Clinical trials: Vascular Neurocognitive Disorder
Alzheimer's Disease With Vascular Pathology
A Study of the Effects of CY6463 in Participants With Alzheimer's Disease With Vascular Pathology
This study is being conducted to test the safety, tolerability, and pharmacokinetics of the investigational drug CY6463 compared with placebo in individuals who are aged 60 years or older and have Alzheimer's disease (AD) along…
- Trial name
- NCT04798989
- Testing
- CY6463
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Tisento Therapeutics
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Post-Stroke Cognitive Impairment (PSCI), Ischemic Stroke
Evaluation of Clinical Efficacy and Mechanism of Hand Jing-Well Acupoint Transcutaneous Electrical Stimulation in Improving Post-Stroke Cognitive Impairment
This study evaluates a non-invasive electrical stimulation therapy applied to specific acupoints on the fingers (called Jing-Well points) to improve thinking and memory problems after stroke.
- Conditions
- Post-Stroke Cognitive Impairment (PSCI), Ischemic Stroke, Cognitive Dysfunction, Cognitive Disorder, Hemorrhagic Strokes
- Trial name
- NCT07736885
- Testing
- Transcutaneous Electrical Stimulation at Jing-Well Acupoints
- Where
- China
- Volunteers
- 70 people
- Sponsor
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Cardiovascular Disease, Osteoporosis
The Trinity, Ulster and Department of Agriculture Cohort Study
Background: Cardiovascular disease (CVD), osteoporosis and dementia are chronic diseases of ageing that impact adversely on the lives of those affected and have major health, social and economic consequences.
- Conditions
- Cardiovascular Disease, Osteoporosis, Alzheimer's Disease, Hypertension
- Trial name
- TUDA (NCT02664584)
- Where
- 3 sites in Ireland, United Kingdom
- Volunteers
- 5,186 people
- Sponsor
- University of Ulster
Subarachnoid Hemorrhage, Aneurysmal, Cognitive Dysfunction
Gamma Entrainment Stimulation for Cognitive Dysfunction After aSAH
The goal of this clinical trial is to Explore and verify whether 40Hz audio and binaural beat 40Hz audio can improve the postoperative cognitive dysfunction seen in patients with aneurysmal subarachnoid hemorrhage.
- Trial name
- GES-aSAH (NCT06346015)
- Testing
- Gamma Entrainment Stimulation
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Intraoperative, Venous Congestion
Venous Congestion And Delirium After Cardiac Surgery
Postoperative delirium (POD) is an acute brain dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances, and is a common complication after cardiac surgery.
- Conditions
- Intraoperative, Venous Congestion, Postoperative Delirium (POD), Cardiac Surgery
- Trial name
- NCT07285187
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POD assessments
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhuan Zhang
Stroke, Transient Ischemic Attack
DOC Utility: Screening of Depression, Obstructive Sleep Apnea and Cognitive Impairment
The primary objective of this study is to determine whether baseline DOC screening can add to clinical and demographic data to predict the occurrence of a composite negative outcome (any of: recurrent stroke, myocardial…
- Conditions
- Stroke, Transient Ischemic Attack, Depression, Obstructive Sleep Apnea
- Trial name
- NCT02363114
- Where
- Canada
- Volunteers
- 6,500 people
- Sponsor
- Dr. Richard H. Swartz
Stroke, Cognitive Impairment
Combining Cognitive and Treadmill Training on Cognition and Walking Performance in Stroke With Cognitive Impairment
Post-stroke cognitive impairment is common in stroke survivors. Cognitive function is related to walking ability. The dual task walking is required for daily activities, however, such ability is even more challenging than single…
- Trial name
- NCT04545138
- Testing
- cognitive training combine treadmill training, Treadmill training
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- National Yang Ming Chiao Tung University
Dementia, Cognitive Change
MIND Diet to Improve Cognitive Function in Mild Stroke Patients
A 6-month pilot randomized controlled trial designed to test the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet + usual medical care versus usual medical care on the rate of cognitive change…
- Conditions
- Dementia, Cognitive Change, Stroke, Cerebral Infarction
- Trial name
- MINDICOMS (NCT05921084)
- Testing
- MIND diet intervention, General dietary advice
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhejiang University
Schizophrenia, Alzheimer's Disease
Side Effects of Newer Antipsychotics in Older Adults
This study will compare four atypical antipsychotic medications in terms of the risk of specific side effects each of them presents in middle-aged and elderly individuals.
- Conditions
- Schizophrenia, Alzheimer's Disease, Dementia
- Trial name
- NCT00245206
- Testing
- Aripiprazole, Olanzapine, Risperidone
- Where
- United States
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Cerebral Amyloid Angiopathy
F-18-AV-45 Uptake, Spot Sign Presence and Cerebral Amyloid Angiopathy (CAA) in Primary Intracranial Hemorrhage (ICH)
Florbetapir F 18 is an experimental radioactive drug that may allow doctors to image changes in the brain using a PET (Positron Emission Tomography) scanner.
- Trial name
- NCT01382849
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
Disorder Related to Renal Transplantation
Curcumin in Kidney Transplant Recipients
The primary goal of this study is to investigate if curcumin is beneficial for kidney transplant recipients, a population with extensive baseline vascular dysfunction and cognitive impairment who have few treatment options.
- Trial name
- NCT03935958
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Illinois Chicago
Coma, Disorders of Consciousness
Recovery Trajectory for Coma and Disorders of Consciousness
This study aims to better understand recovery after coma caused by serious neurologic illness or injury. Patients who are unconscious (in a coma or disorder of consciousness) due to conditions such as stroke, cardiac arrest…
- Conditions
- Coma, Disorders of Consciousness, Cardiac Arrest (CA), Traumatic Brain Injuries
- Trial name
- Coma Cohort (NCT07614074)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Francisco
Stroke Hemorrhagic, Stroke, Ischemic
The Role of Cognition in Motor Learning After Stroke
Stroke leads to lasting problems in using the upper limb (UL) for everyday life activities. While rehabilitation programs depend on motor learning, UL recovery is less than ideal.
- Conditions
- Stroke Hemorrhagic, Stroke, Ischemic, Cognitive Impairment
- Trial name
- NCT05268861
- Testing
- Error Augmentation Feedback, No Error Augmentation Feedback
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Dementia, Alzheimer Disease
Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers
The goal of this clinical trial is to evaluate Kinto's Care Coaching intervention for dementia caregivers. The main questions it aims to answer are: Does the intervention help caregivers to address their general caregiving goals…
- Conditions
- Dementia, Alzheimer Disease, Lewy Body Disease, Vascular Dementia
- Trial name
- NCT05916664
- Testing
- Kinto Care Coaching
- Where
- United States
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Kinto
Atrial Fibrillation
Swiss Atrial Fibrillation Cohort Study
Swiss-AF is a prospective observational, multicentric cohort study in Switzerland. Overall, 2600 patients with documented atrial fibrillation aged >65 years will be included and followed on a yearly basis.
- Trial name
- SWISS-AF (NCT02105844)
- Where
- Switzerland
- Volunteers
- 2,415 people
- Sponsor
- University Hospital, Basel, Switzerland
Cerebral Small Vessel Diseases, Cognitive Impairment
Intermittent Theta Burst Stimulation on Cognitive Impairment of Cerebral Small Vessel Disease
The cerebral small vessel diseases (CVSD) can cause severe and lasting damage to cognition function while the current available treatment of vascular cognitive impairment (VCI) is limited.
- Trial name
- NCT06579664
- Testing
- iTBS
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Beijing Tiantan Hospital
Moyamoya Disease, Moyamoya Syndrome
Development and Validation of Risk Prediction Models for Stroke and Cognitive Impairment in Moyamoya Disease and Moyamoya Syndrome
This multicenter prospective observational cohort study aims to develop and validate individualized risk prediction models for stroke and cognitive decline in patients with moyamoya disease or moyamoya syndrome by integrating…
- Trial name
- NCT07894107
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tiantan Hospital
Mild Cognitive Impairment, Ischemic Stroke
Clinical Trial of Efficacy and Safety of MMH-MAP in the Treatment of Mild Cognitive Impairment in Early Recovery Stage After Ischemic Stroke
The purpose of this study is: to evaluate efficacy of MMH-MAP in the treatment of mild cognitive impairment in subjects in early rehabilitation period of ischemic stroke to evaluate safety of MMH-MAP in the treatment of mild…
- Trial name
- NCT03815292
- Testing
- MMH-MAP
- Where
- 28 sites in Russia
- Volunteers
- 276 people
- Sponsor
- Materia Medica Holding