Clinical trials: Vascular Endothelial Function
Coronary Artery Disease, Endothelial Function
Offset of Ticagrelor's Effect on Endothelial Function as Assessed With Peripheral Arterial Tonometry (EndoPAT Assay)
Ticagrelor administration, whose molecule resembles to adenosine, led to reduction in overall mortality and thrombotic cardiovascular (CV) events when directly compared to clopidogrel in the PLATO trial, implicating possible…
- Trial name
- NCT01957527
- Testing
- Peripheral arterial tonometry (EndoPAT)
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Patras
Renal Function, Endothelial Function
Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
The investigators hypothesize that, among non-hypertensive overweight and obese individuals, treatment of vitamin D deficiency and lowering uric acid concentrations (by either xanthine oxidase inhibition or increased renal…
- Conditions
- Renal Function, Endothelial Function, Blood Pressure, Overweight
- Trial name
- MODERATE (NCT01320722)
- Testing
- Vitamin D ergocalciferol, Probenecid, Allopurinol
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Retinopathy of Prematurity (ROP), Prematurity Complications
Retinopathy of Prematurity - Visual Function and Retinal Structure
Children born prematurely may develop a characteristic retinal disease named retinopathy of prematurity (ROP). This disease could lead to retinal detachment and blindness.
- Conditions
- Retinopathy of Prematurity (ROP), Prematurity Complications, Cerebral Visual Impairment, Visual Field Defect
- Trial name
- NCT07427719
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Oslo University Hospital
Vascular Aging
Sodium Nitrite to Treat Arterial Aging
The proposed research will determine the effectiveness of nitrite, a naturally occurring compound in the body, for improving the health and function of arteries in middle-aged and older adults.
- Trial name
- NCT02022670
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Elevated Blood Pressure, Hypertension
Clinical Effectiveness of Boxing Training in Individuals With Elevated Blood Pressure or Stage 1 Hypertension
The goal of this clinical trial is to determine whether boxing training reduces cardiovascular risk in elevated blood pressure or hypertension stage 1 individuals.
- Trial name
- NCT06413251
- Testing
- Boxing Training, Control flexibility
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Texas, El Paso
Breast Cancer
Effect of Aromatase Inhibitor Therapy on Blood Vessel Function in Postmenopausal Women With Breast Cancer
RATIONALE: Aromatase inhibitor therapy is used in treating postmenopausal women who have hormone-dependent breast cancer. It is not yet known what effect aromatase inhibitor therapy has on blood vessel function.
- Trial name
- NCT00719966
- Testing
- anastrozole, exemestane, letrozole
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Mayo Clinic
Obesity, Morbid, Ischemic Heart Disease
Prevalence and Outcome of Brachial Artery Endothelial Function in Morbidly Obese Patients Undergoing Bariatric Surgery
The relation between obesity and ischemic heart disease (IHD) is under considerable debate. The reduction in all-cause mortality and, more specifically, the reduction in cardiac-related mortality seen after weight-loss surgery…
- Trial name
- NCT00808652
- Testing
- Measurement of flow mediated dilation of brachial artery.
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Sheba Medical Center
Cardiovascular Disease
Effects on Cardiovascular Risk Factors of the Endogenous Hydroxytyrosol Generation After the Combined Intake of Wine and Tyrosol in Humans
The present study will assess whether the beneficial effects of a market moderate-alcohol drinking in the form of white wine in humans could be derived from the endogenous formation of hydroxytyrosol (also known DOPET), a potent…
- Trial name
- DOPET3 (NCT02783989)
- Testing
- white wine, tyrosol
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Parc de Salut Mar
Juvenile Idiopathic Arthritis, Juvenile Arthritis
Effectiveness and Feasibility of a Home-based Exercise Program for Adolescents With Juvenile Idiopathic Arthritis
This study will aim to test the effectiveness and feasibility of a technology-supported home-based exercise program in adolescents with JIA.
- Conditions
- Juvenile Idiopathic Arthritis, Juvenile Arthritis, Juvenile Rheumatoid Arthritis
- Trial name
- THE_JIA (NCT05114343)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Metabolic Syndrome, Vascular Injury
Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury
The objective of this clinical trial is to better understand how lactate, a naturally occurring energy substance, can be used to lessen damage to the vascular system in adults with a high cardiovascular disease risk.
- Conditions
- Metabolic Syndrome, Vascular Injury, Ischemic Preconditioning, Endothelial Function (reactive Hyperemia)
- Trial name
- NCT06825143
- Testing
- Ischemic preconditioning, Intravenous lactate infusion, No ischemic preconditioning (control)
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Gary Van Guilder
Coronary Heart Disease
Endothelial Dysfunction in Subjects With History of Premature Coronary Artery Disease
The aim of this prospective study is to investigate the prevalence of endothelial dysfunction in subjects with family history of premature coronary heart disease.
- Trial name
- NCT00917527
- Testing
- Atorvastatin
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Yonsei University
Endothelial Function (FMD), Preeclampsia
Identifying Biomarkers for Endothelial Dysfunction in Women With Preeclampsia
Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus.
- Conditions
- Endothelial Function (FMD), Preeclampsia, Retinal Vessels
- Trial name
- DAISY (NCT07084727)
- Testing
- Arterial stiffness, Flow-meditad dilatation, Dynamic retinal vessel analyzer
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Peripheral Arterial Disease
The Effects of Omega-3 Fatty Acids on Peripheral Arterial Disease II
Investigators hypothesize that high-dose n-3 polyunsaturated fatty acids (PUFA) oral supplementation will improve systemic inflammation, vascular function, and symptomatic status of patients with PAD.
- Trial name
- OMEGA-PAD II (NCT01979874)
- Testing
- Pro-Omega
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Hypertension
A Study Examining the Effects of Nebivolol Compared to Atenolol on Endothelial Function
This is a randomized, double-blind, placebo-controlled study comparing the efficacy of nebivolol and atenolol at improving small artery elasticity and reducing cardiovascular disease risk in subjects with early vascular disease.
- Trial name
- EVIDENCE (NCT01522950)
- Testing
- Nebivolol, atenolol
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Minnesota
Hypertension
Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels.
- Trial name
- AMORE (NCT01271374)
- Testing
- amlodipine and olmesartan, losartan and HCTZ
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InVasc Therapeutics, Inc.
Peripheral Artery Disease
Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral Artery Disease TENS-PAD Study / TENS-AOMI
Purpose: The investigators team recently carried out a proof of concept study testing the efficacy of one single 45-minute session of 10 Hz TENS prior to walking, versus placebo.
- Trial name
- TENS-PAD (NCT02678403)
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- 4 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Sleep, Cardiovascular Risk Factor
Sleep Duration and Cardiovascular Health
This is a cross-sectional study with an optional intervention that will examine how extreme sleep durations relate to cardiovascular health, physical activity, and sleep quality by studying three groups of participants: short…
- Trial name
- Goldilocks (NCT04804124)
- Testing
- Regularized Sleep Schedule
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Oxidative Stress, Inflammation
CoQ10 Biomarker Trial
The investigators believe that relieving the oxidative stress experienced by hemodialysis patients may help improve cardiovascular health.
- Conditions
- Oxidative Stress, Inflammation, Endothelial Dysfunction
- Trial name
- NCT01408680
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Washington
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study
This purpose of this study is to test the effect of oral melatonin supplementation (8 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114360
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Emory University
Subclinical Atherosclerotic Cardiovascular Disease, Neurocognitive Decline
MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling
The MISTIC study is a non-profit, cross-sectional clinical research project aimed at investigating the relationship between atherosclerosis and both cardiovascular and cognitive function in adult populations.
- Trial name
- MISTIC (NCT07520643)
- Testing
- Peripheral Vascular Imaging, Coro-CT, Neurocognitive Assesment
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS