Clinical trials: Vascular Neurocognitive Disorder
Stroke, Cognition Disorder
The Effects of Cognitive Rehabilitation on Motor Performance, Balance and Fear of Falling in Stroke Patients
One of the most common complications in stroke patients is cognitive impairment. Cognitive impairment affects a large part of the life of stroke patients.
- Conditions
- Stroke, Cognition Disorder, Fear Anxiety
- Trial name
- NCT05490628
- Testing
- Cognitive Rehabilitation, Conventional Therapy
- Volunteers
- 24 people
- Sponsor
- Istanbul University - Cerrahpasa
Depression, Intracranial Atherosclerosis
Intracranial Atherosclerosis and Depression After Coronary Artery Bypass Graft
The purpose of the study is to examine if blood flow in the brain before coronary artery bypass graft surgery has an effect on depression after surgery.
- Conditions
- Depression, Intracranial Atherosclerosis, Coronary Artery Disease
- Trial name
- NOAHS (NCT01838356)
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Yale University
Stroke, Subacute Stroke
Effect of Virtual Reality-Based Music Therapy on Cognitive and Motor Skills in Subacute Stroke Patients
This clinical trial aims to investigate the effects of immersive virtual reality-based music therapy on cognitive and motor functions in individuals aged 50 to 75 years with subacute stroke (between 2 weeks and 6 months…
- Conditions
- Stroke, Subacute Stroke, Virtual Reality, Immersive Virtual Reality
- Trial name
- NCT07010536
- Testing
- VR-Based Music Therapy, Conventional Physiotherapy and Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Suzan Aydın
Ischemic Stroke Hospitalized, Impairment, Cognitive
A Study Testing How Well the Drug Extract of Ginkgo Biloba Leaves Tablets Works for People With Memory or Thinking Problems After a Stroke When Added to Standard Treatment
The goal of this clinical trial is to learn if Extract of Ginkgo Biloba Leaves Tablets help improve thinking and memory in people aged 55 years and older who had an ischemic stroke (a type of stroke caused by a blocked blood…
- Trial name
- GiCIIS (NCT07220538)
- Testing
- Extract of Ginkgo Biloba Leaves Tablets 240 mg (2 x 40 mg, t.i.d.), Standard of care (SoC) Group
- Where
- 34 sites in China
- Volunteers
- 400 people
- Sponsor
- Dr. Willmar Schwabe GmbH & Co. KG
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Dementia
The Sunnybrook Dementia Study
The prospect of disease-modifying therapies in the pipeline for Alzheimer's Disease (AD) has intensified efforts to use brain imaging more effectively for diagnosis and monitoring of dementing illnesses.
- Trial name
- SDS (NCT01800214)
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Aortic Diseases, Cardiac Surgical Procedures
Selective Antegrade Cerebral Perfusion and Perioperative Optic Nerve Sheath Diameter in Ascending Aortic Surgery
In ascending aortic surgery the distal anastomosis may be constructed with the aortic cross-clamp maintained, or, where the extent of the aortic pathology and the geometry of the graft require it, after release of the cross-clamp…
- Conditions
- Aortic Diseases, Cardiac Surgical Procedures, Aortic Aneurysm, Thoracic, Delirium - Postoperative
- Trial name
- SACP-ONSD (NCT07800806)
- Testing
- Optic nerve sheath and optic nerve diameter ultrasonography, Transcranial Doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Postoperative Delirium
An MRI Study of Post-operative Delirium in Patients Undergoing Major Surgery
Hypothesis: Patients with blue cerebrovascular reactivity (CVR) regional maps during a hypercapnic CO2 challenge will be at greater risk of developing post-operative delirium (POD) and stroke following major surgery.
- Trial name
- NCT02126215
- Testing
- MRI CO2 and O2 stress testing
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Stroke, Ischemic, Mild Cognitive Impairment
Dapagliflozin Effect in Cognitive Impairment in Stroke Trial
Background: Dementia is an international public health problem, affecting approximately 50,000,000 people worldwide in 2018 and will triple by 2050; furthermore, reaching an approximate cost of 4 billion dollars.
- Conditions
- Stroke, Ischemic, Mild Cognitive Impairment, Dementia, Vascular, Metabolic Syndrome
- Trial name
- DECIST (NCT05565976)
- Testing
- Dapagliflozin 10mg Tab, Statins (Cardiovascular Agents), Platelet Antiaggregant
- Where
- Mexico
- Volunteers
- 270 people
- Sponsor
- Jaime Daniel Mondragon
Cerebral Hypoxia, Carotid Stenosis
The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels on Cognitive Functions After Carotid Endarterectomy
In this study, we investigated the effect of the capacity to cope with oxidative stress (oxidative stress response during and after clamping) in individuals with cerebral oximetry level between 40- 60 % and above 60 % and their…
- Conditions
- Cerebral Hypoxia, Carotid Stenosis, Cognitive Dysfunction
- Trial name
- NCT05652426
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Duzce University
Cognitive Impairment, Stroke Acute
Cognitive Rehabilitation in Post-stroke Cognitive Impairment
The goal of this 2-year, prospective, single-blind randomized clinical trial is to investigate: the efficacy in reducing the risk of cognitive impairment 6 months after stroke; the generalizability of cognitive reinforcement to…
- Trial name
- CIPS-TER (NCT07251517)
- Testing
- Cognitive telerehabilitation treatment
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- University of Florence
Stroke, Stroke, Acute
Improving Medication Self-Administration and Health After Brain Injury
The purpose of this research study is to assess medication self-administration (MSA) and the impact of three different interventions on improving medication adherence.
- Conditions
- Stroke, Stroke, Acute, Cognitive Impairment, Brain Injuries, Traumatic
- Trial name
- NCT03885674
- Testing
- Video Call Reminder Condition, Automated Text Message Reminder Condition
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Kessler Foundation
Stroke, Cognitive Impairment
Effects of Hyperbaric Oxygen Combined With Aerobic Exercise on Working Memory Among Stroke Patients
This single-center randomized controlled trial enrolled stroke patients with working memory impairment. Participants were randomly divided into the hyperbaric oxygen combined low-intensity focused ultrasound intervention group…
- Trial name
- NCT07772947
- Testing
- Conventional rehabilitation therapy, Moderate-intensity aerobic exercise, Hyperbaric Oxygen Therapy (HBOT)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University
Hypertension
Effect of High Blood Pressure and Antihypertensive Treatment on Brain Functioning in Children
High blood pressure, or hypertension, affects up to 10% of minority children and adolescents. Although complications of high blood pressure, such as stroke and heart attack, are uncommon in childhood, high blood pressure-related…
- Trial name
- NCT00178490
- Testing
- High blood pressure treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Postoperative Delirium (POD), Peripheral Arterial Disease
Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular Intervention
This randomized controlled trial will evaluate whether preoperative ultrasound-guided stellate ganglion block reduces the incidence of postoperative delirium in adults aged 60 years or older undergoing elective peripheral…
- Trial name
- NCT07848113
- Testing
- ropivacaine
- Volunteers
- 168 people
- Sponsor
- Assiut University
Herpes Zoster (HZ), Vascular Dementia
A Study That Collects Participant Data and Biospecimens to Analyze Pathogenic Exosomes That Mediate Increased Vascular Dementia Risk in Individuals With Herpes Zoster.
The purpose of this observational research study is to study if patients with herpes zoster, also known as Shingles, have a higher risk of vascular dysfunction (problems with blood vessels, including stroke) and vascular dementia…
- Trial name
- R01 (NCT06903078)
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Center for Clinical Studies, Texas
Postoperative Delirium, Stroke
Cyclopofol Versus Propofol for Postoperative Delirium in Elderly Patients Having Orthopedic Surgery
Postoperative delirium (POD) is common in elderly patients recovering from surgery and anesthesia. POD has adverse effects on early and long-term prognosis.
- Trial name
- NCT06046638
- Testing
- Cyclopofol, Propofol
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Neurocognitive Disorders, Dementia
The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Elderly
Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension.
- Conditions
- Neurocognitive Disorders, Dementia, Hypertension, Aged, 80 and Over
- Trial name
- TAHOC (NCT05845736)
- Testing
- Antihypertensive Agents
- Where
- France
- Volunteers
- 353 people
- Sponsor
- Central Hospital, Nancy, France
Dyslexia, Acquired, Brain Injuries
Therapy for Reading Problems in Adults After Brain Injury
Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.
- Conditions
- Dyslexia, Acquired, Brain Injuries, Cerebrovascular Accident
- Trial name
- NCT00064805
- Testing
- Cognitive Therapy to Improve Reading
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Vascular Cognitive Impairment, Dementia, Vascular
Efficacy and Safety of Ferrous Iron on the Prevention of Vascular Cognitive Impairment Among Patients With Cerebral Infarction/TIA (FAVORITE)
The prevalence of Vascular Cognitive Impairment(VCI) is high in patients after ischemic stroke or transient ischemic attack(TIA) . Effective therapy for the prevention of VCI remains limited.
- Conditions
- Vascular Cognitive Impairment, Dementia, Vascular, Iron-deficiency, Cerebral Infarction
- Trial name
- FAVORITE (NCT03891277)
- Testing
- Ferrous succinate
- Where
- China
- Volunteers
- 1,006 people
- Sponsor
- Beijing Tiantan Hospital