Clinical trials: Vascular Risk
Deep Vein Thrombosis, Pulmonary Embolus
VERITAS: An Evaluation of the Veniti Vidi Retrievable Inferior Vena Cava Filter System in Patients at Risk for Pulmonary Embolism
This is a prospective, multicenter single arm, nonrandomized study that will include 150 patients at a maximum of 20 investigational sites. It is estimated that it may take 13 months to complete enrollment.
- Trial name
- VERITAS (NCT01787773)
- Testing
- Veniti Inferior Vena Cava Filter
- Where
- 2 sites in Australia, New Zealand
- Sponsor
- Veniti
Chronic Renal Disease, Diabetic Foot
Relationship Between Chronic Renal Disease and Risk Stratification for Chronic Ulcer on the on the Diabetic Foot
Context and hypothesis: The prevalence of diabetes mellitus keeps going to increase, due to the ageing of the population and the high prevalence of overweight and obesity.
- Trial name
- NEPHROPOD (NCT04100551)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Coronary Artery Disease, Glaucoma
Prospective Electronic Polygenic Risk Study - Second Phase
This study will investigate the role of polygenic risk scores (PRS) in preventive health.
- Trial name
- PEPRS2 (NCT05175651)
- Testing
- Genetic risk assessment
- Volunteers
- 10,000 people
- Sponsor
- Scripps Translational Science Institute
Pre-eclampsia, Obesity
ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes
Obesity is a growing problem in East London and every other woman who enters pregnancy is obese or overweight. In addition to obesity, other metabolic risk factors such as raised lipids, high blood pressure and diabetes increase…
- Conditions
- Pre-eclampsia, Obesity, Raised Lipids, High Blood Pressure
- Trial name
- ESTEEM (NCT02218931)
- Testing
- Targeted ESTEEM diet, Non-randomised cohort
- Where
- United Kingdom
- Volunteers
- 3,442 people
- Sponsor
- Queen Mary University of London
Lipid Disorder, Hypercholesterolemia
Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial
Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders (EMERALD) is a protocolized intervention based on American College of Cardiology/American Heart Association and US Preventive Services Task Force guidelines…
- Conditions
- Lipid Disorder, Hypercholesterolemia, Cardiovascular Diseases, Atherosclerosis
- Trial name
- EMERALD RCT (NCT06488105)
- Testing
- Statin (rosuvastatin 10 or 40 mg daily, depending on risk), Healthy Lifestyle Counseling, Outpatient Followup
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Wake Forest University Health Sciences
Coronary Artery Disease
Drug-Coated Balloon in Anticoagulated and Bleeding Risk Patients Undergoing PCI
The purpose of this study is to compare DCB with DES in stable CAD or ACS patients who are at high risk of bleeding. The hypothesis of the DEBATE trial is that the strategy using DCB and a shorter DAPT regimen is non-inferior to…
- Trial name
- DEBATE (NCT04814212)
- Testing
- Percutaneous coronary intervention using drug-coated balloon, Percutaneous coronary intervention using drug-eluting stent
- Where
- 14 sites in Finland, France and 2 more
- Volunteers
- 546 people
- Sponsor
- North Karelia Central Hospital
Coronary Artery Disease, Type II Diabetes Mellitus
Innovative Strategies For Risk Reduction Following CABG
Background: Treatment targets for cardiac risk factor reduction are not being met. Therefore, there is a need for new strategies to assist patients in meeting these goals.
- Trial name
- NCT00462436
- Testing
- Consumption of Dietary Portfolio
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Unity Health Toronto
Diabetes, Diabetes Mellitus
Computer-Assisted Cancer Risk Behavior Counseling
To test whether or not giving patients information before their doctor visits changes the care they receive and what type of information is best to give before the doctor visit.
- Conditions
- Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- NCT00242645
- Testing
- Health Information, Preventive Services, Computer tailored information
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Carotid Artery Atheroma, Cardiovascular Risk Stratification
Randomized Controlled Trial on Carotid Atherosclerosis Screening in Asymptomatic Smokers and Hypertensive Adults: Prevalence and Impact on Cardiovascular Prevention
Title of the study: Carotid Atherosclerosis Screening: Epidemiological Profile and Preventive Intervention. Objective: The main objective of this study is to characterize and identify the prevalence of carotid atherosclerosis in…
- Trial name
- CAROTID-CARE (NCT06848283)
- Testing
- Carotid ultrasonography
- Volunteers
- 4,780 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Meningioma
Somatostatin Receptor PET Imaging to Guide Radiotherapy Dose Escalation in High Risk Meningiomas.
High-risk meningiomas always require postsurgical radiation treatment. Recent evidence has shown that increased radiation therapy dose may be associated with increased intracranial control of disease.
- Trial name
- SPIDER-MEN (NCT06830356)
- Testing
- Dose escalation of radiation therapy, based on somatostatin receptor PET imaging
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Coronary Disease
Thromboxane B2 and Platelet Function Testing as Measures of Aspirin Resistance in Hong Kong Chinese Patients
The hypotheses of the study are that the diagnostic accuracy of Multiplate® device for diagnosis of aspirin resistance is comparable to the serum TXB2 assay and that certain genetic polymorphisms and phenotypic factors…
- Trial name
- NCT04863053
- Testing
- Blood samples will be taken to assess platelet function. There is no change in treatment.
- Where
- Hong Kong
- Volunteers
- 266 people
- Sponsor
- Chinese University of Hong Kong
Stroke
Effect of a PBT Combined With FES on Reactive Balance Persons With in Stroke
The goal of this clinical trial is to evaluate the effect of a 4-week perturbation-based balance training with and without targeted Neuromuscular electrical stimulation on neuromechanic gait fall risk predictor and reactive…
- Trial name
- NCT06237972
- Testing
- 4-week Perturbation-based balance training, Neuromuscular electrical stimulation
- Where
- Chile
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Acute Coronary Syndrome
Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS
A placebo-controlled, randomized, double-blind, parallel group, phase III multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile.
- Trial name
- dal-GenE (NCT02525939)
- Testing
- dalcetrapib
- Where
- 557 sites in United States, Argentina and 30 more
- Volunteers
- 6,147 people
- Sponsor
- DalCor Pharmaceuticals
Peripheral Arterial Disease, Hypercholesterolemia
Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease
The purpose of this study was to evaluate whether an intensified multifactorial intervention program about cardiovascular risk factors in subjects with peripheral arterial disease (with and without diabetes mellitus), can improve…
- Conditions
- Peripheral Arterial Disease, Hypercholesterolemia, Hypertension, Diabetes Mellitus
- Trial name
- NCT00144937
- Testing
- Stepwise therapy for dyslipidemia, hypertension and diabetes, Dietary recommendations, Increase in physical activity
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Hospital de Sabadell
Myocardial Infarction
Innovative Stratification of Arrhythmic Risk (ISAR-Trial): Eldery
The objective of this study was to determine the prognostic utility of established risk predictors following acute ST elevation myocardial infarction in patients over 75 years of age.
- Trial name
- NCT00196300
- Where
- 2 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Coronary Heart Disease, Dyslipidemia
Cardiovascular Risk Factor Management in HIV Infection
There is growing evidence that antiretroviral therapy (ART) increases the risk of coronary heart disease (CHD) through metabolic side effects, such as dyslipidemia, insulin resistance, and type II diabetes.
- Conditions
- Coronary Heart Disease, Dyslipidemia, Diabetes Mellitus, Non-Insulin-Dependent, HIV Infection
- Trial name
- NCT00264394
- Testing
- Updated CHD risk profiles, Guidelines
- Where
- 7 sites in Switzerland
- Volunteers
- 4,097 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Artery Disease, Heart Failure
Clinical Trial of Ventiflow LP Supporting High-risk Percutaneous Coronary Intervention(PCI)
The purpose of this prospective, multicenter, randomized controlled clinical trial is to evaluate the effectiveness of the transcatheter left ventricular assist system (Ventiflow LP) in providing circulatory support to patients…
- Conditions
- Coronary Artery Disease, Heart Failure, High-risk PCI
- Trial name
- NCT06754839
- Testing
- Percutaneous left ventricular assist device(Ventiflow LP), VA-ECMO
- Volunteers
- 250 people
- Sponsor
- Suzhou Hearthill Medical Technology Co.,LTD
Ischemia, Myocardial, Risk Factor, Cardiovascular
Risk Profiling for Patients With Isolated or Combined Coronary and Cerebral Ischemia, and Current Management Status
This study will delineate the risk profile of patients with isolated cerebral or coronary ischemia and those with combined disease.
- Conditions
- Ischemia, Myocardial, Risk Factor, Cardiovascular, Ischemia, Cerebral
- Trial name
- NCT02989077
- Volunteers
- 3,000 people
- Sponsor
- Egyptian Cerebro-Cardio-Vascular Association
Diabetic Foot
The Effect of Thermal Evaluation in Prevention of Diabetic Foot Ulcer
The study was planned as a prospective randomized controlled clinical trial to determine the effect of thermal evaluation in preventing diabetic foot ulcers in patients with Type II Diabetes Mellitus (DM).
- Trial name
- NCT04480801
- Testing
- Thermal Evaluation and Foot Care, Foot Care
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Fatma Özkal
Healthy
Dietary Salt Intake and Vascular Function
The purpose of this study is to look at the effects of high- and low-salt diets on blood vessel function in healthy subjects.
- Trial name
- NCT00590512
- Testing
- High sodium, Low sodium
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
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