Clinical trials: Vascular Diseases, Peripheral
Critical Limb Ischemia
MOTIV BTK Randomized Controlled Trial
Pre-market clinical evaluation of the MOTIV Sirolimus-Eluting Bioresorbable Scaffold for the planned treatment of infrapopliteal lesions.
- Trial name
- NCT05406622
- Testing
- MOTIV Sirolimus-Eluting Bioresorbable Scaffold, Percutaneous Transluminal Angioplasty (PTA) Device
- Where
- 26 sites in United States, Germany
- Volunteers
- 292 people
- Sponsor
- REVA Medical, Inc.
Non-ischemic Cardiomyopathy, Cardiomyopathies
Cardiovascular Multimodality Imaging Study
Determining the etiology of cardiomyopathy is of high clinical importance for optimal treatment strategy and prediction of prognosis.
- Conditions
- Non-ischemic Cardiomyopathy, Cardiomyopathies, Hypertrophic Cardiomyopathy, Right Ventricular Arrhythmogenic Cardiomyopathy
- Trial name
- NCT06610019
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Montefiore Medical Center
Critical Limb Ischemia, Peripheral Artery Disease
Investigating the Safety and Efficacy of the Treatment With the Non-compliant Jade Balloon in TASC C and D Athero-occlusive Infra-inguinal Disease in Patients With Chronic Limb Threatening Limb Ischemia From SingaporE
The objective of this clinical study is to evaluate the 6-month safety and performance outcome of the non-compliant high pressure JADE balloon for the treatment of infrainguinal stenotic occlusive or stenotic TASC C \& D lesions…
- Trial name
- PINNACLE (NCT04534192)
- Testing
- JADE Balloon
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Peripheral Artery Disease, Intermittent Claudication
Home-based Circuit Training for People With Intermittent Claudication
The purpose of the study is to assess the feasibility of undertaking a randomised controlled trial investigating the effectiveness of a 12-week home-based exercise programme for people with intermittent claudication.
- Trial name
- WALKSTRONG (NCT05059899)
- Testing
- Exercise group
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Coventry University
Scleroderma, Raynaud's Syndrome
Efficacy of Botulinum Toxin In Scleroderma-Associated Raynaud's Syndrome
This is a randomized, double-blinded, clinical trial assessing the therapeutic efficacy of Botulinum toxin A (Onabotulinumtoxin A) in treating scleroderma-associated Raynaud's syndrome.
- Trial name
- NCT02165111
- Testing
- Onabotulinumtoxin A, sterile saline solution
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
STROKE
Combined Antagonistic Muscle Magnetic Stimulation and Selective Periferal Neurotomy to Improve Results on Spasticity
The objective of the present trial is to demonstrate Magnetic stimulation as an useful complementary treatment in order to improve patients' evolution without the need of extensive surgical lesion.
- Trial name
- Andreani2 (NCT02226432)
- Testing
- - Postoperative Antagonistic Peripheral Magnetic Stimulation, Selective Peripheral Magnetic Stimulation, Kinesics
- Volunteers
- 15 people
- Sponsor
- Juan Carlos M. Andreani MD
Peripheral Artery Disease, Peripheral Vascular Disease
Evaluation of an Electronic Health Record-based Screening Tool for Peripheral Artery Disease
This protocol represents a pilot randomized-controlled trial evaluating the effect of an electronic health record (EHR)-based peripheral artery disease (PAD) screening tool on rates of new non-invasive testing, diagnosis and…
- Trial name
- NCT04054232
- Testing
- High PAD risk Alert
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Atherosclerosis, Peripheral Arterial Disease
Stella Supera Siberia
Endovascular treatment with stenting is currently used in the treatment of femoro-popliteal lesions. This technique tends to extend to lesions for which the gold standard remains until now the open surgery treatment (lesions TASC…
- Conditions
- Atherosclerosis, Peripheral Arterial Disease, Superficial Femoral Artery Occlusion
- Trial name
- NCT03951727
- Testing
- Endovascular treatment for PAD
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Peripheral Arterial Disease
BIOLUX P-III SPAIN All-Comers Registry
The purpose of the BIOLUX P-III Spain registry is to further investigate the safety and clinical performance of the Passeo-18 Lux Drug Coated Balloon in the treatment of long atherosclerotic femoropoliteal artery lesions in daily…
- Trial name
- NCT03052296
- Testing
- Passeo-18 Lux DCB
- Where
- 5 sites in Spain
- Volunteers
- 44 people
- Sponsor
- Biotronik AG
Peripheral Arterial Disease, Leg Ulcer
Cell Therapy for Lower Limb Ulcers in Patients With Critical Limb Ischemia
Peripheral arterial disease (PAD) can progress to critical limb ischemia (CLI) of the affected lower limb, characterized by pain at rest, ulcerations or gangrene, with a high risk of amputation.
- Trial name
- NCT06326203
- Testing
- CELULAS TRONCO, CONVENTIONAL DRESSING
- Volunteers
- 40 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cardiogenic Shock
Passive Leg Raising for Predicting Fluid Responsiveness in VA-ECMO Assisted Patients
Peripheral Veno-Arterial Extra Corporeal Membrane Oxygenation (VA ECMO) is a temporary assistance that provides a mechanical circulatory support in patients victim of cardiogenic shock (CS) or refractory cardiac arrest.
- Trial name
- PARANOVA (NCT04984603)
- Testing
- PLR in patients under VA-ECMO
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Critical Limb Ischemia
Laser Atherectomy Versus Angioplasty for the Treatment of Critical Limb Ischemia
The reason the investigators are doing this study is to compare the results of laser atherectomy versus angioplasty with or without the placement of a stent in the artery.
- Trial name
- NCT01579123
- Testing
- Angioplasty, Laser atherectomy
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Baylor Research Institute
Diabetes Mellitus, Vascular Complications
Peripheral Vascular REactivity and Muscular Oxygenation in Diabetes Mellitus
Oxygen is required for an optimal muscle function. In patients with diabetes mellitus, hyperglycemia can cause vascular complications.
- Conditions
- Diabetes Mellitus, Vascular Complications, Mitochondrial Diseases
- Trial name
- PREMOD (NCT04226820)
- Testing
- examination: blood pressure assessment, examination: Flow Mediated Dilatation (FMD)-test, examination: handgrip exercise test with Near infrared spectroscopy (NIRS)-monitoring
- Where
- Belgium
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Ghent
Ischemic Heart Disease, Nerve Injury
Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study
Evaluation of potential nerve damage after radial CAG/PCI.
- Conditions
- Ischemic Heart Disease, Nerve Injury, Carpal Tunnel Syndrome
- Trial name
- ACCESS-IV (NCT05365282)
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Aarhus University Hospital Skejby
Peripheral Vascular Diseases
Bone Marrow Autograft in Limb Ischemia
BALI (Bone marrow Autograft in Limb Ischemia) is a randomized double-blind trial comparing implantation of bone marrow - mononuclear cells versus placebo in patients presenting with critical leg ischemia and no surgical option.
- Trial name
- BALI (NCT00904501)
- Testing
- Bone marrow harvest
- Where
- 15 sites in France
- Volunteers
- 40 people
- Sponsor
- CHU de Reims
Atherosclerosis, Intermittent Claudication
Whole-Body MRA at 3T - A Comparison Between Two Different Scan Protocols
To compare to different approaches in whole-body magnetic resonance angiography of patients suffering peripheral arterial disease.
- Trial name
- NCT00834548
- Testing
- Whole body magnetic resonance angiography (WB-MRA)
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Copenhagen University Hospital at Herlev
Peripheral Arterial Disease
MyPADMGT Support of Out-Patients With Peripheral Arterial Disease
The investigators have developed an online program to help people with peripheral arterial disease (PAD) in their extremities to better self-manage their condition.
- Trial name
- Final_PADHSS (NCT04228549)
- Testing
- MyPADMGT, MyPADMGT + Nudging
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- McMaster University
Thoracic Outlet Syndrome
Evaluation of the Muscular FORCE in the Upper Limbs of Patients Presenting a Thoracic Outlet Syndrome
The thoracic outlet syndrome is a rare but debilitating pathology, responsible for upper limb pain. Its frequency is probably underestimated because of diagnostic difficulties.
- Trial name
- EFORD (NCT04145778)
- Testing
- 6-minute walk test
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Critical Limb Ischemia, Peripheral Arterial Disease
Safety and Efficacy Study of Autologous BM-MNC Processed by Two Methods for Treating Patients With Chronic Limb Ischemia
Using autologous bone marrow mononuclear cells (BM-MNC) to treat patients with chronic limb ischemia has been proved safe and effective.
- Conditions
- Critical Limb Ischemia, Peripheral Arterial Disease, Buerger's Disease
- Trial name
- NCT01446055
- Testing
- ResQ processed bone marrow sample, Ficoll conventional cell processing method
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuanwu Hospital, Beijing