Clinical trials: Vascular Endothelium
Exudative Age Related Macular Degeneration
Optical Coherence Tomography Angiography (OCTA) - Directed PDT Triple Therapy
Optical Coherent Tomography Angiography (OCTA)-Directed PDT Triple Therapy for Treatment-Naïve Patients with Exudative Age-related Macular Degeneration (ARMD) versus Standard of Care Anti-VEGF Monotherapy
- Trial name
- NCT04075136
- Testing
- Ranibizumab, Photodynamic laser treatment (PDT), Triamcinolone Acetonide
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Electronic Cigarette Use, Endothelial Dysfunction
Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use
The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as "vaping" - in the United States has increased exponentially since their introduction to the US market in 2007.
- Conditions
- Electronic Cigarette Use, Endothelial Dysfunction, Inflammation
- Trial name
- NCT06489249
- Testing
- Salsalate 750 MG Oral Tablet [DISALCID]
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Heart Failure, Depression
Vascular Effects of Sertraline in Heart Failure
To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression
- Trial name
- NCT00585455
- Testing
- sertraline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Yale University
Peripheral Arterial Disease
Efficiency, Safety and Portability of Neovasculgen
In 2010, we completed a phase 1 to 2a clinical trial of pCMV-vegf165 in patients with chronic lower limb ischemia (stage 2a to 3 according to Fontaine classification modified by A. V.
- Trial name
- Neovasculgen (NCT03068585)
- Testing
- Neovasculgen (Cambiogeneplasmid)
- Where
- 3 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Artgen Biotech
Atherosclerosis, Hypercholesterolemia
Investigating the Effects of Lipid-therapy Intensification With Alirocumab on Endothelial Function, Carotid Arteries, Lipoprotein Particle Subfractions, Inflammation and Post-prandial Lipemia
A prospective, open-label, pilot study with 24 cardiovascular high risk patients (N=24) having insufficient Low density lipoprotein cholesterin (LDL-C) reduction despite standard of care lipid-modifying therapies (LMTs), to…
- Conditions
- Atherosclerosis, Hypercholesterolemia, Post Prandial Lipemia, Cardiovascular Diseases
- Trial name
- ALIROCKS (NCT03559309)
- Testing
- Magnet Resonance Tomography, Carotid Arteries Sonography, Flow-mediated Dilation, Fat-tolerance Test, Laboratory Testing
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
Endothelial Dysfunction, Vascular Stiffness
Sodium Lowering Vascular Effects Trial
The proposed mechanistic trial will test the effect of dietary sodium reduction on cardiac and vascular structure and function in those with elevated blood pressure or hypertension.
- Conditions
- Endothelial Dysfunction, Vascular Stiffness, Left Ventricular Hypertrophy, Left Ventricular Dysfunction
- Trial name
- SOLVE (NCT05388032)
- Testing
- Sodium Reduction Intervention
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Tulane University
Myocardial Infarction
The Influence of Glycaemia and Insulinemia on Vasomotor Endothelial Function After Myocardial Infarction
The objective of this study is to investigative the influence of different levels of glycaemia or insulinemia in vascular endothelium in ischemia/reperfusion lesion after myocardial infarction
- Trial name
- INGLIVEF (NCT02250989)
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Campinas, Brazil
Myocardial Ischemia
Impact of Perivascular Tissue on Endothelial Function in Coronary Artery Bypass Grafting
The success of coronary artery bypass grafting is reliant on the quality of the grafts used. A new technique for harvesting veins used as grafts has been introduced.
- Trial name
- IMPROVE-CABG (NCT01834846)
- Testing
- no-touch, conventional
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Hepatocellular Carcinoma
Zanzalintinib (XL-092) Plus Durvalumab and Tremelimumab in Unresectable Hepatocellular Carcinoma (ZENOBIA)
This study will investigate if modulating the tumor microenvironment with biologic agents like XL-092 will have synergistic effect when combined with checkpoint based immunotherapeutic treatment of patients with hepatocellular…
- Trial name
- ZENOBIA (NCT06698250)
- Testing
- Zanzalintinib, Durvalumab, Tremelimumab
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Anwaar Saeed
Ischemic Stroke, Acute Coronary Syndrome
Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
- Conditions
- Ischemic Stroke, Acute Coronary Syndrome, Obstructive Sleep Apnea Syndrome
- Trial name
- AVC/SCA (NCT00926874)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Hypoxemia, ARDS
Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass
More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass.
- Conditions
- Hypoxemia, ARDS, Lung Injury, Acute, Cardiopulmonary Bypass
- Trial name
- NCT05647382
- Testing
- blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhuan Zhang
Aging
Effect of Ankle Splinting on Vascular Function in Aging
Endothelial function of the skeletal muscle vasculature declines with advancing age. Although aerobic exercise training is commonly prescribed to combat loss of endothelial function in the elderly, the rate of compliance to…
- Trial name
- NCT02144896
- Testing
- Ankle splinting
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Florida
Macular Degeneration
Safety and Efficacy of Repeated Intravitreal Administration of Vascular Endothelial Growth Factor (VEGF) Trap in Patients With Wet Age-Related Macular Degeneration (AMD)
This study examines the effect of intravitreally administered VEGF Trap in patients with wet AMD. The purpose of this trial is to assess the ocular and systemic safety and tolerability of repeated intravitreal doses of VEGF Trap…
- Trial name
- NCT00320788
- Testing
- aflibercept injection (VEGF Trap-Eye, BAY86-5321)
- Where
- 18 sites in United States
- Volunteers
- 159 people
- Sponsor
- Regeneron Pharmaceuticals
Coronary Vasospasm
Endothelial Dysfunction and Coronary Artery Spasm
Non-obstructive coronary artery disease (NOCAD) frequently accounts for myocardial ischemia in women. Endothelial dysfunction is a pathogenic factor in coronary spastic angina (CSA).
- Trial name
- NCT00619294
- Where
- Japan
- Volunteers
- 158 people
- Sponsor
- Kumamoto University
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Macular Degeneration
Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration (AMD)
This study is a phase III, double-masked, randomized, study of the efficacy and safety of VEGF Trap-Eye in patients with neovascular age-related macular degeneration.
- Trial name
- VIEW 2 (NCT00637377)
- Testing
- Ranibizumab, Aflibercept Injection (EYLEA, VEGF Trap-Eye, BAY86-5321)
- Where
- 189 sites in Argentina, Australia and 24 more
- Volunteers
- 1,240 people
- Sponsor
- Bayer
Arterial Hypertension
Cardiovascular Effects of Aerobic and Strength Training in Hypertensive Middle-aged Individuals
Systemic arterial hypertension (SAH) is characterized by elevated and sustained blood pressure levels, related to several risk factors.
- Trial name
- NCT03282942
- Testing
- Strength training group, Aerobic Training Group
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Rio Grande do Sul
Recurrent Pregnancy Loss Without Current Pregnancy
Vascular Endothelial Growth Factor Levels at Hysteroscopic Biopsies Which Taken From Recurrent Pregnancy Loss
The aim of this study is determine vascular endothelial growth factor levels and angiogenesis/vascularity from hysteroscopic endometrial biopsies which taken from patients who has Recurrent Pregnancy Loss.The endometrial vascular…
- Trial name
- NCT01735331
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Vascular Endothelial Growth Factor Overexpression
Effect of Plasma Rich in Growth Factors on Semen Quality
The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.
- Trial name
- NCT02708537
- Testing
- PRGF in candidates for sperm donors
- Where
- 3 sites in Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IVI Bilbao
Chronic Kidney Disease
Endothelial Microparticles: A Novel Marker of Vascular Dysfunction
The primary hypothesis of this proposal is that chronic kidney disease (CKD) and treatment with calcineurin inhibitors (CNIs) are each associated with the release of endothelial microparticles into the plasma.
- Trial name
- NCT02230202
- Testing
- Flow-mediated dilation, single blood draw
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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