Clinical trials: Vascular Neurocognitive Disorder
Stroke, Stroke Sequelae
The StrokeCog Study: Cognitive Rehabilitation Intervention in Stroke
This study aims to progress to the next stage of feasibility testing, by conducting a pilot randomised controlled study with consecutive stroke patients who have mild to moderate cognitive impairment following stroke.
- Conditions
- Stroke, Stroke Sequelae, Cognitive Impairment
- Trial name
- StrokeCog-R (NCT06021470)
- Testing
- Cognitive rehabilitation intervention
- Volunteers
- 64 people
- Sponsor
- Royal College of Surgeons, Ireland
Cerebral Small Vessel Diseases
Visit-to-Visit Variability in Blood Pressure as a Predictor of Poor Cognitive Function
Hypertension in midlife is an independent risk factor of late life cognitive dysfunction or dementia. Chronic hypertension cause vascular damage and cerebral ischemia, which ultimately gives rise to the cognitive dysfunction or…
- Trial name
- BPV-COG (NCT01688505)
- Where
- 5 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Hallym University Medical Center
Stroke, Mild Cognitive Impairment (MCI)
Mindfulness With Dual-Task Training in Post-Stroke Mild Cognitive Impairment
This study aims to investigate whether a combined intervention of mindfulness and dual-task training can improve cognitive function and physical performance in individuals with mild cognitive impairment after stroke.
- Trial name
- NCT07603102
- Testing
- mindfulness, Dual-Task Training, Aerobic Training
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing Mingzhou Rehabilitation Hospital
Parkinson Disease, Parkinson's Disease and Parkinsonism
Complex Eye Movements in Parkinson's Disease and Related Movement Disorders
Diagnosing Parkinson's disease (PD) depends on the clinical history of the patient and the patient's response to specific treatments such as levodopa.
- Conditions
- Parkinson Disease, Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Corticobasal Degeneration
- Trial name
- NCT04925622
- Testing
- Complex eye movement exam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saccadous, Inc.
Brain Ischemia, Adverse Effect of Thrombolytic Drugs
Pre-stroke Cognitive Status and Thrombolytic Therapy
At the acute stage of cerebral ischaemia, the only effective drug that increases the proportion of patients who survive without dependency is thrombolytic therapy by intravenous (i.v.) tissue-plasminogen activator (t-PA).
- Conditions
- Brain Ischemia, Adverse Effect of Thrombolytic Drugs, Impaired Cognition, Dementia
- Trial name
- OPHELIE-COG (NCT01713491)
- Where
- 9 sites in France, Japan
- Volunteers
- 205 people
- Sponsor
- University Hospital, Lille
Coronary Artery Disease
Characterization of Factors Influencing the Cognitive Decline in Patients With Coronary Artery Disease
The real impact of cardiac surgery and coronary angioplasty remains to be clarified and, where appropriate, the influencing factors in a way beneficial or deleterious remain to be identified.
- Trial name
- COGCAR (NCT00946959)
- Testing
- Cardiac surgery
- Where
- France
- Volunteers
- 155 people
- Sponsor
- University Hospital, Lille
Herpes Zoster, Dementia
Postherpetic Neuralgia After Herpes Zoster and Incident Dementia Risk
This retrospective observational cohort study uses de-identified electronic health record data from the TriNetX Global Collaborative Network to evaluate whether postherpetic neuralgia after herpes zoster is associated with an…
- Conditions
- Herpes Zoster, Dementia, Postherpetic Neuralgia (PHN)
- Trial name
- NCT07399288
- Testing
- Exposure: postherpetic neuralgia
- Where
- Taiwan
- Volunteers
- 73,404 people
- Sponsor
- China Medical University Hospital
Alzheimer's Disease
A Retrospective Database Study for the Development and Validation of Algorithms for Intracerebral Hemorrhage and Seizures in Alzheimer's Disease
The primary objective of this study is to develop and validate claims-based algorithms to identify intracerebral hemorrhage >1 cm in diameter, ensuring differentiation from amyloid-related imaging abnormality-microhemorrhage and…
- Trial name
- NCT07723950
- Testing
- No intervention
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Eisai Inc.
Stroke, Cognitive Decline
Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients: an FNIRS Study
This is an fNIRS study performed to investigate Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients.
- Trial name
- NCT06703320
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dingqun Bai
HIV, Arterial Stiffness
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition.
- Conditions
- HIV, Arterial Stiffness, Cognitive Dysfunction
- Trial name
- NCT05965518
- Testing
- High-Intensity Interval Training, Continuous Moderate Exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Delirium, Cognitive Impairment
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Cognitive skills are essential to live independently, manage finances, maintain employment, and function in society. Loss of these cognitive skills puts a tremendous burden on society as seen with dementias, Alzheimer's disease…
- Conditions
- Delirium, Cognitive Impairment, Alzheimer; Early Onset, Trauma
- Trial name
- INSIGHT-ICU (NCT03098459)
- Testing
- Non-interventional observational prospective cohort study
- Where
- United States
- Volunteers
- 432 people
- Sponsor
- Vanderbilt University Medical Center
Dysphagia
Nicergoline Use in Dysphagia Patients
Dysphagia is a complication in patient with stroke, Parkinson's disease or dementia that can lead to aspiration pneumonia. This study aimed to investigate dysphagia improvement after treatment with nicergoline low dose and high…
- Trial name
- NCT05551182
- Testing
- Nicergoline
- Where
- Thailand
- Volunteers
- 92 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Cognitive Impairment, Dementia
Smartphone Multimodal Health Intervention for Neurological Enhancement (SHINE)
This randomized controlled trial will enroll individuals aged ≥ 40 years without dementia who are at high risk for stroke, collecting multi-modal MRI imaging, serum, and fecal samples to investigate the effects of a…
- Conditions
- Cognitive Impairment, Dementia, Artificial Intelligence (AI), Stroke
- Trial name
- NCT07092371
- Testing
- Digital Multimodal Intervention
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Mild Cognitive Disorder, Alzheimer Disease
Digital Dementia Registry Bavaria (digiDEM Bayern): a Multicentre, Prospective, Longitudinal Register Study Including People With Mild Cognitive Impairment and Dementia as Well as Their Family Caregivers
Around 57 million people worldwide live with dementia, with approximately 10 million new cases diagnosed each year. By the end of 2023, around 1.8 million people were living with dementia in Germany, the majority of whom were…
- Conditions
- Mild Cognitive Disorder, Alzheimer Disease, Vascular Dementia, Dementia in Other Diseases Classified Elsewhere
- Trial name
- digiDEM Bayern (NCT07721701)
- Where
- 12 sites in Germany
- Volunteers
- 5,000 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Disorder of Consciousness, Paralysis
Awareness Detection and Communication in Disorders of Consciousness
STUDY OVERVIEW Brain injury can result in a loss of consciousness or awareness, to varying degrees. Some injuries are mild and cause relatively minor changes in consciousness.
- Conditions
- Disorder of Consciousness, Paralysis, Motor Neuron Disease, Stroke
- Trial name
- NCT03827187
- Testing
- Motor imagery based EEG-BCI
- Where
- 18 sites in Ireland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Ulster
Disorder of Consciousness, Traumatic Brain Injury
Sub-study of the NEURODOC Project : Neurophysiological Evaluation of a Routine Care Open Label tDCS Session
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Traumatic Brain Injury, Anoxic Brain Injury, Stroke
- Trial name
- Neurodoc (NCT04035655)
- Testing
- Coma Recovery Scale - revised, Electrophysiological recordings
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Alzheimer Disease (AD), Cardio Vascular Disease
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA).
- Conditions
- Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
- Trial name
- ALOHA (NCT07180147)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marymount University
Subcortical Vascular Dementia
Remote Ischemic Preconditioning for Subcortical Vascular Dementia
The purpose of this study is to determine whether the remote ischemic preconditioning are effective in the treatment of mild to moderate vascular dementia.
- Trial name
- RIPSVD (NCT03022149)
- Testing
- Doctormate® (200mmHg), Doctormate® (60mmHg)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Tianjin Medical University General Hospital
Cognitive Impairment, Stroke
The Efficacy of Gliatiline® on Post-stroke Patients With Vascular Cognitive Impairment no Dementia
To date, there are no approved treatments for vascular cognitive impairment (VCI) and the main therapeutic efforts are aimed at controlling vascular risk factors for countering VCI development or progression.
- Trial name
- GLITTER (NCT01363648)
- Testing
- choline alfoscerate
- Where
- South Korea
- Volunteers
- 222 people
- Sponsor
- Seoul National University Hospital
Stroke, Dementia
Nut Supplementation to Mitigate Post-stroke Cognitive Decline
Stroke is a strong risk factor for dementia, with up to 80% of individuals having lower cognitive function 5 years after a stroke event.
- Trial name
- NUT-me (NCT05902767)
- Testing
- Nuts, Control
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Monash University