Clinical trials: Vascular Insufficiency
Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome
Design and Rationale of the COLT Study
Deep vein thrombosis (DVT) is a condition in which a blood clot forms in the deep veins of the leg and can lead to long-term problems such as leg pain, swelling, and reduced quality of life.
- Conditions
- Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome, Venous Thromboembolism (VTE), Venous Insufficiency
- Trial name
- COLT (NCT07432529)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Volunteers
- 940 people
- Sponsor
- Azienda Sanitaria Locale ASL 6, Livorno
Hypertension
Comparison of Breathing Exercise for Hypertensive Patients
To determine the Effectiveness of diaphragmatic breathing vs. slow breathing techniques on blood pressure and Quality of life in adults with stage 1 hypertension.
- Trial name
- NCT05158569
- Testing
- Slow breathing exercise group, Diaphragmatic breathing exercise group
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Vein, Varicose
Effect of Walking to the Operating Room on Preoperative Anxiety
The operating room environment can be a source of anxiety for the patient, including in the context of outpatient surgery for which anxiolytic medication is rarely used.
- Trial name
- NCT04908527
- Testing
- Walking to OR
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University of Liege
Acute Kidney Injury, Pulmonary Embolism
Acute Kidney Injury in Patients Undergoing Contrast Exposure: VQ vs. CT
Both, CT scans and VQ scans, are used by doctors to look for pulmonary embolism. The most common reason to order a VQ scan is to avoid the IV dye.
- Conditions
- Acute Kidney Injury, Pulmonary Embolism, Contrast-induced Nephropathy
- Trial name
- VQ/CT (NCT03116139)
- Testing
- V/Q imaging, Computed tomography scan
- Where
- 5 sites in United States
- Volunteers
- 253 people
- Sponsor
- Indiana University
Hypertension, Chronic Kidney Diseases
Primary Care CKD Registry
This study examines whether a safety-net primary care CKD registry directed at the entire primary care team can enhance the delivery of guideline concordant CKD care, including BP control, ACEi/ARB use and albuminuria…
- Trial name
- NCT03473509
- Testing
- CKD Registry
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stable Chronic Kidney Disease, Hypertension
Atorvastatin and Sympathetic Activity in Chronic Kidney Disease
Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity which appears to contribute to the pathogenesis of hypertension and cardiovascular organ damage.
- Trial name
- NCT01257009
- Testing
- Atorvastatin
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- UMC Utrecht
Gastric Antral Vascular Ectasia, Cirrhosis
Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias
The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible bleeding.
- Conditions
- Gastric Antral Vascular Ectasia, Cirrhosis, Chronic Kidney Disease
- Trial name
- GAVE (NCT06306963)
- Testing
- Gastric Emptying Breath Test
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Hypotension, Acute Kidney Injury
A Clinical Decision Support Trial to Reduce Intraoperative Hypotension
The purpose of this study is to provide messages to providers if their patient is at high risk of developing intraoperative hypotension based on past medical history and co-morbidities preoperatively and minutes of hypotension…
- Trial name
- NCT04062994
- Testing
- Nudge to reduce intraoperative hypotension
- Where
- 4 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- University of California, Los Angeles
Infection, Heart Failure
Home Hospital for Suddenly Ill Adults
The investigators propose a home hospital model of care that substitutes for treatment in an acute care hospital. Limited studies of the home hospital model have demonstrated that a sizeable proportion of acute care can be…
- Conditions
- Infection, Heart Failure, COPD, Asthma
- Trial name
- NCT03524222
- Testing
- Home Hospitalization
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Brigham and Women's Hospital
Arthritis, Asthma
Mobility Assessment in Multi-morbidity
Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare…
- Conditions
- Arthritis, Asthma, Atrial Fibrillation, Bronchiectasis
- Trial name
- Multi-mobility (NCT06473168)
- Volunteers
- 55 people
- Sponsor
- Northumbria University
Mitral Valve Insufficiency
The RESHAPE-HF1-FU Study
To evaluate the safety and efficiency of the MitraClip system in the treatment of patients with clinically significant mitral regurgitation with New York Heart Association (NYHA) Functional Class II to IV chronic heart failure.
- Trial name
- NCT02444286
- Where
- 2 sites in Germany
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Venous Insufficiency, Lymphedema
Transient Elastography DEdicated to Cosmetology And Dermatology (TEDECAD)
Explorative study on a medical device with two steps. The first pilot step will be on 8 patients (4 with lymphedema and 4 with venous insufficiency).
- Trial name
- TEDECAD (NCT02061254)
- Testing
- Cutometer, High resolution ultrasonography (echography), Elastography
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Fabry Disease, Chronic Kidney Diseases
Fibrosis, Inflammation, Oxygenation of Renal Tissue In FabrY Disease
The overall objective of this study is to investigate Fabry-associated renal organ involvement by using a novel magnetic resonance imaging (MRI) approach, focusing on changes in renal oxygen levels by blood oxygenation-level…
- Trial name
- FORTIFY (NCT06325488)
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Caroline Michaela Kistorp
Traumatic Brain Injury, Subarachnoid Hemorrhage
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure
- Trial name
- NOVEL ICP (NCT04548596)
- Testing
- Transcranial Doppler
- Where
- 3 sites in United States
- Volunteers
- 162 people
- Sponsor
- Emory University
Venous Thrombosis, Postthrombotic Syndrome
Ultrasound-enhanced Thrombolysis Versus Standard Catheter Directed Thrombolysis for Ilio-femoral Deep Vein Thrombosis
Patients with deep vein thrombosis (DVT) of the ilio-femoral veins have increased risk for developing post-thrombotic syndrome (PTS) and recurrent venous thromboembolism compared to more distal DVT.
- Trial name
- BERNUTIFUL (NCT01482273)
- Testing
- CDT+US group, CDT-US group
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypertension, Chronic Kidney Disease
Pharmacokinetics Following Single-dose of Valsartan in Japanese Pediatric Patients
This study will assess the pharmacokinetics and safety following single dose of valsartan in Japanese pediatric patients with hypertension, chronic kidney disease, or nephrotic syndrome.
- Conditions
- Hypertension, Chronic Kidney Disease, Nephrotic Syndrome
- Trial name
- NCT01447485
- Testing
- Valsartan (VAL489)
- Where
- 2 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Post-marketing Surveillance for Hypertensive Patients With Diabetes and/or Chronic Kidney Disease
This study is a post-marketing surveillance in Japan, and it is a local prospective, company sponsored and observational study of patient who have been treated by Adalat CR for hypertension with diabetes and/or chronic kidney…
- Trial name
- NCT01363336
- Testing
- Nifedipine (Adalat CR, BAYA1040)
- Where
- Japan
- Volunteers
- 1,882 people
- Sponsor
- Bayer
Hypertension, Cardiovascular Risk Factor
Activity Trackers for Improving BP
The study aims to determine if use of physical activity trackers coupled with provider feedback will increase awareness of young adults of their physical fitness and improve blood pressure levels.
- Conditions
- Hypertension, Cardiovascular Risk Factor, Physical Activity, Chronic Kidney Diseases
- Trial name
- NCT03325426
- Testing
- FitBit
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of California, San Francisco
Refractory Multiple Myeloma
Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myeloma
This phase II trial studies the side effects and how well tivantinib works in treating patients with relapsed, or relapsed and refractory multiple myeloma.
- Trial name
- NCT01447914
- Testing
- Tivantinib, Diagnostic laboratory biomarker analysis, Questionnaire administration
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Deep Vein Thrombosis
Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis
A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein…
- Trial name
- NCT07622212
- Testing
- Percutaneous mechanical thrombectomy by ClotTriever System, Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
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