Clinical trials: Vascular Function in Healthy Volunteers
Healthy Volunteers
Flavanol-rich Cocoa on Digestive and Cerebrovascular Health in the Colombian Adults
The purpose of this study is to investigate the effects of consuming flavanol-rich cocoa on biomarkers associated with digestive and cerebrovascular health in a group of adults.
- Trial name
- NCT06513052
- Testing
- Commercial cocoa, High flavonols Cocoa
- Where
- Colombia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vidarium, Nutrition, Health and Wellness Research Center
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Healthy
Effect of MOF on Exercise Blood Pressure
The purpose of this study is to establish an effect of monomeric and oligomeric flavanols supplementation on exercise blood pressure and vascular function in healthy volunteers.
- Trial name
- NCT04907097
- Testing
- Monomeric and oligomeric flavanols
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gait Training, Locomotion
Gait Training and Brain Changes in Stroke Patients
This study, conducted in collaboration with the National Rehabilitation Hospital (NRH) in Washington, D.C., will look at changes in brain activation and brain responses that occur with gait (walking) training.
- Trial name
- NCT00334230
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Vascular Function in Healthy Volunteers
Diesel Exhaust Inhalation, Systemic Nitric Oxide Inhibition and Cardiac Output
Exposure to combustion-derived fine particulate air pollution is associated with cardiovascular mortality and morbidity. In previous studies, exposure to diesel exhaust (a major constituent of urban particulate air pollution) has…
- Trial name
- DISCO (NCT01060930)
- Testing
- Intravenous infusion of L-NMMA and Nor-epinephrine
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy Behavior
Effects of Photobiomodulation on Endothelial Function in Healthy Subjects
The endothelial cell layer is responsible for the control of vascular homeostasis, a process mediated by vasoconstricting and vasodilatory substances.
- Trial name
- NCT03252184
- Testing
- Low level laser therapy - 1, Low level laser therapy - 2, Low level laser therapy - 3
- Where
- Brazil
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Rodrigo Della Méa Plentz
Atherosclerosis, Healthy
Racial Differences in Control of Blood Vessel Tone and Blood Flow
Black Americans tend to die more often from and have more diseases associated with heart disease than White Americans. The exact cause of this is unknown, but it is likely a combination of genetics, behavior, risk factors…
- Conditions
- Atherosclerosis, Healthy, Hypertension
- Trial name
- NCT00001747
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Disease
Blood Vessel Study
Background: The endothelium is the inner lining of blood vessels. The cells in this lining help regulate blood flow and immune system function.
- Trial name
- NCT01524549
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Blood Coagulation, Platelet Function
Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation
This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.
- Trial name
- NCT02594345
- Testing
- in vitro study
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
HIV
Sildenafil to Treat HIV-Associated Pulmonary Hypertension
This study will examine how blood pressure in the lungs is controlled in healthy people, people with HIV and people with HIV and pulmonary artery hypertension (high blood pressure in the lungs, also called PAH).
- Trial name
- NCT00327080
- Testing
- MRI, L-NMMA, Acetylcholine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke
Observational Learning in Stroke Patients
This study will determine how people who have had a stroke learn to perform a movement by observation, as compared with people who have not had a stroke.
- Trial name
- NCT00083642
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy, Cardiovascular Diseases
Effect of Betaine, Serine and Folic Acid on Vascular Function in Healthy Volunteers
The purpose of this study is to determine whether reducing the increase in plasma homocysteine concentrations following an oral methionine load affects vascular function in healthy volunteers, irrespective of the…
- Trial name
- NCT00126347
- Testing
- supplementation with betaine, serine, and folic acid
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wageningen Centre for Food Sciences
Healthy, Healthy Participants
Acute Effects of Structured Exercise and Static Stretching on Vascular Function, Neuromuscular Performance, and Metabolic Regulation in Adults
This experimental study investigates the acute cardiovascular and vascular responses to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Participants, Healthy Subjects (HS), Resistance Training Adaptation
- Trial name
- NCT07364149
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Fabry Disease
Safety and Pharmacokinetics of AT1001 (Migalastat HCl) in Healthy Subjects and Subjects With Impaired Renal Function
This study will assess the safety, tolerability, and pharmacokinetics (PK) study of a single dose of 150 mg AT1001 (migalastat HCl, GR181413A) administered orally to healthy subjects with normal renal function and to subjects…
- Trial name
- NCT01730469
- Testing
- AT1001 150 mg
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amicus Therapeutics
Nervous System Diseases, Healthy Subjects
Functional Near-infrared Spectroscopy in Unconscious Patients
The study design is a single-center prospective pilot study. Hypothesis: Results of cerebral fNIRS examination in unconscious patients with severe hemorrhagic or ischemic stroke in the ICU are congruent with the results of SSEP…
- Trial name
- fNIRS (NCT04746820)
- Testing
- single-center prospective pilot study
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Emanuela Keller