Clinical trials: Vascular Reactivity
Coronary Artery Disease, Statin Adverse Reaction
Barriers to Optimal LDL-C Targets in Patients With Atherosclerotic Cardiovascular Disease
In the present cross-sectional observational study, the investigators aimed to: Evaluate the prevalence of achievement of LDL-C targets among a sample of Egyptian ASCVD patients.
- Conditions
- Coronary Artery Disease, Statin Adverse Reaction, LDL Level
- Trial name
- BOLT (NCT06897566)
- Testing
- Fasting lipid profile
- Where
- 2 sites in Egypt
- Volunteers
- 1,000 people
- Sponsor
- Cairo University
ELGAN (22-28SA), Extremely Low Gestational Age Newborns
Cardiovascular Immaturity in Extremely Low Gestational Age Newborns: a Fundamental Prospective Study
Birth is a major turning point in the life of the newborn, as it moves from intrauterine life to extrauterine life. This sudden transition forces the newborn to adapt quickly.
- Conditions
- ELGAN (22-28SA), Extremely Low Gestational Age Newborns, Cardiovascular Immaturity
- Trial name
- ELGAN AMINES (NCT06737965)
- Testing
- Medical abortion, Foetopathology exam, Outcomes mesurement
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Montpellier
Chronic Kidney Disease
Vascular Reactivity in Chronic Kidney Disease (CKD) Patients Receiving Paricalcitol Versus Placebo
This research is studying how Vitamin D may affect blood vessels reaction to stress and blood levels of substances that may increase blockages in the blood vessels in chronic kidney disease (CKD) patients.
- Trial name
- NCT00915876
- Testing
- Paricalcitol
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Amy Barton Pai
Coronary Artery Disease (CAD)
Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel (TRIGGER-PCI)
To determine the efficacy of prasugrel versus clopidogrel for the reduction of adverse cardiovascular outcomes in patients with high platelet reactivity on clopidogrel after successful implantation of coronary drug-eluting…
- Trial name
- TRIGGER-PCI (NCT00910299)
- Testing
- Prasugrel, Clopidogrel
- Where
- 27 sites in United States, Germany
- Volunteers
- 423 people
- Sponsor
- Eli Lilly and Company
Coronary Artery Disease
Potential Impact of Cigarette Smoking on Platelet Reactivity in Patients on Dual Antiplatelet Therapy With P2Y12 Inhibitors
All consecutive patients undergone PTCA in the period between July 2013 and December 2013 are eligible to be enrolled. Study population are divided in : Group 1: smokers on dual antiplatelet therapy with ASA (100 mg once a day)…
- Trial name
- COPTER (NCT02026713)
- Testing
- quit smoking for a 2 weeks period
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Type 2 Diabetes
Study of Metabolic and Haemodynamic Effects of Metformin and Glimepiride in Patients With Type 2 Diabetes Mellitus
Aim: The purpose of this study is to compare the effects of glimepiride(G) and metformin(M) on vascular reactivity, haemostatic factors and glucose and lipid profile in patients with type 2 diabetes.
- Trial name
- NCT01509001
- Testing
- Metformin, Glimepiride
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Acute Coronary Syndrome
Continuous Clopidogrel Dose Adjustment in Acute Coronary Syndrome Patients With High On-treatment Platelet Reactivity
The purpose of this study is to determine whether continuous clopidogrel dose adjustment targeted after platelet function testing improves outcomes during 12 months of follow-up in acute coronary syndrome patients treated with…
- Trial name
- NCT02096419
- Testing
- Clopidogrel dose adjustment
- Where
- Croatia
- Volunteers
- 87 people
- Sponsor
- University of Zagreb
Cardiovascular Diseases, Heart Diseases
Psychophysiology of Cardiovascular Reactivity
To determine why Black Americans have a higher prevalence of hypertension than whites by examining the interactions of psychosocial stressors and suppressed hostility with genetic or constitutional factors.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00005192
- Sponsor
- University of Miami
Platelet Aggregation, Coronary Artery Disease
Comparison of the VerifyNow® Aspirin Test and PRUTest® Platelet Reactivity Tests With Investigational Reagent to Reagents Registered in Japan
This is a multi-center convenience sample prospective study comparing the results of the Verify Now® Aspirin Test and PRUTest® Platelet Reactivity Tests with the Japan investigational reagents to reagents registered in Japan in…
- Trial name
- NCT03615846
- Where
- 2 sites in United States
- Volunteers
- 147 people
- Sponsor
- Accriva Diagnostics
Carotid Artery Disease
Residual Platelet Reactivity in Patients on Antiplatelet Therapy After Carotid Angioplasty With Stenting
A carotid stenosis is treated with invasive procedures of revascularization when the lumen is reduced by more than 70% or when the lumen is reduced by more than 50% in patients who have had symptoms attributable to the affected…
- Trial name
- ARS (NCT01449617)
- Testing
- Aspirin plus clopidogrel
- Where
- Italy
- Volunteers
- 272 people
- Sponsor
- Azienda Ospedaliera di Perugia
Myocardial Infarction
Novel Biomarkers of Thrombotic Risk
Treatment of patients who have had a heart attack with drugs that prevent formation of blood clots has been shown to reduce the patient's risk of subsequent cardiovascular events such as heart attack, stroke, and death.
- Trial name
- NCT02505217
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Vermont
Coronary Artery Disease
Clinical Significance of Platelet Reactivity on Clopidogrel During Off-pump Coronary Artery Bypass
Objective: To evaluate the early and late prognoses of patients according to platelet reactivity after clopidogrel administration and determine whether the measurement of platelet inhibition predicted 1-year clinical outcomes…
- Trial name
- NCT01959191
- Testing
- Dual antiplatelet therapy including aspirin and clopidogrel after off-pump coronary bypass surgery
- Where
- South Korea
- Volunteers
- 859 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Tailored Anti-platelet Therapy After DES Implantation in High-risk Patients
Clopidogrel monotherapy has been found effective in reducing ischaemic cardiovascular and haemorrhagic complications in patients with drug-eluting stent (DES) placement.
- Trial name
- NCT05936606
- Testing
- Clopidogrel monotherapy, Tailored anti-platelet therapy
- Where
- South Korea
- Volunteers
- 3,434 people
- Sponsor
- Yonsei University
Corticosteroids Adverse Reaction
Impact of Antenatal Steroids on Coagulation.
Aim of the research : 1- Detection of the presence or absence of any effect of antenatal corticosteroid administration on coagulopathy, fibrinolysis, and other haematological markers.
- Trial name
- NCT06312852
- Volunteers
- 45 people
- Sponsor
- Assiut University
Cerebral Small Vessel Diseases
Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function
Multicentre, multinational, prospective randomised, open-label, 3 sequence crossover phase III b clinical trial with blinded endpoint assessment (PROBE-design) in 75 patients with sporadic small vessel diseases (SVDs) and in 30…
- Trial name
- TREAT-SVDs (NCT03082014)
- Testing
- Amlodipine, Losartan, Atenolol
- Where
- 5 sites in Germany, Netherlands and 1 more
- Volunteers
- 101 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cardiac Complication, Vascular Diseases
Evaluation of Reporting of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Inhibitors Associated Cardiovascular Adverse reactioN.
Antiangiogenics (AAs) which are vascular endothelial growth factor (VEGF) or VEGF receptor (VEGFR) inhibitors might have high grade adverse events (AEs) on the cardio-vascular system.
- Trial name
- VEGAN (NCT03413176)
- Testing
- Cardiac complication induced by VEGF/VEGFR inhibitor
- Where
- France
- Volunteers
- 150,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Platelet Aggregation, Spontaneous, Coronary Artery Disease
Effect of Low Dose of Colchicine on Platelet Reactivity
Inflammation plays an important role in atherosclerosis and the occurrence of ischemic events. Statins, in addition to their lipid-lowering effect, have also documented anti-inflammatory effect that may partly explain their…
- Trial name
- NCT05956145
- Testing
- Colchicine 0.5 MG
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Chronic Kidney Disease, Anemia
The Effect on Vascular Reactivity Using the Erythropoeitin Alpha on Incident Peritoneal Dialysis Patients
This is a prospective observational study on incident peritoneal dialysis patients on the effect of hemoglobin level and vascular reactivity using the generic erythropoietin alpha.
- Conditions
- Chronic Kidney Disease, Anemia, Complication of Peritoneal Dialysis
- Trial name
- NCT03286712
- Testing
- Renogen
- Where
- Philippines
- Volunteers
- 30 people
- Sponsor
- National Kidney and Transplant Institute, Philippines
Blood Clots, Infection and Inflammatory Reaction
Cobas® Lumira Collection of Venous and Capillary Blood Samples for the Research, Optimization and Calibration of New Diagnostic Devices
This study is a blood sample collection study, collecting venous and capillary blood samples from adult patients in the UK, with a range of health conditions.
- Conditions
- Blood Clots, Infection and Inflammatory Reaction, Heart Disease, Kidney Disease
- Trial name
- EVOLVE (NCT07378514)
- Testing
- Blood samples are obtained and pseudonymized, prior to use for the development, optimization and calibration of diagnostic tests
- Volunteers
- 30,000 people
- Sponsor
- LumiraDx UK Limited
Sleep Apnea, Obstructive
The Effects of CPAP Withdrawal on Cerebral Vascular Reactivity and Brain Oxygenation in OSA
Obstructive sleep apnoea (OSA) is a highly prevalent sleep-related breathing disorder associated with adverse cardiovascular outcome. Underlying mechanisms are subject of debate.
- Trial name
- NCT02493673
- Testing
- Continuous positive airway pressure device
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich