Clinical trials: Vascular Insufficiency
Arterial Hypertension, Chronic Kidney Disease
PRospectIve ObseRvatIonal mulTicenter Study of Patients With Arterial hYpertension and CKD in the Population of Russia
This study is a multi-centre, non-interventional, observational, prospective study with retrospective analysis. The main purpose of the study is to describe the rate of CKD diagnosis in patients with AH and CKD markers.
- Trial name
- PRIORITY-CKD (NCT06372431)
- Where
- 30 sites in Russia
- Volunteers
- 9,914 people
- Sponsor
- AstraZeneca
Superficial Venous Insufficiency, Varicose Veins
RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI
Leaking valves in the veins of the legs causes veins to become large and bloated. These swollen veins are called "varicose veins" and are a very common problem, affecting more than a third of all adults in the UK.
- Trial name
- EVCA (NCT02010437)
- Testing
- Sodium Tetradecyl Sulphate (STS)
- Where
- United Kingdom
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Coronary Artery Disease, End Stage Renal Disease
Coronary Revascularization in Patients On Dialysis in China-Retrospective Registry
Coronary artery disease (CAD) is the leading cause of death in end-stage renal disease (ESRD) patients requiring dialysis. There are limited data on clinical characteristics, treatment strategies and outcomes in this special…
- Conditions
- Coronary Artery Disease, End Stage Renal Disease, Dialysis
- Trial name
- CRUISE-R (NCT05841082)
- Where
- China
- Volunteers
- 1,249 people
- Sponsor
- China-Japan Friendship Hospital
Primary Hypertension, Secondary Hypertension
HaemoDYNAMICs in Primary and Secondary Hypertension
The primary aim of the present study was to examine the haemodynamic changes in primary hypertension and secondary hypertension (renal diseases, endocrine diseases, obesity-associated hypertension) with a non-invasive…
- Conditions
- Primary Hypertension, Secondary Hypertension, Aortic Stenosis, Renal Insufficiency
- Trial name
- DYNAMIC (NCT01742702)
- Testing
- Nitroglycerin 0.25 mg (single dose, no longer given since January 2017), Salbutamol 400 µg (single dose, no longer given since January 2017), L-arginine (10 min infusion, no longer given since January 2017)
- Where
- 2 sites in Finland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tampere University
Calcific Uremic Arteriolopathy (CUA), Calciphylaxis
European Calciphylaxis Registry Network
Observational, registry, prospective, non-interventional collection of CUA patient data. Patient treatment is carried out within clinical routine, at the discretion of the physicians and according to existing treatment…
- Trial name
- EuCalNet (NCT02635373)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- RWTH Aachen University
Coronary Heart Disease, Chronic Kidney Disease
Prevalence of Chronic Kidney Disease and Its Association With Clinical Outcome in Patients With Coronary Heart Disease
This is a prospective, multi-center, hospital-based observational study. The aim of the study is to evaluate the prevalence of chronic kidney disease in patients with stable coronar heart disease.
- Trial name
- NCT02509013
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University First Hospital
Liver Cirrhosis, Hemophilia
Alterations in Coagulation Factor Levels in Patients With End Stage Liver Disease
The goal of this observational study is to learn about the changes in coagulation factor VIII and IX levels in patients undergoing liver transplantation to help guide future management of coagulation factor replacement in…
- Conditions
- Liver Cirrhosis, Hemophilia, Hemophilia A, Hemophilia B
- Trial name
- NCT06014320
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hypotension
Decision Support for Intraoperative Low Blood Pressure
The purpose of this study is to determine whether a decision support system can improve the adherence to thresholds for low blood pressure by anesthesia providers, which in turn prevents their patients from having organ injury.
- Trial name
- NCT02726620
- Testing
- Attending real-time decision support, In-room real-time decision support, Attending feedback emails
- Where
- United States
- Volunteers
- 22,435 people
- Sponsor
- Vanderbilt University Medical Center
Mitral Valve Insufficiency, Mitral Valve Regurgitation
EVEREST II Pivotal Study High Risk Registry (HRR)
Prospective, multi-center, single arm registry. Clinical follow-up at discharge, 30 days, 6, 12, 18 and 24, months, and 3, 4 and 5 years.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation
- Trial name
- HRR (NCT01940120)
- Testing
- Percutaneous mitral valve repair using MitraClip implant
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Abbott Medical Devices
Atherosclerosis
A Study to Assess the Pharmacokinetics, Safety and Tolerability of Repeat Oral Doses of Darapladib (SB-480848) in Subjects With Severe Renal Impairment
In accordance with the recently revised FDA draft renal impairment guidance (March 2010) which advises the conduct of renal impairment study in drugs that are not predominately eliminated through the renal route, the proposed…
- Trial name
- NCT01711723
- Testing
- Darapladib 160 mg
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- GlaxoSmithKline
Aortic Stenosis, Aortic Regurgitation
Rivaroxaban or Aspirin for Biological Aortic Prosthesis
Aortic valve replacement with a biological prosthesis is the most common valve surgery performed with about 1000 operations performed in Denmark each year.
- Conditions
- Aortic Stenosis, Aortic Regurgitation, Thrombosis
- Trial name
- NCT02974920
- Testing
- Rivaroxaban 10 MG, Aspirin
- Where
- 4 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Christian Torp-Pedersen
Stroke, End Stage Renal Disease
Randomised Control Trial for Improving Functional Outcome From Stroke in End Stage Renal Disease Patients
TITLE Randomised Control Trial (RCT) for improving functional outcome from stroke in renal disease patients DESIGN Eandomised Conrol Study AIMS 1.
- Trial name
- NCT01656213
- Testing
- Computer-based target pursuit task (created using E-Prime software) and visual-feedback handgrip force transducer (CurrentDesigns 2012).
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Imperial College London
Acute Coronary Syndrome, Chronic Kidney Disease
Platelet Resistance With Ticagrelor or Standard-Dose Clopidogrel Among CKD and ACS Patients
A 4 week-duration cross-over study on Ticagrelor and Clopidogrel for the Acute Coronary Syndrome (ACS) and Chronic Kidney Disease (CKD) subjects, focusing on the platelet inhibition and safety observation.
- Conditions
- Acute Coronary Syndrome, Chronic Kidney Disease, End-Stage Renal Disease
- Trial name
- APROVE-CKD (NCT02459288)
- Testing
- Clopidogrel first, Ticagrelor first
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Ping-Yen Liu
Death, Postoperative Complications
Study to Determine the Impact of Intraoperative Blood Pressure Management on Postoperative Outcomes (MAP-ALIVE)
The purpose of this study is to determine 1. whether intraoperative hypotension or hypertension is independently associated with postoperative mortality and morbidity 2.
- Conditions
- Death, Postoperative Complications, Myocardial Infarction, Stroke
- Trial name
- MAP-ALIVE (NCT02019342)
- Testing
- FACE quality improvement initiative (see below), Pre-quality improvement initiative
- Where
- 2 sites in United States
- Sponsor
- Washington University School of Medicine
End Stage Renal Disease, Hypertension
Electronic Decision Support for Deprescribing in Patients on Hemodialysis
Dialysis patients are prescribed an average of 10-12 medications per day, from up to 4-5 different clinicians and have the heaviest pill burden of all chronic conditions given their degree of comorbidity.
- Conditions
- End Stage Renal Disease, Hypertension, Diabete Type 2, Renal Failure Chronic
- Trial name
- MedSafer-HD (NCT05585268)
- Testing
- Medication reconciliation supplemented with MedSafer and deprescribing brochures
- Where
- Canada
- Volunteers
- 195 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Venous Thromboembolism
Fondaparinux in Critically Ill Patients With Renal Failure
The primary objective of this study is to determine whether a dose-adjusted prophylaxis fondaparinux regimen of 2.5 milligrams (mg) subcutaneously administered every (q) 48 hours (hr) in patients with renal failure achieves peak…
- Trial name
- NCT01467583
- Testing
- Fondaparinux
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wayne State University
Long-term Renal Dysfunction
Comparison of the Effects of Open and Endovascular Aortic Aneurysm Repair on Long-term Renal Function
Compare the renal complication of endovascular and open repair of acute aortic dissection by including patient treated at NTUH in 2010~2013.
- Trial name
- NCT02220283
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Infection, Heart Failure
Rural Home Hospital: Proof of Concept
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04531280
- Testing
- Home hospital care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Chronic Venous Insufficiency
Long-term Effects of Inspiratory Muscle Training in Chronic Venous Insufficiency
The long-term effectiveness of inspiratory muscle training, which is known in the literature to help venous return by increasing the pump effect of the diaphragm muscle, remains unclear in individuals with chronic venous…
- Trial name
- NCT05982405
- Testing
- Training group: Inspiratory muscle training, Control group: Thoracic expansion exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Democracy University
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