Clinical trials: Vascular Patients
Relapsed Multiple Myeloma
Vaccination With Peptides From Anti-apoptotic Proteins in Relapsed Multiple Myeloma
Anti-apoptotic proteins from the Bcl-2 family are known to play a key role in oncogenesis and are overexpressed in myeloma cells.
- Trial name
- NCT01272466
- Testing
- peptides derived from antiapoptotic proteins
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Herlev Hospital
Multiple Myeloma (MM)
Study to Evaluate t(11;14) Status and BCL2 Expression in Adult Participants With Multiple Myeloma (MM)
Multiple myeloma (MM) is a rare cancer caused by abnormal survival of plasma cells (blood cells). Most trial participants with MM relapse (cancer has come back) or become non- responsive to treatment and remission gets shorter…
- Trial name
- MEDICI (NCT04721002)
- Where
- 40 sites in United States, Argentina and 20 more
- Volunteers
- 514 people
- Sponsor
- AbbVie
Malignant Solid Tumors, Lymphomas
tTF-NGR Phase I Study
In this phase I clinical trial cancer patients suffering from solid tumors or lymphomas, recurring after and/or refractory against standard treatment are treated intravenously (iv) with increasing doses of tTF-NGR(tTF= truncated…
- Trial name
- NCT02902237
- Testing
- tTF-NGR
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital Muenster
Stroke
Evaluate the Effectiveness and Safety of At-Home Rehabilitation Gait Training Using a Hip-assisted Wearable Robot in Stroke Patients
The goal of this clinical trial is to learn whether a wearable monitoring system can help adults who have had a stroke get more out of a home exercise program.
- Trial name
- NCT07716475
- Testing
- hip-assisted wearable robot
- Where
- South Korea
- Volunteers
- 8 people
- Sponsor
- Yonsei University
NSTEMI
A Pilot Proof of Concept, Randomized Controlled, Single-Center Study of a Decision Aid Tool for Older Patients Considering LHC as Treatment for NSTEMI
This study will be a single-center, prospective, un-blinded, randomized controlled trial evaluating a decision aid tool for older patients considering left heart catheterization (LHC) as treatment for non-ST elevation myocardial…
- Trial name
- NCT04270630
- Testing
- Shared Decision Aid
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Coronary Artery Disease
Technical Performance of a New Cardiac Technology "IQ-SPECT" Applied to SCINTI-CT Myocardial Imaging With 99mTc-Sestamibi in Coronary Patients
Cardiological examination is one of the major directions in nuclear medicine for detection of myocardial ischemia in patients with suspected coronary artery disease.
- Trial name
- IQSCINTIMYOC (NCT02524600)
- Testing
- myocardial IQ-SPECT imaging applied to scintigraphic imaging, scintigraphic imaging
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Caen
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Hypertension
Clinical Characteristics and Medication Satisfaction of Kanarb Tablet in Korean Hypertensive Patient(Kanarb-Hypertension Epidemiology Medication Satisfaction Study)
1. Investigate the clinical characteristics, medication satisfaction and quality of life of anti-hypertensive drugs in Korean hypertensive patients 2.
- Trial name
- K-HEMS (NCT02394392)
- Where
- South Korea
- Volunteers
- 12,691 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Multiple Myeloma
Carfilzomib, Lenalidomide, and Dexamethasone Re-induction Followed by the 2nd ASCT in Multiple Myeloma Patients Relapsed After the 1st ASCT
The purpose of this study is to evaluate the efficacy and safety of salvage treatment with carfilzomib/lenalidomide/dexamethasone (KRD) followed by 2nd autologous stem cell transplantation (ASCT) and lenalidomide maintenance in…
- Trial name
- KMM1911 (NCT05497102)
- Testing
- Lenalidomide maintenance
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Samsung Medical Center
Chronic Myeloproliferative Disorders, Leukemia
Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen
RATIONALE: Giving chemotherapy, such as fludarabine and busulfan, before a donor peripheral stem cell transplant helps stop the growth of cancer or abnormal cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- LCCC0510 (NCT00448357)
- Testing
- rabbit anti-thymocyte globulin (ATG), therapeutic allogeneic lymphocytes, busulfan
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Pulmonary Embolism (Diagnosis)
Clinical Management and Outcomes After Lung Scintigraphy for Suspected Pulmonary Embolism in the Emergency Department
This study will review the medical records of adults evaluated for a suspected blood clot in the lungs (pulmonary embolism) in the emergency department at Antalya Training and Research Hospital.
- Trial name
- NCT07905781
- Testing
- Pulmonary Perfusion Scintigraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Antalya Health Sciences University
Stage II Hypertension
Efficacy and Safety of Combination Therapy of Aliskiren/Amlodipine or Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Stage II Hypertension
This study assessed the efficacy and safety of combination therapy of Aliskiren/Amlodipine or Aliskiren/Amlodipine/Hydrochlorothiazide in patients with stage II Hypertension.
- Trial name
- ACADEMY (NCT01070030)
- Testing
- Aliskiren/Amlodipine (150/5 mg/day, 300/10 mg/day) , Aliskiren/Amlodipine/Hydrochlorothiazide (300/10/12.5 mg/day, 300/10/25 mg/day)
- Where
- 3 sites in Thailand
- Volunteers
- 230 people
- Sponsor
- Novartis
Critical Limb Ischemia
Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia
This study will compare the effectiveness of best available surgical treatment with best available endovascular treatment in adults with critical limb ischemia (CLI) who are eligible for both treatment options.
- Trial name
- BEST-CLI (NCT02060630)
- Testing
- Open surgical revascularization, Endovascular revascularization
- Where
- 161 sites in United States, Canada and 3 more
- Volunteers
- 1,843 people
- Sponsor
- Carelon Research
Unilateral Spatial Neglect, Stroke
Comparing Prism Adaptation Training With and Without TENS to Minimize Unilateral Spatial Neglect
This study aims to find out if doing two treatments together-Prism Adaptation Therapy (PAT) and Transcutaneous Electrical Nerve Stimulation (TENS)-will help people who have had a stroke pay better attention to one side of their…
- Trial name
- NCT07157865
- Testing
- Prism adaptation training combined with TENS, PAT only
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Kettering Health Network
Hypertension, Pulmonary
Evaluation of Inhaled Iloprost Effects Using the Breelib Nebulizer, on Clinical Outcomes and Physical Activity of Patients With Advanced Pulmonary Arterial Hypertension
The main aim of the observational VENTASTEP study was to investigate the association between changes in clinical outcome measures and changes in device outcome measures in PAH patients using the new Breelib nebulizer in a real…
- Trial name
- VENTASTEP (NCT03293407)
- Testing
- Iloprost (Ventavis, BAYQ6256), Breelib nebulizer
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Bayer
Atherosclerosis, Cardiovascular Diseases
The Role of Stem Cells on Immune Cells in the Development of Cardiovascular Diseases
An observational pilot proof-of-principle study. 15 patients with significant coronary artery disease and 15 matched controls. To investigate whether long-term activation of the innate immune system, named 'trained innate…
- Trial name
- ATHEROSTEM (NCT03172507)
- Where
- 2 sites in Netherlands
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Frailty, Coronary Artery Disease
Funcional Recovery After Minithoracotomy or Sternotomy for CABG in Frail Patients
Frailty is a major predictor of adverse outcomes following coronary artery bypass grafting (CABG), being associated with increased postoperative complications, prolonged hospitalization, delayed functional recovery, and reduced…
- Conditions
- Frailty, Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
- Trial name
- MINIFRAGILE (NCT07742475)
- Testing
- Minimally Invasive Coronary Artery Bypass Grafting (MICS-CABG), Conventional Coronary Artery Bypass Grafting (Median Sternotomy)
- Volunteers
- 194 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease
Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine
Ticagrelor is associated with more prompt and potent antiplatelet effects compared with clopidogrel, leading to better clinical outcomes, including reduced cardiovascular mortality, across the spectrum of patients with acute…
- Trial name
- NCT02403830
- Testing
- Methylnaltrexone, Morphine, Ticagrelor
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Acute Coronary Syndrome, STEMI
The Effect of Colchicine on Inflammation in ACS Patients
This study will evaluate whether the anti-inflammatory effect of colchicine is beneficial in ACS patients
- Trial name
- NCT06054100
- Testing
- Colchicine Tablets
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Right Heart Failure, Pulmonary Hypertension
Clinical Characteristics and Outcomes of Patients With Pulmonary Hypertension Associated Right Heart Failure
The study aims to describe the clinical characteristics and clarify the predictors of the short- and long-term outcomes of RHF patients, further assist the diagnosis, risk stratification and treatment of RHF.
- Trial name
- NCT06023134
- Testing
- Echocardiography, Right heart catheterization
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Jingyi Ren
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