Clinical trials: Vascular Insufficiency
Acute Kidney Injury After Open Heart Surgery, Venous Congestion After Open Heart Surgery
Evaluation of the Association Between the VEXUS Score and Hemodynamic Status and the Occurrence of Acute Kidney Injury After Open-Heart Surgery
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass and is associated with prolonged intensive care unit stay, increased morbidity, and mortality.
- Trial name
- NCT07805564
- Where
- Vietnam
- Volunteers
- 135 people
- Sponsor
- Hanoi Medical University
Chronic Kidney Disease, Hypertension
The Impact of Mobile APP Intervention ( iCKD APP) on Chronic Kidney Disease Care
Apply Mobile APP Intervention ( iCKD APP) to current chronic kidney disease care program. Conduct a randomized clinical trial to evaluate the clinical effectiveness of this mobile device on health behavior improvement in chronic…
- Trial name
- NCT03649516
- Testing
- iCKD APP
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Kidney Failure, Chronic, Coronary Artery Disease
Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary bypass or valve surgery) in patients with impaired renal function after randomization to either nifedipine infusion at start of surgery…
- Trial name
- NCT00244530
- Testing
- Nifedipine
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University of Oslo School of Pharmacy
High Altitude Polycythemia
Treatment of High Altitude Polycythemia by Acetazolamide
The prevalence of High Altitude Polycythemia (or Chronic Mountain Sickness) is between 8 and 15% in the high altitude regions of South America. There is no pharmacological treatment available.
- Trial name
- NCT00424970
- Testing
- acetazolamide
- Where
- Peru
- Volunteers
- 55 people
- Sponsor
- Association pour la Recherche en Physiologie de l'Environnement
Coronary Artery Disease
Is Glucagon-like Peptide-1 Insufficiency a Residual Risk in Coronary Artery Disease?
In this study, the investigators hypothesized that significant proportion of patients with coronary artery disease (CAD) has reduced capacity of glucagon-like peptide-1 (GLP-1) secretion, which is detectable as blunted response…
- Trial name
- NCT02280837
- Testing
- Determination of plasma GLP-1 level
- Where
- Japan
- Volunteers
- 190 people
- Sponsor
- Sapporo Medical University
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Chronic Kidney Disease, Coronary Artery Disease
Feasibility and Pilot Testing of "My Heart and CKD" Online Shared Decision Aid
Many people with kidney disease also have heart disease. The procedures used to diagnose and treat heart disease (e.g., angiograms, angioplasty, or surgery) can improve symptoms and cardiovascular outcomes, but pose greater risks…
- Trial name
- MyHeart&CKD (NCT06920927)
- Testing
- Decision aid
- Where
- 2 sites in Canada
- Volunteers
- 220 people
- Sponsor
- University of Calgary
Cardiovascular Disease, Chronic Kidney Disease
Vascular Risk After Kidney Transplantation
Hypothesis: Nontraditional risk factors, such as inflammation, vitamin D deficiency, elevated PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease progression after kidney transplant.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Diabetes, Vitamin D Deficiency
- Trial name
- NCT00374595
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- University of Nebraska
Acute Deep Vein Thrombosis
Role of a Novel Exercise Program to Prevent Post-thrombotic Syndrome
Despite standard care, 25%-50% of patients with clots in the deep veins of the arms and legs progress to chronic post-clot problems resulting in significant disability, loss of productivity, and healthcare costs.
- Trial name
- EFFORT2 (NCT02148029)
- Testing
- Exercise, Standard Care
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- VA Office of Research and Development
Cushing Disease Due to Increased ACTH Secretion
Combination Osilodrostat and Cabergoline in Cushing's Disease
Cushing disease remains a challenging endocrine disorder in which persistent or recurrent hypercortisolism often requires medical therapy after surgery or when surgery is not feasible.
- Trial name
- COSCA-ECD (NCT07603466)
- Testing
- osilodrostat, osilodrostat and cabergoline
- Where
- 5 sites in Iraq
- Volunteers
- 50 people
- Sponsor
- University of Basrah
Chronic Kidney Diseases, Acute Kidney Injury
The Stockholm CREAtinine Measurements Project
The Stockholm CREAtinine Measurements (SCREAM) project is a healthcare utilization cohort including, at present, all adult residents in Stockholm between 2006 and 2021.
- Conditions
- Chronic Kidney Diseases, Acute Kidney Injury, Diabetes Mellitus, Cardiovascular Diseases
- Trial name
- SCREAM (NCT06239129)
- Testing
- Initiation of specific medications, Undertaking of specific procedures, Abnormalities in specific laboratory tests
- Volunteers
- 3,200,000 people
- Sponsor
- Karolinska Institutet
Chronic Kidney Diseases
Effects of Prebiotic Supplementation and Exercise on Inflammatory Markers, Vascular Function and Cognition in CKD
The study is primarily designed to examine the effect of 16 weeks of prebiotic supplementation (resistant starch)and moderate intensity aerobic training on markers of inflammation in stage 3-4 patients with chronic kidney disease.
- Trial name
- NCT03689569
- Testing
- Resistant starch, Exercise, Starch
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Springfield College
Infection, Heart Failure
Prediction of Patient Deterioration Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05045742
- Testing
- Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2
- Where
- 2 sites in United States
- Volunteers
- 526 people
- Sponsor
- Brigham and Women's Hospital
Infection, Heart Failure
Remote Physician Care for Home Hospital Patients
This study examines the implications of providing remote physician care to home hospitalized patients compared to usual home hospital care with in-person/in-home physician visits.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04080570
- Testing
- Remote Visit
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease, Endothelial Dysfunction
Study of Protective Effects of Paricalcitol on Inner Layer of Vessels and Its Protective Effect on Inflammation
The study is about possible protective effects of paricalcitol (Zemplar) upon inflammation, blood pressure and kidney function. Kidney Inflammation occurs when white blood cells become abnormally stimulated and accumulate in the…
- Conditions
- Chronic Kidney Disease, Endothelial Dysfunction, Inflammation, Hypertension
- Trial name
- NCT00428246
- Testing
- paricalcitol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Indiana University
CKD, ESRD
Effect of Oxalate and Urate Metabolism on CKD Evolution
The current study primarily aimed to characterize the oxalate and uric acid metabolism in CKD patients and to analyze its association with renal survival prognosis.
- Conditions
- CKD, ESRD, Hyperuricemia, Oxaluria
- Trial name
- NCT04399915
- Where
- Ukraine
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The Institute of Nephrology of the Academy of Medical Sciences of Ukraine
Hypertension, Hyperhomocysteinemia
CSPPT- Chronic Kidney Diseases Study
The purpose of this trial is to confirm that enalapril maleate and folic acid tablets is more effective in preventing renal function decline among the patients with primary hypertension when compared to enalapril maleate.
- Trial name
- CSPPT-CKD (NCT01871740)
- Testing
- Enalapril maleate and folic acid tablets, Enalapril maleate
- Where
- 2 sites in China
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Postoperative Pain, Renal Insufficiency
Pain Management After Cardiac Surgery - Opioids or NSAID
The aim of this randomized controlled study is to shed light on the analgesic properties and side-effect profile of an opiod-based regimen as opposed to an Ibuprofene based regimen.
- Conditions
- Postoperative Pain, Renal Insufficiency, Myocardial Infarction
- Trial name
- NCT02479165
- Testing
- Ibuprofene, Oxycodone
- Volunteers
- 182 people
- Sponsor
- Aalborg University Hospital
Acute Hypoxemic Respiratory Failure, Anticoagulant-induced Bleeding
Strategies for Anticoagulation During Venovenous ECMO
Moderate intensity titrated dose anticoagulation has been used in patients receiving extracorporeal membrane oxygenation (ECMO) to prevent thromboembolism and thrombotic mechanical complications.
- Conditions
- Acute Hypoxemic Respiratory Failure, Anticoagulant-induced Bleeding, Thromboembolism
- Trial name
- SAFE-ECMO (NCT04997265)
- Testing
- Low intensity anticoagulation, Moderate Intensity Anticoagulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Vanderbilt University Medical Center
Acute Kidney Injury, Chronic Kidney Disease
Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS-YA (NCT02599844)
- Testing
- Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
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