Clinical trials: Vascular Disease Risk
Multiple Myeloma
CART-19 Post-ASCT for Multiple Myeloma
This will be a single-arm, open-label study. Patients will be enrolled during induction therapy for multiple myeloma, prior to standard-of-care consolidation with autologous stem cell transplantation (ASCT).
- Trial name
- NCT02794246
- Testing
- CART-19 cells
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Myocardial Infarction
Reduced Antithrombotic Strategy for High Bleeding Risk Patients With Myocardial Infarction
Rationale: Heart attacks are a major cause of death and result from coronary blood clots that require acute coronary intervention and antithrombotic drugs to restore blood flow and prevent new heart attacks.
- Trial name
- Dan-DAPT (NCT05262803)
- Testing
- CYP2C19*2/*3, Shorter DAPT duration
- Where
- 6 sites in Denmark
- Volunteers
- 2,808 people
- Sponsor
- Rikke Sorensen
Stroke, Cardiovascular Diseases
MIDNOR-STROKE- a Long Term Follow-up Study of Patients With First Ever Ischemic Stroke in Central Norway
Annually 13000 Norwegians experience an ischemic stroke. The number of stroke is anticipated to increase with 50% within 2030 due to a growing number of elderly.
- Conditions
- Stroke, Cardiovascular Diseases, Cardiovascular Risk Factor, Brain Ischemia
- Trial name
- NCT03962127
- Testing
- no intervention
- Where
- 8 sites in Norway
- Volunteers
- 800 people
- Sponsor
- Norwegian University of Science and Technology
Stroke
Effect of Sensorimotor Training Versus Dual-task Training
The aim of this study is to determine the comparative effects of sensorimotor training and dual-task training on propriocetion, balance, functional mobility and fall risk in stroke patients.
- Trial name
- NCT07628374
- Testing
- Sensorimotor Training, Dual-Task Training, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
Pulmonary Embolism
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial
Phase II trial of TS23
- Trial name
- NAIL-IT (NCT05408546)
- Testing
- TS23
- Where
- 13 sites in United States
- Volunteers
- 64 people
- Sponsor
- Translational Sciences, Inc.
Venous Thrombosis
Intimate Partner Violence as a Risk Factor for Venous Thromboembolism in Women
The frequency of violence against women, or intimate partner violence (IPV) is more and more underlined and recognized as a cofactor favoring certain somatic and psychic pathologies.
- Trial name
- WAST-VTE (NCT05890924)
- Testing
- WAST questionnaire
- Where
- France
- Volunteers
- 997 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Coronary Artery Disease, Multi Vessel Coronary Artery Disease
Influence of Risk Factors on ISR and Nonintervened Lesions
This study enrolled patients who used to received PCI therapy with nonintervened coronary lesions. Baseline characteristics and laboratory testing were collected to find out the risk factor difference between ISR and…
- Trial name
- NCT06039059
- Where
- China
- Volunteers
- 510 people
- Sponsor
- RenJi Hospital
Exercise Anaphylaxis
The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women
The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women.
- Trial name
- NCT01314573
- Testing
- Sprint interval exercise, Maximal continuous exercise
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Obesity, Hyperlipidemia
Effects of Dietary Antioxidants on Cardiovascular Risk Factors
The aim of the Antioxidant Study was to compare the efficacy of foods naturally rich in antioxidants with that of antioxidants in a pill form on markers of inflammation and plasma cholesterol in healthy adults at risk of…
- Conditions
- Obesity, Hyperlipidemia, Hypertension
- Trial name
- NCT00756405
- Testing
- Antioxidant diet, Antioxidant supplement
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Christopher Gardner
Renovascular Hypertension, Renovascular Hypertension With Renal Failure
Effects of Percutaneous Transluminal Renal Angioplasty of Atherosclerotic Renal Artery Stenosis in High-Risk Patients.
The goal of this clinical trial is to investigate whether percutaneous transluminal renal angioplasty (PTRA) with stent placement of atherosclerotic renal artery stenosis is beneficial in high-risk patients selected according to…
- Conditions
- Renovascular Hypertension, Renovascular Hypertension With Renal Failure, Heart Failure, Renal Artery Stenosis Atherosclerotic
- Trial name
- DAN-PTRAII (NCT05834803)
- Testing
- Optimal medical therapy (OMT), Catheter-based angiography, Measurement of translesional pressure gradients
- Where
- 3 sites in Denmark
- Volunteers
- 80 people
- Sponsor
- University of Aarhus
Atrial Fibrillation, Anticoagulants and Bleeding Disorders
Left Atrial Appendage Occlusion for AF Patients Unable to Use Oral Anticoagulation Therapy
Up to 5% of Atrial Fibrillation (AF) patients may have or develop contraindications to use oral anticoagulation (OAC). Randomized controlled trial (RCT) data suggest that Left Atrial Appendage Occlusion (LAAO) may provide a…
- Trial name
- COMPARE-LAAO (NCT04676880)
- Testing
- Left atrial appendage occlusion (Watchman FLX or Amplatzer Amulet)
- Where
- 14 sites in Netherlands
- Volunteers
- 609 people
- Sponsor
- R&D Cardiologie
Pulmonary Embolism
Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
There are many available treatments for pulmonary embolism (PE), but the best treatment for this condition is not known. The HI-PEITHO study will compare two treatment options that are both available on the market for the…
- Trial name
- HI-PEITHO (NCT04790370)
- Testing
- Anticoagulation with heparin, EkoSonicTM Endovascular System
- Where
- 60 sites in United States, Austria and 7 more
- Volunteers
- 544 people
- Sponsor
- Boston Scientific Corporation
Premature, Thrombosis
Thrombophilic Risk Factors in Preterm and Infants Treated at Ha'Emek Medical Center Between the Years 1990 to 2010
There are several factor that can be related to Neonatal Thrombotic events. Among them hypercoagulability can be the cause of those events.
- Trial name
- NCT01443273
- Testing
- Medical Records study
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Primary Graft Dysfunction, Lung Transplantation
Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation
Primary graft dysfunction (PGD) is a severe lung complication that can occur in the days after lung transplant surgery. This study will analyze blood samples to determine if high levels of certain chemicals may increase the risk…
- Trial name
- NCT00552357
- Where
- United States
- Volunteers
- 1,150 people
- Sponsor
- University of Pennsylvania
Post Stroke, Stroke
Effects of Tai Chi and Dual Task Balance Training in Post Stroke Patients
The aim of the study is to compare the effects of Tai Chi and Dual Task Balance Training on Balance and Fall Risk in Post Stroke Patients
- Trial name
- NCT07854067
- Testing
- Tai Chi, Dual Task Balance Training
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Riphah International University
Venous Thromboembolism
Treatment Patterns and Bleeding Risk of Anticoagulants in Patients With Venous Thromboembolism in Korea
This study is a retrospective, observational, nationwide population-based cohort study utilizing the South Korea's Health Insurance and Review Assessment Service (HIRA) database.
- Trial name
- NCT05022563
- Testing
- Parenteral anticoagulant, Warfarin, Apixaban
- Where
- 2 sites in South Korea
- Volunteers
- 55,759 people
- Sponsor
- Pfizer
Multiple Myeloma, Carfilzomib
The Efficacy and Safety of the Combination Therapy of Daratumumab, Cabozantinib, Pomalidomide, and Dexamethasone (D-KPd) in the Treatment of High-risk First-time Relapsed or Primary Refractory MM Patients
This study is a prospective, single center, single arm phase II clinical trial. The study population consists of patients who have received treatment with VRd or VRd lite regimens for 2-8 courses in the past and have achieved…
- Conditions
- Multiple Myeloma, Carfilzomib, Daratumumab, Pomalidomide
- Trial name
- DKPD (NCT07015021)
- Testing
- Daratumumab, Cafizomide, Pomalidomide
- Volunteers
- 72 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Coronary Artery Disease, Myocardial Infarction
Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe
The "EUropean Comparative Effectiveness Research to assess the use of primary prophylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD)" is a modular research project to study the effectiveness of prophylactic ICDs in a…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Dilated Cardiomyopathy, Implantable Defibrillator User
- Trial name
- EU-CERT-ICD (NCT02064192)
- Where
- 42 sites in Belgium, Bulgaria and 14 more
- Volunteers
- 2,285 people
- Sponsor
- University Medical Center Goettingen
Hypertension, Pregnancy-Induced
Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia
The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by…
- Trial name
- REPAIR (NCT06220721)
- Testing
- Nifedipine ER
- Where
- 2 sites in United States
- Volunteers
- 618 people
- Sponsor
- Medical College of Wisconsin
Myocardial Infarction, Angina Pectoris
Improving Intermediate Risk Management. MARK Study
Cardiovascular risk functions fail to identify more than 50% of patients who develop cardiovascular disease. This is especially evident in the intermediate-risk patients in which clinical management becomes difficult.
- Conditions
- Myocardial Infarction, Angina Pectoris, Stroke, Peripheral Arterial Disease
- Trial name
- MARK (NCT01428934)
- Where
- Spain
- Volunteers
- 2,495 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
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