Clinical trials: Vascular Endothelial Function
Ischemia/Reperfusion Injury
Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion
Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against…
- Trial name
- NCT00526695
- Testing
- Sevoflurane (Preconditioning)
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Vascular Disease, Heart Disease
Gap Junction Potentiation of Endothelial Function With Rotigaptide
Hypothesis - Rotigaptide will improve endothelial function in the context of endothelial dysfunction. The lining of blood vessels (endothelium) can react to hormones in the blood stream causing the blood vessel muscle to relax…
- Trial name
- NCT00901563
- Testing
- Rotigaptide, Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Acute Coronary Syndrome
Endothelial Dysfunction and Plaque Vulnerability
Thinning of fibrous cap in atherosclerotic plaques is associated with plaque vulnerability. The high resolution of optical coherence tomography (OCT) provides an accurate measurement of fibrous cap thickness.
- Trial name
- NCT01578616
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Yokohama City University Medical Center
ST Elevation Myocardial Infarction
Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction
Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure.
- Trial name
- REMOD-TEP (NCT02789098)
- Testing
- (15)-O water positron emission tomography and Biomarkers
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Caen
Endothelial Dysfunction, Autonomic Dysfunction
Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function
The American College of Sports Medicine (ACSM) recommends that resistance exercise performed at greater than 70% one repetition maximum (1 RM) is necessary to induce strength gains and muscular hypertrophy (ACSM, 2009).
- Trial name
- NCT03225898
- Testing
- Resistance Exercise with Blood Flow Restriction, High-intensity Resistance Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kent State University
Peripheral Artery Disease
Evaluation of Concomitant Administration of Cilostazol and Probucol on Biomarkers, Endothelial Function and Safety
Based upon evidence of efficacy and safety of both cilostazol and probucol administration in independent randomized controlled trials in PAD and CAD, the present trial seeks to investigate the effect of concomitant administration…
- Trial name
- NCT01142284
- Testing
- Cilostazol, Probucol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
Obesity, Atherosclerosis
Endothelial Dysfunction in Obese Children
The purpose of this study is to objectify the effect of diet and exercise on early markers of atherosclerosis in obese children.
- Trial name
- EDOC (NCT01461226)
- Testing
- Exercise training, Usual care
- Where
- 3 sites in Belgium
- Volunteers
- 61 people
- Sponsor
- University Hospital, Antwerp
Coronary Heart Disease
Efficacy of Enhanced External Counterpulsation on Ventricular Function
The purpose of this study is to investigate the efficacy of Enhanced External Counterpulsation (EECP) therapy on ventricular function in patients with coronary heart disease
- Trial name
- EECPVF (NCT03106116)
- Testing
- Experimental: Enhanced External Counterpulsation, Standard medical therapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Ischaemia Reperfusion Injury
Effect of Tea on Endothelial Function and Ischaemia-reperfusion Injury
Tea consumption may impact upon the decrease in endothelial function after IR-injury. However, no previous study directly examined the potential of tea to impact upon the change in endothelial function after IR-injury.
- Trial name
- NCT01660516
- Where
- Netherlands
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes, Coronary Artery Disease
Effects of Linagliptin on Endothelial Function
This study is planned to evaluate if linagliptin can improve endothelial function in patients with type 2 diabetes mellitus. In addition, the effect of linagliptin on arginine bioavailability ratios and postchallenge glycaemic…
- Trial name
- NCT02350478
- Testing
- Linagliptin
- Where
- Austria
- Volunteers
- 49 people
- Sponsor
- Medical University of Graz
Atherosclerosis, Healthy
Racial Differences in Control of Blood Vessel Tone and Blood Flow
Black Americans tend to die more often from and have more diseases associated with heart disease than White Americans. The exact cause of this is unknown, but it is likely a combination of genetics, behavior, risk factors…
- Conditions
- Atherosclerosis, Healthy, Hypertension
- Trial name
- NCT00001747
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
n-3 Polyunsaturated Fatty Acids, Selenium
Enriched QUARTET® Hen Eggs and Cardiovascular Function
Role of oxidative stress in the development of cardiovascular diseases is well known and extensively investigated, because of its direct effects on vascular function, but also on the activation of the immune response.
- Conditions
- n-3 Polyunsaturated Fatty Acids, Selenium, Vitamin E, Lutein
- Trial name
- NCT04564690
- Testing
- QUARTET® hen eggs (enriched in n-3 PUFA, selenium, vitamin E and lutein), Regular hen eggs
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Coronary Artery Disease
Ivabradine to Improve Endothelial Function in Patients With Coronary Artery Disease
This study evaluates the effect of ivabradine on endothelial function in patients with coronary artery disease (CAD) after complete revascularization with percutaneous coronary angioplasty (PCI).
- Trial name
- RIVENDEL (NCT02681978)
- Testing
- Ivabradine, Standard medical therapy
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Campus Bio-Medico University
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimize damage to the heart muscle.
- Trial name
- NCT00965393
- Testing
- Forearm vascular study, bradykinin receptor antagonist (HOE-140)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endothelial Dysfunction
The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis
We will study the hypothesis that long-term Tekturna treatment will improve endothelial function and the production and function of endothelial progenitor cells (EPCs) in patients with early atherosclerosis.
- Trial name
- NCT01067326
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Cognitive Impairment, Estrogen Deficiency
Effects of Ovarian Hormone Suppression on Vascular and Cognitive Function
Complaints about memory and thinking are common in women as they go through menopause. The female hormone estrogen is important for both the health of both the brain and the blood vessels.
- Conditions
- Cognitive Impairment, Estrogen Deficiency, Menopause, Endothelial Dysfunction
- Trial name
- NCT03112226
- Testing
- GnRHant + E2
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2, Hypertension
Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents
This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined.
- Conditions
- Diabetes Mellitus, Type 2, Hypertension, Heart Disease, Stroke
- Trial name
- NCT00374361
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Endothelial Dysfunction, Bioavailability
Comparison of Pure Epicatechin and Cocoa on Markers of Vascular Function
Intervention studies support a protective effect of flavonoid-rich foods such as chocolate and tea on cardiovascular disease risk.
- Trial name
- FLAVO2 (NCT02221791)
- Testing
- Pure Epicatechin, High flavan-3-ol cocoa
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Pulmonary Hypertension
Neuromodulation in Patients With Pulmonary Arterial Hypertension
Patients with Group 1 pulmonary hypertension will be enrolled in this study. Investigators will test the hypothesis of low-level tragal stimulation in patients with pulmonary hypertension.
- Trial name
- NIP (NCT06802380)
- Testing
- Low-level tragus stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Oklahoma