Clinical trials: Vascular Occlusive Disease
Ischemic Heart Disease, Ischemic Cardiomyopathy
Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery
Ischemic heart disease (IHD) leads the global mortality statistics. Atherosclerotic plaques in coronary arteries hallmark IHD, drive hypoxia, and may rupture to result in myocardial infarction (MI) and death of contractile…
- Conditions
- Ischemic Heart Disease, Ischemic Cardiomyopathy, Heart Failure, Systolic, Heart Failure NYHA Class III
- Trial name
- AAMS2 (NCT05632432)
- Testing
- Epicardial AAMs-patch transplantation, RNA-stabilized whole blood sampling, Plasma sampling
- Where
- Finland
- Volunteers
- 50 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Coronary Artery Disease, Radial Artery Occlusion
A Study on the Application of Simple and Improved Radial Artery Compression Method After Transradial Coronary Intervention
The objective of this study was to evaluate the specific effect of a simple modified method of thick gauze (9cm*16cm*8mm) combined with a hemostatic device in the prevention of early radial artery occlusion and other related…
- Trial name
- NCT06787287
- Testing
- Modified compression method
- Where
- China
- Volunteers
- 1,624 people
- Sponsor
- Guozhe Sun
Critical Limb Ischemia, Infrapopliteal Arterial Occlusive Disease
Self-Expanding Nitinol Stent Versus Balloon Angioplasty Alone for the Below The Knee Arteries(SENS-BTK)
The objectives of this study are to compare directly conventional balloon angioplasty alone versus. balloon angioplasty with routine stenting - that is, to determine whether angioplasty with self-expanding stent is superior to…
- Trial name
- SENS-BTK (NCT01644487)
- Testing
- self-expanding nitinol stent, balloon angioplasty
- Where
- South Korea
- Volunteers
- 122 people
- Sponsor
- Korea University Guro Hospital
Intermittent Claudication, Peripheral Vascular Disease
Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication
The purpose of this Phase 2 clinical research study is to examine the safety of an experimental gene transfer agent, Ad2/HIF-1α/VP16, and its ability to stimulate the growth of new blood vessels from existing blood vessels (a…
- Conditions
- Intermittent Claudication, Peripheral Vascular Disease, Atherosclerosis
- Trial name
- WALK (NCT00117650)
- Testing
- Ad2/HIF-1α/VP16
- Where
- 47 sites in United States, Germany and 1 more
- Volunteers
- 289 people
- Sponsor
- Genzyme, a Sanofi Company
Atherosclerosis
Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium
Current oral anti-coagulation for atrial fibrillation is most commonly performed with warfarin. Warfarin is a vitamin K antagonist that has been shown in non-randomized trials to increase vascular calcification.
- Trial name
- NCT02376010
- Testing
- rivaroxaban, Warfarin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Peripheral Arterial Disease, Intermittent Claudication
Moderate Intensity Functional Training as Adjuvant Treatment in Patients With Peripheral Arterial Disease
Traditional aerobic training and muscle resistance ('strength') training have been shown to be effective for improving functional and health-related quality of life (HRQoL) outcomes in peripheral arterial disease (PAD).
- Trial name
- NCT05126680
- Testing
- Supervised exercise therapy: intermittent treadmill walking exercise and moderate intensity functional training, Supervised exercise therapy: intermittent treadmill walking exercise
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- European University Miguel de Cervantes
Peripheral Arterial Disease, Intermittent Claudication
Utility, Safety, and Effectiveness of the Bard LifeStent 5F Vascular Stent System
The medical device being examined in this study is the Bard® LifeStent® 5F Vascular Stent System. It is intended for use in patients who suffer from peripheral artery disease (PAD).
- Trial name
- REALITY III (NCT03071146)
- Testing
- Bard® LifeStent® 5F Vascular Stent System
- Where
- 4 sites in Germany
- Volunteers
- 30 people
- Sponsor
- C. R. Bard
Carotid Stenosis, Mild Cognitive Impairment
Dental Carotid Cognitive Study
Periodontal Disease (PD) is present in 60+% of adults >65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive…
- Conditions
- Carotid Stenosis, Mild Cognitive Impairment, Periodontitis
- Trial name
- NCT03755362
- Testing
- Standard Treatment, Intensive Treatment
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Maryland, Baltimore
Aging, Walking, Difficulty
Chronic Wounds and Blood Circulation Detection
Lower limb circulatory insufficiency and the associated chronic wounds are common health problems among the elderly. These issues not only affect the individual's mobility and quality of life but also potentially increase medical…
- Conditions
- Aging, Walking, Difficulty, Chronic Limb-Threatening Ischemia, Chronic Disease
- Trial name
- NCT07330635
- Testing
- Intervention 1: Mixed exercise program, Intervention 2: High-intensity rowing exercise, Intervention 3: Vibration exercise
- Where
- Taiwan
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Coronary Artery Disease
Tele - Cardiac Rehabilitation - Providing Secondary Prevention and Supervised Exercise Without Boundaries of Time and Space - PILOT 1
We aim to enroll subjects eligible to cardiac rehabilitation that are defined as low-risk according to national guidelines. We plan to gradually reduce the number of institution based CR and increase the tele monitored exercise…
- Trial name
- NCT03228225
- Testing
- Tele Cardiac Rehabilitation
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Congestive Heart Failure, Ischemic Cardiomyopathy
Study Tests Whether a Standardized LVR Performed With the Blue Egg Device Improves Cardiopulmonary Exercise Capacity
The purpose of the present prospective, randomized study is to investigate the clinical effectiveness of standardized left ventricular reconstruction surgery (LVR).
- Conditions
- Congestive Heart Failure, Ischemic Cardiomyopathy, Coronary Artery Disease, Myocardial Diseases
- Trial name
- NCT00326690
- Testing
- Blue Egg Device
- Where
- 10 sites in United States, Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- BioVentrix
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Arterial Disease
Comparison of Lower Limb Endovascular Interventions With and Without the EndoNaut Workstation
To demonstrate that the use of EndoNaut for endovascular procedures on the femoropopliteal axis has a clinical impact for the patient (decrease in irradiation and the volume of contrast product) as well as for nursing staff…
- Trial name
- COMPAR-MI (NCT04709991)
- Testing
- Endovascular procedure
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Therenva
Acute Ischemic Stroke, Large Vessel Occlusion
Sevoflurane vs. Propofol for General Anesthesia in Patients With Acute Ischemic Stroke Treated With Endovascular Therapy
Acute ischemic stroke occurs when a blood clot blocks blood flow to part of the brain. Patients with this condition may require endovascular therapy, a procedure used to remove the clot and restore blood flow.
- Trial name
- SAVE (NCT07902791)
- Testing
- Sevoflurane, propofol (drug)
- Where
- Spain
- Volunteers
- 314 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Healthy Participants
A Study to Investigate the Safety, Tolerability and Pharmacodynamics of AZD4144 in Participants With Obesity
The aim of this study is to evaluate the safety and tolerability, and pharmacodynamics (PD) of AZD4144 administered as repeated daily oral dosing.
- Trial name
- NCT06942923
- Testing
- AZD4144
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Age-related Macular Degeneration, Coronary Artery Disease
Ranibizumab and the Risk of Arterial Thromboembolic Events
The investigators assume that ranibizumab might be dangerous in patients with history of coronary artery disease or cerebrovascular events.
- Conditions
- Age-related Macular Degeneration, Coronary Artery Disease, Cerebrovascular Disorders
- Trial name
- RATE (NCT01319188)
- Testing
- 0.5 mg of ranibizumab, 0.5 mg of ranibizumab + photodynamic therapy
- Where
- 2 sites in Netherlands, Russia
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Ural State Medical University
Coronary Artery Disease
Genotype Information and Functional Testing Study
This study is a sub-study of GRAVITAS (clinicaltrials.gov identifier NCT00645918). The purpose of this study is to assess which genes influence residual platelet reactivity on standard dose clopidogrel therapy, and also to…
- Trial name
- GIFT (NCT00992420)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Scripps Health
Coronary Artery Disease, Mitral Valve Insufficiency
Physical and Functional Recovery From Cardiac Surgery in Hospitalized Patients: A Feasibility Pilot Study
Ambulation following surgery has been found to be beneficial for patients; however, nurses and doctors struggle with getting post-operative, hospitalized patients to walk on their own.
- Conditions
- Coronary Artery Disease, Mitral Valve Insufficiency, Aortic Valve Stenosis, Aortic Valve Regurgitation
- Trial name
- NCT02375282
- Testing
- Ambulation orderly
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Baystate Medical Center
Peripheral Artery Disease
Metformin, Muscle Energetics, and Vascular Function in Older Adults With Peripheral Artery Disease
The investigators are doing this research study to find out if taking Metformin improves walking ability in patients with peripheral arterial disease (PAD).
- Trial name
- NCT01901224
- Testing
- Metformin 1000 mg
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease
Prophylactic Administration of Levosimendan in Patients Undergoing Coronary Surgery
The present pilot study aims to investigate the effectiveness of the preoperative infusion of levosimendan in patients with impaired left ventricular function undergoing coronary artery bypass grafting.
- Trial name
- NCT01318460
- Testing
- Levosimendan infusion
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- AHEPA University Hospital
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