolerability of low-dose statin therapy vs. the association between a low-dose statin and a nutraceutical-based protocol in high-dose statin-intolerant patients…
- Trial name
- ADHERENCE (NCT02001883)
- Testing
- Association low-dose statin and nutraceuticals
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Hypertension, Diabetes Mellitus
Dissemination of the Cardiovascular Risk Service
The objective of this study is to evaluate the implementation of of a remote, pharmacist-led cardiovascular risk service (CVRS) in 12 large, organizationally and culturally diverse hospitals and health-systems, many with high…
- Trial name
- CVRSLive (NCT03660631)
- Testing
- CVRS Intervention
- Where
- 14 sites in United States
- Volunteers
- 542 people
- Sponsor
- Korey Kennelty
Meningioma
A Comparative Study of Prophylactic Anticoagulation in Meningioma Surgery
The aim of the study is to compare different strategies for prevention of venous thromboembolism related to intracranial meningioma surgery.
- Trial name
- NCT01941602
- Testing
- prophylactic enoxaparin, non-prophylactic
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 979 people
- Sponsor
- St. Olavs Hospital
Breast Cancer
Coronary Artery Calcium and Cardiovascular Risk Factors Analysis After RT or Breast Cancer
This is a no-profit, national, monocenter, retrospective, and prospective low-intervention study. It is a low-intervention study in terms of diagnostic additional procedure (CT scan).
- Trial name
- RadioTherapy (NCT05775822)
- Testing
- CT scan and blood sample collection
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- Centro Cardiologico Monzino
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