Clinical trials: Vascular Neurocognitive Disorder
Disorder of Consciousness, Stroke
Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases
The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients.
- Trial name
- NCT05706831
- Testing
- Combinatory effect of music stimulation and neurostimulation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Mild Cognitive Impairment, Cerebrovascular Disease
EGb 761 in the Syndrome of MCI With Concomitant CVD
EGb 761 has been demonstrated to be useful in improving cognitive and global clinical outcomes in patients with cognitive impairment or dementia, when administered at a daily dosage of 240mg in randomised controlled trials…
- Trial name
- NCT04525144
- Testing
- Tebonin Forte
- Where
- Singapore
- Volunteers
- 134 people
- Sponsor
- National Neuroscience Institute
Dementia Associated With Cerebrovascular Disease
Safety of Donepezil in Patients With Dementia Associated With Cerebrovascular Disease
one year extension study following a previous double-blind study to evaluate safety of the drug
- Trial name
- NCT00188812
- Testing
- donepezil hcl
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Pseudobulbar Affect (PBA), Stroke
Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA)
The objectives of the study are to evaluate the safety, tolerability, and effectiveness of NUEDEXTA capsules containing 20 mg DM (Dextromethorphan)/10 mg Q (Quinidine) for treatment of Pseudobulbar Affect (PBA) in patients with…
- Conditions
- Pseudobulbar Affect (PBA), Stroke, Dementia, Traumatic Brain Injury (TBI)
- Trial name
- PRISM II (NCT01799941)
- Testing
- Nuedexta (DM 20 mg/Q 10 mg)
- Where
- United States
- Volunteers
- 367 people
- Sponsor
- Avanir Pharmaceuticals
Salivary Alpha-amylase, Delirium
Perioperative Salivary Alpha-amylase as a Predictor of Delirium After Lower Extremity Vascular Bypass Surgery
The aim of this study is to evaluate the role of salivary Alpha-amylase as a predictor biomarker of POD in elderly patients undergoing limb bypass surgery.
- Conditions
- Salivary Alpha-amylase, Delirium, Lower Extremity, Vascular Bypass Surgery
- Trial name
- NCT06242275
- Testing
- Salivary Alpha-amylase
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Alzheimer Disease, Dementia
Innovations in Dementia Empowerment and Action
The lack of efficacious research-based interventions for such vulnerable older adults with Alzheimer's disease and related dementias (AD/RD) and their caregivers (CGs) is a significant public health problem.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Parkinson Disease Dementia
- Trial name
- IDEA (NCT03550131)
- Testing
- Innovations in Dementia Empowerment and Action (IDEA), Reducing Disabilities in Alzheimer's Disease (RDAD)
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University of Washington
Transient Ischemic Attack, Vascular Cognitive Impairment
Reshaping the Path of Vascular Cognitive Impairment (VCI)
The investigators will conduct a proof-of-concept randomized controlled trial study to provide preliminary evidence of efficacy of a resistance exercise training program for maintaining white matter health and improving cognitive…
- Conditions
- Transient Ischemic Attack, Vascular Cognitive Impairment, Subcortical Vascular Dementia
- Trial name
- NCT02669394
- Testing
- Resistance exercise training, Control: stretching and relaxation program
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of British Columbia
Alzheimer's Disease, Vascular Dementia
BAC in Patient With Alzheimer's Disease or Vascular Dementia
The primary objective of this study is to evaluate the efficacy of BAC patients with Alzheimer's disease or vascular dementia.The secondary objective of this study is to evaluate the safety of BAC patients with Alzheimer's…
- Trial name
- NCT02467413
- Testing
- BAC, BAC Matched Vehicle
- Where
- Taiwan
- Sponsor
- Botanicure Co., Ltd.
Brain and Central Nervous System Tumors, Radiation Toxicity
Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor
RATIONALE: Donepezil and EGb761 may be effective in improving neurocognitive function (such as thinking, attention, concentration, and memory) and may improve quality of life in patients who have undergone radiation therapy to…
- Trial name
- NCT00070161
- Testing
- EGb761, donepezil hydrochloride, cognitive assessment
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Wake Forest University Health Sciences
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Ischemic Stroke, Delirium
DEliriuM in STroke: the Link Between Stroke, Delirium and Long-term Cognitive Impairment
Primary objective of this study: determine whether PSD is a risk factor for PSCI, independent of brain frailty and premorbid cognitive functioning. Secondary objectives: 1.
- Conditions
- Ischemic Stroke, Delirium, Cognitive Impairment
- Trial name
- DE-MIST (NCT06650436)
- Testing
- EEG, MRI, Depression screening and neuropsychological tests
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cognitive Impairment, Executive Dysfunction
Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
Complaints about memory and thinking are common in women as they go through menopause and estrogen levels fall. The ovarian hormone estrogen is important for supporting normal cognitive function, and changes in brain activity and…
- Conditions
- Cognitive Impairment, Executive Dysfunction, Endothelial Dysfunction, Cardiovascular Disease
- Trial name
- NCT02122198
- Testing
- Leuprolide acetate, Estradiol, Medroxyprogesterone
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension, Cognitive Impairment
Validation of New Tools for the Assessment of Cognitive Functions and Connectivity Network in Hypertensive Patients
The relationship among hypertension, aging and cognitive decline is complex and not completely understood. Purpose of this project will be evaluating early markers of cognitive deterioration in patients with arterial…
- Trial name
- NCT02310217
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Neuromed IRCCS
Arterial Stiffness, White Matter Lesions
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
The ACE Trial, funded by the National Institute on Ageing/National Institutes of Health (NIH), is a multicenter clinical trial. The ACE Trial will determine if taking the dietary supplement Equol could slow the progression of…
- Conditions
- Arterial Stiffness, White Matter Lesions, Cognitive Decline
- Trial name
- ACE (NCT05741060)
- Testing
- S-equol
- Where
- 3 sites in United States
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Akira Sekikawa
Mild Cognitive Impairment
Filipino Multicomponent Intervention to Maintain Cognitive Performance in High Risk Population (FINOMAIN)
FINOMAIN is a community-based, cluster randomized controlled trial (cRCT) of dance intervention INDAK and standardized vascular care.
- Trial name
- FINOMAIN (NCT04301544)
- Testing
- INDAK (Improving Neurocognition through Dance and Kinesthetics), Nutrition Counseling, Standardized Vascular Care
- Where
- Philippines
- Volunteers
- 72 people
- Sponsor
- St. Luke's Medical Center, Philippines
Microvascular Disease, Microvascular Complications
Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Dementia, Diabetes Mellitus Type 2
- Trial name
- SVAT (NCT06628297)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Vascular Dementia
Study of STA-1 Capsule in Patients With Vascular Dementia (Marrow-Sea Deficiency)
The objectives of this phase II study of STA-1 capsule was to make preliminary evaluation on clinical efficacy and safety of STA-1 capsule in order that based on the dosage and study structure planned in this project, the dosage…
- Trial name
- NCT01475578
- Testing
- STA-1, Ergoloid Mesylates tablet
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Sinphar Pharmaceutical Co., Ltd
Alzheimer s Disease, Vascular Cognitive Impairment
Adaptation of the Mini-Mental State Examination (MMSE) for the Reunion Island Population
The Mini-Mental State Examination (MMSE) is the most widely used cognitive screening and monitoring test for neurocognitive disorders in current clinical practice.
- Trial name
- MMSE-RUN (NCT07251647)
- Testing
- MMSE-RUN and MMSE GRECO
- Where
- 7 sites in Reunion
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Dementia, Music Therapy
Music Effects on Dementia
Older adults constitute a population whose age-related physiological and cognitive changes predispose them to conditions that are less likely to occur in younger individuals.
- Conditions
- Dementia, Music Therapy, Caregiver Burden of People With Dementia, Neuropsychiatric Symptom
- Trial name
- NCT07542535
- Testing
- Music Therapy
- Where
- Mexico
- Volunteers
- 7 people
- Sponsor
- Instituto Nacional de Geriatria, Mexico
Cerebral Small Vessel Diseases
Clinical Observation for the Therapeutic Effect of mNGF on Cognitive Decline in Cerebral Small Vessel Disease
This study was a multicenter, prospective, randomized controlled trial. In this study, 510 patients with cognitive impairment of cerebral small vessel disease who met the inclusion criteria are randomly included in multiple…
- Trial name
- NCT04041349
- Testing
- mouse nerve growth factor
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhujiang Hospital