Clinical trials: Vascular Insufficiency
Chronic Kidney Disease, Hypertension
Lifestyle Intervention In CKD
This research study will test whether a 12-week healthy lifestyle program offered through a cardiac rehabilitation center can help lower blood pressure and improve kidney health in adults with advanced chronic kidney disease.
- Trial name
- CKD-LIFE (NCT07633145)
- Testing
- Multi-component lifestyle intervention, Usual Care Control
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Duke University
Chronic Kidney Diseases, Heart Failure
Patient Education Video to Reduce OTC NSAIDs
The goal of this study is to assess the efficacy of a brief 3 to 5-minute educational video on influencing intent to change behavior regarding potentially harmful over-the-counter (OTC) NSAID use in adults with chronic kidney…
- Conditions
- Chronic Kidney Diseases, Heart Failure, Hypertension
- Trial name
- NCT06575205
- Testing
- Educational video
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- Carilion Clinic
Chronic Kidney Disease, Anemia
SGLT2 Inhibitors in Non-Diabetic CKD: Effects on Vascular Calcification and Anemia
The goal of this clinical trial is to learn if the drug dapagliflozin (an SGLT2 inhibitor) can help protect the kidneys, improve anemia, and support heart health in adults with chronic kidney disease (CKD) who do not have…
- Conditions
- Chronic Kidney Disease, Anemia, Cardiovascular Calcification
- Trial name
- NCT07344922
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
End Stage Renal Failure
A Trial of Interrupted vs Continuous Suturing Techniques for Radiocephalic Fistulae
Patients with end-stage renal failure require dialysis to remove toxins from their blood. Haemodialysis is best provided through a native arterio-venous fistula (AVF).
- Trial name
- NCT01704313
- Testing
- Interrupted, Continuous
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Emma Aitken
Chronic Kidney Disease, Hypertension
Genetic Testing to Understand and Address Renal Disease Disparities Across the United States
GUARDD-US is a prospective, multicenter, unblinded, two arm randomized pragmatic clinical trial. Participants will be randomized in a 1:1 ratio to immediate APOL1 gene testing and return of results (ROR) to participant and…
- Trial name
- GUARDD-US (NCT04191824)
- Testing
- Timing of return of results
- Where
- 14 sites in United States
- Volunteers
- 6,789 people
- Sponsor
- Duke University
End Stage Renal Disease, Hemodialysis
Effects of On-Line Hemodiafiltration(HDF) on Vascular Health in Chronic Hemodialysis Patients
The purpose of this study is to determine whether on-line hemodiafiltration ameliorate the endothelial dysfunction compared with the low flux hemodialysis in end stage renal disease patients on maintenance hemodialysis.
- Trial name
- NCT00532597
- Testing
- On-line hemodiafiltration, Low flux hemodialysis
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Eulji General Hospital
End Stage Renal Disease, Hypertension
Blood Pressure Slopes and Ultrafiltration in Hemodialysis Patients
Kidney failure has been recognized as one of the most costly chronic conditions among United States Veterans. Approximately 13,000 Veterans develop kidney failure each year, and most require hemodialysis initiation.
- Conditions
- End Stage Renal Disease, Hypertension, Extracellular Volume Overload, Intradialytic Hypotension
- Trial name
- NCT04163614
- Testing
- IBPS-Guided Ultrafiltration
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Chronic Kidney Diease, Diabetes Mellitus
Chronic Kidney Disease and Metabolic Disorders in the Elderly
The goal of this observational study is to investigate the impact of metabolic comorbidities on outcomes in elderly Chinese adults, through two parallel sub-cohorts: one comprising elderly individuals without chronic kidney…
- Conditions
- Chronic Kidney Diease, Diabetes Mellitus, Hypertension, Hyperlipidemia
- Trial name
- NCT07494526
- Where
- 2 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
End-stage Renal Disease, Hypertension
Renal Denervation to Improve Outcomes in Patients With End-stage Renal Disease
Sympathetic activation is a hallmark of end-stage renal disease and adversely affects cardiovascular prognosis. Hypertension is present in the vast majority of these patients and plays a key role in the progressive deterioration…
- Trial name
- NCT02021019
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 3 people
- Sponsor
- Baker Heart and Diabetes Institute
Peripheral Arterial Disease, Venous Insufficiency
Evaluation of the Safety of Compressive Socks to Treat Venous Insufficiency in Patients With Peripheral Arterial Disease
Elastic compression stockings are recommended in the treatment venous insufficiency. Degressive compressive stockings have been used for many decades and are characterized by a high pressure applied at the ankle and a decreasing…
- Trial name
- NCT02431819
- Testing
- contention socks
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Contrast-induced Nephropathy, Acute Kidney Injury
The Use of Inorganic Nitrate for the Prevention of Contrast-induced Nephropathy
Contrast-induced nephropathy (CIN), an acute kidney injury resulting from the administration of intravascular iodinated contrast media, is an important cause of morbidity/mortality following coronary angiographic procedures in…
- Conditions
- Contrast-induced Nephropathy, Acute Kidney Injury, Acute Coronary Syndrome
- Trial name
- NITRATE-CIN (NCT03627130)
- Testing
- Potassium Nitrate, Potassium Chloride
- Where
- United Kingdom
- Volunteers
- 640 people
- Sponsor
- Barts & The London NHS Trust
Venous Insufficiency
The Effectiveness of Trans-catheter Foam Sclerotherapy of Pelvic and Atypical Lower Limb Varicosities
pelvic congestion is the most recognized consequence of pelvi-perineal venous insufficiency . chronic pelvic pain prevalence is about 26.6 %in egypt.
- Trial name
- NCT03652025
- Testing
- embolotherapy of incompetent gonadal and iliac veins
- Volunteers
- 20 people
- Sponsor
- Assiut University
Pregnancy Complications, Proteinuria in Pregnancy
Sonoclot to Evaluate Thrombotic Risk in Proteinuric Pregnancy
There is a lack of consensus on whether women with proteinuric kidney disease benefit from prophylactic anticoagulation during pregnancy to reduce the risk of venous thromboembolism.
- Conditions
- Pregnancy Complications, Proteinuria in Pregnancy, Chronic Kidney Diseases, Venous Thromboembolism
- Trial name
- NCT05108389
- Testing
- Viscoelastic haemostasis monitor output
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Wound Healing, Diabetic Foot
EDX110 - Efficacy and Safety in the Management of Hard-to-heal Wounds
Post-market study to determine the efficacy of EDX110 dressing system in hard-to-heal wounds.
- Conditions
- Wound Healing, Diabetic Foot, Foot Ulcer, Diabetic, Venous Ulcer
- Trial name
- NCT06640985
- Testing
- EDX110 wound dressing system
- Where
- Chile
- Volunteers
- 43 people
- Sponsor
- ConvaTec Inc.
Hypertension, Chronic Kidney Disease
Pharmacokinetics Following Single-dose of Valsartan in Japanese Pediatric Patients
This study will assess the pharmacokinetics and safety following single dose of valsartan in Japanese pediatric patients with hypertension, chronic kidney disease, or nephrotic syndrome.
- Conditions
- Hypertension, Chronic Kidney Disease, Nephrotic Syndrome
- Trial name
- NCT01447485
- Testing
- Valsartan (VAL489)
- Where
- 2 sites in Japan
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Varicose Veins, Venous Reflux
Retrospective Review of Saphenous Vein Incompetence: Venaseal Versus Endovenous Thermal Ablation
This study is a retrospective, chart review of treatment of patients with symptomatic varicose veins. Treated limbs must have the Great Saphenous Vein and/or Small Saphenous Vein treated with either cyanoacrylate closure…
- Conditions
- Varicose Veins, Venous Reflux, Venous Insufficiency
- Trial name
- VALUE (NCT04006184)
- Testing
- Chart review
- Where
- United States
- Volunteers
- 547 people
- Sponsor
- Lake Washington Vascular
Varicose Veins, Chronic Venous Disorder
First- or Second- Class Compression Hosiery After Endovenous Laser With Sclerotherapy and Ambulatory Phlebectomy
Investigators hypothesize that first class compression therapy during the postoperative period will improve patient adherence due to easier application and reduced discomfort.
- Conditions
- Varicose Veins, Chronic Venous Disorder, Chronic Venous Insufficiency (CVI), Venous Reflux
- Trial name
- FISCHER (NCT06913764)
- Testing
- class I compression stockings of the RAL-GZ 387 standard: 1 month using, class II compression stockings of the RAL-GZ 387 standard: 1 month using
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Moscow City Hospital named after A.K. Eramishantsev
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study A, RCT
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- ENCOMPASS (NCT04790604)
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Deep Vein Thrombosis, Venous Stasis
Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)
The purpose of this study is to determine if the use of image-guided, endovascular therapy (EVT) is an effective strategy with which to reduce Post Thrombotic Syndrome (PTS) disease severity and improve quality of life in…
- Conditions
- Deep Vein Thrombosis, Venous Stasis, Venous Insufficiency, Venous Leg Ulcer
- Trial name
- C-TRACT (NCT03250247)
- Testing
- Stents
- Where
- 29 sites in United States
- Volunteers
- 225 people
- Sponsor
- Washington University School of Medicine
Chronic Venous Disease, Venous Insufficiency
Venous Insufficiency and Neuromuscular Stimulation
The investigators will be evaluating the immediate and longer term effect of treatment with a medical device on the symptoms of chronic venous disease.
- Conditions
- Chronic Venous Disease, Venous Insufficiency, Deep Venous Obstruction
- Trial name
- VeINS (NCT02137499)
- Testing
- geko device
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
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