Clinical trials: Vascular Risk
Venous Thromboembolism
RIVET - Retrospective Cohort Study on the Risk of Venous Thromboembolism
The risk of venous thromboembolism (VTE) associated with the use of chlormadinone acetate (CMA) compared to the gold-standard progestin levonorgestrel (LNG) as component of combined oral contraceptives (COC) is currently unknown.
- Trial name
- RIVET-RCS (NCT02828904)
- Where
- Germany
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Endothelial Function, Aerobic Exercise
VascuFit: Exercise and Vascular Aging
Exercise is a cornerstone of health care helping to improve and maintain a good organ functionality, including vascular function, in health and disease.
- Conditions
- Endothelial Function, Aerobic Exercise, Middle-aged Adults Sedentary, Elevated CV-risk)
- Trial name
- VascuFit (NCT05235958)
- Testing
- non-linear periodized exercise (NLPE), Exercise counselling
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Karsten Königstein
Cardiovascular Diseases, Myocardial Infarction
Effect of Drug Therapy on Reinfarction Risk in Women
To evaluate the safety of calcium-channel blockers in the secondary prevention of myocardial infarction in women.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005389
- Sponsor
- University of Washington
Psoriasis, Cardiovascular Diseases
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
In a prospective cohort study (n = 1.000), the investigators aim to investigate the correlation between cardiac biomarkers and advanced echocardiography and determine whether these are prognostic markers of heart disease in…
- Conditions
- Psoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
- Trial name
- PSOCADIA (NCT04950218)
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
Cardiac Rupture
Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction
The purpose of this study is to validate a practical risk score to predict the mechanical complication of ST-elevation myocardial infarction (STEMI).
- Trial name
- NCT02484326
- Testing
- Grouping by different risk stratification
- Where
- China
- Volunteers
- 3,779 people
- Sponsor
- Chinese PLA General Hospital
Atherosclerosis, Cardiovascular Risk Factor
Early Vascular Ageing in the YOUth
This is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on Intima-Media-Thickness of the carotid artery and the…
- Conditions
- Atherosclerosis, Cardiovascular Risk Factor, Cardiovascular Diseases, Cardiovascular Pathology
- Trial name
- EVA4YOU (NCT04598685)
- Where
- Austria
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Cardiovascular Diseases, Heart Diseases
Risk Factors for CV Disease in a Dialysis Cohort
To investigate whether traditional risk factors and novel risk factors predict higher risk of atherosclerotic cardiovascular disease (ASCVD) in a prospective study of incident dialysis patients.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Kidney Failure, Chronic
- Trial name
- NCT00006297
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Heart Diseases
Social Support and CHD Risk Factors--A Community Study
To examine the mechanism through which social support affects morbidity and mortality from coronary heart disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005343
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Depression, Depressive Symptoms
Beating the Blues for Your Heart
The objective of this clinical trial is to evaluate whether a computerized depression treatment, delivered before the onset of heart disease, reduces the risk of heart disease in the future.
- Conditions
- Depression, Depressive Symptoms, Cardiovascular Disease (CVD), Coronary Artery Disease (CAD)
- Trial name
- BtB-Heart (NCT01605552)
- Testing
- Beating the Blues (BtB), Usual Care
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Indiana University
Thromboprophylaxis, Thromboembolism, Venous
Thromboembolic Risk Assessment in Patients Admitted With Acute Medical Diseases to Conventional and At Home Hospitalization
The thromboembolic disease is a common complication of patients admitted to conventional hospitalization units. To prevent such complications, thromboprophylaxis is indicated in high-risk patients identified with validated…
- Conditions
- Thromboprophylaxis, Thromboembolism, Venous, Atrial Fibrillation, Physical Inactivity
- Trial name
- TROMBODOM (NCT06110949)
- Testing
- Triaxial accelerometry
- Where
- Spain
- Volunteers
- 1,953 people
- Sponsor
- Universidad Pública de Navarra
Coronary Stenosis
EluNIR Ridaforolimus Eluting Coronary Stent System in Patients at High Bleeding Risk (HBR)- EluNIR HBR Study
The study will enroll approximately 316 subjects with a wide spectrum of PCI indications (stable angina as well as ACS), who are considered to be at high risk of bleeding.
- Trial name
- NCT03877848
- Testing
- Percutaneous Coronary Intervention (PCI)
- Where
- Israel
- Volunteers
- 319 people
- Sponsor
- Medinol Ltd.
Coronary Artery Disease
Atorvastatin Pre-Treatment Influences the Risk of Percutaneous Coronary Intervention Study
This study investigates potential protective effect of atorvastatin pre-treatment in patient with stable coronary artery disease undergoing percutaneous coronary intervention (PCI).
- Trial name
- TIPS (NCT00469326)
- Testing
- Atorvastatin
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital, Motol
Blood Pressure, Hypertension
PACESETTER: Program to Avoid Cerebrovascular Events Through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor
Program to Avoid Cerebrovascular Events through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor (PACESETTER) aims to assess the incorporation of its stroke intervention into 2 safety net/academic health…
- Conditions
- Blood Pressure, Hypertension, Mhealth
- Trial name
- NCT03401489
- Testing
- PACESETTER
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Northern California Institute of Research and Education
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Coronary Artery Disease, Coronary Computed Tomography Angiography
Trustworthy, Integrated Artificial Intelligence Tools for Predicting High-risk CORonary PlaqueS
Coronary artery disease (CAD) is among the leading cause of death and disability. Identification of patients at high risk of cardiovascular events is pivotal.
- Trial name
- AI-CORPS (NCT06410690)
- Where
- 2 sites in Italy
- Volunteers
- 4,000 people
- Sponsor
- Centro Cardiologico Monzino
Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI), High Bleeding Risk
Genotype-Guided Abbreviated DAPT Versus Un-Guided De-escalation Therapy in Patients With ACS and HBR
The aim of this study is to assess the safety and efficacy of the CYP2C19 genotype-guided abbreviated dual antiplatelet therapy (DAPT) strategy versus the un-guided stepwise intensity de-escalation of DAPT strategy in patients…
- Trial name
- GUIDE-HBR (NCT06763744)
- Testing
- P2Y12 antagonist monotherapy, clopidogrel + aspirin
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Heart Failure With Reduced Ejection Fraction
STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI
STRATUS-PCI is a pilot clinical trial that compares two ways of running a small heart pump called Impella CP during a high-risk procedure to open blocked heart arteries (percutaneous coronary intervention, or PCI) in patients…
- Trial name
- STRATUS-PCI (NCT07588399)
- Testing
- Impella CP
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Rayyan Hemetsberger
Plasma Cell Myeloma
Isatuximab in Combination With Lenalidomide and Dexamethasone in High-risk Smoldering Multiple Myeloma
Primary Objectives: Safety run-in Part: To confirm the recommended dose of isatuximab when combined with lenalidomide and dexamethasone in participants with high-risk smoldering multiple myeloma (SMM) Randomized Phase 3 Part: To…
- Trial name
- NCT04270409
- Testing
- Isatuximab SAR650984, Lenalidomide, Dexamethasone
- Where
- 105 sites in United States, Australia and 22 more
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- Sanofi
Diabetic Retinopathy
Analysis of DR Progression to Identify Risks and Need for Treatment
The goal of this observational study is to understand whether vascular and structural changes in the eyes caused by diabetes can help predict which people are more likely to experience worsening diabetic retinopathy (a…
- Trial name
- ALERT (NCT07417410)
- Where
- Portugal
- Volunteers
- 1,000 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Cardiovascular Diseases, Heart Diseases
Minnesota Heart Survey - Risk Factor Survey
To continue surveillance of cardiovascular disease risk factors in the seven-county area of Minneapolis-St. Paul.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Cerebrovascular Accident, Coronary Disease
- Trial name
- MHS (NCT00005145)
- Sponsor
- University of Minnesota
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