Clinical trials: Vascular Disease Risk
Ischemic Stroke, Hemorrhagic Stroke
Correlation Between Intestinal Microecology Imbalance and Stroke in Young Adults
The relationship between the intestinal microecology and stroke has become a research hotspot in neurology field today. Maintaining the balance of the intestinal microbiota are expected to bring new breakthroughs for prevention…
- Trial name
- NCT05113043
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 6th People's Hospital
Aneurism
Genetic Profile In Patients With Ruptured and Unruptured Intracranial Aneurysms
The project will involve multiple units within our Institute (Neurosurgery, Cerebrovascular Diseases, Neurology IV), as well as additional neurosurgical centers across Italy, for the enrollment of patients with saccular…
- Trial name
- ANEUBIO (NCT07233915)
- Where
- Italy
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Covid19, Diabetes
Camostat and Artemisia Annua vs Placebo in COVID-19 Outpatients
This is a randomized, double-blind, placebo-controlled, multi-arm, multicenter, phase II trial design to allow a rapid efficacy and toxicity assessment of potential therapies (camostat mesilate and artemisia annua) immediately…
- Conditions
- Covid19, Diabetes, Hypertension, Obesity
- Trial name
- NCT04530617
- Testing
- Camostat Mesilate, Artemisia Annua Leaf
- Where
- Mexico
- Volunteers
- 246 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cardiovascular Disease
the Canadian Health Improvement Network to Upgrade Prevention Services
RATIONALE Controlling cardiovascular risk factors has been proven to be effective in prevention and management of cardiovascular disease (CVD).
- Trial name
- CHIN-UPS (NCT02310685)
- Testing
- Comprehensive e-health wellness program
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- McGill University
Stroke, Risk Factor, Cardiovascular
Telematic Model Integrated in the Transversal Care of the Secondary Prevention of Patients With Stroke
In Spain, stroke is the leading cause of death in women and disability in adults, which is why it is currently one of the most important public health problems.
- Trial name
- NCT03732417
- Testing
- Secondary prevention of cardiovascular risk factors
- Where
- Spain
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Acute Kidney Injury
Identification of Preoperative Parameters to Predict Acute Kidney Injury Risk Following Vascular or Digestive Surgery
The study aims to identify the preoperative parameters associated with the risk of postoperative acute kidney injury (in particular the parameters of the SPARK score) in patients of the Besançon University Hospital who have…
- Trial name
- SCOPING (NCT05660174)
- Where
- France
- Volunteers
- 2,626 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiovascular Disease, Cerebrovascular Accident
A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels
The primary objective of this study is to determine the degree of additional reduction in cardiovascular risk that was accrued to patients by lowering their LDL-C beyond the currently accepted minimum target level for patients…
- Conditions
- Cardiovascular Disease, Cerebrovascular Accident, Coronary Heart Disease
- Trial name
- TNT (NCT00327691)
- Testing
- Atorvastatin
- Where
- 314 sites in United States, Australia and 12 more
- Volunteers
- 8,600 people
- Sponsor
- Pfizer
Schizophrenia, Schizoaffective Disorder
The Effects of Rimonabant, on Weight and Metabolic Risk Factors
1) To examine the efficacy of rimonabant in decreasing weight and metabolic parameters/cardiovascular disease risk in people with schizophrenia receiving second generation antipsychotics 2) To examine the safety and tolerability…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Obesity, Hypertension
- Trial name
- NCT00547118
- Testing
- Rimonabant
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Maryland, Baltimore
Internal Carotid Artery Stenosis
SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MegaHertz (MHz) diagnostic probe on the reduction of risk of brain infarctions due to the…
- Trial name
- SONOBUSTER (NCT01591005)
- Testing
- sonolysis, endarterectomy, carotid stenting
- Where
- Czechia
- Volunteers
- 242 people
- Sponsor
- University Hospital Ostrava
Venous Thromboembolism
Construction and External Validation of a Predictive Clinico-biological Score of the Risk of Venous Thrombosis in Women Under Combined Oral Contraceptives
the investigators hypothesize that some of these polymorphisms contribute to VTE risk in women using COC, and that their screening could to help assess individual risk of VTE before COC prescription.
- Trial name
- PILGRIM (NCT03309293)
- Testing
- blood samples
- Where
- France
- Volunteers
- 1,454 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
ISCHEMIC STROKE
Hair Cortisol and the Risk of Stroke
The purpose of this study is to prospectively examine the relation between ischemic stroke and hair cortisol concentration. The investigators hypothesize that patients with ischemic stroke have higher levels of hair cortisol…
- Trial name
- NCT02090270
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Cystic Fibrosis (CF), Cardiovascular (CV) Risk
Heart and Blood Vessels Health in People With Cystic Fibrosis
Cystic fibrosis (CF) is a disease that affects over 11,000 people in the UK. It is a genetic condition that affects many organs including the lungs, pancreas, kidneys and liver.
- Conditions
- Cystic Fibrosis (CF), Cardiovascular (CV) Risk, Flow-mediated Dilation Evaluation of the Brachial Artery, Pulse Wave Analysis
- Trial name
- CHi-CF (NCT07692594)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Stroke, Ischemic, Stroke Hemorrhagic
The REACTplusNMES Trial: A Double-blinded RCT
The aim of this study is to compare the effectiveness of 6-weeks of reactive balance training (REACT) with and without neuromuscular electrical stimulation (NMES) to paretic lower limb muscles on biomechanical, clinical…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Cerebrovascular
- Trial name
- REACT+NMES (NCT06127602)
- Testing
- Reactive balance training with Neuromuscular Electrical Stimulation, Reactive balance training without Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Illinois Chicago
Secondary Prevention of Coronary Heart Disease
Artificial Intelligence-Enhanced Management for Coronary Heart Disease (AIM-CHD) : Impact on Cholesterol and Other CHD Risk Factors
The goal of this clinical trial is to find out if an artificial intelligence (AI)-enhanced mobile app can help people with coronary heart disease (CHD) better manage their health after being discharged from the hospital.
- Trial name
- AIM-CHD (NCT06686056)
- Testing
- AIM-CHD Mobile Health Intervention, Usual post-discharge care
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Carotid Stenosis
Diabetes and Risk of Ischemic Stroke.
Diabetes in an independent risk factor for ischemic stroke, whose associated mortality rate is higher and sequelae more serious than for nondiabetics.
- Trial name
- NCT06401902
- Testing
- carotid clamping
- Where
- France
- Volunteers
- 3,739 people
- Sponsor
- Institut Mutualiste Montsouris
Multiple Myeloma
A Study of Dara-RVd and Teclistamab-RVd in People With Multiple Myeloma
The purpose of this study is to find out whether Tec-RVd (teclistamab, lenalidomide, bortezomib, and dexamethasone) after 3 treatment Cycles of Dara-RVd (daratumumab, lenalidomide, bortezomib, and dexamethasone) is a safe…
- Trial name
- NCT07099391
- Testing
- Dara-RVd, Tec-RVd
- Where
- 7 sites in United States
- Volunteers
- 65 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Vascular Diseases, Hypercholesterolemia
The Effect of Plant Sterols on the Blood Lipid Profile of Subjects With and at High Risk of Type 2 Diabetes Mellitus
Double-blind, randomised, placebo-controlled, parallel group study with two intervention arms. The study will be conducted in 150 subjects and the primary objective is to show a fasting LDL-cholesterol and triglyceride lowering…
- Conditions
- Vascular Diseases, Hypercholesterolemia, Diabetes Mellitus
- Trial name
- NCT02288585
- Testing
- Plant sterols
- Where
- 2 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Multiple Myeloma
A Study to Evaluate the Safety of bb2121 in Subjects With High Risk, Newly Diagnosed Multiple Myeloma (NDMM)
This is a multicenter, open-label, phase 1, single arm study intended to determine the optimal target dose and safety of bb2121 in subjects with HR (R-ISS Stage III per IMWG criteria) NDMM.
- Trial name
- KarMMa-4 (NCT04196491)
- Testing
- bb2121, Fludarabine, Cyclophosphamide
- Where
- 22 sites in United States
- Volunteers
- 13 people
- Sponsor
- Celgene
Preeclampsia, Pregnancy Induced Hypertension
Preeclampsia: A Marker for Future Cardiovascular Risk in Women
This study will compare blood vessel and hormone differences between women who have a history of a pregnancy complicated by preeclampsia or high blood pressure, and women who have a history of uncomplicated pregnancy in the last…
- Trial name
- NCT01519297
- Testing
- Irbesartan
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Multiple Myeloma, Lymphoma
Trial of an Augmented Mobilization Strategy With Plerixafor (Mozobil®) in a Population at Risk for Poor Stem Cell Mobilization
Poor mobilization of hematopoietic progenitors needed to support autologous transplantation is a serious clinical problem. We are investigating the role of plerixafor administered in an at risk population to augment successful…
- Trial name
- NCT01037517
- Testing
- Plerixafor, Observation: Nonintervention
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- CancerCare Manitoba
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