Clinical trials: Vascular Neurocognitive Disorder
Cardiac Surgery
Perioperative Cerebral Function Assessment for Cardiac Surgery
Perioperative neurological complications in cardiovascular surgical procedures are associated with a significant risk of mortality and disability.
- Trial name
- PEACE (NCT06660602)
- Testing
- cardiac surgery
- Where
- China
- Volunteers
- 1,845 people
- Sponsor
- China National Center for Cardiovascular Diseases
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mechanical Ventilator Weaning, Acute Brain Injury
Brain-injured Patients Extubation Readiness Study
The BIPER study is a stepped wedge cluster randomised clinical trial aiming to decrease extubation failure in critically-ill brain-injured patients with residual impaired consciousness using a simple clinical score.
- Conditions
- Mechanical Ventilator Weaning, Acute Brain Injury, Altered Level of Consciousness, Mechanical Ventilation
- Trial name
- Biper (NCT04080440)
- Testing
- Extubation readiness clinical score, Usual Care
- Where
- 21 sites in France
- Volunteers
- 660 people
- Sponsor
- University Hospital, Clermont-Ferrand
Hypertension (HTN), Vascular Diseases
The BASIC-S Feasibility Study for Vascular Risk Reduction
Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging.
- Conditions
- Hypertension (HTN), Vascular Diseases, Stroke, Dementia
- Trial name
- BASIC-S (NCT07755631)
- Testing
- BASIC-S Intervention, Standard / Usual Care
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Andrew Appleton
Cognitive Impairment, Alzheimer Disease
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study
A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults…
- Conditions
- Cognitive Impairment, Alzheimer Disease, Vascular Cognitive Impairment, Dementia
- Trial name
- SINGER (NCT05007353)
- Testing
- Structured Lifestyle Intervention, Self-Guided Intervention
- Where
- 3 sites in Singapore
- Volunteers
- 1,212 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Stroke, Stroke, Acute
Impact of COVID-19 Vaccines on Cerebrovascular Health
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines may reduce the transmission of and achieve population immunity against the COVID-19 pandemic, which accounted for more than 3.75million…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Dementia
- Trial name
- NCT04992195
- Testing
- Laboratory tests and Montreal Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hypotension, Orthostatic, Parkinson Disease
Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease
Study on orthostatic Hypotension in Parkinson's disease
- Conditions
- Hypotension, Orthostatic, Parkinson Disease, Autonomic Failure, Cognitive Impairment
- Trial name
- PaKogOH (NCT03900000)
- Testing
- Physiotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- RWTH Aachen University
Cerebral Small Vessel Diseases, Dementia, Mixed
WHIte MAtter Hyperintensity Shape and Glymphatics
In a society with increased life expectancy, the economic, social and personal burden of dementia increases. Dementia is often caused by a combination of neurovascular and neurodegenerative diseases.
- Conditions
- Cerebral Small Vessel Diseases, Dementia, Mixed, Dementia, Vascular, Mild Cognitive Impairment
- Trial name
- WHIMAS (NCT06010511)
- Testing
- 3T MRI scan, 7T MRI scan, Neuropsychological assessment
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Stroke, Cognition Disorders
Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment
This clinical trial aims to explore the effect of dual-site theta-gamma cross-frequency coupled transcranial alternating current stimulation in the frontal and parietal region on the working memory ability of patients with…
- Trial name
- NCT07573501
- Testing
- occupational therapy, real tACS
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Ke Dong, MD
Mild Cognitive Impairment, Alzheimer Disease
Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers
This study aims to provide clinical validation of EyeQuant, a fully automated retinal image analysis system for computation of vascular biomarkers indicative of cognitive disorders, using retinal fundus photographs collected from…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Vascular Dementia
- Trial name
- NCT04567745
- Testing
- Retinal fundus photography
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Stroke, Visual Impairment
Effectiveness of AV-stimulation in Immersive VR to Improve Visual Perception and Driving Performance
The goal of this clinical trial is to evaluate the effectiveness of an immersive virtual-reality (IVR) based stimulation program, in improving visual perception for people who have lost their driver's license due to perceptual or…
- Conditions
- Stroke, Visual Impairment, Low Vision, Virtual Reality
- Trial name
- Re:DriVR (NCT05703360)
- Testing
- Audiovisual Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Aphasia, Primary Progressive Aphasia
Circuitry Assessment and Reinforcement Training Effects on Recovery
This study investigates if electroencephalography (EEG) neurofeedback training is more beneficial than sham feedback training for the improvement of communication, anxiety, and sleep quality in individuals with aphasia.
- Conditions
- Aphasia, Primary Progressive Aphasia, Stroke
- Trial name
- CARTER (NCT04290988)
- Testing
- EEG Neurofeedback
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University
Stroke, Stroke (CVA) or TIA
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors.
- Conditions
- Stroke, Stroke (CVA) or TIA, Dementia, Vascular, Cerebrovascular Disorders
- Trial name
- IC3 (NCT05885295)
- Testing
- MRI brain, Blood tests, cognitive assessments
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Coronary Artery Disease, Postoperative Cognitive Dysfunction
Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
It is previously reported that the cerebral oxygen desaturation during cardiac surgery is associated with an increased incidence of cognitive impairment.
- Conditions
- Coronary Artery Disease, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT00917124
- Testing
- INVOS
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- University of Zagreb
Alzheimer s Disease, Vascular Dementia
Predictors of Emergency Department Use in Frail Patients
When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed.
- Conditions
- Alzheimer s Disease, Vascular Dementia, Frailty, Elderly
- Trial name
- THE-Spoke 10 (NCT07259499)
- Testing
- Plasma phosphorylated Tau 181
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Pisa
Orthopedic Disorder, Neurologic Disorder
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
To determine the safety and efficacy of Amniotic and Umbilical Cord Tissue for the treatment of the following condition categories: Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions.
- Conditions
- Orthopedic Disorder, Neurologic Disorder, Urologic Diseases, Erectile Dysfunction
- Trial name
- NCT03899298
- Testing
- Amniotic and Umbilical Cord Tissue Procedure
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- R3 Stem Cell
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Atrial Fibrillation (AF), Stroke
Population-based Atrial Fibrillation Screening in Individuals With NT-proBNP Above Median in the Tromsø Study
The aim is to investigate whether screening with long-term ECG monitoring in individuals with elevated NT-proBNP leads to a lower incidence of ischeamic stroke and death from vascular causes.
- Conditions
- Atrial Fibrillation (AF), Stroke, NT-pro-BNP, Cognitive Function and Well-Being
- Trial name
- PAFS-Tromsø (NCT07343895)
- Testing
- Long term heart rythm monitoring by ECG247
- Where
- 2 sites in Norway
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Ischemic Stroke
Gut Microbiota and Serum Markers for Cognitive Impairment and Poor Prognosis After Ischemic Stroke
Post-stroke cognitive impairment(PSCI) is one of the most important factors causing disabilities after stroke. Recent study found that gut microbiota plays a key role in neurological diseases.
- Trial name
- NCT04688138
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Intracerebral Hemorrhage
Short-term And Longer-term Cognitive Impact Of Neurochecks
The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI).
- Trial name
- NCT06219889
- Testing
- Frequency of neurochecks
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego