Clinical trials: Vascular Insufficiency
Coronary Artery Disease, Chronic Renal Failure
Coronary Rotational Atherectomy Elective vs. Bailout in Severely Calcified Lesions and Chronic Renal Failure
The current role of the rotational atherectomy is for non-dilatable coronary lesions and for severely calcified lesions that may interfere with optimal stent expansion.
- Trial name
- CRATER (NCT05353946)
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Spain
- Volunteers
- 124 people
- Sponsor
- Guillermo Galeote; MD, PhD
Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD)
Euvolemia-Based Assessment of Pulmonary Hypertension in Stable Hemodialysis Patients
Pulmonary hypertension (PH) is a frequent and clinically significant complication in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (HD).
- Conditions
- Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD), Hemodialysis Patients, Volume Overload
- Trial name
- EU-PHASE-HD (NCT07676786)
- Testing
- Observational Assessment
- Where
- 2 sites in Romania
- Volunteers
- 30 people
- Sponsor
- Stefan Lujinschi
Pre-Eclampsia, Hypertension
Collection of Whole Blood Samples for the Evaluation of Preeclampsia (Pre-E) Biomarkers From Pregnant Women
Whole blood sample procurement study from pregnant women with signs and symptoms of Preeclampsia.
- Conditions
- Pre-Eclampsia, Hypertension, Proteinuria in Pregnancy, Thrombocytopenia
- Trial name
- NCT03767803
- Testing
- Non-interventional study
- Where
- 24 sites in United States
- Volunteers
- 344 people
- Sponsor
- Progenity, Inc.
Diabetes Mellitus, Hypertension
Evidence-based Laboratory Test Order Sets in Primary Care
Cluster randomised controlled trial to evaluate what the effect is of evidence-based order sets aimed at five indications on the appropriateness of laboratory test ordering in primary care.
- Conditions
- Diabetes Mellitus, Hypertension, Cardiovascular Diseases, Fatigue
- Trial name
- NCT02950142
- Testing
- CPOE with order sets for lab testing, CPOE without order sets for lab testing
- Where
- Belgium
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Venous Leg Ulcers
Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2
This study is being done to find out if an investigational product called HP802-247 can help people with venous leg ulcers. Investigational means that HP802-247 has not been approved by the U.S.
- Trial name
- NCT01737762
- Testing
- HP802-247, Vehicle
- Where
- 43 sites in United States, Canada and 1 more
- Volunteers
- 155 people
- Sponsor
- Healthpoint
Chronic Kidney Disease, Anemia
SGLT2 Inhibitors in Non-Diabetic CKD: Effects on Vascular Calcification and Anemia
The goal of this clinical trial is to learn if the drug dapagliflozin (an SGLT2 inhibitor) can help protect the kidneys, improve anemia, and support heart health in adults with chronic kidney disease (CKD) who do not have…
- Conditions
- Chronic Kidney Disease, Anemia, Cardiovascular Calcification
- Trial name
- NCT07344922
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Venous Insufficiency
Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency
The purpose of this study is to assess the therapeutic efficacy and safety of Venocur Triplex®, administered BID for 60 days in patients with Chronic Venous Insufficiency rated between CEAP 2 and 4, in comparison to a Placebo…
- Trial name
- NCT00835822
- Testing
- Venocur Triplex®
- Where
- 4 sites in Brazil
- Volunteers
- 216 people
- Sponsor
- Abbott
Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome
Design and Rationale of the COLT Study
Deep vein thrombosis (DVT) is a condition in which a blood clot forms in the deep veins of the leg and can lead to long-term problems such as leg pain, swelling, and reduced quality of life.
- Conditions
- Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome, Venous Thromboembolism (VTE), Venous Insufficiency
- Trial name
- COLT (NCT07432529)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Volunteers
- 940 people
- Sponsor
- Azienda Sanitaria Locale ASL 6, Livorno
Chronic Kidney Disease, Coronary Artery Disease
Feasibility and Pilot Testing of "My Heart and CKD" Online Shared Decision Aid
Many people with kidney disease also have heart disease. The procedures used to diagnose and treat heart disease (e.g., angiograms, angioplasty, or surgery) can improve symptoms and cardiovascular outcomes, but pose greater risks…
- Trial name
- MyHeart&CKD (NCT06920927)
- Testing
- Decision aid
- Where
- 2 sites in Canada
- Volunteers
- 220 people
- Sponsor
- University of Calgary
Renal Dysfunction, Hypertension
Effect of Obesity on Long-term Clinical Outcomes After Kidney Donation
Several studies have shown that renal function in patients who have donated a kidney (but are otherwise healthy) remains stable and within normal limits.
- Trial name
- R-21 (NCT01368822)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Venous Thromboembolism
Fondaparinux in Critically Ill Patients With Renal Failure
The primary objective of this study is to determine whether a dose-adjusted prophylaxis fondaparinux regimen of 2.5 milligrams (mg) subcutaneously administered every (q) 48 hours (hr) in patients with renal failure achieves peak…
- Trial name
- NCT01467583
- Testing
- Fondaparinux
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wayne State University
Kidney Transplantation, Acute Kidney Tubular Necrosis
Effect of BM-MSCs in DCD Kidney Transplantation
This study is designed to determine the efficacy and safety of allogeneic bone marrow-derived mesenchymal stem cells in kidney transplantation from Chinese donation after citizen's death (DCD).
- Trial name
- NCT02561767
- Testing
- bone marrow-derived mesenchymal stem cells, Saline, Induction therapy (ATG or Basiliximab)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Post Thrombotic Syndrome, Venous Thromboses
Exercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome
Post-thrombotic syndrome (PTS) is the most frequently observed chronic complication of deep vein thrombosis (DVT), with an estimated cumulative incidence of 20-50%.
- Conditions
- Post Thrombotic Syndrome, Venous Thromboses, Claudication, Intermittent
- Trial name
- ETERecaVSPT (NCT05794932)
- Testing
- Stress test
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Montpellier
Chronic Kidney Disease Requiring Chronic Dialysis
Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.
Patients with end-stage renal disease undergoing hemodialysis (HD) are burdened with extremely high mortality rates (15% per year) and during the early stage (≤120days) the mortality rate is even higher (27% per year).
- Trial name
- AKIM-CKD (NCT05266092)
- Testing
- Observational study
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
IgA Nephropathy, Renal Insufficiency, Chronic
Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy?
Global Burden of Diseases ranks chronic kidney disease (CKD) as the 12th leading cause of death, with an estimated 20% increase from 2010 to 2019.
- Conditions
- IgA Nephropathy, Renal Insufficiency, Chronic, IgA Vasculitis, IGA Glomerulonephritis
- Trial name
- IA-GRACE-IgANT (NCT06676384)
- Testing
- Oral prednisolone and SoC, Gut-directed budesonide and SoC, Mycophenolate mofetil (MMF) and SoC
- Where
- 12 sites in India
- Volunteers
- 585 people
- Sponsor
- Christian Medical College, Vellore, India
High Risk Non-cardiac Surgery, Death
Cerebral Oximetry and Perioperative Outcome in Non-Cardiac Surgery
Cerebral desaturations occur frequently in patients undergoing non-cardiac surgery. The definition of what constitutes a cerebral desaturation, the incidence of the phenomenon, the association between desaturations and…
- Conditions
- High Risk Non-cardiac Surgery, Death, Delirium, Kidney Injury
- Trial name
- NCT01838733
- Testing
- Observational study
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- University of Manitoba
Myocardial Infarction, Inflammation
Inflammation in Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand.
- Conditions
- Myocardial Infarction, Inflammation, Critical Illness
- Trial name
- NCT02385487
- Where
- United States
- Sponsor
- NYU Langone Health
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Ischemic Stroke, Vertebral Artery Stenosis
Drug-eluting Stenting Versus Medical Treatment for Extracranial Vertebral Artery Stenosis
Posterior circulation stroke accounts for 20% of all ischemic stroke. Approximately one quarter of posterior circulation strokes are due to stenosis in the vertebral artery and basilar artery.
- Trial name
- VISTA (NCT05885932)
- Testing
- Drug-eluting stenting plus aspirin and clopidogrel or ticagrelor, Aspirin and clopidogrel or ticagrelor, mono anti-platelet therapy
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Xuanwu Hospital, Beijing
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