Clinical trials: Vascular Neurocognitive Disorder
Stroke
Clinical Effect Size of an Educational Intervention in the Home and Compliance on People Who Suffer From Stroke
Background. Cognitive, communication and physical weakness combined with environmental changes frequently cause changes in roles, routines and daily occupations.
- Trial name
- NCT01980641
- Testing
- Educational intervention, Smartphone-based application
- Where
- 2 sites in Spain
- Volunteers
- 34 people
- Sponsor
- University of Malaga
Dementia, Alzheimer Disease
A Study of the Effectiveness and Safety of Risperidone in the Treatment of Behavioral Disturbances in Patients With Dementia
The purpose of the study is to compare the safety and efficacy of risperidone (an antipsychotic medication) to that of placebo in the treatment of behavioral disturbances associated with dementia.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular
- Trial name
- NCT00249145
- Testing
- risperidone
- Volunteers
- 349 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Diabetes Mellitus, Hypertension
Community-based E-Health Program for Older Adults Living With Chronic Diseases
With increased aging population, there is a higher rate of having chronic diseases and cognitive impairment. In order to achieve successful aging, it is important for community-dwelling older adults to perform better…
- Conditions
- Diabetes Mellitus, Hypertension, Hyperlipidemias
- Trial name
- CeHP (NCT04560296)
- Testing
- Community-based E-Health Program, usual self-management and follow up with doctors/nurse
- Where
- 9 sites in Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Hypertension, Cognitive Decline
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
The study will test a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income hypertensive patients in…
- Trial name
- IMPACTS-MIND (NCT04797403)
- Testing
- Stepped-care protocol adapted from the SPRINT intensive-treatment algorithm
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Tulane University
Ischemic Stroke, Intracerebral Hemorrhage
Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke.
- Conditions
- Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular
- Trial name
- DISCOVERY (NCT04916210)
- Where
- 31 sites in United States
- Volunteers
- 8,000 people
- Sponsor
- Massachusetts General Hospital
Atherosclerosis, Osteoporosis
Research on Aging Project in Iceland: Second Stage
Background: Researchers are interested in studying the environmental and genetic factors that play a role in health and living conditions as people age. Since 2002, the U.S.
- Conditions
- Atherosclerosis, Osteoporosis, Obesity, Glucose Abnormalities
- Trial name
- NCT01322568
- Where
- Iceland
- Volunteers
- 5,764 people
- Sponsor
- National Institute on Aging (NIA)
Cardiovascular Disease, Dementia
Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia
DAN-ZOSTER is a nationwide randomized study investigating whether vaccination against herpes zoster (shingles) can reduce the risk of cardiovascular disease and dementia in older adults.
- Trial name
- DAN-ZOSTER (NCT07485283)
- Testing
- Recombinant Herpes Zoster Vaccine (Shingrix)
- Where
- 2 sites in Denmark
- Volunteers
- 168,460 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Alzheimer's Disease, Dementia With Lewy Bodies
Imaging of Brain Amyloid Plaques in the Aging Population
This is a prospective, open label, non-therapeutic, diagnostic imaging study. The purpose of this study is to utilize Pittsburgh Compound B positron emission imaging (PiB PET) to ascertain the relationship between change in…
- Conditions
- Alzheimer's Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Vascular Dementia
- Trial name
- NCT00950430
- Testing
- Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451)
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dementia, Movement Disorders
Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.
The goal of this clinical study is to compare the current standard-of-care PET/CT scanner with the new NeuroEXPLORER PET/CT, with the aim of demonstrating the added diagnostic value of the new scanner.
- Conditions
- Dementia, Movement Disorders, ALS - Amyotrophic Lateral Sclerosis, Epilepsy
- Trial name
- NCT07595666
- Testing
- Standard-of-care PET/CT, NeuroEXPLORER
- Where
- Belgium
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- prof. dr. Koen Van Laere
Subarachnoid Hemorrhage, Anxiety
Massage Technique for Pain, Anxiety and Delirium in SAH Patients
This research study seeks to explore the effects of massage techniques on pain and anxiety relief among patients with subarachnoid hemorrhages in the ICU setting in comparison to subarachnoid hemorrhagic patients using standard…
- Conditions
- Subarachnoid Hemorrhage, Anxiety, Pain, Delirium
- Trial name
- NCT01982656
- Testing
- Massage
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sara E. Hocker, M.D
Moyamoya Disease
Study on the Mechanism of Cognitive Impairment in Patients with Moyamoya Disease
The purpose of this study is to comprehensively evaluate the risk factors for cognitive decline in patients with moyamoya disease, identify imaging target areas associated with cognitive damage in the brain, and explore the…
- Trial name
- NCT06832839
- Testing
- Revascularization
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Multiple Sclerosis, Epilepsy
Psychometric Evaluation in Patients With Brain Damage During Neuroinflammation
The presence of a damage to the central and / or peripheral nervous system resulting from diseases of a different nature (such as, Multiple Sclerosis, Parkinson's disease, dementia, head trauma, stroke, epilepsy or other…
- Conditions
- Multiple Sclerosis, Epilepsy, Parkinson Disease, Dementia
- Trial name
- NCT05450237
- Testing
- Psychometric Evaluations
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Neuromed IRCCS
Alzheimer Disease, Amyotrophic Lateral Sclerosis
The Ontario Neurodegenerative Disease Research Initiative
The Ontario Neurodegenerative Disease Research Initiative (ONDRI) is a province-wide collaboration studying dementia and how to improve the diagnosis and treatment of neurodegenerative diseases including: Alzheimer's disease (AD)…
- Conditions
- Alzheimer Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson Disease
- Trial name
- ONDRI (NCT04104373)
- Testing
- Observational Cohort
- Where
- 12 sites in Canada
- Volunteers
- 522 people
- Sponsor
- Ontario Neurodegeneration Disease Research Initiative
Dementia
Research on the Early and Prognosis Diagnosis of Vascular Dementia
Around 10% of stroke survivors develop dementia within 3 months after stroke and over 20% more stroke patients have dementia in the subsequent 3 years.
- Trial name
- NCT03152630
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Lacunar Strokes
Constitution of a Clinico-radiological Database and a Biobank for Patients With Lacunar Infarcts
The aim of this study is to determine in patients with a recent lacunar strokes (<15 days), the natural history of cognitive disturbances and disability.
- Trial name
- DHU-LAC (NCT03552926)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dementia, Alzheimer Disease
The BRAIN App (Phase 2 SBIR)
There are currently 6.7 million Americans living with dementia and, without significant breakthroughs, this figure will double to 12.7 million by 2050. There are about 46,000 long-term care (LTC) facilities in the U.S.
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- NCT06298474
- Testing
- The BRAIN App
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hopeful Aging
Cerebrovascular Disease, Ischemic Stroke
Florida Cerebrovascular Disease Biorepository and Genomics Center
The purpose of this study is to create a state-wide biorepository and resource center for cerebrovascular diseases in Florida, which will include collecting medical history information and blood from subjects affected by…
- Conditions
- Cerebrovascular Disease, Ischemic Stroke, Transient Ischemic Attack, Intracerebral Hemorrhage
- Trial name
- NCT05491980
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Mayo Clinic
Vascular Dementia, Subcortical Vascular Dementia
Effect of Zydena (Udenafil) on Cerebral Blood Flow and Peripheral Blood Viscosity
The purpose of this study is to determine whether Zydena (Udenafil) has effect on cerebral blood flow and peripheral blood viscosity in normal and subcortical vascular cognitive impairment subjects.
- Trial name
- SMCZN01 (NCT01466543)
- Testing
- Zydena (Udenafil)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Dementia, Alzheimer Disease
Effects of a Multicomponent Exercise Intervention on Physical and Cognitive Function of Older Adults With Dementia
Dementia is a leading cause of death and disability that was declared as one of the greatest health and social care challenges of the 21st century.
- Conditions
- Dementia, Alzheimer Disease, Vascular Dementia, Neurocognitive Disorders
- Trial name
- Body&Brain (NCT04095962)
- Testing
- Exercise
- Where
- Portugal
- Volunteers
- 110 people
- Sponsor
- Universidade do Porto